| 12107655 |
Moretto A, Lotti M: The relationship between isofenphos cholinergic toxicity and the development of polyneuropathy in hens and humans. Arch Toxicol. 2002 Jun;76(5-6):367-75. Epub 2002 May 16.
To explain this difference the following hypotheses were tested: (1) phoxim is a promoter of isofenphos-induced OPIDP; (2) whereas neuropathy target esterase (NTE) is thought to be the target of OPIDP, activation of isofenphos by liver microsomes causes the formation of more potent NTE inhibitor (s) in humans than in hens; (3) in contrast to hen NTE, the sensitivity of the human enzyme to such inhibitor (s) is higher than that of acetylcholinesterase (AChE), the target of cholinergic toxicity. |
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