| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | demeton-S |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7237776 | Lewis PJ, Lowing RK, Gompertz D: Automated discrete kinetic method for erythrocyte acetylcholinesterase and plasma cholinesterase. Clin Chem. 1981 Jun;27(6):926-9. To emphasize the need for measuring both erythrocyte acetylcholinesterase and plasma cholinesterase activity in workers exposed to organophosphate pesticides, we present a study of serial activities of both enzymes in a person accidentally exposed to demeton-S-methyl. |
9(0,0,1,4) | Details |
| 16766477 | Cho TM, Wild JR, Donnelly KC, Tiffany-Castiglioni E: Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J Toxicol Environ Health A. 2006 Aug;69(15):1413-29. Anti-AChE activities of mipafox, methyl parathion, and demeton-S were partially ameliorated, depending on OP concentration. |
9(0,0,1,4) | Details |
| 11052723 | Gao JR, Zhu KY: Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae). J Agric Food Chem. 2000 Oct;48(10):4717-22. The OR-1 clone showed lower levels of resistance to phenyl (parathion and parathion-methyl) and heterocyclic (chlorpyrifos) OPs than to aliphatic OPs (dimethoate, omethoate, disulfoton, and demeton-S-methyl), whereas the OR-2 clone showed a rather broad spectrum of resistance to nearly all OP insecticides examined. In vitro inhibition of acetylcholinesterase (AChE) using six selected OP oxon analogues showed that alterations of AChE were involved in resistance to all OP compounds examined in both the OR-1 and OR-2 clones. |
3(0,0,0,3) | Details |
| 10421489 | Richards P, Johnson M, Ray D, Walker C: Novel protein targets for organophosphorus compounds. Chem Biol Interact. 1999 May 14;119-120:503-11. Rates of reaction of these labelling sites with a range of OP compounds were compared to that of acetylcholinesterase. Neither labelling band reacted with chlorfenvinphos or demeton-s-methyl at significant rates. |
3(0,0,0,3) | Details |
| 15532677 | Benting J, Nauen R: Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates resistance to pirimicarb and omethoate. Pest Manag Sci. 2004 Nov;60(11):1051-5. Here, we describe for the first time that recombinantly expressed AChE1 from A gossypii carrying the S431F mutation is insensitive to pirimicarb and omethoate, but sensitive to demeton-S-methyl and hypersensitive to carbofuran. |
2(0,0,0,2) | Details |
| 7726573 | Lai K, Stolowich NJ, Wild JR: Characterization of P-S bond hydrolysis in organophosphorothioate pesticides by organophosphorus hydrolase. Arch Biochem Biophys. 1995 Apr 1;318(1):59-64. The extensive use of organophosphorothioate insecticides in agriculture has resulted in the risk of environmental contamination with a variety of broadly based neurotoxins that inhibit the acetylcholinesterases of many different animal species. Phosphorothiolate esters, such as demeton-S, provided noncompetitive inhibition for paraoxon (a P-O triester) hydrolysis, suggesting that the binding of these two different classes of substrates was not identical. |
2(0,0,0,2) | Details |
| 15629114 | Fischer S, Arad A, Margalit R: Lipsome-formulated enzymes for organophosphate scavenging: butyrylcholinesterase and Demeton-S. Arch Biochem Biophys. 2005 Feb 1;434(1):108-15. Monolayers of PC-12 cells were selected for feasibility testing based on: high affinity binding of the bioadhesive liposomes-DeltaG0 release upon binding ranged from -9 to -12 kcal/mol ligand; ability to mimic an organophosphate attack upon intact cells and measuring its impact on intracellular acetylcholinesterase. |
1(0,0,0,1) | Details |
| 954759 | Okonek S, Boelcke G, Hollmann H: Therapeutic properties.of haemodialysis and blood exchange transfusion in organophosphate poisoning. Eur J Intensive Care Med. 1976;2(1):13-8. Human blood was contaminated with nitrostigmine, dimethoate and demeton-S-methyl sulfoxide. Acetylcholinesterase activity increased only briefly in the period of blood exchange transfusion and decreased gradually afterwards. |
1(0,0,0,1) | Details |
| 20132373 | Schofield DA, Dinovo AA: Generation of a mutagenized organophosphorus hydrolase for the biodegradation of the organophosphate pesticides malathion and demeton-S. J Appl Microbiol. 2010 Jan 11. Activity was associated with organophosphate detoxification as the hydrolysed substrate lost the ability to inhibit acetylcholinesterase. |
1(0,0,0,1) | Details |
| 11118318 | Gopal S, Rastogi V, Ashman W, Mulbry W: Mutagenesis of organophosphorus hydrolase to enhance hydrolysis of the nerve agent VX. Biochem Biophys Res Commun. 2000 Dec 20;279(2):516-9. Based on the crystal structure of OPH and the similarities it shares with acetylcholinesterase, eight OPH mutants were constructed with the goal of increasing OPH activity toward VX. The activities of crude extracts from these mutants were measured using VX, demeton-S methyl, diisopropylfluoro- ethyl parathion, paraoxon, and EPN as substrates. |
1(0,0,0,1) | Details |
| 2539961 | Besser R, Hopf HC, Gutmann L, Dillmann U: [The decrement-increment phenomenon in disorders of neuromuscular transmission by inhibition of acetylcholinesterase]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1989 Mar;20(1):28-33. |
1(0,0,0,1) | Details |
| 2841086 | Besser R, Dillmann U, Gutmann L, Hopf HC: [The repetitive muscular action potential in neuromuscular transmission disorders due to acetylcholinesterase inhibition]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1988 Jun;19(2):85-91. |
1(0,0,0,1) | Details |