| Name | eukaryotic translation initiation factor 5A |
|---|---|
| Synonyms | EIF 5A; EIF5A; EIF5A1; Eukaryotic initiation factor 5A isoform 1; Eukaryotic translation initiation factor 5A; Eukaryotic translation initiation factor 5A 1; Rev binding factor; eIF 4D… |
| Name | butylamine |
|---|---|
| CAS | 2-butanamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9188485 | Wolff EC, Folk JE, Park MH: Enzyme-substrate intermediate formation at 329 of human deoxyhypusine synthase. J Biol Chem. 1997 Jun 20;272(25):15865-71. Separate experiments showing efficient transfer of labeled butylamine moiety from enzyme intermediate to eIF-5A precursor strongly support a reaction mechanism involving an imine intermediate. |
114(1,2,2,4) | Details |
| 9396730 | Tome ME, Fiser SM, Payne CM, Gerner EW: Excess accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. Biochem J. 1997 Dec 15;328 ( Pt 3):847-54. Accumulation of excess intracellular inhibits the formation of hypusine in vivo, a reaction that proceeds by the transfer of the butylamine moiety of to residue in eukaryotic initiation factor 5A (eIF-5A). |
34(0,1,1,4) | Details |
| 10736626 | Caraglia M, Tagliaferri P, Budillon A, Abbruzzese A: Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy. Adv Exp Med Biol. 1999;472:187-98. Hypusine is formed by the transfer of the butylamine portion from to the epsilon-amino group of a specific residue of eIF-5A precursor and the subsequent hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety. |
34(0,1,1,4) | Details |
| 7721768 | Wolff EC, Lee YB, Chung SI, Folk JE, Park MH: Deoxyhypusine synthase from rat testis: purification and characterization. J Biol Chem. 1995 Apr 14;270(15):8660-6. This NAD-dependent enzyme catalyzes the formation of deoxyhypusine by transfer of the butylamine portion of to the epsilon-amino group of a specific residue in the eIF-5A precursor. |
33(0,1,1,3) | Details |
| 10630376 | Kang KR, Chung SI: Characterization of yeast deoxyhypusine synthase: PKC-dependent phosphorylation in vitro and functional domain identification. Exp Mol Med. 1999 Dec 31;31(4):210-6. The biosynthesis of hypusine [Nepsilon-(4-amino-2-hydroxybutyl)- occurs in the eIF-5A precursor protein through two step posttranslational modification involving deoxyhypusine synthase which catalyzes transfer of the butylamine moiety of to the epsilon-amino group of a designated residue and subsequent hydroxylation of this intermediate. |
31(0,1,1,1) | Details |
| 11104695 | Lee CH, Park MH: Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates. Biochem J. 2000 Dec 15;352 Pt 3:851-7. Deoxyhypusine synthase catalyses the NAD-dependent transfer of the butylamine moiety from the polyamine, to a specific residue of a single cellular protein, eukaryotic translation-initiation factor 5A (eIF5A) precursor. |
31(0,1,1,1) | Details |
| 12232418 | Mehta AM, Saftner RA, Mehta RA, Davies PJ: Identification of Posttranslationally Modified 18-Kilodalton Protein from Rice as Eukaryotic Translation Initiation Factor 5A. Plant Physiol. 1994 Dec;106(4):1413-1419. Differential labeling of the protein with labeled amines provided evidence that the butylamine moiety of is the immediate precursor of the hypusine residue in the protein. |
5(0,0,0,5) | Details |