Protein Information

Name MAD2
Synonyms MAD 2; MAD2; MAX interacting protein 1; MXI 1; MXI1; MXI1 protein; MAX interactor 1; MXD 2…

Compound Information

Name benomyl
CAS

Reference List

PubMed Abstract RScore(About this table)
18178775 Park CJ, Park JE, Karpova TS, Soung NK, Yu LR, Song S, Lee KH, Xia X, Kang E, Dabanoglu I, Oh DY, Zhang JY, Kang YH, Wincovitch S, Huffaker TC, Veenstra TD, McNally JG, Lee KS: Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics. Eukaryot Cell. 2008 Mar;7(3):444-53. Epub 2008 Jan 4.

In addition, cdc5-11 required MAD2 for both cell growth and the benomyl-remedial phenotype.
6(0,0,1,1) Details
1651172 Li R, Murray AW: Feedback control of mitosis in budding yeast. Cell. 1991 Aug 9;66(3):519-31.

We isolated budding yeast mutants sensitive to the anti-microtubule drug benomyl.
We cloned MAD2, which encodes a putative calcium-binding protein whose disruption is lethal.
1(0,0,0,1) Details
10436016 Chen RH, Brady DM, Smith D, Murray AW, Hardwick KG: The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol Biol Cell. 1999 Aug;10(8):2607-18.


We have cloned the MAD2 gene, which encodes a protein of 196 amino acids that remains at a constant level during the cell cycle.
1(0,0,0,1) Details
7622604 Guenette S, Magendantz M, Solomon F: Suppression of a conditional mutation in alpha-tubulin by overexpression of two checkpoint genes. J Cell Sci. 1995 Mar;108 ( Pt 3):1195-204.

Excess BUB3 rescues both the loss of viability and microtubule defects but not the benomyl supersensitivity associated with tub1-729.
Overexpression of BUB1, which interacts genetically with BUB3 and which is involved in the same checkpoint pathway, also rescues the cold sensitivity of tub1-729, but another checkpoint gene, MAD2, does not.
1(0,0,0,1) Details
11134360 Steuerwald N, Cohen J, Herrera RJ, Sandalinas M, Brenner CA: Association between spindle assembly checkpoint expression and maternal age in human oocytes. Mol Hum Reprod. 2001 Jan;7(1):49-55.


The mitotic arrest deficient (MAD2) and budding uninhibited by benomyl (BUB1) genes encode conserved kinetochore-associated proteins believed to be components of the checkpoint regulatory pathway.
1(0,0,0,1) Details