benomyl

Identification (Source:EPA,EU)

ID 130
Name benomyl
CAS 17804-35-2
IUPAC methyl 1-(butylcarbamoyl)benzimidazol-2-ylcarbamate
Inchi IInChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)
CIPAC 206
EPA Code 099101
Formula C14H18N4O3
SMILES O=C(n1c2ccccc2nc1NC(=O)OC)NCCCC
Status Not Approved

Classification

Mode of Action Systemic with protectant and eradicant activity. Also has ovicidal activity against mites. Inhibition of mitosis and cell division.
Pesticide Type Fungicide, Miticide
Chemical Group Benzimidazole
Classification carbamate nematicides
carbamate acaricides
benzimidazolylcarbamate fungicides
benzimidazole fungicides

Properties (Source:PubChem)

Molecular Weight 290.32
Physical State Tan coloured crystals
AlogP 2.965
H-Bond Donor 2
H-Bond Acceptor 4
Surface Area 291.34
Polar Surface Area 85.25

Structure



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3D similarity method

2D similarity method

Compound Database



Bioactivity Database

KEGG (5,928)

PDB (7,072)


Similarity Threshold

Ecotoxicology (Source:PPDB,IPM)

Species Method Study Time Dose Type Value
Algae Acute 72 hour EC50, growth 2 mg l-1
Aquatic crustaceans Acute 96 hour LC50 0.14 mg l-1
Aquatic invertebrates Chronic 21 day NOEC 0.025 mg l-1
Aquatic invertebrates Acute 48 hour EC50 0.28 mg l-1
Aquatic plants Acute 7 day EC50, biomass 2.2 mg l-1
Birds Acute LD50 1000 mg kg-1
Earthworms Acute 14 day LD50 10.5 mg kg-1
Fish Acute 96 hour LC50 0.17 mg l-1
Fish Chronic 21 day NOEC 0.011 mg l-1
Honeybees Acute 48 hour LD50 10 μg bee-1
Mammals Acute oral LD50 > 10000 mg kg-1
Mammals Short term dietary NOEL 2500 ppm diet
Mammals Short term dietary NOEL 125 mg kg-1
Bio-concentration factor CT50 Not available days
Bio-concentration factor BCF 27

Related targets

Target Name RScore (About this table)
FLR1 593(5,10,14,23) Details
alpha tubulin 320(2,5,8,55) Details
ALDH2 187(1,4,4,17) Details
Aldehyde dehydrogenases (protein family or complex) 153(1,3,3,13) Details
cytochrome P450 (protein family or complex) 113(1,2,2,3) Details
dynein (protein family or complex) 125(1,1,3,35) Details
XRN1 86(1,1,1,6) Details
chitinase 83(1,1,1,3) Details
CENP B 81(1,1,1,1) Details
aldo keto reductase (protein family or complex) 81(1,1,1,1) Details
Cdc20p 66(0,2,2,6) Details
kinesin 59(0,1,1,29) Details
CDR1 53(0,1,2,18) Details
PP2A 39(0,1,1,9) Details
YAP1 34(0,1,1,4) Details
activin A 33(0,1,1,3) Details
protein kinase A (protein family or complex) 33(0,1,1,3) Details
VIK1 32(0,1,1,2) Details
neural cell adhesion molecule 32(0,1,1,2) Details
protein a 32(0,1,1,2) Details
histone deacetylase (protein family or complex) 32(0,1,1,2) Details
cytochrome P450 monooxygenase 31(0,1,1,1) Details
dihydrofolate reductase 31(0,1,1,1) Details
CDC20 31(0,1,1,1) Details
NCAM 31(0,1,1,1) Details
MDR1 48(0,0,3,33) Details
gamma tubulin (protein family or complex) 29(0,0,0,29) Details
casein 18(0,0,3,3) Details
SAC3 14(0,0,1,9) Details
brains 12(0,0,2,2) Details
budding uninhibited by benomyl 12(0,0,0,12) Details
alcohol dehydrogenases (protein family or complex) 12(0,0,1,7) Details
C18 11(0,0,1,6) Details
G beta 11(0,0,1,6) Details
CDR2 11(0,0,1,6) Details
MAD2 10(0,0,1,5) Details
histone H4 10(0,0,1,5) Details
BIN3 9(0,0,1,4) Details
BIN2 9(0,0,1,4) Details
Myosin 9(0,0,1,4) Details
arylsulfatase 9(0,0,1,4) Details
Ajuba 9(0,0,0,9) Details
glutamyl transpeptidase 8(0,0,1,3) Details
LYS2 8(0,0,1,3) Details
Ran binding protein 1 7(0,0,0,7) Details
CSM1 7(0,0,1,2) Details
CDC5 7(0,0,1,2) Details
Mediator complex (protein family or complex) 7(0,0,1,2) Details
CARB 7(0,0,1,2) Details
microtubule associated protein 7(0,0,0,7) Details
PLC1 7(0,0,1,2) Details
coronin (protein family or complex) 7(0,0,0,7) Details
cyclin B1 6(0,0,1,1) Details
C40 6(0,0,1,1) Details
TFIIS 6(0,0,0,6) Details
ha 1 6(0,0,1,1) Details
dynactin (protein family or complex) 6(0,0,0,6) Details
RMI1 6(0,0,1,1) Details
AP4 6(0,0,1,1) Details
protein is 6(0,0,0,6) Details
ubiquitin 6(0,0,0,6) Details
MMS 6(0,0,1,1) Details
cyclin B2 6(0,0,1,1) Details
PAT1 6(0,0,0,6) Details
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