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benomyl

Identification (Source:EPA,EU)

ID	130
Name	benomyl
CAS	17804-35-2
IUPAC	methyl 1-(butylcarbamoyl)benzimidazol-2-ylcarbamate
Inchi	IInChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)
CIPAC	206
EPA Code	099101
Formula	C14H18N4O3
SMILES	O=C(n1c2ccccc2nc1NC(=O)OC)NCCCC
Status	Not Approved

Classification

Mode of Action	Systemic with protectant and eradicant activity. Also has ovicidal activity against mites. Inhibition of mitosis and cell division.
Pesticide Type	Fungicide, Miticide
Chemical Group	Benzimidazole
Classification	carbamate acaricides carbamate nematicides benzimidazolylcarbamate fungicides benzimidazole fungicides

Properties (Source:PubChem)

Molecular Weight	290.32
Physical State	Tan coloured crystals
AlogP	2.965
H-Bond Donor	2
H-Bond Acceptor	4
Surface Area	291.34
Polar Surface Area	85.25

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	2 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.14 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.025 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.28 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	2.2 mg l-1
Birds	Acute		LD50	1000 mg kg-1
Earthworms	Acute	14 day	LD50	10.5 mg kg-1
Fish	Acute	96 hour	LC50	0.17 mg l-1
Fish	Chronic	21 day	NOEC	0.011 mg l-1
Honeybees	Acute	48 hour	LD50	10 μg bee-1
Mammals	Acute oral		LD50	> 10000 mg kg-1
Mammals	Short term dietary		NOEL	2500 ppm diet
Mammals	Short term dietary		NOEL	125 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	27

Related targets

Target Name	RScore (About this table)
FLR1	593(5,10,14,23)	Details
alpha tubulin	320(2,5,8,55)	Details
ALDH2	187(1,4,4,17)	Details
Aldehyde dehydrogenases (protein family or complex)	153(1,3,3,13)	Details
cytochrome P450 (protein family or complex)	113(1,2,2,3)	Details
dynein (protein family or complex)	125(1,1,3,35)	Details
XRN1	86(1,1,1,6)	Details
chitinase	83(1,1,1,3)	Details
CENP B	81(1,1,1,1)	Details
aldo keto reductase (protein family or complex)	81(1,1,1,1)	Details
Cdc20p	66(0,2,2,6)	Details
kinesin	59(0,1,1,29)	Details
CDR1	53(0,1,2,18)	Details
PP2A	39(0,1,1,9)	Details
YAP1	34(0,1,1,4)	Details
activin A	33(0,1,1,3)	Details
protein kinase A (protein family or complex)	33(0,1,1,3)	Details
VIK1	32(0,1,1,2)	Details
neural cell adhesion molecule	32(0,1,1,2)	Details
protein a	32(0,1,1,2)	Details
histone deacetylase (protein family or complex)	32(0,1,1,2)	Details
cytochrome P450 monooxygenase	31(0,1,1,1)	Details
dihydrofolate reductase	31(0,1,1,1)	Details
CDC20	31(0,1,1,1)	Details
NCAM	31(0,1,1,1)	Details
MDR1	48(0,0,3,33)	Details
gamma tubulin (protein family or complex)	29(0,0,0,29)	Details
casein	18(0,0,3,3)	Details
SAC3	14(0,0,1,9)	Details
brains	12(0,0,2,2)	Details
budding uninhibited by benomyl	12(0,0,0,12)	Details
alcohol dehydrogenases (protein family or complex)	12(0,0,1,7)	Details
C18	11(0,0,1,6)	Details
G beta	11(0,0,1,6)	Details
CDR2	11(0,0,1,6)	Details
MAD2	10(0,0,1,5)	Details
histone H4	10(0,0,1,5)	Details
BIN3	9(0,0,1,4)	Details
BIN2	9(0,0,1,4)	Details
Myosin	9(0,0,1,4)	Details
arylsulfatase	9(0,0,1,4)	Details
Ajuba	9(0,0,0,9)	Details
glutamyl transpeptidase	8(0,0,1,3)	Details
LYS2	8(0,0,1,3)	Details
Ran binding protein 1	7(0,0,0,7)	Details
CSM1	7(0,0,1,2)	Details
CDC5	7(0,0,1,2)	Details
Mediator complex (protein family or complex)	7(0,0,1,2)	Details
CARB	7(0,0,1,2)	Details
microtubule associated protein	7(0,0,0,7)	Details
PLC1	7(0,0,1,2)	Details
coronin (protein family or complex)	7(0,0,0,7)	Details
cyclin B1	6(0,0,1,1)	Details
C40	6(0,0,1,1)	Details
TFIIS	6(0,0,0,6)	Details
ha 1	6(0,0,1,1)	Details
dynactin (protein family or complex)	6(0,0,0,6)	Details
RMI1	6(0,0,1,1)	Details
AP4	6(0,0,1,1)	Details
protein is	6(0,0,0,6)	Details
ubiquitin	6(0,0,0,6)	Details
MMS	6(0,0,1,1)	Details
cyclin B2	6(0,0,1,1)	Details
PAT1	6(0,0,0,6)	Details

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