| Name | kinesin |
|---|---|
| Synonyms | KIF5C; KIF5A; NKHC; KINN; Kinesin family member 5C; Kinesin heavy chain isoform 5C; Kinesin heavy chain neuron specific 2; NKHC 2… |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11679072 | Requena N, Alberti-Segui C, Winzenburg E, Horn C, Schliwa M, Philippsen P, Liese R, Fischer R: Genetic evidence for a microtubule-destabilizing effect of conventional kinesin and analysis of its consequences for the control of nuclear distribution in Aspergillus nidulans. Mol Microbiol. 2001 Oct;42(1):121-32. In addition, kinesin-deficient strains were less sensitive to the microtubule destabilizing drug benomyl, and disruption of conventional kinesin suppressed the cold sensitivity of an alpha-tubulin mutation (tubA4). |
37(0,1,1,7) | Details |
| 10087265 | Manning BD, Barrett JG, Wallace JA, Granok H, Snyder M: Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol. 1999 Mar 22;144(6):1219-33. Disruption of VIK1 causes increased resistance to the microtubule depolymerizing drug benomyl and partially suppresses growth defects of cik1Delta mutants. |
3(0,0,0,3) | Details |
| 9281582 | Cottingham FR, Hoyt MA: Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol. 1997 Sep 8;138(5):1041-53. We demonstrate that kinesin-related Kip3p makes a major contribution to spindle positioning in the absence of dynein. Microtubules in kip2Delta cells were shorter and more sensitive to benomyl than wild-type, in contrast to the longer and benomyl-resistant microtubules found in dyn1Delta and kip3Delta cells. |
3(0,0,0,3) | Details |
| 15189985 | Rischitor PE, Konzack S, Fischer R: The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae. Eukaryot Cell. 2004 Jun;3(3):632-45. A disruption of kipB demonstrated that it is not essential for vegetative growth. kipB mutant strains were resistant to high concentrations of the microtubule-destabilizing drug benomyl, suggesting that KipB destabilizes microtubules. kipB mutations caused a failure of spindle positioning in the cell, a delay in mitotic progression, an increased number of bent mitotic spindles, and a decrease in the depolymerization of cytoplasmic microtubules during interphase and mitosis. |
3(0,0,0,3) | Details |
| 10525539 | Cottingham FR, Gheber L, Miller DL, Hoyt MA: Novel roles for saccharomyces cerevisiae mitotic spindle motors. J Cell Biol. 1999 Oct 18;147(2):335-50. The single cytoplasmic dynein and five of the six kinesin-related proteins encoded by Saccharomyces cerevisiae participate in mitotic spindle function. The cytoplasmic and nuclear roles of both these motors could be partially substituted for by the microtubule-destabilizing agent benomyl, suggesting that these motors perform an essential microtubule-destabilizing function. |
3(0,0,0,3) | Details |
| 15766794 | Korolyev E, Steinberg-Neifach O, Eshel D: Mutations in the yeast kinesin-like Cin8p are alleviated by osmotic support. FEMS Microbiol Lett. 2005 Mar 15;244(2):379-83. |
2(0,0,0,2) | Details |
| 9128252 | Saunders W, Hornack D, Lengyel V, Deng C: The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules. J Cell Biol. 1997 Apr 21;137(2):417-31. Addition of the microtubule polymerization inhibitors nocodazol or benomyl to the medium or deletion of the nonessential alpha-tubulin TUB3 gene can mostly correct the abnormal microtubule arrays and other growth defects of kar3 mutants, suggesting that these phenotypes result from excessive microtubule polymerization. |
2(0,0,0,2) | Details |
| 19364082 | Alberti C: Cytoskeleton structure and dynamic behaviour: quick excursus from basic molecular mechanisms to some implications in cancer chemotherapy. Eur Rev Med Pharmacol Sci. 2009 Jan-Feb;13(1):13-21. Some anticytoskeleton agents are under evaluation for their applications in tumor chemotherapy; benomyl, griseofulvin, sulfonamides, that are used as antimycotic and antimicrobial drugs, appear to have a powerful antitumor potential by targeting microtubule assembly dinamics, together with exhibiting, in comparison with taxane and Vinca alkaloids, a more limited toxicity. Molecular motors that drive molecule cargo translocation along the cytoskeletal highway, either through endocytic or secretory-exocytic mechanisms, include kinesin and cytoplasmic dynein, traveling on microtubule, and myosin family members, traveling along actin meshwork. |
1(0,0,0,1) | Details |
| 11085270 | Steinberg-Neifach O, Eshel D: Simultaneous expression of both MAT loci in haploid cells suppresses mutations in yeast microtubule motor genes. Mol Gen Genet. 2000 Oct;264(3):300-5. The kinesin-related Cin8p and cytoplasmic dynein are microtubule-associated motor proteins required for anaphase spindle elongation in the yeast Saccharomyces cerevisiae. The presence of the two MAT loci also rendered haploid cells more resistant to the antimicrotubule drug benomyl. |
1(0,0,0,1) | Details |
| 9584089 | Efimov VP, Morris NR: A screen for dynein synthetic lethals in Aspergillus nidulans identifies spindle assembly checkpoint genes and other genes involved in mitosis. Genetics. 1998 May;149(1):101-16. Mutations in six other genes, including sldA and sldB, show a strong synthetic lethal interaction with a mutation in the mitotic kinesin bimC and, thus, are likely to play a role in mitosis. Mutations in sldA and sldB also confer hypersensitivity to the microtubule-destabilizing drug benomyl. sldA and sldB were cloned by complementation of their mutant phenotypes using an A. nidulans autonomously replicating vector. |
1(0,0,0,1) | Details |
| 11907275 | Wedlich-Soldner R, Schulz I, Straube A, Steinberg G: Dynein supports motility of endoplasmic reticulum in the fungus Ustilago maydis. Mol Biol Cell. 2002 Mar;13(3):965-77. The endoplasmic reticulum (ER) of most vertebrate cells is spread out by kinesin-dependent transport along microtubules, whereas studies in Saccharomyces cerevisiae indicated that motility of fungal ER is an actin-based process. Both the gradient and the Golgi apparatus were sensitive to brefeldin A or benomyl treatment, suggesting that the gradient represents microtubule-dependent vesicle trafficking between ER and Golgi. |
1(0,0,0,1) | Details |
| 9348527 | Manning BD, Padmanabha R, Snyder M: The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol Biol Cell. 1997 Oct;8(10):1829-44. KAR3 encodes a kinesin-related protein that interacts with Cik1p. Furthermore, rom2 delta strains exhibit increased sensitivity to the microtubule depolymerizing drug benomyl. |
1(0,0,0,1) | Details |
| 9472039 | Lillie SH, Brown SS: Smy1p, a kinesin-related protein that does not require microtubules. . J Cell Biol. 1998 Feb 23;140(4):873-83. We have previously reported that a defect in Myo2p, a myosin in budding yeast (Saccharomyces cerevisiae), can be partially corrected by overexpression of Smy1p, which is by sequence a kinesin-related protein (Lillie, S.H., and S.S. In addition, other perturbations of microtubules, such as treatment with benomyl or introduction of tubulin mutations, do not exacerbate the Myo2p defect. |
1(0,0,0,1) | Details |