| Name | Aldehyde dehydrogenases (protein family or complex) |
|---|---|
| Synonyms | aldehyde dehydrogenase; aldehyde dehydrogenases |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9585485 | Staub RE, Quistad GB, Casida JE: Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice. Chem Res Toxicol. 1998 May;11(5):535-43. Benomyl (a non-thio fungicide) inhibits hepatic mitochondrial low-Km aldehyde dehydrogenase (mALDH or ALDH2) in ip-treated mice by 50% (IC50) at 7.0 mg/kg, which is surprisingly the same potency range as that for several dithiocarbamate fungicides (and the related abuse drug disulfiram) and thiocarbamate herbicides previously known for their -sensitizing action. |
112(1,2,2,2) | Details |
| 10513990 | Staub RE, Quistad GB, Casida JE: S-methyl N-butylthiocarbamate sulfoxide: selective carbamoylating agent for mouse mitochondrial aldehyde dehydrogenase. Biochem Pharmacol. 1999 Nov 1;58(9):1467-73. Liver mitochondrial low-Km aldehyde dehydrogenase (ALDH2, EC 1.2.1.3), the isoform responsible for the conversion of to is inhibited by the sulfoxide bioactivation products of Et2NC (O) SMe (from the aversion drug disulfiram), Pr2NC (O) SEt (the herbicide S-ethyl N,N-dipropylthiocarbamate), and BuNHC (O) SMe (from the fungicide benomyl). |
32(0,1,1,2) | Details |
| 18061070 | Hink U, Daiber A, Kayhan N, Trischler J, Kraatz C, Oelze M, Mollnau H, Wenzel P, Vahl CF, Ho KK, Weiner H, Munzel T: Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. J Am Coll Cardiol. 2007 Dec 4;50(23):2226-32. Epub 2007 Nov 19. In vivo GTN tolerance was mimicked in vitro by incubation of nontolerant vessels with the ALDH-2 inhibitor benomyl. |
4(0,0,0,4) | Details |
| 12871571 | Murphy TC, Amarnath V, Gibson KM, Picklo MJ Sr: Oxidation of by succinic semialdehyde dehydrogenase (ALDH5A). J Neurochem. 2003 Jul;86(2):298-305. HNE is oxidized to a non-toxic metabolite in the rat cerebral cortex by mitochondrial aldehyde dehydrogenases (ALDHs). |
2(0,0,0,2) | Details |
| 15331769 | Daiber A, Oelze M, Coldewey M, Bachschmid M, Wenzel P, Sydow K, Wendt M, Kleschyov AL, Stalleicken D, Ullrich V, Mulsch A, Munzel T: Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates. Mol Pharmacol. 2004 Dec;66(6):1372-82. Epub 2004 Aug 26. The ALDH-2 inhibitor benomyl reduced the vasodilator potency, but not the efficacy, of GTN, pentaerythritol tetranitrate (PETN), and pentaerythritol trinitrate in -constricted rat aorta, whereas vasodilator responses to isosorbide-5-mononitrate, pentaerythritol dinitrate, pentaerythritol mononitrate, and the endothelium-dependent vasodilator were not affected. |
1(0,0,0,1) | Details |
| 11142365 | Shen ML, Benson LM, Johnson KL, Lipsky JJ, Naylor S: Effect of enzyme inhibitors on protein quaternary structure determined by on-line size exclusion chromatography-microelectrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2001 Jan;12(1):97-104. Aldehyde dehydrogenases (ALDH) are a family of enzymes primarily involved in the oxidation of various aldehydes. In this study, recombinant rat liver mitochondrial ALDH (rmALDH) was inhibited in vitro with four different inhibitors, namely, disulfiram (MW, 296.5), prunetin (MW, 284.3), benomyl (MW, 290.3), and N-tosyl- chloromethyl ketone (TPCK) (MW, 351.8). |
1(0,0,0,1) | Details |
| 17010440 | Leiphon LJ, Picklo MJ Sr: Inhibition of detoxification in CNS mitochondria by fungicides. Neurotoxicology. 2007 Jan;28(1):143-9. Epub 2006 Sep 1. In this present study, we examined the potential of multiple agricultural pesticides for their ability to inhibit the function of whole, respiring rat brain mitochondria using the oxidation of the lipid- (HNE) as a biomarker for mitochondrial aldehyde dehydrogenase (ALDH) activity in situ. These compounds included rotenone, maneb, mancozeb, and benomyl. |
1(0,0,0,1) | Details |