Protein Information

Name dynactin (protein family or complex)
Synonyms Dynactin; Dynactins

Compound Information

Name benomyl
CAS

Reference List

PubMed Abstract RScore(About this table)
10837229 Xiang X, Han G, Winkelmann DA, Zuo W, Morris NR: Dynamics of cytoplasmic dynein in living cells and the effect of a mutation in the dynactin complex actin-related protein Arp1. Curr Biol. 2000 May 18;10(10):603-6.

These dynamics of GFP-NUDA were not observed in cells treated with a microtubule-destabilizing drug, benomyl, suggesting they are microtubule-dependent.
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10512672 Minke PF, Lee IH, Plamann M: Microscopic analysis of Neurospora ropy mutants defective in nuclear distribution. Fungal Genet Biol. 1999 Oct;28(1):55-67.


We have shown that three of the ro genes, ro-1, ro-3, and ro-4, encode subunits of either cytoplasmic dynein or the dynein activator complex, dynactin.
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16942924 Heinrich D, Sackmann E: Active mechanical stabilization of the viscoplastic intracellular space of Dictyostelia cells by microtubule-actin crosstalk. Acta Biomater. 2006 Nov;2(6):619-31. Epub 2006 Aug 30.

The role of the actin cortex, the microtubule (MT) aster and their crosstalk is explored by comparing the behaviour of wild-type cells, myosin II null mutants, latrunculin A and benomyl treated cells.
The tails are due to spontaneous filament deflections (with speeds up to 10 microm/s) attributed to pre-stressing of the MT by local cortical tensions, generated by dynactin motors generating plus-end directed forces in the MTs.
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16729061 Ye P, Peyser BD, Pan X, Boeke JD, Spencer FA, Bader JS: Gene function prediction from congruent synthetic lethal interactions in yeast. Mol Syst Biol. 2005;1:2005.0026. Epub 2005 Nov 22.

We predicted benomyl sensitivity and nuclear migration defects using congruence; these phenotypes were uncorrelated with direct synthetic lethality.
We also predicted YLL049W as a new member of the dynein-dynactin pathway and provided new supporting experimental evidence.
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