| Name | CDR1 |
|---|---|
| Synonyms | CDR; CDR; CDR 1; CDR1; CDR34; CDR62A; Cerebellar degeneration related antigen 1; Cerebellar degeneration related autoantigen 1… |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8891134 | Sanglard D, Ischer F, Monod M, Bille J: Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother. 1996 Oct;40(10):2300-5. This phenomenon was shown to be linked to an increase in the amounts of mRNA of a C. albicans ABC (ATP-binding cassette) transporter gene called CDR1 and of a gene conferring benomyl resistance (BENr), the product of which belongs to the class of major facilitator multidrug efflux transporters (D. |
31(0,1,1,1) | Details |
| 15273122 | Karababa M, Coste AT, Rognon B, Bille J, Sanglard D: Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters. Antimicrob Agents Chemother. 2004 Aug;48(8):3064-79. Upregulation of these genes can also be achieved by exposure to fluphenazine, resulting in specific upregulation of CDR1 and CDR2 and by exposure to benomyl, resulting in specific CaMDR1 upregulation. |
9(0,0,1,4) | Details |
| 9532737 | Krishnamurthy S, Gupta V, Prasad R, Panwar SL, Prasad R: Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones. FEMS Microbiol Lett. 1998 Mar 15;160(2):191-7. CaMDR1 (benomyl-resistant) expression, however, did not differ among all the resistant isolates. |
5(0,0,0,5) | Details |
| 9605502 | Hernaez ML, Gil C, Pla J, Nombela C: Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals. Yeast. 1998 Apr 30;14(6):517-26. Moderate increases were observed for calcofluor, 5'-fluorcytosine, cilofungin and while no induction was found for the antifungals benomyl and amphotericin B or peroxide at subinhibitory concentrations. |
4(0,0,0,4) | Details |
| 10459807 | Maesaki S, Marichal P, Vanden Bossche H, Sanglard D, Kohno S: Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans strains. J Antimicrob Chemother. 1999 Jul;44(1):27-31. A fluconazole-resistant strain C40 that expressed the benomyl resistance gene (CaMDR) also showed a low R6G efflux (0.16 +/- 0.06 nmol/10 (8) cells) as did the sensitive strains. |
3(0,0,0,3) | Details |
| 9605504 | Krishnamurthy S, Chatterjee U, Gupta V, Prasad R, Das P, Snehlata P, Hasnain SE, Prasad R: Deletion of transmembrane domain 12 of CDR1, a multidrug transporter from Candida albicans, leads to altered drug specificity: expression of a yeast multidrug transporter in baculovirus expression system. Yeast. 1998 Apr 30;14(6):535-50. While the expression of deltaCDR1 in yeast resulted in impaired sensitivity to drugs like cycloheximide, anisomycin, sulfomethuron methyl and antifungal nystatin, its ability to confer resistance remained unaltered to drugs such as o-phenanthroline, 4-nitroquinoline-N-oxide, cerulenin, azoles, oligomycin, erythromycin, and benomyl. |
1(0,0,0,1) | Details |
| 8585712 | Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J: Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother. 1995 Nov;39(11):2378-86. This gene was cloned from C. albicans for conferring benomyl resistance in Saccharomyces cerevisiae. |
0(0,0,0,0) | Details |