Protein Information

Name Myosin
Synonyms Myosin

Compound Information

Name benomyl
CAS

Reference List

PubMed Abstract RScore(About this table)
16942924 Heinrich D, Sackmann E: Active mechanical stabilization of the viscoplastic intracellular space of Dictyostelia cells by microtubule-actin crosstalk. Acta Biomater. 2006 Nov;2(6):619-31. Epub 2006 Aug 30.

The role of the actin cortex, the microtubule (MT) aster and their crosstalk is explored by comparing the behaviour of wild-type cells, myosin II null mutants, latrunculin A and benomyl treated cells.
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9472039 Lillie SH, Brown SS: Smy1p, a kinesin-related protein that does not require microtubules. . J Cell Biol. 1998 Feb 23;140(4):873-83.

We have previously reported that a defect in Myo2p, a myosin in budding yeast (Saccharomyces cerevisiae), can be partially corrected by overexpression of Smy1p, which is by sequence a kinesin-related protein (Lillie, S.H., and S.S.
In addition, other perturbations of microtubules, such as treatment with benomyl or introduction of tubulin mutations, do not exacerbate the Myo2p defect.
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19364082 Alberti C: Cytoskeleton structure and dynamic behaviour: quick excursus from basic molecular mechanisms to some implications in cancer chemotherapy. Eur Rev Med Pharmacol Sci. 2009 Jan-Feb;13(1):13-21.

Some anticytoskeleton agents are under evaluation for their applications in tumor chemotherapy; benomyl, griseofulvin, sulfonamides, that are used as antimycotic and antimicrobial drugs, appear to have a powerful antitumor potential by targeting microtubule assembly dinamics, together with exhibiting, in comparison with taxane and Vinca alkaloids, a more limited toxicity.
Molecular motors that drive molecule cargo translocation along the cytoskeletal highway, either through endocytic or secretory-exocytic mechanisms, include kinesin and cytoplasmic dynein, traveling on microtubule, and myosin family members, traveling along actin meshwork.
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10618165 Suelmann R, Fischer R: Mitochondrial movement and morphology depend on an intact actin cytoskeleton in Aspergillus nidulans. Cell Motil Cytoskeleton. 2000 Jan;45(1):42-50.


Movement of organelles along actin filaments requires actin-dependent motor proteins, such as myosin.
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