Protein Information

Name budding uninhibited by benomyl
Synonyms BUB 3; BUB3; BUB3 budding uninhibited by benzimidazoles 3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast); BUB3L; Budding uninhibited by benomyl; Mitotic checkpoint componentBUB3; Mitotic checkpoint protein BUB3…

Compound Information

Name benomyl
CAS

Reference List

PubMed Abstract RScore(About this table)
7622604 Guenette S, Magendantz M, Solomon F: Suppression of a conditional mutation in alpha-tubulin by overexpression of two checkpoint genes. J Cell Sci. 1995 Mar;108 ( Pt 3):1195-204.

Transformation of mutant cells with genomic libraries repeatedly identified three different suppressors: the two wild-type alpha-tubulin genes, TUB1 and TUB3; and BUB3.
Excess BUB3 rescues both the loss of viability and microtubule defects but not the benomyl supersensitivity associated with tub1-729.
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9584089 Efimov VP, Morris NR: A screen for dynein synthetic lethals in Aspergillus nidulans identifies spindle assembly checkpoint genes and other genes involved in mitosis. Genetics. 1998 May;149(1):101-16.

Sequencing revealed homology to the spindle assembly checkpoint genes BUB1 and BUB3 from Saccharomyces cerevisiae.
Mutations in sldA and sldB also confer hypersensitivity to the microtubule-destabilizing drug benomyl. sldA and sldB were cloned by complementation of their mutant phenotypes using an A. nidulans autonomously replicating vector.
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12242018 Baek WK, Park JW, Lim JH, Suh SI, Suh MH, Gabrielson E, Kwon TK: Molecular cloning and characterization of the human budding uninhibited by benomyl (BUB3) promoter. Gene. 2002 Jul 24;295(1):117-23.

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18710370 Ferrand A, Chevrier V, Chauvin JP, Birnbaum D: Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase. Biol Cell. 2009 Apr;101(4):221-35.


We show that Ajuba interacts with Aurora B and BUBR1 [BUB (budding uninhibited by benomyl)-related 1], two major components of the mitotic checkpoint.
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11134360 Steuerwald N, Cohen J, Herrera RJ, Sandalinas M, Brenner CA: Association between spindle assembly checkpoint expression and maternal age in human oocytes. Mol Hum Reprod. 2001 Jan;7(1):49-55.


The mitotic arrest deficient (MAD2) and budding uninhibited by benomyl (BUB1) genes encode conserved kinetochore-associated proteins believed to be components of the checkpoint regulatory pathway.
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