| Name | ALDH2 |
|---|---|
| Synonyms | ALDH class 2; ALDH 2; ALDH E2; ALDH2; ALDHI; ALDM; Aldehyde dehydrogenase 2; DHAM… |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9585485 | Staub RE, Quistad GB, Casida JE: Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice. Chem Res Toxicol. 1998 May;11(5):535-43. Benomyl (a non-thio fungicide) inhibits hepatic mitochondrial low-Km aldehyde dehydrogenase (mALDH or ALDH2) in ip-treated mice by 50% (IC50) at 7.0 mg/kg, which is surprisingly the same potency range as that for several dithiocarbamate fungicides (and the related abuse drug disulfiram) and thiocarbamate herbicides previously known for their -sensitizing action. |
81(1,1,1,1) | Details |
| 18061070 | Hink U, Daiber A, Kayhan N, Trischler J, Kraatz C, Oelze M, Mollnau H, Wenzel P, Vahl CF, Ho KK, Weiner H, Munzel T: Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. J Am Coll Cardiol. 2007 Dec 4;50(23):2226-32. Epub 2007 Nov 19. In vivo GTN tolerance was mimicked in vitro by incubation of nontolerant vessels with the ALDH-2 inhibitor benomyl. |
36(0,1,1,6) | Details |
| 10513990 | Staub RE, Quistad GB, Casida JE: S-methyl N-butylthiocarbamate sulfoxide: selective carbamoylating agent for mouse mitochondrial aldehyde dehydrogenase. Biochem Pharmacol. 1999 Nov 1;58(9):1467-73. Liver mitochondrial low-Km aldehyde dehydrogenase (ALDH2, EC 1.2.1.3), the isoform responsible for the conversion of to is inhibited by the sulfoxide bioactivation products of Et2NC (O) SMe (from the aversion drug disulfiram), Pr2NC (O) SEt (the herbicide S-ethyl N,N-dipropylthiocarbamate), and BuNHC (O) SMe (from the fungicide benomyl). |
36(0,1,1,6) | Details |
| 15331769 | Daiber A, Oelze M, Coldewey M, Bachschmid M, Wenzel P, Sydow K, Wendt M, Kleschyov AL, Stalleicken D, Ullrich V, Mulsch A, Munzel T: Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates. Mol Pharmacol. 2004 Dec;66(6):1372-82. Epub 2004 Aug 26. The bioactivation-related metabolism of GTN to glyceryl-1,2-dinitrate by isolated RAW macrophages was reduced by the ALDH-2 inhibitors benomyl and daidzin, as well as by GTN at concentrations > 1 microM. |
33(0,1,1,3) | Details |
| 12871571 | Murphy TC, Amarnath V, Gibson KM, Picklo MJ Sr: Oxidation of by succinic semialdehyde dehydrogenase (ALDH5A). J Neurochem. 2003 Jul;86(2):298-305. Two possible ALDH enzymes which might oxidize HNE in CNS mitochondria are ALDH2 and succinic semialdehyde dehydrogenase (SSADH/ALDH5A). |
1(0,0,0,1) | Details |
| 17010440 | Leiphon LJ, Picklo MJ Sr: Inhibition of detoxification in CNS mitochondria by fungicides. Neurotoxicology. 2007 Jan;28(1):143-9. Epub 2006 Sep 1. These compounds included rotenone, maneb, mancozeb, and benomyl. |
0(0,0,0,0) | Details |