| Name | FLR1 |
|---|---|
| Synonyms | F box and leucine rich repeat; F box protein FBL4/FBL5; FBL 4; FBL 5; FBL4; FBL5; F box and leucine rich repeat protein 5; F box protein FBL4… |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11162502 | Tenreiro S, Fernandes AR, Sa-Correia I: Transcriptional activation of FLR1 gene during Saccharomyces cerevisiae adaptation to growth with benomyl: role of Yap1p and Pdr3p. Biochem Biophys Res Commun. 2001 Jan 12;280(1):216-22. The adaptation of Saccharomyces cerevisiae to growth in the presence of the antimitotic fungicide benomyl involves the dramatic activation of FLR1 transcription, taking place during benomyl-induced latency following sudden exposure to the fungicide. |
231(2,4,5,6) | Details |
| 10572257 | Broco N, Tenreiro S, Viegas CA, Sa-Correia I: FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulator. Yeast. 1999 Nov;15(15):1595-608. The present study also provides, for the first time, evidence that the adaptation of yeast cells to growth in the presence of benomyl involves the dramatic activation of FLR1 gene expression during benomyl-induced latency (up to 400-fold). |
176(2,2,4,6) | Details |
| 16352614 | Romero C, Desai P, DeLillo N, Vancura A: Expression of FLR1 transporter requires phospholipase C and is repressed by Mediator. J Biol Chem. 2006 Mar 3;281(9):5677-85. Epub 2005 Dec 12. Instead, benomyl sensitivity of plc1Delta cells is caused by a defect in expression of FLR1, and the suppression of benomyl sensitivity in plc1Delta sin4Delta cells occurs by derepression of FLR1 transcription. |
119(1,2,3,4) | Details |
| 11056165 | Nguyen DT, Alarco AM, Raymond M: Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents. J Biol Chem. 2001 Jan 12;276(2):1138-45. We show that the transcription of FLR1 is induced upon cell treatment with the oxidizing agents diamide, diethylmaleate, peroxide, and tert-butyl hydroperoxide, the antimitotic drug benomyl, and the alkylating agent methylmethane sulfonate and that this induction is mediated by Yap1p through the three YREs. |
36(0,1,1,6) | Details |
| 17046176 | Chen KH, Miyazaki T, Tsai HF, Bennett JE: The bZip transcription factor Cgap1p is involved in multidrug resistance and required for activation of multidrug transporter gene CgFLR1 in Candida glabrata. Gene. 2007 Jan 15;386(1-2):63-72. Epub 2006 Aug 24. Northern blot analysis indicated that Cgap1p regulates the benomyl-induced expression of CgFLR1, a homolog of S. cerevisiae FLR1, which encodes a transporter of the major facilitator superfamily. |
31(0,1,1,1) | Details |