Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name scilliroside
CAS

Reference List

PubMed Abstract RScore(About this table)
3022811 Katgely BW, Bridges RJ, Rummel W: Inhibition of the intestinal transport of uracil by hexoses and amino acids. Biochim Biophys Acta. 1986 Nov 17;862(2):429-34.

Scilliroside, an inhibitor of the basolateral (Na+ + K+)-ATPase, dose-dependently inhibited the transport of uracil consistent with the Na+ dependency of uracil transport.
Scilliroside, an inhibitor of the basolateral (Na+ + K+)-ATPase, dose-dependently inhibited the transport of uracil consistent with the Na+ dependency of uracil transport.
1(0,0,0,1) Details
12180967 Scheiner-Bobis G, Hubschle T, Diener M: Action of palytoxin on apical H+/K+-ATPase in rat colon. . Eur J Biochem. 2002 Aug;269(16):3905-11.

The palytoxin-induced Isc was blocked by vanadate but was resistant to ouabain or scilliroside, suggesting the conversion of a vanadate-sensitive H+/K+-ATPase into an electrogenic cation transporter.
82(1,1,1,2) Details
4250728 Robinson JW: The difference in sensitivity to cardiac steroids of (Na++K+)-stimulated ATPase and amino acid transport in the intestinal mucosa of the rat and other species. J Physiol. 1970 Jan;206(1):41-60.

The rat intestinal enzyme is 50% inhibited by a concentration of 1 x 10 (-4) M ouabain, 1 x 10 (-5) M scillaren A and 4 x 10 (-6) M scilliroside.
5(0,0,0,5) Details
9298532 Schultheiss G, Diener M: Regulation of apical and basolateral K+ conductances in rat colon. . Br J Pharmacol. 1997 Sep;122(1):87-94.

This response was composed of a pump current generated by the Na (+)-K (+)-ATPase and of a current cross a quinine-sensitive basolateral K+ conductance. 3.
The pump current, measured as Na (+)-dependent or scilliroside-sensitive current in the absence of a K+ gradient, was significantly greater in the distal than in the proximal colon.
1(0,0,0,1) Details