Protein Information

Name dopamine beta hydroxylase
Synonyms DBH; DBM; Dopamine beta hydroxylase; Dopamine beta monooxygenase; Dopamine beta hydroxylase precursor; dopamine beta hydroxylase (dopamine beta monooxygenase); DBH; Dopamine beta hydroxylases…

Compound Information

Name simazine
CAS

Reference List

PubMed Abstract RScore(About this table)
10910990 Das PC, McElroy WK, Cooper RL: Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12) cells in vitro. Toxicol Sci. 2000 Aug;56(2):324-31.

These data indicate that both atrazine and simazine inhibit the cellular synthesis of DA mediated by the tyrosine hydroxylase (TH), and NE mediated by dopamine beta-hydroxylase (DbetaH), and, as a result, there is a partial or significant inhibition of NE release.
31(0,1,1,1) Details
14550852 Das PC, McElroy WK, Cooper RL: Potential mechanisms responsible for chlorotriazine-induced alterations in catecholamines in pheochromocytoma (PC12) cells. Life Sci. 2003 Oct 31;73(24):3123-38.

In this study we evaluated the effect of atrazine, simazine and cyanazine on the protein expression of the enzymes responsible for the synthesis of dopamine [tyrosine hydroxylase (TH)] and norepinephrine [dopamine-beta-hydroxylase (DbetaH)].
31(0,1,1,1) Details