Protein Information

Name 3 hydroxy 3 methylglutaryl CoA reductase
Synonyms 3 Hydroxy 3 methylglutaryl CoA reductase; 3 Hydroxy 3 methylglutaryl Coenzyme A reductase; Beta hydroxy beta methyl glutaryl CoA reductase; HMG CoA reductase; HMG Coenzyme A reductase; HMGCR; 3 Hydroxy 3 methylglutaryl Coenzyme A reductases; Beta hydroxy beta methyl glutaryl CoA reductases…

Compound Information

Name gibberellins
CAS gibberellins

Reference List

PubMed Abstract RScore(About this table)
9000379 Woitek S, Unkles SE, Kinghorn JR, Tudzynski B: 3-Hydroxy-3-methylglutaryl-CoA reductase gene of Gibberella fujikuroi: isolation and characterization. Curr Genet. 1997 Jan;31(1):38-47.

3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR) is the first specific enzyme of the isoprenoid pathway, which leads to several classes of primary and secondary metabolites such as sterols, quinones, carotenoids and gibberellins.
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6462147 Russell DW, Davidson H: Regulation of cytosolic HMG-CoA reductase activity in pea seedlings: contrasting responses to different hormones, and hormone-product interaction, suggest hormonal modulation of activity. Biochem Biophys Res Commun. 1982 Feb 26;104(4):1537-43.

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19522814 Mansouri H, Asrar Z, Mehrabani M: Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. J Integr Plant Biol. 2009 Jun;51(6):553-61.


In the present study we investigated the effect of gibberellic acid (GA (3)) on changes in the amounts of many produced terpenoids and the activity of the key enzymes, 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), in these pathways.
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6400479 Demain AL: A new era of exploitation of microbial metabolites. . Biochem Soc Symp. 1983;48:117-32.


In its hydroxyacid form (mevinolinic acid), mevinolin is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from liver.
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