Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name carbofuran
CAS

Reference List

PubMed Abstract RScore(About this table)
8588950 Pant N, Prasad AK, Srivastava SC, Shankar R, Srivastava SP: Effect of oral administration of carbofuran on male reproductive system of rat. Hum Exp Toxicol. 1995 Nov;14(11):889-94.

In addition, significant alterations were observed in the activities of marker testicular enzymes viz. sorbitol dehydrogenase (SDH), glucose-6-P-dehydrogenase (G6PDH) (decreased), lactate dehydrogenase (LDH) and gamma-glutamyl transpeptidase (gamma-GT) (increased) depending on dose. 5.
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7966439 Gupta RC, Goad JT, Kadel WL: Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. J Toxicol Environ Health. 1994 Nov;43(3):291-304.

Noncholinergic markers included high-energy phosphates (adenosine triphosphate, ATP; phosphocreatine, PCr; and their metabolites), and the activity of creatine kinase (CK) and lactate dehydrogenase (LDH) and their isoenzymes and subforms.
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15179037 Kim SJ, Kim JE, Ko BH, Moon IS: Carbofuran induces apoptosis of rat cortical neurons and down-regulates surface alpha7 subunit of acetylcholine receptors. Mol Cells. 2004 Apr 30;17(2):242-7.

CF was cytotoxic with an IC50 approximately 730 and approximately 640 microm when assessed by the lactate dehydrogenase (LDH) assay and propidium iodide (PI) staining, respectively, 3 days after treatment.
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15620756 Rendon-von Osten J, Ortiz-Arana A, Guilhermino L, Soares AM: In vivo evaluation of three biomarkers in the mosquitofish (Gambusia yucatana) exposed to pesticides. Chemosphere. 2005 Feb;58(5):627-36.

In this study, the acute toxicity and the in vivo effects of commercial chlorpyrifos, carbofuran and glyphosate formulations on cholinesterase (ChE), glutathione S-transferase (GST) and lactate dehydrogenase (LDH) activities of the mosquitofish (Gambusia yucatana) were investigated.
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1958080 Gupta RC, Goad JT, Kadel WL: In vivo alterations in lactate dehydrogenase (LDH) and LDH isoenzymes patterns by acute carbofuran intoxication. Arch Environ Contam Toxicol. 1991 Aug;21(2):263-9.
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19778259 Gera N, Kiran R, Mahmood A: Subacute effects of carbofuran on enzyme functions in rat small intestine. . Toxicol Mech Methods. 2009 Feb;19(2):141-7.

The activity of lactate dehydrogenase was enhanced (p < 0.001) in 7 days and 30 days induced carbofuran toxicity.
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12731274 Duan Z, Zhang Y, Li H, Cui J: [Dynamic observation of carbofuran on symbolic enzymes in testis of rats] . Wei Sheng Yan Jiu. 2003 Jan;32(1):8-9.

The activities of beta-glucuronidase (beta-G), glucose-6-phosphate dehydrogenase (G-6-PD) and lactate dehydrogenase isoenzyme-x (LDHx) in serum and testis homogenate were determined for the rats given carbofuran at the dises of 0.3, 1.5 and 3.0 mg/kg orally for 7, 35 and 77 days.
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19854236 Tonomura Y, Mori Y, Torii M, Uehara T: Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats. Toxicology. 2009 Dec 21;266(1-3):48-54. Epub 2009 Oct 23.


The biomarkers assayed were fatty acid binding protein 3 (Fabp3), myosin light chain 1 (MLC1), cardiac troponin I (cTnI), cardiac troponin T (cTnT), aspartate transaminase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK).
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