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carbofuran

Identification (Source:EPA,EU)

ID	133
Name	carbofuran
CAS	1563-66-2
IUPAC	2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
Inchi	InChI=1S/C12H15NO3/c1-12(2)7-8-5-4-6-9(10(8)16-12)15-11(14)13-3/h4-6H,7H2,1-3H3,(H,13,14)
CIPAC	276
EPA Code	090601
Formula	C12H15NO3
SMILES	CC2(C)CC1=C(C(=CC=C1)OC(NC)=O)O2
Status	Not Approved

Classification

Mode of Action	Systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type	Insecticide, Nematicide, Acaricide, Metabolite
Chemical Group	Carbamate
Classification	carbamate nematicides carbamate acaricides benzofuranyl methylcarbamate insecticides

Properties (Source:PubChem)

Molecular Weight	221.26
Physical State	White crystalline powder
AlogP	2.234
H-Bond Donor	1
H-Bond Acceptor	3
Surface Area	223.48
Polar Surface Area	47.56

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	6.5 mg l-1
Algae	Chronic	96 hour	NOEC, growth	3.2 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.008 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.0094 mg l-1
Birds	Acute		LD50	0.71 mg kg-1
Birds	Short term dietary		LC50/LD50	1.6 mg/kg bw/day
Earthworms	Chronic	14 day	NOEC, reproduction	> 0.84 mg kg-1
Earthworms	Acute	14 day	LD50	224 mg kg-1
Fish	Chronic	21 day	NOEC	0.0022 mg l-1
Fish	Acute	96 hour	LC50	0.18 mg l-1
Honeybees	Acute	48 hour	LD50	0.036 μg bee-1
Mammals	Acute oral		LD50	7 mg kg-1
Mammals	Short term dietary		NOEL	0.1 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	0.016 mg l-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.004 mg kg-1
	Bio-concentration factor		BCF	12
	Bio-concentration factor		CT50	0.5 days

Related targets

Target Name	RScore (About this table)
Acetylcholinesterase	3078(25,49,74,233)	Details
anticholinesterase	1508(13,21,40,133)	Details
CYP3A	335(3,5,8,20)	Details
cytochrome P450 (protein family or complex)	214(2,3,5,14)	Details
ATPase	167(2,2,2,7)	Details
NA K ATPase	114(1,2,2,4)	Details
CYP2B6	89(1,1,2,4)	Details
glycogen phosphorylase	83(1,1,1,3)	Details
caspases (protein family or complex)	82(1,1,1,2)	Details
succinate dehydrogenase (protein family or complex)	82(1,1,1,2)	Details
ha 1	81(1,1,1,1)	Details
alkaline phosphatase	75(0,2,3,10)	Details
glucose 6 phosphatase	68(0,2,3,3)	Details
NMDA receptor (protein family or complex)	62(0,2,2,2)	Details
BSAC	39(0,1,2,4)	Details
sucrase	38(0,1,2,3)	Details
glutamyl transpeptidase	33(0,1,1,3)	Details
demethylase	33(0,1,1,3)	Details
cytochrome c	32(0,1,1,2)	Details
Glutamate pyruvate transaminase	32(0,1,1,2)	Details
interleukin (protein family or complex)	31(0,1,1,1)	Details
CK 1	31(0,1,1,1)	Details
CF 1 (protein family or complex)	31(0,1,1,1)	Details
acid phosphatase	31(0,1,1,1)	Details
CK 3	31(0,1,1,1)	Details
CDs 1	31(0,1,1,1)	Details
lactate dehydrogenase (protein family or complex)	28(0,0,4,8)	Details
glutathione S transferase	22(0,0,3,7)	Details
single chain Fv	19(0,0,2,9)	Details

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