| Name | olfactory receptor |
|---|---|
| Synonyms | HSHT 2; Olfactory receptor; HSHT2; OR19 8; OR7E24P; OR7E24Q; Olfactory receptor OR19 14… |
| Name | carvone |
|---|---|
| CAS | 2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14991840 | Josephson EM, Yilma S, Vodyanoy V, Morrison EE: Structure and function of long-lived olfactory organotypic cultures from postnatal mice. J Neurosci Res. 2004 Mar 1;75(5):642-53. The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb. We also recorded electro-olfactography responses to puffs of vapor collected over an odorant mixture containing ethyl (+) carvone, and (-) carvone from cultures as old as 21 DIV. |
3(0,0,0,3) | Details |
| 15703336 | Laska M, Genzel D, Wieser A: The number of functional olfactory receptor genes and the relative size of olfactory brain structures are poor predictors of olfactory discrimination performance with enantiomers. Chem Senses. 2005 Feb;30(2):171-5. All animals from both species were able to discriminate between the optical isomers of carvone, dihydrocarvone, dihydrocarveole and dihydrocarvyl whereas they failed to distinguish between the (+)- and (-)-forms of perillaaldehyde and |
2(0,0,0,2) | Details |
| 19657081 | Lapid H, Seo HS, Schuster B, Schneidman E, Roth Y, Harel D, Sobel N, Hummel T: Odorant concentration dependence in electroolfactograms recorded from the human olfactory epithelium. J Neurophysiol. 2009 Oct;102(4):2121-30. Epub 2009 Aug 5. Electroolfactograms (EOGs) are the summated generator potentials of olfactory receptor neurons measured directly from the olfactory epithelium. Each of 22 subjects (12 women, mean age = 23.3 yr) was tested with two odorants, either and linalool (n = 12) or and l-carvone (n = 10), each delivered at four concentrations diluted with warm (37 degrees C) and humidified (80%) odorless air. |
2(0,0,0,2) | Details |
| 9614232 | Bozza TC, Kauer JS: Odorant response properties of convergent olfactory receptor neurons. . J Neurosci. 1998 Jun 15;18(12):4560-9. DL-projecting ORNs showed responses to compounds with widely different structures, including carvone, and acetophenone. |
2(0,0,0,2) | Details |
| 9875846 | Krautwurst D, Yau KW, Reed RR: Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell. 1998 Dec 23;95(7):917-26. Here, we report the generation of an expression library containing a large and diverse repertoire of mouse olfactory receptor sequences in the transmembrane II-VII region. Three receptors were identified to respond to micromolecular concentrations of carvone, (-) citronellal, and respectively. |
1(0,0,0,1) | Details |
| 16306170 | Lehmkuhle MJ, Normann RA, Maynard EM: Trial-by-trial discrimination of three enantiomer pairs by neural ensembles in mammalian olfactory bulb. J Neurophysiol. 2006 Mar;95(3):1369-79. Epub 2005 Nov 23. In this report, the single-trial encoding limits of random ensembles of putative single- and multiunit M/T cells in the anesthetized rat OB during presentations of enantiomers of carvone, and 2-butanol are investigated using simultaneous multielectrode recording techniques. This may explain how ensembles of broadly tuned OB neurons contribute to olfactory perception and may explain how small numbers of individual units receiving input from distinct olfactory receptor neurons can be combined to form a robust representation of odorants. |
1(0,0,0,1) | Details |
| 16793858 | Joshi D, Volkl M, Shepherd GM, Laska M: Olfactory sensitivity for enantiomers and their racemic mixtures--a comparative study in CD-1 mice and spider monkeys. Chem Senses. 2006 Sep;31(7):655-64. Epub 2006 Jun 22. Using a conditioning paradigm, the olfactory sensitivity of six CD-1 mice for the enantiomers of carvone and of as well as for their racemic mixtures was investigated. As mice and spider monkeys are thought to share a similar number of functional olfactory receptor genes, the findings further suggest that differences in the relative abundance of chiral-specific olfactory receptor types might account for the observed difference in mixture additivity at threshold level between the two species. |
1(0,0,0,1) | Details |
| 10587501 | Scott JW, Brierley T: A functional map in rat olfactory epithelium. . Chem Senses. 1999 Dec;24(6):679-90. We argue that the spatial distributions of responses are correlated with the olfactory receptor gene expression zones. We tested three terpene compounds (carvone, and across the epithelium along the medial surface of the endoturbinate bones. |
1(0,0,0,1) | Details |
| 3536906 | Sklar PB, Anholt RR, Snyder SH: The odorant-sensitive adenylate cyclase of olfactory receptor cells. J Biol Chem. 1986 Nov 25;261(33):15538-43. Most fruity, floral, minty, and herbaceous odorants stimulate the enzyme. 3,7-Dimethyl-2,6-octadienenitrile (citralva), menthone, D-carvone, L-carvone, and 2-isobutyl-3-methoxypyrazine display similar potencies in activating the adenylate cyclase upto concentrations of 100 microM. |
1(0,0,0,1) | Details |
| 8858838 | Kashiwayanagi M, Kawahara H, Kanaki K, Nagasawa F, Kurihara K: Ca2+ and Cl (-)-dependence of the turtle olfactory response to odorants and forskolin. Comp Biochem Physiol A Physiol. 1996 Sep;115(1):43-52. In the turtle olfactory system, large responses to odorants appeared after application of cAMP of forskolin at high concentrations to the isolated olfactory receptor neurons or the olfactory epithelium, suggesting that a cAMP-independent pathway greatly contributes to the generation of odor responses. Elimination of mucosal Ca2+ by addition of 2 mM EGTA to the stimulating solution partially inhibited the cAMP-independent responses to 0.1 mM citralva but did not affect those to 0.1 mM lilial or 0.1 mM l-carvone. |
1(0,0,0,1) | Details |
| 9114247 | Scott JW, Shannon DE, Charpentier J, Davis LM, Kaplan C: Spatially organized response zones in rat olfactory epithelium. . J Neurophysiol. 1997 Apr;77(4):1950-62. In this study we tested whether odors of different chemical structures produce maximal responses along longitudinally oriented regions following the olfactory receptor gene expression zones described in the literature. These experiments compared the odorants and which are simple hydrocarbons, with carvone and menthone, which differ from the hydrocarbons by the presence of ketone groups. |
1(0,0,0,1) | Details |
| 8207942 | Hahn I, Scherer PW, Mozell MM: A mass transport model of olfaction. J Theor Biol. 1994 Mar 21;167(2):115-28. The mechanisms included are: (i) convective bulk flow of odorant molecules to the olfactory region of the nasal cavity by inhaled air, (ii) lateral transport of odorant molecules from the flowing gas stream in the olfactory region onto the olfactory mucus surface, (iii) sorption of odorant molecules into the mucus at the air-mucus interface, (iv) diffusion of odorant molecules through the mucus layer, and (v) interaction of odorant molecules with the olfactory receptor cells. The model predicts that, given adequate mucus surface for sorption, increase in the flow rate results in an increase in perceived odor intensity for the readily sorbed or highly soluble odorants (such as carvone) and a decrease in odor intensity for the poorly sorbed or insoluble odorants (such as |
1(0,0,0,1) | Details |