| Name | integrin |
|---|---|
| Synonyms | Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12694655 | Kokenyesi R, Murray KP, Benshushan A, Huntley ED, Kao MS: Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. Gynecol Oncol. 2003 Apr;89(1):60-72. RESULTS: PC880 cells adhered well to fibronectin, laminin, and vitronectin in an integrin-dependent manner. Treatment of PC880 cells with sodium chlorate also decreased invasiveness (80% of control), further confirming the role of cell surface proteoglycans. |
4(0,0,0,4) | Details |
| 11788350 | Osses N, Brandan E: ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression. Am J Physiol Cell Physiol. 2002 Feb;282(2):C383-94. To assess the role of the extracellular matrix (ECM) in skeletal muscle differentiation, the specific inhibitors of proteoglycan synthesis, sodium chlorate and beta-D-xyloside, were used. Integrin-mediated signaling of focal adhesion kinase was partially inhibited by and beta-D-xyloside, an effect reversed by the addition of exogenous ECM gel. |
1(0,0,0,1) | Details |
| 14684735 | Gao R, Brigstock DR: Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha (v) beta (3) and heparan sulfate proteoglycan. J Biol Chem. 2004 Mar 5;279(10):8848-55. Epub 2003 Dec 17. These findings offer the possibility of developing novel antifibrotic therapies that target the integrin-binding domain. Third, destruction or inhibition of synthesis of cell surface HSPGs with, respectively, heparinase or sodium chlorate abrogated HSC adhesion to CCN2 (4). |
1(0,0,0,1) | Details |
| 8725286 | Choy M, Oltjen SL, Otani YS, Armstrong MT, Armstrong PB: Fibroblast growth factor-2 stimulates embryonic cardiac mesenchymal cell proliferation. Dev Dyn. 1996 Jun;206(2):193-200. Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2. Inhibition of sulfation of cell surface glycosaminoglycans by treatment with sodium chlorate significantly reduced both the formation of the fibronectin matrix and cell proliferation in response to FGF-2, suggesting an involvement of the low-affinity sulfated glycosaminoglycan FGF receptor system. |
1(0,0,0,1) | Details |
| 16361307 | Gao R, Brigstock DR: A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut. 2006 Jun;55(6):856-62. Epub 2005 Dec 16. CCN2 (4) supported PSC adhesion or migration were blocked by anti-integrin alpha5beta1 antibodies or by treatment of cells with heparinase or sodium chlorate. |
45(0,1,2,10) | Details |