Protein Information

Name IgE
Synonyms IGHE; Ig epsilon chain C region; IgE; immunoglobulin heavy constant epsilon; Ig epsilon chain C regions; IgEs; immunoglobulin heavy constant epsilons

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
9508673 Kim HM, Lee EH, Kim CY, Chung JG, Kim SH, Lim JP, Shin TY: Antianaphylactic properties of eugenol. . Pharmacol Res. 1997 Dec;36(6):475-80.

Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE.
243(3,3,3,3) Details
8889799 Hilton I, Dearman RJ, Fielding I, Basketter DA, Kimber I: Evaluation of the sensitizing potential of eugenol and isoeugenol in mice and guinea pigs. J Appl Toxicol. 1996 Sep-Oct;16(5):459-64.

In the same assay, exposure to eugenol was associated with a statistically significant increase in serum IgE concentrations when initial application concentrations of 2.5% were used.
7(0,0,1,2) Details
9125128 Shin BK, Lee EH, Kim HM: Suppression of L-histidine decarboxylase mRNA expression by methyleugenol. Biochem Biophys Res Commun. 1997 Mar 6;232(1):188-91.


Methyleugenol also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE.
2(0,0,0,2) Details
18261158 Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Kim HS, Lee KR, Kim YK, Radinger M, Her E, Choi WS: Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells. Clin Exp Allergy. 2008 May;38(5):794-804. Epub 2008 Feb 2.

In high-performance liquid chromatography analysis, quercetin-3-beta-D-glucoside and eugenol were identified as the major active components.
OBJECTIVES: To investigate the effect of many Korean plants on the IgE-mediated allergic response in mast cells and in vivo, and its mechanism of action.
1(0,0,0,1) Details
11981653 Piirila P, Hodgson U, Estlander T, Keskinen H, Saalo A, Voutilainen R, Kanerva L: Occupational respiratory hypersensitivity in dental personnel. Int Arch Occup Environ Health. 2002 Apr;75(4):209-16. Epub 2002 Feb 1.


The occupational rhinitis diagnoses studied at the FIOH were based on work-related symptoms and a change in the status of the nasal mucosa during challenge testing; and the diagnosis of occupational asthma based on reactions in challenge testing, or on IgE positivity and peak flow monitoring at work and during days off.
1(0,0,0,1) Details
12492520 Kunisada M, Adachi A, Asano H, Horikawa T: Anaphylaxis due to formaldehyde released from root-canal disinfectant. Contact Dermatitis. 2002 Oct;47(4):215-8.

Radioallergosorbent test showed that she had a high level of formaldehyde-specific IgE in her serum.
Patch testing showed that she also had delayed-type allergy to formaldehyde, paraformaldehyde and eugenol.
1(0,0,0,1) Details