| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | aldicarb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8540222 | Montesissa C, De Liguoro M, Amorena M, Lucisano A, Carli S: In vitro comparison of aldicarb oxidation in various food-producing animal species. Vet Hum Toxicol. 1995 Aug;37(4):333-6. The microsomal activities of mono-ooxygenase enzymes (flavin-containing and cytochrome P-450-dependent mixed function oxygenases) were compared by measuring the quantity of the 2 oxidized metabolites, ALD sulfoxide and ALD sulfone, produced during 60 min of incubation. |
2(0,0,0,2) | Details |
| 10330685 | Perkins EJ, el-Alfy A, Schlenk D: In vitro sulfoxidation of aldicarb by hepatic microsomes of channel catfish, Ictalurus punctatus. Toxicol Sci. 1999 Mar;48(1):67-73. Both the cytochrome P450 (CYP) and the flavin monooxygenase systems (FMO) are involved in this process. |
1(0,0,0,1) | Details |
| 9931232 | Sturm A, Hansen P: Altered cholinesterase and monooxygenase levels in Daphnia magna and Chironomus riparius exposed to environmental pollutants. Ecotoxicol Environ Saf. 1999 Jan;42(1):9-15. These results suggest that cytochrome P450-dependent monooxygenase activities may be useful variables in toxicity tests with aquatic insects. Parathion, dichlorvos, and aldicarb caused dose-related inhibition of cholinesterase (ChE) in 24-h bioassays with both species. |
1(0,0,0,1) | Details |
| 15178073 | Schlenk D, Yeung C, Rettie A: Unique monooxygenation pattern indicates novel flavin-containing monooxygenase in liver of rainbow trout. Mar Environ Res. 2004 Aug-Dec;58(2-5):499-503. Utilizing prochiral methyl tolyl sulfides (MTS) and isoform-selective antibodies, an attempt was made to identify specific FMO isoforms which may be involved in sulfoxidation reactions which have been shown to bioactivate thioether pesticides, such as aldicarb. Rainbow trout hepatic microsomes treated with detergent to eliminate cytochrome P450 contributions catalyzed the formation of the sulfoxide of MTS in 75% S enantiomeric excess. |
1(0,0,0,1) | Details |
| 12369596 | Montesissa C, Huveneers MB, Hoogenboom LA, Amorena M, De Liguoro M, Lucisano A: The oxidative metabolism of aldicarb in pigs: in vivo-in vitro comparison. Drug Metabol Drug Interact. 1994;11(2):127-38. Selective in vitro inhibition of flavin-containing and cytochrome P-450 monooxygenases confirmed that the former enzymes catalyze mainly sulfoxide production whereas the latter that of sulfone. |
1(0,0,0,1) | Details |
| 1785205 | Schlenk D, Buhler DR: Role of flavin-containing monooxygenase in the in vitro biotransformation of aldicarb in rainbow trout (Oncorhynchus mykiss). Xenobiotica. 1991 Dec;21(12):1583-9. |
0(0,0,0,0) | Details |
| 9772213 | El-Alfy A, Schlenk D: Potential mechanisms of the enhancement of aldicarb toxicity to Japanese medaka, Oryzias latipes, at high salinity. Toxicol Appl Pharmacol. 1998 Sep;152(1):175-83. |
0(0,0,0,0) | Details |
| 11719702 | Wang J, Grisle S, Schlenk D: Effects of salinity on aldicarb toxicity in juvenile rainbow trout (Oncorhynchus mykiss) and striped bass (Morone saxatilis x chrysops). Toxicol Sci. 2001 Dec;64(2):200-7. |
0(0,0,0,0) | Details |