| Name | Asc 1 |
|---|---|
| Synonyms | ASC 1; Asc1; Activating signal cointegrator 1; HsT17391; TRIP 4; TRIP4; Thyroid hormone receptor interactor 4; Thyroid receptor interacting protein 4… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16026768 | Xie X, Dumas T, Tang L, Brennan T, Reeder T, Thomas W, Klein RD, Flores J, O'Hara BF, Heller HC, Franken P: Lack of the -serine- transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 2005 Aug 9;1052(2):212-21. Asc-1 transports small neutral amino acids with high affinity especially for and (K (i): 8-12 microM), two endogenous co-agonists that activate (NMDA) receptors through interacting with the strychnine-insensitive binding-site. |
37(0,1,1,7) | Details |
| 17432963 | Rutter AR, Fradley RL, Garrett EM, Chapman KL, Lawrence JM, Rosahl TW, Patel S: Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci. 2007 Mar;25(6):1757-66. In the mammalian central nervous system, transporter-mediated reuptake may be critical for terminating the neurotransmitter action of at the strychnine insensitive site of the NMDA receptor. The Na (+) independent amino acid transporter -serine- transporter 1 (Asc-1) has been proposed to account for synaptosomal uptake by virtue of its high affinity for and widespread neuronal expression throughout the brain. |
6(0,0,0,6) | Details |
| 18805436 | Yang CR, Svensson KA: Allosteric modulation of NMDA receptor via elevation of brain and the therapeutic potentials for schizophrenia. Pharmacol Ther. 2008 Dec;120(3):317-32. Epub 2008 Aug 27. Endogenous and both act as co-agonists on the strychnine-insensitive GlyB site on the NMDA receptor, and along with co-activate the NMDA receptor. Forebrain synaptic and levels are regulated by the Transporter-1 (GlyT1) and the -serine- transporter-1 (Asc-1), respectively; in addition to metabolism by D-Amino Acid Oxidase (DAAO). |
2(0,0,0,2) | Details |