strychnine

Identification (Source:EPA,EU)

ID 336
Name strychnine
CAS 57-24-9
IUPAC strychnidin-10-one
Inchi InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
CIPAC
EPA Code
Formula C21H22N2O2
SMILES O1C([H])([H])C([H])=C(C2([H])[H])[C@]([H])(C([H])([H])[C@@]([H])([C@]3(c4c5c([H])c([H])c([H])c4[H])C([H])([H])C6([H])[H])N26)[C@@]([H])([C@]1([H])C([H])([H])C7=O)[C@]3([H])N57
Status Not Approved

Classification

Mode of Action
Pesticide Type
Chemical Group
Classification Avicides
botanical rodenticides

Properties (Source:PubChem)

Molecular Weight 334.41158
Physical State
AlogP 1.145
H-Bond Donor 0
H-Bond Acceptor 3
Surface Area 279.82
Polar Surface Area 32.78

Structure



ChemMapper Search Option (Docunmentation of ChemMapper)

3D similarity method

2D similarity method

Compound Database



Bioactivity Database

KEGG (5,928)

PDB (7,072)


Similarity Threshold

Related targets

Target Name RScore (About this table)
glycine receptors (protein family or complex) 18419(111,374,467,1184) Details
NMDA receptor (protein family or complex) 8249(66,141,150,674) Details
glutamate receptors (protein family or complex) 866(7,14,16,86) Details
acetylcholine receptor (protein family or complex) 749(7,11,13,59) Details
ATPase 673(7,9,12,38) Details
glutamate receptor 699(6,11,11,69) Details
chloride channel (protein family or complex) 530(3,10,13,65) Details
5 HT3 412(3,8,8,22) Details
NA K ATPase 176(2,2,2,16) Details
cytochrome P450 (protein family or complex) 169(2,2,2,9) Details
Calpains (protein family or complex) 166(2,2,2,6) Details
GABA receptor (protein family or complex) 390(1,9,9,70) Details
CA1 253(1,5,6,48) Details
gephyrin 213(1,3,8,48) Details
mu opioid receptors 152(1,3,3,12) Details
somatostatin 148(1,3,3,8) Details
GLYT2 162(1,2,2,52) Details
NMDA receptor 1 135(1,2,2,25) Details
SDCN 103(1,1,3,13) Details
protein kinase C (protein family or complex) 101(1,1,1,21) Details
enkephalin 92(1,1,2,7) Details
corticotropin releasing factor 90(1,1,2,5) Details
Ca x 87(1,1,2,2) Details
IL 10 85(1,1,1,5) Details
G protein coupled receptors 84(1,1,1,4) Details
FMLP 84(1,1,1,4) Details
P17 84(1,1,1,4) Details
monoamine oxidase A 82(1,1,1,2) Details
kynurenine aminotransferase I 82(1,1,1,2) Details
most 1 81(1,1,1,1) Details
THPO 81(1,1,1,1) Details
serotonin receptor 125(0,4,4,5) Details
brains 101(0,3,3,11) Details
complex is 98(0,3,3,8) Details
adenylyl cyclase 95(0,3,3,5) Details
G protein 88(0,2,2,28) Details
transducin 68(0,2,2,8) Details
muscles 76(0,1,3,36) Details
Acetylcholinesterase 70(0,1,4,25) Details
Substance P 67(0,1,2,32) Details
GABA B receptors 62(0,1,1,32) Details
GLYT1 61(0,1,1,31) Details
taste receptors (protein family or complex) 54(0,1,2,19) Details
CA3 46(0,1,2,11) Details
Asc 1 45(0,1,1,15) Details
NR2B 44(0,1,1,14) Details
alpha 2 adrenergic receptors (protein family or complex) 43(0,1,1,13) Details
dynorphin 42(0,1,1,12) Details
NK1 42(0,1,1,12) Details
Gustducin 40(0,1,1,10) Details
neurokinin 1 receptor 40(0,1,1,10) Details
P15 38(0,1,1,8) Details
AIDA 37(0,1,1,7) Details
KCC2 37(0,1,1,7) Details
beta adrenoceptor (protein family or complex) 37(0,1,1,7) Details
anticholinesterase 35(0,1,1,5) Details
Engrailed 1 35(0,1,1,5) Details
Potassium channel (protein family or complex) 34(0,1,1,4) Details
GlyBP 34(0,1,1,4) Details
SC2 34(0,1,1,4) Details
P2X receptor (protein family or complex) 34(0,1,1,4) Details
Delta opioid receptors 34(0,1,1,4) Details
5 HT1A 34(0,1,1,4) Details
5 HT2C 33(0,1,1,3) Details
taurine transporter 32(0,1,1,2) Details
SK2 32(0,1,1,2) Details
ceases 32(0,1,1,2) Details
PINCH 31(0,1,1,1) Details
TC 1 31(0,1,1,1) Details
pig 2 31(0,1,1,1) Details
voltage gated potassium channels 31(0,1,1,1) Details
synapsin I 31(0,1,1,1) Details
GABA(A) receptor 31(0,1,1,1) Details
AP4 32(0,0,0,32) Details
TFEC 31(0,0,5,6) Details
orexin 23(0,0,1,18) Details
ACPD 21(0,0,0,21) Details
GABA transaminase 18(0,0,0,18) Details
alpha 2 adrenergic 16(0,0,1,11) Details
vascular endothelial growth factor 15(0,0,0,15) Details
sodium channel (protein family or complex) 15(0,0,1,10) Details
calcitonin 14(0,0,2,4) Details
CYP2B 13(0,0,2,3) Details
Cl 2 12(0,0,1,7) Details
caspase 3 12(0,0,0,12) Details
MEST 12(0,0,1,7) Details
protein kinase A (protein family or complex) 11(0,0,0,11) Details
calcium channel (protein family or complex) 10(0,0,0,10) Details
SOD1 10(0,0,0,10) Details
tumor necrosis factor alpha 10(0,0,0,10) Details
P10 10(0,0,0,10) Details
benzodiazepine receptor (protein family or complex) 10(0,0,0,10) Details
PCP2 10(0,0,0,10) Details
cone photoreceptors (protein family or complex) 10(0,0,0,10) Details
vanilloid receptor 1 9(0,0,0,9) Details
P19 9(0,0,0,9) Details
P glycoprotein 9(0,0,1,4) Details
c fos 9(0,0,0,9) Details
Frings 8(0,0,1,3) Details
NR2A 8(0,0,0,8) Details
CDMT 8(0,0,1,3) Details
vesicular GABA transporter 7(0,0,0,7) Details
EAAT5 7(0,0,0,7) Details
glutamic acid decarboxylase 7(0,0,0,7) Details
CD50 7(0,0,1,2) Details
TM3 7(0,0,0,7) Details
Anas 7(0,0,1,2) Details
chloride channel protein 6(0,0,1,1) Details
P37 6(0,0,1,1) Details
bcl 2 6(0,0,0,6) Details
Vesicular glutamate transporter 2 6(0,0,0,6) Details
choline acetyltransferase 6(0,0,0,6) Details
metabotropic glutamate receptor 4 6(0,0,0,6) Details
PACAP 6(0,0,0,6) Details
catalase 6(0,0,0,6) Details
ATPase is 6(0,0,1,1) Details
amino acid transporter 6(0,0,0,6) Details
THIO 6(0,0,1,1) Details
glutathione S transferase 6(0,0,1,1) Details
phospholipase C 6(0,0,0,6) Details
lactate dehydrogenase (protein family or complex) 5(0,0,0,5) Details
CACA 5(0,0,0,5) Details
P12 5(0,0,0,5) Details
tyrosine hydroxylase 5(0,0,0,5) Details
glycine receptor beta subunit 5(0,0,0,5) Details
integrator (protein family or complex) 5(0,0,0,5) Details
interleukin 1beta 5(0,0,0,5) Details
Melanopsin 5(0,0,0,5) Details
cyclooxygenase 2 4(0,0,0,4) Details
alkaline phosphatase 4(0,0,0,4) Details
P14 4(0,0,0,4) Details
aldehyde oxidase 4(0,0,0,4) Details
T12 4(0,0,0,4) Details
PKCgamma 4(0,0,0,4) Details
NR3B 4(0,0,0,4) Details
T10 4(0,0,0,4) Details
NR3A 4(0,0,0,4) Details
SSTR2 4(0,0,0,4) Details
T13 3(0,0,0,3) Details
P11 3(0,0,0,3) Details
A17 3(0,0,0,3) Details
P40 3(0,0,0,3) Details
5 HT 1B receptor 3(0,0,0,3) Details
dynein (protein family or complex) 3(0,0,0,3) Details
phosphoserine phosphatase 3(0,0,0,3) Details
E14 3(0,0,0,3) Details
protein phosphatases 3(0,0,0,3) Details
GLRA1 3(0,0,0,3) Details
calmodulin 3(0,0,0,3) Details
transferase 3(0,0,0,3) Details
C18 3(0,0,0,3) Details
caspase 9 3(0,0,0,3) Details
olfactory receptor 3(0,0,0,3) Details
5 HT2 3(0,0,0,3) Details
AT1 3(0,0,0,3) Details
pallid 3(0,0,0,3) Details
slc6a5 2(0,0,0,2) Details
AMPA 2 2(0,0,0,2) Details
PW1 2(0,0,0,2) Details
P5 6 2(0,0,0,2) Details
P250 2(0,0,0,2) Details
CB1 2(0,0,0,2) Details
guanine nucleotide exchange factor 2(0,0,0,2) Details
phenylethanolamine N methyltransferase 2(0,0,0,2) Details
P18 2(0,0,0,2) Details
mGluR6 2(0,0,0,2) Details
CLAP 2(0,0,0,2) Details
Mineralocorticoid receptors 2(0,0,0,2) Details
cone arrestin 2(0,0,0,2) Details
SC1 2(0,0,0,2) Details
PARP 2(0,0,0,2) Details
NK 1 2(0,0,0,2) Details
yl 1 2(0,0,0,2) Details
cis 4 2(0,0,0,2) Details
PI3 kinase (protein family or complex) 2(0,0,0,2) Details
FRAP 2(0,0,0,2) Details
NKCC1 2(0,0,0,2) Details
MT2 2(0,0,0,2) Details
Glucagon like peptide 1 2(0,0,0,2) Details
ZP3 2(0,0,0,2) Details
CLIP 2(0,0,0,2) Details
nestin 2(0,0,0,2) Details
Fyn 2(0,0,0,2) Details
D amino acid oxidase 2(0,0,0,2) Details
OASIS 2(0,0,0,2) Details
glial glutamate transporter 2(0,0,0,2) Details
oxytocin receptor 2(0,0,0,2) Details
mGlu5 2(0,0,0,2) Details
muscarinic M2 receptors 2(0,0,0,2) Details
p24 2(0,0,0,2) Details
E12 2(0,0,0,2) Details
alpha 1A adrenoceptor 2(0,0,0,2) Details
cytochrome c 2(0,0,0,2) Details
estrogen receptor 2(0,0,0,2) Details
ceruloplasmin 2(0,0,0,2) Details
ERK1 2(0,0,0,2) Details
adenylate cyclase 2(0,0,0,2) Details
alanine aminotransferase 2(0,0,0,2) Details
MS2 2(0,0,0,2) Details
protein tyrosine kinase 2(0,0,0,2) Details
angiotensin II 2(0,0,0,2) Details
P13 2(0,0,0,2) Details
dopamine transporter 2(0,0,0,2) Details
Ca v 2(0,0,0,2) Details
mGluR1 2(0,0,0,2) Details
pituitary adenylate cyclase activating polypeptide 2(0,0,0,2) Details
dopamine D2 receptor 2(0,0,0,2) Details
P16 2(0,0,0,2) Details
heme oxygenase 1 2(0,0,0,2) Details
catechol O methyltransferase 2(0,0,0,2) Details
P22 2(0,0,0,2) Details
serotonin receptors (protein family or complex) 2(0,0,0,2) Details
glial fibrillary acidic protein 2(0,0,0,2) Details
EP2 1(0,0,0,1) Details
serine protease inhibitor 1(0,0,0,1) Details
48 kDa protein 1(0,0,0,1) Details
ASCT2 1(0,0,0,1) Details
Homo sapiens 1(0,0,0,1) Details
tumor suppressor p53 1(0,0,0,1) Details
BK channel 1(0,0,0,1) Details
phospholipase A2 1(0,0,0,1) Details
brain derived neurotrophic factor 1(0,0,0,1) Details
superoxide dismutase 1(0,0,0,1) Details
MAPK (protein family or complex) 1(0,0,0,1) Details
phosphodiesterase 1(0,0,0,1) Details
albumin 1(0,0,0,1) Details
aspartate aminotransferase 1(0,0,0,1) Details
histidine decarboxylase 1(0,0,0,1) Details
CF 1 (protein family or complex) 1(0,0,0,1) Details
follicle stimulating hormone (protein family or complex) 1(0,0,0,1) Details
caspase 8 1(0,0,0,1) Details
protein as 1(0,0,0,1) Details
caspase (protein family or complex) 1(0,0,0,1) Details
myoglobin 1(0,0,0,1) Details
p65 1(0,0,0,1) Details
AP 1 (protein family or complex) 1(0,0,0,1) Details
endothelin 1 1(0,0,0,1) Details
GABA transporter 1(0,0,0,1) Details
neuropeptide Y 1(0,0,0,1) Details
P23 1(0,0,0,1) Details
NPPB 1(0,0,0,1) Details
purinergic receptor 1(0,0,0,1) Details
arginine vasopressin 1(0,0,0,1) Details
myeloperoxidase 1(0,0,0,1) Details
succinate dehydrogenase (protein family or complex) 1(0,0,0,1) Details
T11 1(0,0,0,1) Details
mitochondrial ATPase 1(0,0,0,1) Details
cyclin A 1(0,0,0,1) Details
protein is 1(0,0,0,1) Details
CF1 1(0,0,0,1) Details
brain 1 1(0,0,0,1) Details
cholecystokinin 1(0,0,0,1) Details
Lipoxygenase (protein family or complex) 1(0,0,0,1) Details
beta is 1(0,0,0,1) Details
cystathionine gamma lyase 1(0,0,0,1) Details
transmembrane receptors 1(0,0,0,1) Details
HCN1 1(0,0,0,1) Details
membrane inserted 1(0,0,0,1) Details
vesicular glutamate transporter 3 1(0,0,0,1) Details
alpha 1B adrenoceptor 1(0,0,0,1) Details
PAFR 1(0,0,0,1) Details
RB2 1(0,0,0,1) Details
lactate dehydrogenase a 1(0,0,0,1) Details
phosphodiesterases (protein family or complex) 1(0,0,0,1) Details
aminolevulinate dehydratase 1(0,0,0,1) Details
collagenase type IV 1(0,0,0,1) Details
G protein gamma (protein family or complex) 1(0,0,0,1) Details
serine racemase 1(0,0,0,1) Details
MFT 1(0,0,0,1) Details
Cs 5 1(0,0,0,1) Details
Chrna9 1(0,0,0,1) Details
orexin receptors 1(0,0,0,1) Details
neutral amino acid transporters 1(0,0,0,1) Details
NK receptor 1(0,0,0,1) Details
NR4 1(0,0,0,1) Details
ear 2 1(0,0,0,1) Details
karyopherin alpha3 1(0,0,0,1) Details
vGLUT1 1(0,0,0,1) Details
cytokeratin 2e 1(0,0,0,1) Details
Ray 1(0,0,0,1) Details
MAOB 1(0,0,0,1) Details
EC2 1(0,0,0,1) Details
CaMK II 1(0,0,0,1) Details
endothelin 3 1(0,0,0,1) Details
OX2 1(0,0,0,1) Details
CK 10 1(0,0,0,1) Details
H1.5 1(0,0,0,1) Details
activator 1 (protein family or complex) 1(0,0,0,1) Details
phospholipase C beta 2 1(0,0,0,1) Details
ferritin (protein family or complex) 1(0,0,0,1) Details
cystathionine beta synthase 1(0,0,0,1) Details
GTPase 1(0,0,0,1) Details
NCAM 1(0,0,0,1) Details
neural cell adhesion molecule 1(0,0,0,1) Details
cyclin B1 1(0,0,0,1) Details
progesterone receptor 1(0,0,0,1) Details
F12 1(0,0,0,1) Details
staring 1(0,0,0,1) Details
E16 1(0,0,0,1) Details
beta lactoglobulin 1(0,0,0,1) Details
kappa opioid receptor 1(0,0,0,1) Details
cyclin dependent kinase (protein family or complex) 1(0,0,0,1) Details
androgen receptor 1(0,0,0,1) Details
calpain inhibitor 1(0,0,0,1) Details
mM 1 1(0,0,0,1) Details
PCBC 1(0,0,0,1) Details
rhodopsin 1(0,0,0,1) Details
synaptophysin 1(0,0,0,1) Details
Ciliary neurotrophic factor 1(0,0,0,1) Details
filaggrin 1(0,0,0,1) Details
SIDS 1(0,0,0,1) Details
factor A 1(0,0,0,1) Details
Q10 1(0,0,0,1) Details
beta arrestin 2 1(0,0,0,1) Details
ACCA 1(0,0,0,1) Details
WAF1 1(0,0,0,1) Details
sec 1 1(0,0,0,1) Details
ring 2 1(0,0,0,1) Details
PN 1 1(0,0,0,1) Details
guanylate cyclase 0(0,0,0,0) Details
NK 2 0(0,0,0,0) Details
alcohol dehydrogenase (protein family or complex) 0(0,0,0,0) Details
apoprotein 0(0,0,0,0) Details
CD18 0(0,0,0,0) Details
CD11b 0(0,0,0,0) Details
purinergic receptors 0(0,0,0,0) Details
G alpha o 0(0,0,0,0) Details
not 7 0(0,0,0,0) Details
Pax6 0(0,0,0,0) Details
ear 3 0(0,0,0,0) Details
Gly 1 0(0,0,0,0) Details
MT4 0(0,0,0,0) Details
nerve growth factors 0(0,0,0,0) Details
hand 1 0(0,0,0,0) Details
NMDAR2C 0(0,0,0,0) Details
HCN2 0(0,0,0,0) Details
V1 2 0(0,0,0,0) Details
CD64 0(0,0,0,0) Details
adenosine A1 receptor 0(0,0,0,0) Details
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