| Name | dynorphin |
|---|---|
| Synonyms | Beta neoendorphin; Beta neoendorphin dynorphin; Beta neoendorphin dynorphin precursor; Dynorphin; Enkephalin B; Leu enkephalin; Leumorphin; PDYN… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7472439 | Randic M, Cheng G, Kojic L: kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. J Neurosci. 1995 Oct;15(10):6809-26. Monosynaptic and polysynaptic excitatory postsynaptic potentials (EPSPs) were evoked by orthodromic electrical stimulation of A delta or C primary afferent fibers in the dorsal root after blocking inhibitory inputs with bicuculline and strychnine, NMDA receptors with D-2-amino-5-phosphonovaleric acid and mu- and delta-opioid receptors with CTAP and ICI 174,864, respectively. Bath application of dynorphin A1-17 or U-69, 593 caused dual modulation of the peak amplitude of presumed monosynaptic AMPA receptor-mediated EPSPs, decreasing synaptic potentials at nanomolar concentrations in a majority of SG cells examined (dynorphin, 63%; U-69,593, 91%), and increasing EPSPs at micromolar concentrations. |
6(0,0,0,6) | Details |
| 7813551 | Long JB, Skolnick P: 1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury. Eur J Pharmacol. 1994 Aug 22;261(3):295-301. The protective effects of a variety of competitive and non-competitive (NMDA) receptor antagonists indicate that activation of the NMDA receptor complex is essential for dynorphin A-induced spinal cord injury. 1-Aminocyclopropanecarboxylic acid (ACPC) is a high affinity, partial agonist at strychnine-insensitive glycine receptors associated with the NMDA receptor complex. |
36(0,1,1,6) | Details |