Protein Information

Name T10
Synonyms ADP ribosyl cyclase; ADP ribosyl cyclase 1; Acute lymphoblastic leukemia cells antigen CD38; CD38; CD38 antigen; CD38 antigen (p45); CD38 molecule; Cyclic ADP ribose hydrolase…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
12618352 Su CK, Phoon SL, Yen CT: Identification of active thoracic spinal segments responsible for tonic and bursting sympathetic discharge in neonatal rats. Brain Res. 2003 Mar 21;966(2):288-99.

Bath application of bicuculline and strychnine, which removes endogenous GABA (A) and glycine receptor activities, transforms the quasi-periodic tonic SND into synchronized bursts (bSND).
Nerve-cord preparation with either T6-8 or T10-12 segments could generate a substantial amount of tonic SND that retained comparable oscillating patterns.
2(0,0,0,2) Details
11600626 Frech MJ, Perez-Leon J, Wassle H, Backus KH: Characterization of the spontaneous synaptic activity of amacrine cells in the mouse retina. J Neurophysiol. 2001 Oct;86(4):1632-43.

Only four amacrine cells showed glycinergic sIPSCs that were inhibited by strychnine (1 microM).
However, GlyRs (mean T10/90: 2.4 +/- 0.08 ms) activated significantly slower than GABA (A) Rs (mean T10/90: 1.2 +/- 0.03 ms).
1(0,0,0,1) Details
14980391 Yang Z, Smith L, Coote JH: Paraventricular nucleus activation of renal sympathetic neurones is synaptically depressed by nitric oxide and glycine acting at a spinal level. Neuroscience. 2004;124(2):421-8.

Neurones in the latter nucleus were stimulated by microinjecting DLH and drugs were applied to the spinal cord via an intrathecal catheter with the tip positioned at T9-T10.
Enhancement of synaptically induced renal nerve activity was also observed following intrathecal glycine receptor inhibitor strychnine.
1(0,0,0,1) Details