Protein Information

Name 5 HT2C
Synonyms 5 HT 2C; 5 HT2C; 5 HTR2C; 5 hydroxytryptamine (serotonin) receptor 2C; 5 hydroxytryptamine 2C receptor; 5 hydroxytryptamine receptor 2C; 5HT 1C; HTR1C…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
8539344 Molewijk HE, van der Poel AM, Olivier B: The ambivalent behaviour "stretched approach posture" in the rat as a paradigm to characterize anxiolytic drugs. Psychopharmacology. 1995 Sep;121(1):81-90.

Finally, the 5-HT2C receptor antagonist ritanserine, the CCKA receptor antagonist devazepide, the CCKB receptor antagonist L-365.260 and the strychnine-insensitive glycine site antagonist 7-Cl-kynurenic acid were without effect on the behaviours in this paradigm using single doses.
31(0,1,1,1) Details
8319089 Lewis DI, Sermasi E, Coote JH: Excitatory and indirect inhibitory actions of 5-hydroxytryptamine on sympathetic preganglionic neurones in the neonate rat spinal cord in vitro. Brain Res. 1993 May 7;610(2):267-75.

The 5-HT-induced IPSPs were reversibly blocked by superfusion with strychnine, suggesting they were mediated by glycine.
The results suggest that the excitatory action of 5-HT on SPN is mediated via an atypical 5-HT2 receptor or a 5-HT1C-like receptor.
1(0,0,0,1) Details
16760346 Harvey PJ, Li X, Li Y, Bennett DJ: Endogenous monoamine receptor activation is essential for enabling persistent sodium currents and repetitive firing in rat spinal motoneurons. J Neurophysiol. 2006 Sep;96(3):1171-86. Epub 2006 Jun 7.


Application of 5-HT2A, 5-HT2C, and alpha1-NE receptor antagonists (ketanserin, RS 102221, and WB 4101, respectively) significantly reduced the Na PICs, and a combined application of these three monoamine antagonists completely eliminated the Na PIC, in both acute and chronic spinal rats.
1(0,0,0,1) Details