Protein Information

Name P18
Synonyms AIMP 3; P18; AIMP3; EEF1E1; Elongation factor p18; Eukaryotic translation elongation factor 1 epsilon 1; Homolog of rat elongation factor p18; Multisynthetase complex auxiliary component p18…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
10564356 Jiang Z, Rempel J, Li J, Sawchuk MA, Carlin KP, Brownstone RM: Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. Eur J Neurosci. 1999 Oct;11(10):3481-7.

The electrophysiological data were obtained during rhythmic bursting produced by application of N-methyl-D-aspartate (NMDA) and strychnine to the isolated spinal cord at various postnatal ages.
The immunohistochemical evidence demonstrates a dramatic change in the cellular profile of both the alpha1C and alpha1D subunits of L-type calcium channels during postnatal development; the labelling of both subunits increases with age, approximating the adult pattern by P18.
1(0,0,0,1) Details
18234240 Pedroarena CM, Kamphausen S: Glycinergic synaptic currents in the deep cerebellar nuclei. . Neuropharmacology. 2008 Apr;54(5):784-95. Epub 2007 Dec 23.

Spontaneous glycinergic IPSCs were very rare but direct presynaptic depolarization by superfusion with elevated potassium concentration or application of 4-aminopyridine consistently evoked strychnine sensitive IPSCs.
Immuno-histochemical investigations using a specific marker for glycinergic fibers and terminals showed low density of immuno-fluorescent puncta, putative glycinergic boutons surrounding P18-P23 DCNs, in agreement with the rare spontaneous synaptic activity.
1(0,0,0,1) Details