| 14568560 |
Kondratskaya EL, Pankratov YV, Lalo UV, Chatterjee SS, Krishtal OA: Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. Neurochem Int. 2004 Feb;44(3):171-7.
The effect of ginkgolide B on LTP did not alter considerably if GlyRs were blocked by strychnine (2 microM).
Ginkgolide J which is the weakest blocker of PAFR (IC (50)=54 microM, as compared to IC (50)=2.5 microM for ginkgolide B) inhibits GlyR-operated channels with IC (50)=2.0 microM. |
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