| Name | serotonin receptor |
|---|---|
| Synonyms | 5 hydroxytryptamine receptor 6; serotonin receptor; 5 HT 6; 5 HT6; 5 hydroxytryptamine (serotonin) receptor 6; 5 hydroxytryptamine 6 receptor; HTR 6; HTR6… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9886686 | Maksay G: Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands. Neuropharmacology. 1998 Dec;37(12):1633-41. |
31(0,1,1,1) | Details |
| 16467527 | Kato G, Yasaka T, Katafuchi T, Furue H, Mizuno M, Iwamoto Y, Yoshimura M: Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci. 2006 Feb 8;26(6):1787-94. Serotonin receptor antagonists were unexpectedly without effect, but a GABAA receptor antagonist, bicuculline, or a glycine receptor antagonist, strychnine, completely suppressed the RVM stimulation-induced increase in IPSCs. |
31(0,1,1,1) | Details |
| 16687139 | Jensen AA, Gharagozloo P, Birdsall NJ, Zlotos DP: Pharmacological characterisation of strychnine and brucine analogues at and alpha7 nicotinic acetylcholine receptors. Eur J Pharmacol. 2006 Jun 6;539(1-2):27-33. Epub 2006 May 9. In this study, we have characterised the pharmacological properties of tertiary and quaternary analogues as well as bisquaternary dimers of strychnine and brucine at human alpha1 and alpha1beta glycine receptors and at a chimera consisting of the amino-terminal domain of the alpha7 nicotinic receptor (containing the orthosteric ligand binding site) and the ion channel domain of the 5-HT3A serotonin receptor. |
31(0,1,1,1) | Details |
| 9927615 | Rothlin CV, Katz E, Verbitsky M, Elgoyhen AB: The alpha9 nicotinic acetylcholine receptor shares pharmacological properties with type A and type 3 serotonin receptors. Mol Pharmacol. 1999 Feb;55(2):248-54. Thus, the type A gamma-aminobutyric acid receptor antagonist bicuculline, the glycinergic antagonist strychnine, and the type 3 serotonin receptor antagonist ICS-205,930 block -evoked currents in alpha9-injected Xenopus laevis oocytes with the following rank order of potency: strychnine > ICS-205,930 > bicuculline. |
31(0,1,1,1) | Details |
| 12504915 | Maksay G, Biro T: Dual cooperative allosteric modulation of binding to ionotropic glycine receptors. Neuropharmacology. 2002 Dec;43(7):1087-98. Glycine receptors (GlyRs) were studied via [(3) H] strychnine binding to synaptosomal membranes of rat spinal cord. A ternary allosteric model was applied for the effects of tropeines, minaxolone, nitrendipine, Zn (2+), muscarinic and serotonin receptor ligands. |
1(0,0,0,1) | Details |