Protein Information

Name CYP2B
Synonyms CYP2B; CYP2B7; CYP2B7P; CYP2B protein; CYP2B7P1; CYP2B7P1 protein; CYP2B7P1 proteins

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7906730 Fujisaki H, Mise M, Ishii Y, Yamada H, Oguri K: Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase. J Pharmacol Exp Ther. 1994 Feb;268(2):1024-31.

Although this inducer increased CYP2B cytochrome P450s (P450s) to the maximum levels after 4 consecutive days of administration, the maximal increase by strychnine was attained after 3 days of administration.
12(0,0,2,2) Details
8850324 Yamada H, Minematsu Y, Nakamura T, Mise M, Fujisaki H, Oguri K: Brucine as a potent inducer of CYP2B3, the third member of the CYP2B subfamily P450 in rats. Biol Pharm Bull. 1996 Feb;19(2):291-3.

We have indicated that strychnine and brucine induce concurrently an unknown P450 (2B-UP) which cross-reacts with anti-CYP2B1 antibody (Fujisaki et al., J.
1(0,0,0,1) Details