| 18632940 |
Keck T, Lillis KP, Zhou YD, White JA: Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. J Neurosci. 2008 Jul 16;28(29):7359-69.
We find that strychnine-sensitive GlyRs are open in the resting CA1 pyramidal cell, creating a state of tonic inhibition that "shunts" the magnitude of EPSPs evoked by electrical stimulation of the Schaffer collateral inputs.
During RDE, GlyRs are less responsive to local glycine application, suggesting that a reduction in the number or sensitivity of membrane-inserted GlyRs underlies RDE. |
1(0,0,0,1) |
Details |