| Name | glycine receptors (protein family or complex) |
|---|---|
| Synonyms | Glycine receptor; Glycine receptors |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7901329 | Becquet D, Hery M, Deprez P, Faudon M, Fache MP, Giraud P, Hery F: / interactions on the control of release in raphe primary cultures. Brain Res. 1997 Oct 3;770(1-2):256-60. Strychnine (50 microM) blocked the inhibitory effect of indicating an action through strychnine-sensitive inhibitory glycine receptors. |
162(2,2,2,2) | Details |
| 7675197 | Milbrandt JC, Caspary DM: Age-related reduction of [3H] strychnine binding sites in the cochlear nucleus of the Fischer 344 rat. Neuroscience. 2004;124(4):929-44. The present study used quantitative receptor autoradiography to examine the effects of aging on the binding profile of the strychnine-sensitive glycine receptor in the Fischer 344 rat. |
162(2,2,2,2) | Details |
| 7834198 | Kuijpers GA, Vergara LA, Calvo S, Yadid G: Inhibitory effect of strychnine on acetylcholine receptor activation in bovine medullary chromaffin cells. Life Sci. 2008 Aug 1;83(5-6):149-54. Epub 2008 Jun 15. Strychnine, which is known as a potent and selective antagonist of the inhibitory glycine receptor in the central nervous system, inhibits the nicotinic stimulation of catecholamine release from bovine cultured chromaffin cells in a concentration-dependent (1-100 microM) manner. |
162(2,2,2,2) | Details |
| 7957739 | Wamsley JK, Sofia RD, Faull RL, Narang N, Ary T, McCabe RT: Interaction of felbamate with [3H] DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain. Proc West Pharmacol Soc. 1994;37:81-3. |
149(1,3,4,4) | Details |
| 12505932 | Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI 2nd, Stabernack CR, Sonner JM: Glycine receptors mediate part of the immobility produced by inhaled anesthetics. J Neurophysiol. 1994 Dec;72(6):2903-10. Then MAC was re-determined during an infusion of 3, 12, 24, or 48 (isoflurane only) micro g/min of strychnine (strychnine blocks glycine receptors) in artificial cerebrospinal fluid. |
134(1,2,5,9) | Details |
| 9765506 | Weaver CD, Partridge JG, Yao TL, Moates JM, Magnuson MA, Verdoorn TA: Activation of and glutamate receptors increases intracellular in cells derived from the endocrine pancreas. J Assoc Res Otolaryngol. 2005 Sep;6(3):280-96. The glycine receptors were permeable to Cl- and blocked by the selective antagonist strychnine. |
118(1,2,3,3) | Details |
| 8549613 | Kehne JH, Baron BM, Harrison BL, McCloskey TC, Palfreyman MG, Poirot M, Salituro FG, Siegel BW, Slone AL, Van Giersbergen PL, et al.: MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles. Alcohol Alcohol. 1999 Mar-Apr;34(2):175-82. Thus, two glycine receptor antagonists which have similar in vitro binding profiles as selective ligands for the strychnine-insensitive glycine receptor, demonstrate different in vitro and in vivo functional profiles. |
116(1,2,2,6) | Details |
| 19307742 | Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, Karst M, Dengler R, Haeseler G, Ahrens J: Modulation of glycine receptor function by the synthetic cannabinoid HU210. Eur J Neurosci. 1994 Oct 1;6(10):1544-57. As we hypothesized that non-CB receptor mechanisms of HU210 might contribute to its anti-inflammatory and anti-nociceptive effects we investigated the interaction of HU210 with strychnine-sensitive alpha (1 ) glycine receptors by using the whole-cell patch clamp technique. |
114(1,2,2,4) | Details |
| 15342271 | Xu H, Zhou KQ, Huang YN, Chen L, Xu TL: activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus. Hear Res. 2008 Mar;237(1-2):32-48. Epub 2007 Dec 28. |
113(1,2,2,3) | Details |
| 18985319 | Ahrens J, Leuwer M, Demir R, Krampfl K, de la Roche J, Foadi N, Karst M, Haeseler G: Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive alpha1- and alpha1beta-receptors. Exp Neurol. 1994 Oct;129(2):244-50. These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations. |
113(1,2,2,3) | Details |
| 9334935 | Duggan S, Milne B, Loomis C: Use of differential normal pulse voltammetry for the measurement of locus coeruleus catecholaminergic metabolism in an acute anaesthetized rodent model of allodynia: effect of mexiletine. Pharmacol Toxicol. 1994 Aug;75(2):73-81. Results of this study indicate that LC CAOC, an index of LC neuronal activity: (a) is a sensitive biochemical index of strychnine-allodynia; (b) is temporally correlated with the cardiovascular and motor responses evoked by hair deflection during glycine receptor blockade; and (c) can be used to quantitate allodynia in the strychnine model. |
113(1,2,2,3) | Details |
| 7816200 | Spanswick D, Pickering AE, Gibson IC, Logan SD: Inhibition of sympathetic preganglionic neurons by spinal glycinergic interneurons. Protein Sci. 1997 May;6(5):983-98. Strychnine antagonized all inhibitory postsynaptic potentials suggesting that they were mediated via glycine receptors. |
112(1,2,2,2) | Details |
| 11860273 | Rasmussen H, Rasmussen T, Triller A, Vannier C: Strychnine-blocked glycine receptor is removed from synapses by a shift in insertion/degradation equilibrium. Brain Res Dev Brain Res. 2003 Aug 12;144(1):73-82. |
243(3,3,3,3) | Details |
| 16375888 | Philippe G, Nguyen L, Angenot L, Frederich M, Moonen G, Tits M, Rigo JM: Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor. Anesthesiology. 1996 May;84(5):1215-22. |
243(3,3,3,3) | Details |
| 7713059 | White HS, Harmsworth WL, Sofia RD, Wolf HH: Felbamate modulates the strychnine-insensitive glycine receptor. . Eur J Pharmacol. 2006 Jun 6;539(1-2):27-33. Epub 2006 May 9. |
243(3,3,3,3) | Details |
| 8383742 | McCabe RT, Wasterlain CG, Kucharczyk N, Sofia RD, Vogel JR: Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. Neuroscience. 2003;122(2):449-57. Because glycinergic mechanisms have been demonstrated to be involved with seizure disorders and neuroprotection, we investigated the binding interaction of felbamate with strychnine-insensitive glycine receptors and compared these findings with brain and plasma levels of felbamate after drug treatment. |
194(2,3,3,4) | Details |
| 17900376 | Renna JM, Strang CE, Amthor FR, Keyser KT: Strychnine, but not PMBA, inhibits neuronal nicotinic acetylcholine receptors expressed by rabbit retinal ganglion cells. J Neurosci Res. 1995 Jun 1;41(2):259-69. Thus, the effects of strychnine application may be to inhibit glycine receptors expressed by ganglion cell or to inhibit amacrine cell alpha7 nAChRs, both of which would result in an increase in the ganglion cell responses. |
193(2,3,3,3) | Details |
| 7808436 | Bloomenthal AB, Goldwater E, Pritchett DB, Harrison NL: Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+. J Pharmacol Exp Ther. 1993 Jun;265(3):1380-6. |
170(2,2,3,5) | Details |
| 19564396 | Duan L, Yang J, Slaughter MM: inhibition of ionotropic glycine receptors. . Mol Reprod Dev. 2001 Feb;58(2):205-15. We found that is a structural analogue of strychnine and a competitive antagonist at ionotropic glycine receptors (GlyRs). |
163(2,2,2,3) | Details |
| 12612034 | Chattipakorn SC, McMahon LL: Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus. Pharmacol Rev. 1993 Sep;45(3):309-79. |
6(0,0,1,1) | Details |
| 8908245 | Gopal KV, Gross GW: Auditory cortical neurons in vitro: initial pharmacological studies. Eur J Pharmacol. 1998 May 8;348(2-3):271-7. Strychnine also changed the burst activity to a simpler pattern and enhanced the burst amplitude, indicating presence of glycine receptors in cortical tissue. |
6(0,0,1,1) | Details |
| 11457589 | Sergeeva OA, Haas HL: Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse. Neuroscience. 2001;103(3):799-810. |
6(0,0,0,6) | Details |
| 17331993 | Veruki ML, Gill SB, Hartveit E: Spontaneous IPSCs and glycine receptors with slow kinetics in wide-field amacrine cells in the mature rat retina. Neurosci Behav Physiol. 2007 Mar;37(3):271-6. Glycinergic spIPSCs were blocked reversibly by strychnine (300 nM). |
3(0,0,0,3) | Details |
| 11850512 | Mori M, Gahwiler BH, Gerber U: and as endogenous agonists at glycine receptors in rat hippocampus in vitro. Brain Res. 2003 Feb 14;963(1-2):165-77. In the presence of ionotropic and GABA (B) receptor antagonists, pressure-application of onto CA3 pyramidal cells induced a current associated with increased conductance, which was inhibited by strychnine. |
3(0,0,0,3) | Details |
| 12909685 | Iizuka M: GABAA and glycine receptors in regulation of intercostal and abdominal expiratory activity in vitro in neonatal rat. Alcohol Clin Exp Res. 2010 Jan;34(1):39-45. Epub 2009 Oct 23. Under normal pH conditions, application of strychnine (0.2- 2.0 microM; a glycine receptor antagonist) to the brainstem did not evoke expiratory bursts. |
3(0,0,0,3) | Details |
| 7650761 | Aprison MH, Galvez-Ruano E, Lipkowitz KB: On a molecular comparison of strong and weak antagonists at the glycinergic receptor. Pharmacology. 2009;83(4):217-22. Epub 2009 Feb 10. Using molecular modeling techniques, we studied nine antagonists in order to try to identify the molecular descriptors that characterize strychnine as a strong antagonist and N,N-dimethyl-muscimol, iso-THIA, THIA, N-methyl-THIP, iso-THAZ, THAZ, iso-THPO, and iso-THAO (see Experimental for chemical names) as weak antagonists. Published molecular biological data show that such an amino acid is present in the portion of the polypeptides identified in the glycine receptor. |
2(0,0,0,2) | Details |
| 15728841 | Gonzalez-Forero D, Alvarez FJ: Differential postnatal maturation of GABAA, glycine receptor, and mixed synaptic currents in Renshaw cells and ventral spinal interneurons. J Neurophysiol. 1996 Aug;76(2):1224-35. |
2(0,0,0,2) | Details |
| 16905250 | Wang W, Xu TL: homeostasis differentially affects (A) receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture. Eur J Neurosci. 1997 Nov;9(11):2340-7. Moreover, inhibition of KCC2 did not change the depressive effect of strychnine on neuronal circuits. |
2(0,0,0,2) | Details |
| 18355923 | Akay T, Fouad K, Pearson KG: New technique for drug application to the spinal cord of walking mice. J Biol Chem. 2004 May 28;279(22):22983-91. Epub 2004 Mar 18. We then describe the influence of applying a glycine-receptor antagonist onto the lumbar segments of the spinal cord to demonstrate that the method is effective in modifying the functioning of neuronal systems in the spinal cord. |
1(0,0,0,1) | Details |
| 18632940 | Keck T, Lillis KP, Zhou YD, White JA: Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. J Neurosci. 2008 Jul 16;28(29):7359-69. Previous studies have demonstrated the presence of functional glycine receptors (GlyRs) in hippocampus. We find that strychnine-sensitive GlyRs are open in the resting CA1 pyramidal cell, creating a state of tonic inhibition that "shunts" the magnitude of EPSPs evoked by electrical stimulation of the Schaffer collateral inputs. |
1(0,0,0,1) | Details |
| 16093340 | Chen X, Shu S, Bayliss DA: Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons. J Neurosci Methods. 2008 Jun 15;171(1):39-47. Epub 2008 Feb 12. With (A) and glycine receptor channels blocked, propofol caused membrane hyperpolarization and suppressed action potential discharge in cortical neurons; these effects were occluded by the I (h) blocker, ZD-7288. |
1(0,0,0,1) | Details |
| 9660894 | Dutschmann M, Herbert H: and GABAA receptors in the rat Kolliker-Fuse area control cardiorespiratory responses evoked by trigeminal ethmoidal nerve stimulation. Br J Pharmacol. 2003 Mar;138(6):1021-5. Unilateral injections (n = 5) of the glycine receptor antagonist strychnine into the KF area did not produce any significant effects on EN5-evoked autonomic responses. 6. In the present study, we examined the involvement of AMPA/kainate, (gamma-aminobutyric acidA (GABAA) and glycine receptors in the Kolliker-Fuse (KF) nucleus in the mediation of the nasotrigeminal reflex responses. 2. |
1(0,0,0,1) | Details |
| 11050110 | Kulik A, Nishimaru H, Ballanyi K: Role of and in - and -induced depolarization and [Ca2+] i rise in fetal rat motoneurons in situ. Eur J Pharmacol. 1994 Aug 22;261(3):295-301. Our findings show that HCO (3)(-) efflux has a major contribution to depolarizations mediated by (A) and glycine receptor-coupled anion channels in prenatal neurons. The - and -evoked [Ca (2+)](i) transients were suppressed by bicuculline and strychnine, respectively. |
1(0,0,0,1) | Details |
| 18768681 | Xu Y, Sulaiman P, Feddersen RM, Liu J, Smith RG, Vardi N: Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response. Auton Neurosci. 2007 Oct 30;136(1-2):69-81. Epub 2007 May 29. Whole-cell recordings from rod bipolar cells showed, both under Ames medium and after blocking (A/C) and glycine receptors, that PCP2-null rod bipolar cells were more depolarized than wild-type cells with greater inward current when clamped to -60 mV. |
1(0,0,0,1) | Details |
| 8624015 | Mason P, Owens CA, Hammond DL: Antagonism of the antinocifensive action of halothane by intrathecal administration of GABAA receptor antagonists. Int J Dev Neurosci. 1998 Aug;16(5):413-21. In contrast, the antinocifensive effect of the increase in halothane concentration was not attenuated by the GABAB receptor antagonist CGP 35348 or the glycine receptor antagonist strychnine. Saline, a GABAA, a GABAB, or glycine receptor antagonist was then injected intrathecally. |
1(0,0,0,1) | Details |
| 8858931 | Wood PL, Hawkinson JE, Goodnough DB: Formation of from in brain synaptosomes. J Neurophysiol. 2000 Oct;84(4):2171-4. is a stereospecific agonist of the -associated glycine receptor, with an affinity equal to or greater than that of but with no affinity for the strychnine-sensitive glycine receptor. |
0(0,0,0,0) | Details |
| 10322093 | Nakayama K, Nishimaru H, Iizuka M, Ozaki S, Kudo N: Rostrocaudal progression in the development of periodic spontaneous activity in fetal rat spinal motor circuits in vitro. J Neurosci. 1996 Mar 1;16(5):1836-43. Concomitant application of and strychnine (5 microM), a glycine receptor antagonist, abolished all spontaneous bursts, suggesting that the major transmitter mediating the spontaneous bursts changes from to in the cervical region by E16.5, but not in the lumbar region during this period. |
0(0,0,0,0) | Details |
| 17386936 | Wang GH, Jiang ZL, Fan XJ, Zhang L, Li X, Ke KF: Neuroprotective effect of against focal cerebral ischemia in rats possibly mediated by activation of both GABAA and glycine receptors. J Biol Chem. 2010 Feb 5;285(6):3730-9. Epub 2009 Dec 3. Such effect is possibly mediated by the activation of both (A) receptors and strychnine-sensitive glycine receptors. |
82(1,1,1,2) | Details |
| 12878709 | Jiang Z, Krnjevic K, Wang F, Ye JH: activates strychnine-sensitive glycine receptors in neurons freshly isolated from nucleus accumbens of young rats. Neurochem Int. 1996 Oct;29(4):423-34. |
82(1,1,1,2) | Details |
| 7687278 | St John PA, Stephens SL: Adult-type glycine receptors form clusters on embryonic rat spinal cord neurons developing in vitro. J Pharmacol Exp Ther. 2000 Dec;295(3):1051-60. The time course of development and the cellular and subcellular distributions of adult-type, strychnine-binding glycine receptors (GlyRs) were examined on rat spinal cord neurons in vitro using both the GlyR antagonist strychnine and a specific antibody against the receptor. |
82(1,1,1,2) | Details |
| 7472357 | Biella G, Sotgiu ML: Evidence that inhibitory mechanisms mask inappropriate somatotopic connections in the spinal cord of normal rat. Naunyn Schmiedebergs Arch Pharmacol. 1995 Jul;352(1):11-6. The drugs used were: strychnine, as a selective antagonist at glycine receptors; and as agonists at excitatory glutamatergic receptors; as an agonist at the inhibitory glycine receptor; and the local anesthetic lidocaine, as a reversible local conduction blocker both in the periphery and in the spinal cord. 3. |
81(1,1,1,1) | Details |
| 8041498 | Paton JF, Ramirez JM, Richter DW: Mechanisms of respiratory rhythm generation change profoundly during early life in mice and rats. Neuroscience. 2001;106(1):183-91. Our findings demonstrate that during the first two weeks of life there are profound changes in both the motor pattern of rhythmic XII neurons and sensitivity of the respiratory rhythm to strychnine blockade of glycine receptors. |
81(1,1,1,1) | Details |
| 16171972 | Garcia-Alcocer G, Martinez-Torres A, Miledi R: Strychnine induces embryotoxicity in rat neurulation. Brain Res. 2007 Aug 3;1161:11-20. Epub 2007 Jun 12. Administering strychnine, a potent antagonist of glycine receptors, to pregnant rats caused marked toxic effects on the ensuing embryos. |
81(1,1,1,1) | Details |
| 7813551 | Long JB, Skolnick P: 1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury. Br J Pharmacol. 1993 Sep;110(1):50-3. The protective effects of a variety of competitive and non-competitive (NMDA) receptor antagonists indicate that activation of the NMDA receptor complex is essential for dynorphin A-induced spinal cord injury. 1-Aminocyclopropanecarboxylic acid (ACPC) is a high affinity, partial agonist at strychnine-insensitive glycine receptors associated with the NMDA receptor complex. |
37(0,1,2,2) | Details |
| 12354281 | Beckstead MJ, Phelan R, Trudell JR, Bianchini MJ, Mihic SJ: Anesthetic and effects on spontaneously opening glycine receptor channels. J Pharmacol Exp Ther. 2005 Nov;315(2):696-703. Epub 2005 Jul 20. Strychnine-sensitive glycine receptors mediate inhibitory neurotransmission occurring in the brain stem and spinal cord. |
36(0,1,1,6) | Details |
| 7812607 | Saitoh T, Ishida M, Maruyama M, Shinozaki H: A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Exp Brain Res. 1998 Apr;119(3):297-306. |
32(0,1,1,2) | Details |
| 10218807 | Rozzo A, Ballerini L, Nistri A: Antagonism by (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid of synaptic transmission in the neonatal rat spinal cord in vitro: an electrophysiological study. Neurosci Lett. 2006 Oct 2;406(1-2):11-6. Epub 2006 Aug 14. Following block of (A) receptors by bicuculline (20 microM) and of glycine receptors by strychnine (1 microM), regular bursting activity recorded from ventral roots developed spontaneously and persisted unchanged for many hours. |
32(0,1,1,2) | Details |
| 12151932 | Yamauchi M, Sekiyama H, Shimada SG, Collins JG: Halothane suppression of spinal sensory neuronal responses to noxious peripheral stimuli is mediated, in part, by both (A) and glycine receptor systems. J Physiol. 2002 Oct 1;544(Pt 1):97-106. The authors tested the hypothesis that gamma-aminobutyric acid receptor type A (A)) and strychnine-sensitive glycine receptor systems mediate halothane depression of spinal sensory neuronal responses to noxious stimuli. |
32(0,1,1,2) | Details |
| 17145135 | Kanda T, Iwamoto Y, Yoshida K, Shimazu H: Glycinergic inputs cause the pause of pontine omnipause neurons during saccades. Neuropharmacology. 2007 Apr;52(5):1199-209. Epub 2007 Mar 26. To reveal functions of glycinergic and GABAergic inputs, we investigated effects of iontophoretic application of strychnine, a glycine receptor antagonist, and bicuculline, a GABAA receptor antagonist, on discharge patterns of OPNs in alert cats. |
31(0,1,1,1) | Details |
| 9851655 | Rodriguez-Ithurralde D, Maruri A, Rodriguez X: Motor neurone acetylcholinesterase release precedes neurotoxicity caused by systemic administration of excitatory amino acids and strychnine. J Biol Chem. 2004 Jan 9;279(2):876-83. Epub 2003 Oct 16. We investigated histochemical and histopathological changes in cell populations of the mouse spinal ventral horn upon in vivo stimulation of glutamate receptors with (ASP, 10-50 mg/kg, intraperitoneal: i.p.), or blockade of glycine receptors with strychnine (STRY, 2 mg/kg, i.p.). |
31(0,1,1,1) | Details |
| 16033910 | Chen YP, Chen SR, Pan HL: Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. Neuroscience. 1995 Jan;64(2):525-35. On the other hand, the glycine receptor antagonist strychnine (4 microM) significantly decreased the effect of morphine in both nerve-injured and control animals. |
31(0,1,1,1) | Details |
| 8989406 | Klug A, Park TJ, Pollak GD: and influence binaural processing in the inferior colliculus of the mustache bat. J Neurosci Methods. 2008 Sep 15;174(1):97-102. Epub 2008 Jul 23. To study these questions, we recorded from 61 EI neurons in the inferior colliculus of the mustache bat before and during the iontophoretic application of the glycine receptor antagonist, strychnine. |
31(0,1,1,1) | Details |
| 12213259 | Wong JY, Ross SA, McColl C, Massalas JS, Powney E, Finkelstein DI, Clark M, Horne MK, Berkovic SF, Drago J: Proconvulsant-induced seizures in alpha (4) nicotinic acetylcholine receptor subunit knockout mice. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R901-10. Epub 2007 May 23. We investigated the response of alpha (4) nAChR subunit knockout mice to the (GABA) receptor antagonists; pentylenetetrazole (PTZ) and bicuculline (BIC), the glutamate receptor agonist kainic acid (KA), the glycine receptor antagonist strychnine and the K (+) channel blocker 4-aminopyridine (4-AP). |
31(0,1,1,1) | Details |
| 17982916 | Lee MC, Hwang JC, Lin JT, Tung LC: Characteristics of GABA receptors on the ocellar L-neurons of American cockroach Periplaneta americana. J Neurophysiol. 1995 Oct;74(4):1701-13. More interestingly, administration of strychnine, glycine receptor antagonist, largely attenuated the depolarization response of the L-neurons to cercal stimulation. |
31(0,1,1,1) | Details |
| 12663257 | Chen Z, Travers JB: Inactivation of amino acid receptors in medullary reticular formation modulates and suppresses ingestion and rejection responses in the awake rat. Neuroscience. 2004;123(3):715-24. Bilateral infusions of the (A) receptor antagonist bicuculline or the glycine receptor antagonist strychnine enhanced the amplitude of IO stimulation-induced oral responses. |
31(0,1,1,1) | Details |
| 16493648 | Gdovin MJ, Jackson VV, Zamora DA, Leiter JC: Effect of prevention of lung inflation on metamorphosis and respiration in the developing bullfrog tadpole, Rana catesbeiana. Epilepsy Res. 1995 Jan;20(1):41-8. Bath application of the (A) and glycine receptor antagonists, bicuculline and strychnine, had greater effects on control tadpole gill burst activity and produced a similar large-amplitude bursting pattern in both control and barrier tadpoles, that was insensitive to CO (2) chemoreceptor stimulation. |
31(0,1,1,1) | Details |
| 15601738 | Protti DA, Flores-Herr N, Li W, Massey SC, Wassle H: Light signaling in scotopic conditions in the rabbit, mouse and rat retina: a physiological and anatomical study. J Neurosci. 2006 Feb 8;26(6):1787-94. Consistent with this result, strychnine, a glycine receptor antagonist, was unable to abolish these off responses. |
31(0,1,1,1) | Details |
| 9754925 | Tapia JC, Aguilar LF, Sotomayor CP, Aguayo LG: affects the function of a neurotransmitter receptor protein without altering the membrane lipid phase. J Neurophysiol. 2007 Dec;98(6):3666-76. Epub 2007 Oct 3. Using patch-clamp and fluorescence techniques we found that (10-200 mM) potentiated strychnine-sensitive glycine receptors without having detectable effects on lipid order parameters in mouse spinal cord neurons. |
6(0,0,1,1) | Details |
| 9786497 | Mascia MP, Wick MJ, Martinez LD, Harris RA: Enhancement of glycine receptor function by role of phosphorylation. Clin Exp Pharmacol Physiol. 2001 May-Jun;28(5-6):451-8. |
3(0,0,0,3) | Details |
| 9622242 | Danober L, Pape HC: Strychnine-sensitive responses in neurons of the lateral amygdala: an electrophysiological and immunocytochemical characterization. J Physiol. 1996 Nov 15;497 ( Pt 1):131-43. Electrophysiological and staining techniques in the in vitro slice preparation of the rat and guinea-pig lateral amygdala were combined with immunocytochemical approaches, in order to characterize the neuronal substrate, the ionic basis and the pharmacological properties of -mediated responses, and to map the distribution and composition of the mediating glycine receptors. |
3(0,0,0,3) | Details |
| 11178872 | Pierce KD, Handford CA, Morris R, Vafa B, Dennis JA, Healy PJ, Schofield PR: A nonsense mutation in the alpha1 subunit of the inhibitory glycine receptor associated with bovine myoclonus. Proteins. 2007 Jun 1;67(4):950-60. Binding studies have previously shown that myoclonus is associated with specific loss of [(3) H] strychnine-binding sites from spinal cord and brain stem in affected calves. |
3(0,0,0,3) | Details |
| 19860810 | Chau P, Stomberg R, Fagerberg A, Soderpalm B, Ericson M: Glycine receptors involved in acamprosate's modulation of accumbal levels: an in vivo microdialysis study. J Comp Physiol A. 1999 Jan;184(1):85-98. Pretreatment either with 10 microM strychnine in the nAc or 100 microM mecamylamine in the VTA, completely antagonized the acamprosate-induced elevation of accumbal levels. |
2(0,0,0,2) | Details |
| 19619564 | Zhang HX, Lyons-Warren A, Thio LL: The transport inhibitor is an inhibitory glycine receptor agonist. Neurosci Lett. 2001 Mar 2;300(1):5-8. We examined this possibility using whole-cell recordings from cultured embryonic mouse hippocampal neurons and found that evoked a dose-dependent, strychnine sensitive, Cl (-) current that cross-inhibited currents. |
2(0,0,0,2) | Details |
| 9614239 | Kotak VC, Korada S, Schwartz IR, Sanes DH: A developmental shift from GABAergic to glycinergic transmission in the central auditory system. Eur J Pharmacol. 1997 Aug 13;332(3):321-6. Consistent with the electrophysiological observations, there was a reduction in staining for the beta2,3-GABAA receptor subunit from P4 to P14, whereas staining for the glycine receptor-associated protein gephyrin increased. GABAergic and glycinergic components were identified by blocking transmission with bicuculline and strychnine (SN), respectively. |
1(0,0,0,1) | Details |
| 10381800 | Wang MY, Rampil IJ, Kendig JJ: directly depresses AMPA and currents in spinal cord motor neurons independent of actions on GABAA or glycine receptors. J Pharmacol Exp Ther. 1999 Jul;290(1):362-7. Block of inhibitory gamma-aminobutyric acidA and glycine receptors by bicuculline (50 microM) and strychnine (5 microM), respectively, did not significantly reduce the effects of on currents. |
1(0,0,0,1) | Details |
| 9867632 | Froehner SC: Gathering glycine receptors at synapses. Pain. 1994 May;57(2):217-23. |
1(0,0,0,1) | Details |
| 11701143 | Zheng F, Johnson SW: Glycine receptor-mediated inhibition of and non- neurons of the rat ventral tegmental area in vitro. Anesthesiology. 2002 Aug;97(2):412-7. (0.1-3 mM) caused a strychnine-sensitive and -dependent reduction in membrane input resistance in both types of neuron. |
1(0,0,0,1) | Details |
| 8713182 | Chiba C, Saito T: Development of responses to excitatory and inhibitory amino acids in spiking cells during retinal regeneration in the adult newt. J Auton Nerv Syst. 1996 Jun 10;59(1-2):17-26. AMPA/KA, GABAA, and glycine receptors, each of which were electrophysiologically and pharmacologically similar to those in the normal retina, appeared in spiking cells before regenerating retina had segregated into two synaptic layers. |
1(0,0,0,1) | Details |
| 17920294 | Weiss J, O'Sullivan GA, Heinze L, Chen HX, Betz H, Wassle H: Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice. Pharmacology. 2008;81(3):195. Epub 2008 Jan 9. Amacrine cells are known to express strychnine-sensitive glycine receptors (GlyRs), however, it is not known which of the four GlyRalpha subunits (alpha1-4) are expressed in this diverse group of cells. |
1(0,0,0,1) | Details |
| 18692523 | Lavrov I, Cheng J: Methodological optimization of applying neuroactive agents for the study of locomotor-like activity in the mudpuppies (Necturus maculatus). Brain Res. 1993 May 21;611(2):300-12. Superfusion of strychnine, a glycine receptor antagonist, blocked the walking-like activity at concentrations of 3-5 microM, while its bolus application altered -induced, but not -induced, walking-like activity to a synchronized pattern. |
0(0,0,0,0) | Details |
| 7912632 | Shuker MA, Bowser-Riley F, Davies SN: Possible antagonist properties of drugs that affect high pressure neurological syndrome. Ann Nutr Metab. 2007;51(4):379-86. Epub 2007 Aug 29. Previous studies have suggested that a series of drugs modelled on part of the strychnine molecule interfere with the development of high pressure neurological syndrome (HPNS) and it was presumed that this effect was via an action on inhibitory glycinergic transmission. |
0(0,0,0,0) | Details |
| 11465553 | Wong SM, Cheng G, Homanics GE, Kendig JJ: Enflurane actions on spinal cords from mice that lack the beta3 subunit of the (A) receptor. Neuroreport. 2002 Sep 16;13(13):1667-73. The antagonist strychnine elevated the pEPSP to a significantly greater extent in -/- than in +/+ cords, but the interactions between strychnine and enflurane did not differ between -/- and +/+ cords. |
0(0,0,0,0) | Details |
| 9671104 | Garcia MC, Celuch SM, Adler-Graschinsky E: Involvement of and glutamate receptors in the blood pressure responses to intrathecally injected sodium nitroprusside in anesthetized rats. Exp Neurol. 2007 Feb;203(2):493-501. Epub 2006 Oct 13. The blood pressure responses to sodium nitroprusside were not modified by blockade of muscarinic receptors with methyl atropine (164 nmol, i.t.), or of nicotinic receptors with hexamethonium (211 nmol, i.t.), of alpha1-adrenoceptors with prazosin (3.1 nmol, i.t.), of alpha2-adrenoceptors with yohimbine (2.8 micromol/kg, i.v.), of receptors with methysergide (5.1 micromol/kg, i.v.), or of glycine receptors with strychnine (65 nmol, i.t.). |
0(0,0,0,0) | Details |
| 12804573 | Llanos MN, Ronco AM, Aguirre MC: Specific strychnine binding sites on acrosome-associated membranes of golden hamster spermatozoa. J Neurochem. 1996 Oct;67(4):1485-90. Glycine receptor agonists and inhibited strychnine binding by 20-30%. |
82(1,1,1,2) | Details |
| 12803134 | Wang DS, Zhu HL, Li JS: acts on glycine receptors in the rat sacral dorsal commissural neurons. J Neurochem. 1998 Nov;71(5):2159-68. The results indicate that beta-ALA activates the strychnine-sensitive glycine receptors in the SDCN neurons, and suggest that beta-ALA may act as a functional neurotransmitter in the mammalian SDCN. |
82(1,1,1,2) | Details |
| 17217420 | Carrasco MA, Castro PA, Sepulveda FJ, Cuevas M, Tapia JC, Izaurieta P, van Zundert B, Aguayo LG: Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons. J Physiol. 2002 Aug 1;542(Pt 3):685-97. |
82(1,1,1,2) | Details |
| 12932897 | Jansen M, Dannhardt G: Antagonists and agonists at the site of the NMDA receptor for therapeutic interventions. J Exp Zool A Comp Exp Biol. 2006 Apr 1;305(4):335-47. Contrary to the inhibitory glycine receptor (A)) the binding site on the NMDA receptor (B)) is strychnine-insensitive. |
81(1,1,1,1) | Details |
| 9384243 | Mennini T, Mancini L, Reggiani A, Trist D: GV 150526A, 7-Cl- and HA 966 antagonize the enhancement of -induced [3H] and [3H] release. J Neurophysiol. 2009 Dec;102(6):3169-79. Epub 2009 Sep 23. In addition HA 966 shows regional differences in its interaction with the strychnine-insensitive glycine receptor, being about six times more potent on striatal than on hippocampal synaptosomes, suggesting a possible heterogeneity of sites recognized by HA 966 or different intrinsic activity in the two brain regions. |
81(1,1,1,1) | Details |
| 8028768 | Berger P, Farrel K, Sharp F, Skolnick P: Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex. Pharmacol Biochem Behav. 2003 Jul;75(4):831-5. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of antagonists. |
37(0,1,2,2) | Details |
| 15862540 | Hilgier W, Oja SS, Saransaari P, Albrecht J: prevents -induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors. Brain Res. 2001 Nov 23;919(2):313-7. In this study, coinfusion with of a GABAA receptor antagonist bicuculline or a glycine receptor antagonist strychnine (100 microM each), separately, restored -induced release of to the extracellular fluid to approximately 29% and 18% of the level measured in the absence of respectively. |
32(0,1,1,2) | Details |
| 12867529 | Kawa K: Glycine receptors and glycinergic synaptic transmission in the deep cerebellar nuclei of the rat: a patch-clamp study. J Pharm Belg. 1995 Mar-Jun;50(2-3):194-203. Thus this study has revealed that strychnine-sensitive glycine receptors are expressed in neurons of the DCN of rats and that glycinergic transmission mediated by these receptors is functional in these neurons from stages immediately after birth. |
32(0,1,1,2) | Details |
| 17110030 | Han SK, Park JR, Park SA, Chun SW, Lee JC, Lee SY, Ryu PD, Park SJ: inhibits substantia gelatinosa neurons in mice trigeminal subnucleus caudalis via alpha (2) and beta adrenoceptors. Neuropharmacology. 1999 Feb;38(2):243-51. NA-induced hyperpolarizing effects were maintained in the presence of tetrodotoxin (TTX), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), d,l-2-amino-5-phosphonopentanoic acid (AP5), picrotoxin and strychnine, a Na (+) channel, ionotropic glutamate receptor, (A) and glycine receptor antagonists, respectively, indicating that the effects of NA are direct on the postsynaptic SG neurons. |
31(0,1,1,1) | Details |
| 16376148 | Lechner SM: -based therapeutic approaches: inhibitors of transport. . Eur J Neurosci. 2002 Oct;16(8):1523-30. In addition, recent electrophysiological findings and data from transgenic mouse models suggest that GlyT1 might also play a role in terminating the actions of at strychnine-sensitive glycine receptors, and therefore GlyT1 antagonists also have potential for the treatment of conditions where activation of inhibitory pathways in the central nervous system might be beneficial. |
31(0,1,1,1) | Details |
| 8018849 | Lambert DM, Poupaert JH, Maloteaux JM, Dumont P: Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration. J Physiol. 1998 May 15;509 ( Pt 1):245-54. The lack of Z- affinity for the strychnine sensitive glycine receptor and the strychnine insensitive glycine receptor associated with the NMDA receptor may indicate that Z- acts either via a prodrug mechanism or per se via an alternative mechanism. |
31(0,1,1,1) | Details |
| 16950410 | Abdin MJ, Morioka N, Morita K, Kitayama T, Kitayama S, Nakashima T, Dohi T: Analgesic action of on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord. Neurochem Res. 1993 Oct;18(10):1051-5. Furthermore, pretreatment with strychnine, a glycine receptor antagonist, blocked the antinociception induced by RJR-2403, and |
31(0,1,1,1) | Details |
| 7931498 | Yang L, Pollak GD: The roles of GABAergic and glycinergic inhibition on binaural processing in the dorsal nucleus of the lateral lemniscus of the mustache bat. J Neurophysiol. 2005 Jun;93(6):3479-88. Epub 2004 Dec 15. We studied the monaural and binaural response properties of 99 neurons in the dorsal nucleus of the lateral lemniscus (DNLL) of the mustache bat before and during the iontophoretic application of antagonists that blocked -A (GABAA) receptors (bicuculline) or glycine receptors (strychnine). |
31(0,1,1,1) | Details |
| 7796124 | Nowak G, Ordway GA, Paul IA: Alterations in the (NMDA) receptor complex in the frontal cortex of suicide victims. J Neurophysiol. 1994 Jun;71(6):1999-2013. This adaptation consists of a reduction in the potency of to displace [3H] 5,7-dichlorokynurenic acid from strychnine-insensitive glycine receptors and a reduction in high affinity, -displaceable [3H] CGP-39653 binding to glutamate receptors. |
31(0,1,1,1) | Details |
| 17534125 | Chen Y, Dai TJ, Zeng YM: Strychnine-sensitive glycine receptors mediate the analgesic but not hypnotic effects of emulsified volatile anesthetics. J Neurol Sci. 1998 Oct;160 Suppl 1:S80-6. The present study was designed to investigate the role of strychnine-sensitive glycine receptors in hypnosis and analgesia induced by emulsified volatile anesthetics. |
6(0,0,1,1) | Details |
| 17462677 | Igartua I, Solis JM, Bustamante J: -induced long-term synaptic potentiation is mediated by the transporter GLYT1. J Physiol. 2004 Aug 15;559(Pt 1):35-40. Epub 2004 Jul 8. This LTP-GLY is independent of both strychnine-sensitive glycine receptors and nifedipine-sensitive channels. |
6(0,0,1,1) | Details |
| 12618352 | Su CK, Phoon SL, Yen CT: Identification of active thoracic spinal segments responsible for tonic and bursting sympathetic discharge in neonatal rats. Life Sci. 1994;55(1):27-34. Bath application of bicuculline and strychnine, which removes endogenous (A) and glycine receptor activities, transforms the quasi-periodic tonic SND into synchronized bursts (bSND). |
6(0,0,1,1) | Details |
| 7674119 | Lambert DM, Geurts M, Scriba GK, Poupaert JH, Dumont P: [Simple derivatives of amino acid neurotransmitters. Br J Pharmacol. 1999 Mar;126(5):1230-6. They act mainly in the spinal cord and in the brain stem via the strychnine sensitive glycine receptor. |
6(0,0,1,1) | Details |
| 12356883 | Gentet LJ, Clements JD: Binding site stoichiometry and the effects of phosphorylation on human alpha1 homomeric glycine receptors. J Neurophysiol. 2002 Jan;87(1):640-4. The unbinding of three strychnine molecules and the cooperative binding of two molecules were required to activate the channel. |
3(0,0,0,3) | Details |
| 8408073 | Cascio M, Schoppa NE, Grodzicki RL, Sigworth FJ, Fox RO: Functional expression and purification of a homomeric human alpha 1 glycine receptor in baculovirus-infected insect cells. Eur J Pharmacol. 1996 Dec 19;317(2-3):191-6. These channels were gated by but not in the presence of strychnine. |
3(0,0,0,3) | Details |
| 7700595 | Martin H, Warner DS, Todd MM: Effects of glycine receptor antagonism on spreading depression in the rat. J Biol Chem. 1993 Oct 15;268(29):22135-42. |
3(0,0,0,3) | Details |
| 14622922 | Muller F, Heinke B, Sandkuhler J: Reduction of glycine receptor-mediated miniature inhibitory postsynaptic currents in rat spinal lamina I neurons after peripheral inflammation. Alcohol Clin Exp Res. 1998 May;22(3):704-9. |
3(0,0,0,3) | Details |
| 11784780 | van Zundert B, Alvarez FJ, Yevenes GE, Carcamo JG, Vera JC, Aguayo LG: Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons. Neuroscience. 1999 Mar;90(3):1085-92. Application of colchicine via the culture media or the patch-pipette, however, did not affect the whole cell current rundown (73 +/- 6% of control after 1 h), the sensitivity of the GlyR to (EC (50) = 29 +/- 1 microM), or strychnine inhibition (47 +/- 5% of control after 100 nM strychnine). |
2(0,0,0,2) | Details |
| 15893641 | Deleuze C, Alonso G, Lefevre IA, Duvoid-Guillou A, Hussy N: Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus: further evidence for their involvement in glia-to-neuron communication. J Pharmacol Sci. 2010 Mar 19;112(3):352-60. Epub 2010 Feb 20. First, we show that blockade of GlyRs with strychnine has no effect on either the amplitude or frequency of miniature inhibitory postsynaptic currents recorded in SON neurons, whereas they were all suppressed by the (A) antagonist gabazine. |
2(0,0,0,2) | Details |
| 9766836 | Sorkin LS, Puig S, Jones DL: Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain. 1998 Aug;77(2):181-90. This is in contrast to our previous work with glycine receptor antagonism where only the evoked response to hair follicle activation was significantly enhanced. The inability of AP-7 to reverse the bicuculline-associated hyperreactivity also contrasts with the AP-7 reversal of the strychnine-associated hyperreactivity. |
1(0,0,0,1) | Details |
| 7500379 | Galvez-Ruano E, Lipkowitz KB, Aprison MH: On identifying a second molecular antagonistic mechanism operative at the glycine receptor. Neuropharmacology. 1997 Aug;36(8):1057-64. We used molecular modeling techniques to examine six reported antagonists of with varying Ki values against strychnine. |
1(0,0,0,1) | Details |
| 12766618 | Davies DL, Trudell JR, Mihic SJ, Crawford DK, Alkana RL: potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. J Physiol. 1998 Mar 1;507 ( Pt 2):473-83. concentration response curves, strychnine/ interactions, and zinc (Zn2+) modulation of GlyR function was also tested. |
1(0,0,0,1) | Details |
| 7531579 | Legendre P, Korn H: Glycinergic inhibitory synaptic currents and related receptor channels in the zebrafish brain. Jpn J Physiol. 1995;45(5):869-87. Applications of 0.5-1 microM strychnine in the presence of tetrodotoxin eliminated > 90% of the inhibitory currents in the preparation. Outside-out recordings showed at least two classes of glycine receptor channels, one having multiple conductance levels with a main state of 81-86 pS and another displaying only one opening level of 41-43 pS. |
1(0,0,0,1) | Details |
| 7506752 | Thoreson WB, Miller RF: Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina. Am J Physiol Regul Integr Comp Physiol. 2002 Apr;282(4):R999-R1005. AMPA-evoked currents exhibited a significant dependence and were suppressed by -A (GABAA) antagonists bicuculline and picrotoxin; a uptake blocker, nipecotic acid; and a antagonist, strychnine. These results indicate that the conductance increase induced by AMPA in the presence of 2 mM is largely the result of -dependent synaptic inputs onto GABAA and glycine receptors of ON bipolar cells. 4. |
1(0,0,0,1) | Details |
| 15817633 | Wang F, Xiao C, Ye JH: activates excitatory non-synaptic glycine receptors on neurones in ventral tegmental area of young rats. Brain Res. 2005 May 10;1043(1-2):242-6. In voltage-clamped neurones, induced a current which was antagonized by strychnine and by picrotoxin, but not by bicuculline. |
1(0,0,0,1) | Details |
| 10908659 | Mascia MP, Trudell JR, Harris RA: Specific binding sites for and anesthetics on ligand-gated ion channels. Amino Acids. 2009 Jan;36(1):21-7. Epub 2008 Jan 15. The inhibitory strychnine-sensitive and type A receptors are positively modulated by anesthetics and and site-directed mutagenesis techniques have identified amino acid residues important for the action of volatile anesthetics and in these receptors. We demonstrated that the anesthetic propanethiol, or alternatively, propyl methanethiosulfonate, covalently binds to residues introduced into a specific second transmembrane site in glycine receptor and type A receptor subunits and irreversibly enhances receptor function. |
1(0,0,0,1) | Details |
| 9570802 | Protti DA, Llano I: currents and signaling in rod bipolar cells of rat retinal slices. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9305-10. Concomitant with Ca2+ entry, depolarization induced the appearance of transient outward currents that resembled IPSCs and were blocked by and glycine receptor antagonists, suggesting that they arise from activation of amacrine feedback synapses. |
1(0,0,0,1) | Details |
| 8393521 | Vandenberg RJ, Rajendra S, French CR, Barry PH, Schofield PR: The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site. Mol Pharmacol. 1996 Aug;50(2):402-6. Mutation of the at position 143 to resulted in essentially unaltered GlyRs, showing only modest decreases in strychnine affinity (Kd, 8.1 +/- 1.4 nM versus 13.4 +/- 1.3 nM), displacement of strychnine binding (Ki, 25 +/- 5 microM versus 49 +/- 9 microM), and activation of currents (EC50, 27 +/- 6 microM versus 114 +/- 14 microM). Using site-directed mutagenesis of the inhibitory glycine receptor (GlyR), we have specifically tested this hypothesis. |
1(0,0,0,1) | Details |
| 11600626 | Frech MJ, Perez-Leon J, Wassle H, Backus KH: Characterization of the spontaneous synaptic activity of amacrine cells in the mouse retina. Pain. 1998 Jul;77(1):87-95. Only four amacrine cells showed glycinergic sIPSCs that were inhibited by strychnine (1 microM). In addition to ionotropic glutamate receptors, amacrine cells express two types of inhibitory receptors, (A) receptors (A) Rs) and glycine receptors (GlyRs). |
1(0,0,0,1) | Details |
| 8527722 | Wannier T, Orlovsky G, Grillner S: Reticulospinal neurones provide monosynaptic glycinergic inhibition of spinal neurones in lamprey. Endocrinology. 2005 Oct;146(10):4302-11. Epub 2005 Jun 23. The present study demonstrates that a group of reticulospinal neurones inhibit their target neurones by an action on glycine receptors. IPSPs elicited from single reticulospinal neurones or from electrical stimulation of the reticular formation are suppressed by administration of strychnine, suggesting that is the neurotransmitter of these inhibitory reticulospinal neurones. |
1(0,0,0,1) | Details |
| 16551908 | Yang CX, Xu H, Zhou KQ, Wang MY, Xu TL: Modulation of A receptor function by thiopental in the rat spinal dorsal horn neurons. J Pharmacol Exp Ther. 2002 Feb;300(2):526-34. I (Thio) was sensitive to bicuculline, a A receptor antagonist, but not to strychnine, a glycine receptor antagonist. |
0(0,0,0,0) | Details |
| 10824678 | Bieda MC, Copenhagen DR: Inhibition is not required for the production of transient spiking responses from retinal ganglion cells. Pharmacol Biochem Behav. 1995 Nov;52(3):621-7. We found that picrotoxin (a (A) and (C) receptor antagonist), bicuculline (a (A) receptor antagonist), and strychnine (a glycine receptor antagonist), applied either singly or in combination, always failed to convert transient responses to sustained responses. |
0(0,0,0,0) | Details |
| 12123749 | Maksay G, Biro T, Laube B: Hyperekplexia mutation of glycine receptors: decreased gating efficacy with altered binding thermodynamics. Eur J Neurosci. 2002 Apr;15(8):1299-305. [(3) H] Strychnine binding was studied to recombinant human alpha (1) and the hyperekplexia mutant alpha (1) R271L glycine receptors (GlyRs) transiently expressed in human embryonic kidney (HEK)-293 cell cultures at 0, 18 and 37 degrees. |
82(1,1,1,2) | Details |
| 18690053 | Grudzinska J, Schumann T, Schemm R, Betz H, Laube B: Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel. J Neurosci. 2009 Jul 1;29(26):8372-87. The divalent cation Zn2+ has been shown to regulate inhibitory neurotransmission in the mammalian CNS by affecting the activation of the strychnine-sensitive glycine receptor (GlyR). |
82(1,1,1,2) | Details |
| 12352621 | Du JL, Xu LY, Yang XL: Glycine receptors and transporters on bullfrog retinal Muller cells. J Physiol. 2007 Sep 15;583(Pt 3):1021-40. Epub 2007 Jul 26. The -induced current was partially suppressed by strychnine, and the remaining strychnine-resistant component was sacrosine-sensititve, suggesting that these two components may be mediated by glycine receptors and transporters, respectively. |
82(1,1,1,2) | Details |
| 8922750 | Wu J, Harata N, Akaike N: Potentiation by sevoflurane of the -induced current in acutely dissociated CA1 pyramidal neurones from rat hippocampus. Eur J Neurosci. 1995 Jun 1;7(6):1188-98. But ISev was insensitive to strychnine (Str), an antagonist of the glycine receptor. 4. |
81(1,1,1,1) | Details |
| 10698677 | Kamijima M, Casida JE: Regional modification of [(3) H] Ethynylbicycloorthobenzoate binding in mouse brain (A) receptor by endosulfan, fipronil, and avermectin B (1a). Pharmacol Biochem Behav. 1997 Aug;57(4):909-13. AVM increased [(3) H] EBOB binding in most regions and was the only one of the three agents inhibiting in vitro [(3) H] strychnine binding to the glycine receptor. |
81(1,1,1,1) | Details |
| 16317347 | Racz I, Schutz B, Abo-Salem OM, Zimmer A: Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice. Neuropharmacology. 2002 Jul;43(1):55-64. Mice deficient for alpha3-subunit of strychnine-sensitive glycine receptors lack the (2)-induced inhibition of glycinergic neurotransmission and recover faster from inflammation-induced hyperalgesia. |
75(0,2,4,5) | Details |
| 14706783 | Okabe A, Kilb W, Shimizu-Okabe C, Hanganu IL, Fukuda A, Luhmann HJ: Homogenous glycine receptor expression in cortical plate neurons and Cajal-Retzius cells of neonatal rat cerebral cortex. Respir Physiol Neurobiol. 2002 Sep 4;132(3):265-77. The glycinergic responses of both cells were blocked by the glycinergic antagonist strychnine and were unaffected by the GABAergic antagonist bicuculline (100 microM), the receptor antagonist (+/-)-2-amino-5-phosphonopentatonic acid (60 microM) and by picrotoxin (30 microM), an antagonist of alpha homomeric glycine receptors. |
36(0,1,1,6) | Details |
| 15555633 | Ran I, Mathers DA, Puil E: Pentobarbital induces thalamic oscillations in brain slices, modulated by and glycine receptors. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R68-83. Epub 2003 Mar 27. (B) antagonism (CGP 35348, 100 nM), or antagonism of glycine receptors (strychnine, 1 microM) suppressed oscillations at 1-4 and 11-15 Hz. |
36(0,1,1,6) | Details |
| 18806798 | Miller PS, Topf M, Smart TG: Mapping a molecular link between allosteric inhibition and activation of the glycine receptor. J Neurophysiol. 2005 Aug;94(2):1606-22. Epub 2005 May 4. Using strychnine-sensitive glycine receptors, we identified a scaffold of hydrophobic residues enabling allosteric communication between -agonist binding loops A and D, and the Zn (2+)-inhibition site. |
32(0,1,1,2) | Details |
| 19394327 | Muth-Selbach U, Hermanns H, Stegmann JU, Kollosche K, Freynhagen R, Bauer I, Lipfert P: Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. Mol Cell Neurosci. 2002 Feb;19(2):201-15. Additionally, since in our study lidocaine-induced antinociception was antagonized by both glycineB-site modulators and strychnine our results may favor the hypothesis of a general -like action of lidocaine or some of its metabolites on inhibitory strychnine-sensitive receptors and on strychnine-insensitive glycine receptors. |
32(0,1,1,2) | Details |
| 11731563 | Ressot C, Collado V, Molat JL, Dallel R: Strychnine alters response properties of trigeminal nociceptive neurons in the rat. Curr Opin Pharmacol. 2006 Feb;6(1):75-81. Epub 2005 Dec 22. We evaluated the effect of intravenous administration of strychnine, a glycine receptor antagonist, on the responses of Sp5O convergent neurons evoked by innocuous peripheral electrical and mechanical stimuli in halothane-anesthetized rats. |
31(0,1,1,1) | Details |
| 7472446 | Kandler K, Friauf E: Development of glycinergic and glutamatergic synaptic transmission in the auditory brainstem of perinatal rats. J Neurophysiol. 1996 Jun;75(6):2300-11. Regardless of their polarity, contralaterally elicited PSPs were reversibly blocked by the glycine receptor antagonist strychnine. |
31(0,1,1,1) | Details |
| 18691329 | Chapman RJ, Issberner JP, Sillar KT: Group I mGluRs increase locomotor network excitability in Xenopus tadpoles via presynaptic inhibition of glycinergic neurotransmission. Brain Res. 2003 Nov 21;991(1-2):171-9. Applications of the glycine receptor antagonist strychnine occluded the effects of providing preliminary evidence that group I receptors affect motor network output by reducing glycinergic transmission. |
31(0,1,1,1) | Details |
| 8871232 | Vinay L, Barthe JY, Grillner S: Central modulation of stretch receptor neurons during fictive locomotion in lamprey. Eur J Neurosci. 2008 Sep;28(5):903-13. Epub 2008 Aug 8. If the glycine receptor antagonist strychnine (1 microM) was applied in one pool, the phasic hyperpolarizing phase disappeared without affecting the excitatory phase. 4. |
31(0,1,1,1) | Details |
| 15026133 | Belluzzi O, Puopolo M, Benedusi M, Kratskin I: Selective neuroinhibitory effects of in slices of rat main olfactory bulb. Neuropharmacology. 1999 Jun;38(6):785-92. (A) antagonists, bicuculline and picrotoxin, blocked the actions, whereas the glycine receptor antagonist strychnine and (B) antagonists, CGP 55845A and CGP 35348, were ineffective. |
31(0,1,1,1) | Details |
| 18840508 | Kopp-Scheinpflug C, Dehmel S, Tolnai S, Dietz B, Milenkovic I, Rubsamen R: -mediated changes of onset reliability at a mammalian central synapse. Hear Res. 2006 Oct;220(1-2):95-105. Epub 2006 Sep 1. Iontophoretic application of the glycine receptor antagonist strychnine caused a significant decrease in spontaneous and sound-evoked firing rates throughout the neurons' excitatory response areas, with the largest changes at the respective characteristic frequency (CF). |
31(0,1,1,1) | Details |
| 9351519 | Green MA, Halliwell RF: Selective antagonism of the (A) receptor by ciprofloxacin and biphenylacetic acid. Pain. 1996 Dec;68(2-3):283-92. Responses mediated by 5-HT3, nicotinic and P2X receptors in the vagus nerve and strychnine-sensitive glycine receptors in the optic nerve were little or unaffected by ciprofloxacin (100 microM), BPAA (100 microM) or the combination of these drugs (both at 100 microM). 6. |
31(0,1,1,1) | Details |
| 15687375 | Yuan Y, Atchison WD: Methylmercury induces a spontaneous, transient slow inward current in Purkinje cells of rat cerebellar slices. Eur J Pharmacol. 1997 Oct 8;336(2-3):275-81. However, it was insensitive to the glycine receptor antagonist strychnine. |
31(0,1,1,1) | Details |
| 8714663 | Le Beau FE, Rees A, Malmierca MS: Contribution of - and -mediated inhibition to the monaural temporal response properties of neurons in the inferior colliculus. Brain Res. 1995 Mar 27;675(1-2):157-64. To determine the contribution of inhibition to the generation of the temporal response patterns of neurons in the inferior colliculus (IC), the effects of iontophoretically applied and the GABAA and glycine receptor antagonists, bicuculline and strychnine were studied on 121 neurons in the IC of urethan-anesthetised guinea pig. 2. |
31(0,1,1,1) | Details |
| 9622453 | Darstein M, Albrecht C, Lopez-Francos L, Knorle R, Holter SM, Spanagel R, Feuerstein TJ: Release and accumulation of neurotransmitters in the rat brain: acute effects of in vitro and effects of long-term voluntary intake. J Physiol. 1996 Mar 15;491 ( Pt 3):799-812. Slices of the rat caudatoputamen were prelabeled with [3H] and release of [3H] was stimulated through either (NMDA) receptors or strychnine-sensitive glycine receptors. |
6(0,0,1,1) | Details |
| 17728537 | Zhang CG, Kim SJ: induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Neuroreport. 2003 Aug 6;14(11):1507-10. |
6(0,0,1,1) | Details |
| 12957506 | Miyazato M, Sugaya K, Nishijima S, Ashitomi K, Hatano T, Ogawa Y: Inhibitory effect of intrathecal on the micturition reflex in normal and spinal cord injury rats. Neurochem Res. 1996 Oct;21(10):1221-6. Expression of strychnine-sensitive glycine receptor alpha-1 (GlyR alpha1) mRNA in the lumbosacral cord was also assessed in both rats. |
6(0,0,1,1) | Details |
| 8223947 | Wu FS, Gibbs TT, Farb DH: Dual activation of GABAA and glycine receptors by inverse modulation by and 5 alpha-pregnan-3 alpha-ol-20-one. Neuroreport. 2005 Dec 19;16(18):2025-8. The response to resembles the response as it is inhibited by strychnine (a competitive antagonist) or (a negative modulator of the response). |
3(0,0,0,3) | Details |
| 11133613 | Zhang Y, Wu S, Eger EI 2nd, Sonner JM: Neither (A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane. Exp Neurol. 2003 Sep;183(1):232-40. Inhaled anesthetics produce immobility (a cardinal aspect of general anesthesia) by an action on the spinal cord, possibly by potentiating the responses of gamma-amino- (A)) and glycine receptors to and |
3(0,0,0,3) | Details |
| 15505453 | Grasshoff C, Antkowiak B: Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Brain Res Bull. 2002 Sep 15;58(5):461-8. Recently, compelling evidence has been provided that the spinal actions of propofol involve type A (GABAA) receptors, whereas the contribution of glycine receptors remains uncertain. |
2(0,0,0,2) | Details |
| 10630206 | Chen Q, Moulder K, Tenkova T, Hardy K, Olney JW, Romano C: Excitotoxic cell death dependent on inhibitory receptor activation. . J Physiol. 1997 Nov 1;504 ( Pt 3):683-94. We have shown (in isolated chick embryo retina) that at least some of the lethal Cl- entry is through and glycine receptors. |
2(0,0,0,2) | Details |
| 10762330 | Harvey RJ, Schmieden V, Von Holst A, Laube B, Rohrer H, Betz H: Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. J Neurophysiol. 1996 Nov;76(5):3087-101. We show that a mouse GlyR alpha4 subunit full-length cDNA directs the formation of functional homo-oligomeric strychnine-sensitive GlyRs in Xenopus laevis oocytes and mammalian cells, and that these resemble GlyRs composed of the alpha1 subunit in pharmacological profile and single-channel properties. |
2(0,0,0,2) | Details |
| 9535100 | Sergeeva OA: Comparison of - and -evoked currents in two types of neurons isolated from the rat striatum. Neuropsychopharmacology. 2008 Feb;33(3):701-11. Epub 2007 May 23. Strychnine-sensitive -activated currents and -activated currents were compared in two types of neurons acutely isolated from striatal slices by vibrodissociation: large cells, presumably cholinergic giant aspiny neurons (GAN) and medium sized cells, presumed medium spiny neurons (MSN). These results predict the presence of alpha- and beta-subunits of the glycine receptor in the striatum. |
1(0,0,0,1) | Details |
| 10835046 | Lim R, Alvarez FJ, Walmsley B: mediates presynaptic inhibition at glycinergic synapses in a rat auditory brainstem nucleus. Biochemistry. 2002 Feb;67(2):233-9. Our immunohistochemical results show prominent punctate labelling of postsynaptic clusters of glycine receptors and of the receptor clustering protein gephyrin over the surface of bushy cells. This observation was supported by the effect of strychnine (1 microM), which was to decrease the evoked IPSC (to 10 % of control IPSC amplitude) and to produce a greater than 90 % block of spontaneous miniature IPSCs. |
1(0,0,0,1) | Details |
| 15872071 | Momose-Sato Y, Honda Y, Sasaki H, Sato K: Optical imaging of large-scale correlated wave activity in the developing rat CNS. BMC Pharmacol. 2004 Aug 9;4:16. This wave activity was inhibited by -, -, - and glycine-receptor antagonists in addition to gap junction blockers such as and 18beta-glycyrrhetinic acid. |
1(0,0,0,1) | Details |
| 8635460 | Hartenstein B, Schenkel J, Kuhse J, Besenbeck B, Kling C, Becker CM, Betz H, Weiher H: Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice. J Physiol. 1998 Feb 1;506 ( Pt 3):795-808. Mutations in inhibitory glycine receptor (GlyR) subunit genes are associated with neuromotor diseases in man and mouse. |
1(0,0,0,1) | Details |
| 20186763 | Wang GH, Jiang ZL, Chen ZQ, Li X, Peng LL: Neuroprotective effect of against temporary cerebral ischemia in rats. Anesthesiology. 1996 May;84(5):1205-14. These effects were blocked by strychnine in both MCAO rats and cultured hippocampal neurons. It is suggested that could exert a neuroprotective effect on the ischemic-reperfused brain and on the hypoxia- or -exposed hippocampal neurons, which may be mediated by activating glycine receptors. (c) 2010 Wiley-Liss, Inc. |
1(0,0,0,1) | Details |
| 10515985 | Ikeda H, Asai T, Randic M, Murase K: Robust suppression of afferent-induced excitation in the rat spinal dorsal horn after conditioning low-frequency stimulation. J Neurophysiol. 1999 Oct;82(4):1957-64. However, treatments with the (A) receptor antagonist bicuculline (1 microM) and the glycine receptor antagonist strychnine (0.3 microM) did not affect suppression induction and maintenance. |
0(0,0,0,0) | Details |
| 7855218 | Ginski MJ, Witkin JM: Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists. Psychopharmacology. 1994 May;114(4):573-82. An antagonist of the strychnine-insensitive glycine receptor (7-chlorokynurenic acid) did not affect performance on either test. |
0(0,0,0,0) | Details |
| 18762389 | Faingold CL: Electrical stimulation therapies for CNS disorders and pain are mediated by competition between different neuronal networks in the brain. Eur J Pharmacol. 1999 Jul 2;376(1-2):149-57. Many studies indicate that treatment of unanesthetized animals with antagonists (bicuculline or strychnine) of inhibitory neurotransmitter or glycine) receptors can cause CMR neurons to become consistently responsive to external inputs (e.g., peripheral nerve, sensory, or electrical stimuli in the brain) to which these neurons did not previously respond. |
0(0,0,0,0) | Details |
| 10344778 | Biala G, Kotlinska J: Blockade of the acquisition of -induced conditioned place preference by N-methyl-D-aspartate receptor antagonists. Eur J Pharmacol. 1999 Feb 12;367(1):125-30. Both dizocilpine (0.1 mg/kg, i.p.), a non-competitive antagonist of the NMDA receptor, and L-701,324 (5 mg/kg, per os), an antagonist acting at the strychnine-insensitive site of NMDA receptor complex, when co-administered repeatedly with prevented the acquisition of ethanol-induced CPP. |
0(0,0,0,0) | Details |
| 10367956 | Jensen RJ: Responses of directionally selective retinal ganglion cells to activation of AMPA glutamate receptors. J Biol Chem. 2009 Jun 5;284(23):15847-56. Epub 2009 Mar 13. Pretreatment of retinas with the glycine receptor antagonist strychnine (1-2 microM) did not alter the effects of AMPA. |
0(0,0,0,0) | Details |
| 12430956 | Paton JF, Dutschmann M: Central control of upper airway resistance regulating respiratory airflow in mammals. J Physiol. 2004 Feb 1;554(Pt 3):649-58. Epub 2003 Nov 28. Our findings show that strychnine blockade of glycine receptors within the brainstem changes the eupneic three-phase respiratory pattern into two phases. |
82(1,1,1,2) | Details |
| 9886686 | Maksay G: Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands. Neuropharmacology. 1998 Dec;37(12):1633-41. |
81(1,1,1,1) | Details |
| 14575889 | Li GL, Yang XL: Glycinergic input to carp retinal ganglion cells may be mediated by glycine receptors with homologous kinetics. Eur J Pharmacol. 1995 Nov 30;291(3):221-7. Strychnine (1 microM), a glycine receptor antagonist, completely blocked the response to 100 microM |
69(0,2,3,4) | Details |
| 17207866 | McCool BA, Chappell A: Strychnine and modulation of amygdala-associated anxiety-like behavior is 'state' dependent. Pol J Pharmacol. 2003 Jul-Aug;55(4):649-53. Strychnine-sensitive glycine receptors are expressed in many adult forebrain regions, yet the biological function of these receptors outside the spinal cord/brainstem is poorly understood. |
68(0,2,3,3) | Details |
| 8062927 | Saul B, Schmieden V, Kling C, Mulhardt C, Gass P, Kuhse J, Becker CM: Point mutation of glycine receptor alpha 1 subunit in the spasmodic mouse affects agonist responses. Biochem Pharmacol. 2002 Jul 15;64(2):285-8. Homozygotic spasmodic (spd/spd) mice suffer from a motor disorder resembling poisoning by the glycine receptor antagonist strychnine. |
35(0,1,1,5) | Details |
| 14622925 | Busselberg D, Bischoff AM, Richter DW: A combined blockade of and -dependent channels abolishes the respiratory rhythm. Biochem J. 2005 Sep 1;390(Pt 2):447-53. In wild type mice, selective blockade of glycine receptors with low concentrations of strychnine (0.03-0.3 microM) provoked considerable changes in neuronal discharge characteristics: The cycle phase relationship of inspiratory, post-inspiratory and expiratory specific patterns of membrane potential changes was altered profoundly. |
35(0,1,1,5) | Details |
| 7874121 | Buckwalter MS, Cook SA, Davisson MT, White WF, Camper SA: A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra1) results in progressive neurological symptoms and juvenile death. Neurochem Res. 2003 Jun;28(6):893-901. This receptor is the major adult glycine receptor, and the site of action of the poison strychnine. |
35(0,1,1,5) | Details |
| 11962256 | Yamashina S, Konno A, Wheeler MD, Rusyn I, Rusyn EV, Cox AD, Thurman RG: Endothelial cells contain a -gated chloride channel. . Brain Res. 1993 Oct 15;625(1):38-44. Furthermore, the inhibitory effects of were prevented by 1 microM strychnine, a glycine receptor antagonist, or when cells were incubated in Cl (-)-free buffer. |
32(0,1,1,2) | Details |
| 12661758 | Noh JH, Choi S, Lee JH, Betz H, Kim JI, Park CS, Lee SM, Nah SY: Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes. Mol Pain. 2006 Nov 27;2:36. Glycine receptor antagonist strychnine completely blocked the inward current elicited by plus ginsenoside Rf. |
32(0,1,1,2) | Details |
| 12352624 | Miyakawa N, Uchino S, Yamashita T, Okada H, Nakamura T, Kaminogawa S, Miyamoto Y, Hisatsune T: A glycine receptor antagonist, strychnine, blocked NMDA receptor activation in the neonatal mouse neocortex. J Neurochem. 1997 Jul;69(1):399-405. |
32(0,1,1,2) | Details |
| 9464928 | Kotak VC, Sanes DH: Deafferentation weakens excitatory synapses in the developing central auditory system. J Neurosci. 2001 Sep 15;21(18):7303-12. The glycine receptor antagonist strychnine did eliminate the IPSP-associated depolarization in these neurons. |
31(0,1,1,1) | Details |
| 20060035 | Gemba-Nishimura A, Inoue T, Nakamura S, Nakayama K, Mochizuki A, Shintani S, Yoshimura S: Properties of synaptic transmission from the reticular formation dorsal to the facial nucleus to trigeminal motoneurons during early postnatal development in rats. J Neurosci. 2005 Feb 23;25(8):2010-23. Combined bath application of the non- (non-NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and the NMDA receptor antagonist DL-2-amino-5-phosphonopentanoic acid (APV) reduced these optical responses, and addition of the glycine receptor antagonist strychnine and the (A) receptor antagonist bicuculline further reduced the remaining responses. |
31(0,1,1,1) | Details |
| 8099620 | Nowak G, Trullas R, Layer RT, Skolnick P, Paul IA: Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with and 1-aminocyclopropanecarboxylic acid. Anesthesiology. 2001 Feb;94(2):333-9. These effects were compared to a chronic regimen of 1-aminocyclopropanecarboxylic acid, a high-affinity partial agonist at strychnine-insensitive glycine receptors which mimics the effects of in preclinical models predictive of antidepressant action. |
31(0,1,1,1) | Details |
| 8923484 | Simpson RK Jr, Gondo M, Robertson CS, Goodman JC: Reduction in the mechanonociceptive response by intrathecal administration of and related compounds. Br J Pharmacol. 1994 Mar;111(3):951-5. Force required to produce the pain response was significantly increased after administration and reduced using strychnine, a specific glycine receptor (Gly l) antagonist. |
31(0,1,1,1) | Details |
| 8146214 | Peterson SL: Diazepam potentiation by in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. J Pharm Sci. 2000 Jul;89(7):867-75. These results provide evidence that the potentiation of the anticonvulsant activity of DZP in clonic seizures induced by PTZ may be mediated by the strychnine-insensitive glycine receptor. |
31(0,1,1,1) | Details |
| 19359371 | Chapman RJ, Cilia La Corte PF, Asghar AU, King AE: Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. The glycine receptor antagonist strychnine (4 microM) and the (A) receptor antagonist bicuculline (10 microM) diminished and abolished, respectively, field population spiking and both antagonists reduced the power of 4-12 Hz oscillations. |
31(0,1,1,1) | Details |
| 9259023 | Furuya Y, Ogura H: Competitive and strychnine-insensitive -site antagonists disrupt prepulse inhibition. J Pharmacol Exp Ther. 1997 Jan;280(1):46-52. PPI was also disrupted by bilateral intracerebroventricular administration of 5,7-dichlorokyn urenate (10 and 20 micrograms/side X 2), an antagonist at the strychnine-insensitive glycine receptor, which is an allosteric binding site in the NMDA receptor-channel complex. |
31(0,1,1,1) | Details |
| 17411024 | Gelmi ML, Fontana G, Pocar D, Pontremoli G, Pellegrino S, Bombardelli E, Riva A, Balduini W, Carloni S, Cimino M: Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for and gamma-aminobutyric acid receptors. Neuroscience. 1996 Jun;72(3):833-46. New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on and strychnine-sensitive glycine receptors present in rat brain and spinal cord. |
6(0,0,1,1) | Details |
| 11805213 | Findlay GS, Wick MJ, Mascia MP, Wallace D, Miller GW, Harris RA, Blednov YA: Transgenic expression of a mutant glycine receptor decreases sensitivity of mice. J Physiol. 2003 Oct 1;552(Pt 1):73-87. Epub 2003 Jul 10. Under the control of synapsin I regulatory sequences, transgenic expression of S267Q mutant GlyR alpha (1) subunits in the nervous system was demonstrated using [(3) H] strychnine binding and immunoblotting. |
3(0,0,0,3) | Details |
| 7925268 | Langosch D, Laube B, Rundstrom N, Schmieden V, Bormann J, Betz H: Decreased agonist affinity and conductance of mutant glycine receptors associated with human hereditary hyperekplexia. J Biol Chem. 2003 Oct 3;278(40):38637-45. Epub 2003 Jul 28. In contrast, the ability of the competitive antagonist strychnine to block -induced currents was similar in all cases. |
3(0,0,0,3) | Details |
| 10400960 | Oleskevich S, Alvarez FJ, Walmsley B: Glycinergic miniature synaptic currents and receptor cluster sizes differ between spinal cord interneurons. J Neurosci. 2006 May 3;26(18):4880-90. We have analyzed the structure of glycinergic receptor clusters on rat ventral horn interneurons using antibodies against the glycine receptor clustering protein, gephyrin. |
3(0,0,0,3) | Details |
| 11487628 | Dumoulin A, Triller A, Dieudonne S: IPSC kinetics at identified GABAergic and mixed GABAergic and glycinergic synapses onto cerebellar Golgi cells. J Neurophysiol. 1995 Sep;74(3):1324-34. Corelease of the two transmitters at Lugaro cell synapses is suggested by the fact that both (A) and glycine receptors open during individual L-IPSCs. |
2(0,0,0,2) | Details |
| 11994124 | Nguyen L, Malgrange B, Belachew S, Rogister B, Rocher V, Moonen G, Rigo JM: Functional glycine receptors are expressed by postnatal nestin-positive neural stem/progenitor cells. Brain Res Bull. 1994;35(3):205-9. Whole-cell patch-clamp experiments further demonstrated that triggers in 33.5% of these cells currents that can be reversibly blocked by strychnine and picrotoxin. |
2(0,0,0,2) | Details |
| 11549721 | Hussy N, Bres V, Rochette M, Duvoid A, Alonso G, Dayanithi G, Moos FC: Osmoregulation of secretion via activation of neurohypophysial nerve terminals glycine receptors by glial Nat Struct Mol Biol. 2008 Oct;15(10):1084-93. Epub 2008 Sep 21. On purified neurohypophysial nerve endings, activation of strychnine-sensitive GlyRs by or primarily inhibits the high K (+)-induced rise in [Ca (2+)](i) and subsequent release of |
2(0,0,0,2) | Details |
| 11226317 | Garcia-Alcocer G, Garcia-Colunga J, Martinez-Torres A, Miledi R: Characteristics of glycine receptors expressed by embryonic rat brain mRNAs. Neurosci Lett. 1998 Feb 27;243(1-3):9-12. Strychnine inhibited all of the Gly-currents, with an IC (50) of 56 +/- 3 nM for encephalon, 97 +/- 4 nM for midbrain, and 72 +/- 4 nM for brainstem mRNAs. |
1(0,0,0,1) | Details |
| 11152721 | Aoki F, Wannier T, Grillner S: Slow dorsal-ventral rhythm generator in the lamprey spinal cord. . Eur J Neurosci. 2008 Apr;27(8):2076-88. In the isolated lamprey spinal cord, a very slow rhythm (0.03-0.11 Hz), superimposed on fast -induced locomotor activity (0.26-2.98 Hz), could be induced by a blockade of (A) or glycine receptors or by administration of (1 s, 3 s)-l-aminocyclopentane-1,3-dicarboxylic acid a metabotropic glutamate receptor agonist. |
1(0,0,0,1) | Details |
| 15275654 | Ruggieri RD, Pierobon P, Kass-Simon G: Pacemaker activity in hydra is modulated by glycine receptor ligands. . J Neurophysiol. 2001 Jan;85(1):211-8. In the mammalian central nervous system, the neurotransmitter, acts both on an inhibitory, strychnine-sensitive receptor (GlyR) and an excitatory, strychnine-insensitive site at the NMDA receptor. |
1(0,0,0,1) | Details |
| 18440992 | Hou M, Duan L, Slaughter MM: Synaptic inhibition by acting at a metabotropic receptor in tiger salamander retina. J Neurophysiol. 1998 Oct;80(4):1686-701. In retina, we found a strychnine-insensitive response in bipolar and ganglion cells. The EC (50) of the metabotropic response is 3 mum, an order of magnitude lower than the ionotropic glycine receptor in the same retina. |
1(0,0,0,1) | Details |
| 15483115 | Ye JH, Wang F, Krnjevic K, Wang W, Xiong ZG, Zhang J: Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area. J Physiol. 2008 Jun 15;586(Pt 12):2913-26. Epub 2008 Apr 25. Strychnine (1 microm) blocked the action of when applied alone, it reduced the amplitude of eIPSCs and the frequency of sIPSCs, indicating a tonic facilitation of GABAergic excitation by some endogenous agonist (s). |
1(0,0,0,1) | Details |
| 12873928 | Yamauchi M, Shimada SG, Sekiyama H, Collins JG: Neither spinal -A nor strychnine-sensitive glycine receptor systems are the sole mediators of halothane depression of spinal dorsal horn sensory neurons. Neuroscience. 2003;117(2):397-403. |
0(0,0,0,0) | Details |
| 9021766 | Simpson RK Jr, Gondo M, Robertson CS, Goodman JC: Reduction in thermal hyperalgesia by intrathecal administration of and related compounds. J Neurosci. 2003 Sep 3;23(22):8051-9. Neuropathic rats created by unilateral partial ligation of the sciatic nerve were treated with intrathecal infusion of strychnine, MK-801, or 5-7 DKA at 0.1 mumol for 2 hours at a rate of 10 microliters/min. |
0(0,0,0,0) | Details |
| 9154344 | Nolan MF, Gibson IC, Logan SD: Actions of the anaesthetic Saffan on rat sympathetic preganglionic neurones in vitro. Neurochem Res. 1997 Jan;22(1):75-9. Responses to Saffan were blocked by the GABAA receptor antagonists bicuculline (5-20 microM) and picrotoxin (20 microM), but not by the glycine receptor antagonist strychnine (20 microM) indicating that they were mediated by GABAA receptors. 4. |
0(0,0,0,0) | Details |
| 12742643 | Singh JN, Deshpande SB: Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats. J Comp Neurol. 1996 May 20;369(1):83-92. A glycine receptor antagonist, strychnine (1 microM), failed to block the depression by the toxin up to 28 microM; however, the depression was attenuated significantly at 84 microM of the toxin. |
0(0,0,0,0) | Details |
| 7971741 | Bartlett SE, Dodd PR, Smith MT: Pharmacology of morphine and morphine-3- at opioid, excitatory amino acid, and binding sites. J Clin Psychopharmacol. 1999 Dec;19(6):506-12. In addition, morphine-3- and morphine did not inhibit the binding of 3H-strychnine (glycine receptor antagonist) to synaptic membranes prepared from bovine spinal cord. |
0(0,0,0,0) | Details |
| 17655979 | Maksay G, Biro T, Laube B, Nemes P: Hyperekplexia mutation R271L of alpha1 glycine receptors potentiates allosteric interactions of nortropeines, propofol and with [3H] strychnine binding. J Neurosci Res. 1996 Feb 1;43(3):346-54. |
112(1,2,2,2) | Details |
| 8096422 | Biella G, Sotgiu ML: Central effects of systemic lidocaine mediated by spinal receptors: an iontophoretic study in the rat spinal cord. Pharmacol Biochem Behav. 1994 Feb;47(2):241-6. The effects of systemic lido on the drug-induced frequency changes and the interaction with the glycine receptors, using strychnine as a probe, were studied. |
112(1,2,2,2) | Details |
| 16018586 | Salceda R, Aguirre-Ramirez M: Characterization of strychnine-sensitive glycine receptor in the intact frog retina: modulation by protein kinases. J Neurophysiol. 1999 Jul;82(1):312-9. We studied 3H- and 3H-strychnine specific binding to glycine receptor (GlyR) in intact isolated frog retinas. |
112(1,2,2,2) | Details |
| 17234181 | Mascia MP, Bachis E, Obili N, Maciocco E, Cocco GA, Sechi GP, Biggio G: Thiocolchicoside inhibits the activity of various subtypes of recombinant (A) receptors expressed in Xenopus laevis oocytes. Brain Res. 2009 Jun 30;1278:27-33. Epub 2009 May 3. Thiocolchicoside inhibited the function of recombinant human strychnine-sensitive glycine receptors composed of the alpha1 subunit with a potency (median inhibitory concentration of 47 microM) lower than that apparent with recombinant (A) receptors. |
81(1,1,1,1) | Details |
| 8821829 | Venkatachalam MA, Weinberg JM, Patel Y, Saikumar P, Dong Z: Cytoprotection of kidney epithelial cells by compounds that target amino acid gated channels. Anesth Analg. 2003 Aug;97(2):417-23 Two classes of compounds showed cytoprotective activity in this system: (1) ligands at chloride channel receptors, such as strychnine and avermectin B1a; (2) chloride channel blockers, including cyanotriphenylboron and niflumic acid, both of which are known to bind to channel domains of CNS glycine receptors. |
81(1,1,1,1) | Details |
| 19194159 | Nguyen HT, Li KY, daGraca RL, Delphin E, Xiong M, Ye JH: Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. J Neurosci. 1995 Oct;15(10):6890-904. Propofol-induced LORR was examined in the presence and absence of strychnine (a glycine receptor antagonist), GABAzine (a A receptor antagonist), as well as ketamine (an antagonist of subtype of glutamate receptors). |
66(0,2,2,6) | Details |
| 7516705 | Walstrom KM, Hess GP: Mechanism for the channel-opening reaction of strychnine-sensitive glycine receptors on cultured embryonic mouse spinal cord cells. J Neurophysiol. 1998 Jun;79(6):3189-96. |
65(0,2,2,5) | Details |
| 19204413 | Ahrens J, Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, Karst M, Haeseler G: The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. Laryngoscope. 1998 Jan;108(1 Pt 1):26-31. As we hypothesized that non-CB receptor mechanisms of cannabidiol might contribute to its anti-inflammatory and neuroprotective effects, we investigated the interaction of cannabidiol with strychnine-sensitive alpha (1 ) and alpha (1) beta glycine receptors by using the whole-cell patch clamp technique. |
64(0,2,2,4) | Details |
| 9539222 | Elster L, Banke T, Kristiansen U, Schousboe A, Wahl P: Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells. Hepatology. 2000 Sep;32(3):542-6. Expression of the glycine receptor was investigated in membranes prepared from primary cultures of mouse cerebellar granule cells and postnatal mouse cerebellum using the antagonist [3H] strychnine for ligand binding. |
34(0,1,1,4) | Details |
| 9490812 | Lewis TM, Sivilotti LG, Colquhoun D, Gardiner RM, Schoepfer R, Rees M: Properties of human glycine receptors containing the hyperekplexia mutation alpha1 (K276E), expressed in Xenopus oocytes. Neurochem Int. 2004 Jun;44(7):521-7. The maximum response to also appeared much reduced, whereas the equilibrium constant for the glycine receptor antagonist strychnine was unchanged. 3. |
34(0,1,1,4) | Details |
| 12404628 | Breitinger HG, Becker CM: The inhibitory glycine receptor-simple views of a complicated channel. Pharmacology. 2007;80(2-3):151-7. Epub 2007 May 29. The strychnine-sensitive glycine receptor is the principal mediator of fast inhibitory synaptic transmission in the mammalian spinal cord and brain stem. |
34(0,1,1,4) | Details |
| 10861587 | Lian H, Steiner SS, Sofia RD, Woodhead JH, Wolf HH, White HS, Shen GS, Rhodes CA, McCabe RT: A self-complementary, self-assembling microsphere system: application for intravenous delivery of the antiepileptic and neuroprotectant compound felbamate. Amino Acids. 2010 Jan;38(1):57-64. Epub 2008 Nov 21. Felbamate (FBM) is a novel antiepileptic drug (AED) and neuroprotectant (NP) compound that interacts with strychnine-insensitive (SI) glycine receptors in brain (IC (50) = 374 microM). |
32(0,1,1,2) | Details |
| 9925021 | Nakayama M, Caspary DM, Konrad HR, Milbrandt JC, Helfert RH: Age-related changes in [3H] strychnine binding in the vestibular nuclei of rats. Neuroscience. 2002;112(2):299-307. Glycine receptors were localized using [3H] strychnine binding. |
32(0,1,1,2) | Details |
| 19861413 | Vogel N, Kluck CJ, Melzer N, Schwarzinger S, Breitinger U, Seeber S, Becker CM: Mapping of disulfide bonds within the amino-terminal extracellular domain of the inhibitory glycine receptor. Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):371-8. Epub 2008 Nov 5. The strychnine-sensitive glycine receptor (GlyR) is a ligand-gated chloride channel and a member of the superfamily of loop (Cys-loop) neurotransmitter receptors, which also comprises the nicotinic acetylcholine receptor (nAChR). |
32(0,1,1,2) | Details |
| 8890920 | Wang H, Cui WY, Liu CG: Regulatory effects of acutely repeated treatment towards central muscarinic receptors. Neuroscience. 2001;103(2):561-79. In conscious rats, the dose-response curves of muscarinic agonists arecoline and pilocarpine, cholinesterase inhibitors soman and physostigmine rather than GABA receptor antagonist pentylenetetrazol or glycine receptor antagonist strychnine for producing EEG seizures were shifted leftwards by acutely repeated injections of |
31(0,1,1,1) | Details |
| 7948829 | Mettens P, Cheron G, Godaux E: Role of the vestibular commissure in gaze-holding in the cat: a pharmacological evaluation. Hear Res. 1999 Jan;127(1-2):103-7. In order to test this hypothesis, we injected either bicuculline, a GABA receptor antagonist, or strychnine, a glycine receptor antagonist, into the medial vestibular nucleus of alert cats. |
31(0,1,1,1) | Details |
| 14980391 | Yang Z, Smith L, Coote JH: Paraventricular nucleus activation of renal sympathetic neurones is synaptically depressed by and acting at a spinal level. Brain Res Brain Res Rev. 2004 Dec;47(1-3):33-45. Enhancement of synaptically induced renal nerve activity was also observed following intrathecal glycine receptor inhibitor strychnine. |
31(0,1,1,1) | Details |
| 9214458 | Carini R, Bellomo G, Grazia De Cesaris M, Albano E: protects against hepatocyte killing by KCN or hypoxia by preventing intracellular Na+ overload in the rat. Mol Cell Neurosci. 2008 Jan;37(1):40-55. Epub 2007 Aug 23. Pretreating hepatocytes with the glycine-receptor antagonist, strychnine (1 mmol/L), similarly prevented Na+ overload and cell killing. |
31(0,1,1,1) | Details |
| 12429224 | Wu HQ, Lee SC, Scharfman HE, Schwarcz R: L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. J Neurosci. 2005 Mar 2;25(9):2267-76. Blockade of the strychnine-insensitive site of the NMDA receptor is considered an attractive strategy for the development of novel neuroprotective and anticonvulsive agents. 7-Cl- (7-Cl-KYNA) is a potent, selective antagonist of the /glycine receptor but penetrates poorly through the blood-brain barrier. |
31(0,1,1,1) | Details |
| 9409718 | Straub H, Kohling R, Speckmann EJ: Strychnine-induced epileptiform activity in hippocampal and neocortical slice preparations: suppression by the organic antagonists and flunarizine. Alcohol Clin Exp Res. 2005 Jan;29(1):17-26. Application of the glycine receptor blocker strychnine is known to evoke epileptiform phenomena. |
6(0,0,1,1) | Details |
| 19776366 | Palazzo E, Guida F, Migliozzi A, Gatta L, Marabese I, Luongo L, Rossi C, de Novellis V, Fernandez-Sanchez E, Soukupova M, Zafra F, Maione S: Intraperiaqueductal gray and exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat. J Neurosci. 1997 Aug 15;17(16):6483-91. We have studied the involvement of the N-methyl-D-aspartate receptor (NMDAR) site and the strychnine-sensitive glycine receptor (GlyR) in the ventrolateral periaqueductal gray (VL-PAG) on nociceptive behavior (tail flick) and pain-related changes on neuronal activity in the rostral ventromedial medulla (RVM). |
6(0,0,1,1) | Details |
| 7887983 | Forray MI, Andres ME, Bustos G, Gysling K: Regulation of endogenous release from the bed nucleus of stria terminalis. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):181-7. Epub 2003 Aug 16. However, exhibited a significant effect by itself, suggesting the existence of strychnine-sensitive glycine receptors in vBNST. |
6(0,0,1,1) | Details |
| 7708201 | Pan ZH, Slaughter MM: Comparison of the actions of and related amino acids on isolated third order neurons from the tiger salamander retina. Alcohol Clin Exp Res. 2005 Jan;29(1):38-45. Using cross desensitization, the structure-function relationship of short chain amino acids on the glycine receptor were examined. |
3(0,0,0,3) | Details |
| 12351266 | Dong XP, Xu TL: The actions of propofol on -A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Neurochem Res. 2005 Mar;30(3):411-6. Propofol induced Cl (-) currents (I (Cl)), which were sensitive to bicuculline and, to a lesser extent, to strychnine. |
3(0,0,0,3) | Details |
| 7717569 | McFarlane C, Warner DS, Nader A, Dexter F: Glycine receptor antagonism. Eur J Med Chem. 2003 Jul-Aug;38(7-8):661-70. |
3(0,0,0,3) | Details |
| 9331923 | Heppenstall PA, Fleetwood-Walker SM: Glycine receptor regulation of neurokinin1 receptor function in rat dorsal horn neurones. J Neurosci. 2008 Sep 3;28(36):8873-84. However, in the presence of the antagonists, strychnine or phenylbenzene-omega-phosphono-alpha-amino acid (PMBA), GR82334 displayed inhibitory properties. |
3(0,0,0,3) | Details |
| 19217931 | Wang H, Turner JG, Ling L, Parrish JL, Hughes LF, Caspary DM: Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus. J Neurophysiol. 1994 Jun;71(6):2014-24. The pharmacologic consequences of these age-related subunit changes were assessed using [3H] strychnine binding. |
2(0,0,0,2) | Details |
| 10465682 | David-Watine B, Shorte SL, Fucile S, de Saint Jan D, Korn H, Bregestovski P: Functional integrity of green fluorescent protein conjugated glycine receptor channels. J Neurophysiol. 1999 May;81(5):2592-5. The apparent affinities of this receptor for agonists and and the antagonist (strychnine) are unchanged, and single channel kinetics are not altered. |
2(0,0,0,2) | Details |
| 16949227 | Xu H, Wang W, Tang ZQ, Xu TL, Chen L: acts as a glycine receptor agonist in slices of rat inferior colliculus. Epilepsy Behav. 2008 Jan;12(1):25-9. Epub 2007 Nov 5. All these effects were reversible after washout and could be blocked by 3 microM strychnine, an antagonist of glycine receptors, but not by 10 microM bicuculline, an antagonist of (A) receptors. |
2(0,0,0,2) | Details |
| 9246463 | Schofield PR, Lynch JW, Rajendra S, Pierce KD, Handford CA, Barry PH: Molecular and genetic insights into ligand binding and signal transduction at the inhibitory glycine receptor. Exp Brain Res. 1999 Nov;129(2):172-84. |
1(0,0,0,1) | Details |
| 8558472 | Zhang ZW, Berg DK: Patch-clamp analysis of -induced currents in chick ciliary ganglion neurons. Biosens Bioelectron. 2006 Jan 15;21(7):1272-82. Epub 2005 Jul 11. Expression of functional glycine receptors during development was examined at embryonic day 8 (E8), 11, 14, and 18. Strychnine reversibly inhibited the -induced responses. |
1(0,0,0,1) | Details |
| 10631757 | Pandeya SN, Ponnilavarasan I, Pandey A, Lakhan R, Stables JP: Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties. Eur J Neurosci. 1994 Aug 1;6(8):1275-80. Presumably these compounds could further act on glycine receptors. |
1(0,0,0,1) | Details |
| 8899663 | Rodriguez-Ithurralde D, Olivera S, La Paz A, Vincent O, Rondeau A: effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn. J Neurophysiol. 2009 Jun;101(6):3135-46. Epub 2009 Apr 15. To study the mechanisms by which -elicited acetylcholinesterase release (GEAR) might play a part in the pathogenesis of excitotoxically triggered motor neurone disease, and to investigate the interaction of GEAR with spinal glycinergic mechanisms, we measured acetylcholinesterase (AChE) and cholinergic markers, after stimulating ventral horn slices and synaptosomes from the mouse spinal cord, with both - and glycine-receptor agonists. GLY potentiated the GEAR response in the presence of strychnine, suggesting (NMDA) receptor involvement, and was also able to evoke a strychnine-sensitive AChE release in the absence of exogenous GLU. |
1(0,0,0,1) | Details |
| 10460250 | Levi S, Chesnoy-Marchais D, Sieghart W, Triller A: Synaptic control of and (A) receptors and gephyrin expression in cultured motoneurons. Neuroreport. 1994 Dec 30;6(1):77-80. We have evaluated the influence of the secretory phenotype of presynaptic boutons on the accumulation of postsynaptic glycine receptors (GlyRs), type A GABA receptors (A) Rs), and gephyrin clusters. |
1(0,0,0,1) | Details |
| 9547397 | Pierrefiche O, Schwarzacher SW, Bischoff AM, Richter DW: Blockade of synaptic inhibition within the pre-Botzinger complex in the cat suppresses respiratory rhythm generation in vivo. Chin J Physiol. 2007 Aug 31;50(4):178-86. The role of synaptic inhibition in respiratory rhythm generation was analysed by microinjections of GABAA and glycine receptor antagonists into the bilateral pre-Botzinger complex (PBC) of anaesthetized cats. Bilateral injections of strychnine (50 or 100 microM) greatly reduced phrenic burst amplitudes leading to increased burst frequency or irreversibly blocked rhythmic phrenic discharges. |
1(0,0,0,1) | Details |
| 8169857 | Paul IA, Nowak G, Layer RT, Popik P, Skolnick P: Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. Brain Res Dev Brain Res. 2003 Aug 12;144(1):57-71. Chronic (14 day) but not acute (1 day) treatment of mice with clinically active antidepressants produces a significant (approximately 1.8-4.3 fold) reduction in the potency of to inhibit [3H]-5,7-dichlorkynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine receptors in neocortical membranes. |
0(0,0,0,0) | Details |
| 11952420 | Menzikov SA, Menzikova OV: Effect of activators and blockers of ligand-regulated ion channels on the activity of the Cl-stimulated Mg2+-ATPase of the plasma membrane fraction from bream (Abramis brama L.) brain. EMBO J. 1994 Mar 15;13(6):1318-24. The activation of "basal" Mg (2+)-ATPase by neuromediators was decreased by blockers of the corresponding receptors (picrotoxin, strychnine, benztropine mesylate, and D-2-amino-5-phosphonovaleric acid). |
0(0,0,0,0) | Details |
| 12468442 | Pimentel FF, Bonagamba LG, Machado BH: Pressor response to chemoreflex activation before and after microinjection of into the NTS of awake rats. J Neurophysiol. 1996 Jul;76(1):227-41. Strychnine, a glycine receptor antagonist, attenuated the increase in MAP, and in this new experimental condition (n = 5) the pressor response to chemoreflex activation was not altered. |
0(0,0,0,0) | Details |
| 19571128 | Crook JD, Davenport CM, Peterson BB, Packer OS, Detwiler PB, Dacey DM: Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina. Neuron. 1995 Jan;14(1):169-75. The GABAa/c receptor antagonist picrotoxin and the glycine receptor antagonist strychnine did not affect chromatic balance or the basic coextensive receptive field structure, suggesting that the LM-OFF field is not generated by an inner retinal inhibitory pathway. |
0(0,0,0,0) | Details |
| 9051309 | Takahama K, Fukushima H, Isohama Y, Kai H, Miyata T: Inhibition of currents by dextromethorphan in neurones dissociated from the guinea-pig nucleus tractus solitarii. Anesth Analg. 2002 Oct;95(4):907-14 The half-maximum inhibitory concentration (IC50) of DM was 3.3 microM, about 85 times higher than that of strychnine. 3. |
0(0,0,0,0) | Details |
| 9427682 | Levi S, Vannier C, Triller A: Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters. J Neurophysiol. 1998 Sep;80(3):1327-40. The glycine receptor is inhibited by strychnine. |
107(1,1,5,7) | Details |
| 15301692 | Farroni JS, McCool BA: Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors. Life Sci. 1999;65(9):879-87. |
101(0,3,4,6) | Details |
| 10719083 | McCool BA, Botting SK: Characterization of strychnine-sensitive glycine receptors in acutely isolated adult rat basolateral amygdala neurons. Biochem Biophys Res Commun. 2010 Mar 19;393(4):587-91. Epub 2010 Feb 10. In addition to its cytoprotective and osmoregulatory roles, may also serve as an agonist at (A)- and strychnine-sensitive glycine receptors. |
100(0,3,4,5) | Details |
| 7812798 | Wamsley JK, Sofia RD, Faull RL, Ary T, Narang N, McCabe RT: Use of [3H] 5,7 dichlorokynurenic acid to identify strychnine-insensitive glycine receptors in human postmortem brain. J Neurosci. 2008 Apr 16;28(16):4136-50. [3H] 5,7 Dichlorokynurenic acid ([3H] DCKA) was used to define conditions for obtaining selective binding to strychnine-insensitive glycine receptors. |
94(1,1,3,4) | Details |
| 8970606 | Currin RT, Caldwell-Kenkel JC, Lichtman SN, Bachmann S, Takei Y, Kawano S, Thurman RG, Lemasters JJ: Protection by Carolina rinse solution, acidotic pH, and against lethal reperfusion injury to sinusoidal endothelial cells of rat livers stored for transplantation. Neurol Res. 1998 Mar;20(2):161-8. Strychnine, which binds to glycine receptors in the central nervous system, protected equally well. |
81(1,1,1,1) | Details |
| 8587649 | Perez-Leon JA, Salceda R: Different specific binding sites of [3H] and [3H] strychnine in synaptosomal membranes isolated from frog retina. Brain Res. 2000 Mar 24;859(2):341-51. The pharmacological binding pattern indicates the presence of the strychnine sensitive glycine receptor as well as other sites. |
81(1,1,1,1) | Details |
| 16723477 | Margalit E, Thoreson WB: Inner retinal mechanisms engaged by retinal electrical stimulation. Brain Res. 2002 Aug 23;947(1):25-33. These synaptic currents reversed around ECl and were blocked by picrotoxin, strychnine, or both, suggesting they were mediated by GABAa/c and glycine receptors. |
81(1,1,1,1) | Details |
| 12044448 | Kilb W, Ikeda M, Uchida K, Okabe A, Fukuda A, Luhmann HJ: Depolarizing responses in Cajal-Retzius cells of neonatal rat cerebral cortex. Brain Res. 1993 Feb 19;603(2):201-6. The membrane depolarization was abolished in the presence of the glycinergic antagonists strychnine (30 microM) and phenylbenzene-omega-phosphono-alpha-amino acid (100 microM), while the (A) receptor antagonist bicuculline (100 microM) and the glutamatergic antagonist (+/-)-2-amino-5-phosphonopentatonic acid (60 microM) were without effect, suggesting that the -induced membrane responses were mediated exclusively by the strychnine-sensitive glycine receptor. |
64(0,2,2,4) | Details |
| 15993440 | Ghavanini AA, Mathers DA, Puil E: Glycinergic inhibition in thalamus revealed by synaptic receptor blockade. . Brain Res. 1996 Mar 11;712(1):74-83. Exogenously applied and increased membrane conductance, effects antagonized by strychnine, indicative of functional glycine receptors. |
63(0,2,2,3) | Details |
| 17707353 | Hernandes MS, de Magalhaes L, Troncone LR: stimulates the release of labeled but not nor from superfused rat striatal tissue. J Neurophysiol. 2001 Dec;86(6):3069-72. The prototypical glycine receptor antagonist strychnine at 10 microM completely abolished (3) H- release. |
34(0,1,1,4) | Details |
| 10205013 | Hosie AM, Akagi H, Ishida M, Shinozaki H: Actions of 3-[2-phosphonomethyl [1,1-biphenyl]-3-yl] (PMBA) on cloned glycine receptors. J Physiol. 2005 Jun 1;565(Pt 2):503-16. Epub 2005 Apr 7. PMBA is a novel antagonist of strychnine-sensitive glycine receptors in the rat spinal cord, however, its mode of action is unknown. |
34(0,1,1,4) | Details |
| 19445923 | Cheng W, Yin Q, Cheng MY, Chen HS, Wang S, Feng T, Zeng YM, Liu GJ: Intracerebroventricular or intrathecal injection of produces analgesia in thermal nociception and chemical nociception via glycine receptors. J Biol Chem. 1994 Jul 22;269(29):18739-42. was injected intracerebroventricularly or intrathecally and strychnine, a glycine receptor antagonist, was injected intracerebroventricularly or intrathecally before injection. |
34(0,1,1,4) | Details |
| 8003681 | Chiba C, Saito T: APB (2-amino-4-phosphonobutyric acid) activates a conductance in ganglion cells isolated from newt retina. Science. 1998 Jul 17;281(5375):419-24. Strychnine, a glycine receptor blocker, inhibited the APB response. |
32(0,1,1,2) | Details |
| 9798943 | Lynch JW, Jacques P, Pierce KD, Schofield PR: potentiation of the glycine receptor chloride channel is mediated by allosteric pathways. Eur J Pharmacol. 1993 Nov 15;247(3):305-11. Molecular mechanisms of zinc potentiation were investigated in recombinant human alpha1 glycine receptors (GlyRs) by whole-cell patch-clamp recording and [3H] strychnine binding assays. |
32(0,1,1,2) | Details |
| 7965003 | Sivilotti L, Woolf CJ: The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. Ann N Y Acad Sci. 1999 Apr 30;868:667-76. Intrathecal injections of subconvulsant doses of the glycine receptor antagonist, strychnine (7 nmol) or the -A (GABAA) receptor antagonist, bicuculline (8 nmol) produced similar but longer lasting changes. |
32(0,1,1,2) | Details |
| 18353913 | Taepavarapruk N, Taepavarapruk P, John J, Lai YY, Siegel JM, Phillips AG, McErlane SA, Soja PJ: State-dependent changes in and levels in cat lumbar spinal cord. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4113-8. Recent studies have indicated that the glycine receptor antagonist strychnine and the type A A) receptor antagonist bicuculline reduced the rapid-eye-movement (REM) sleep-specific inhibition of sensory inflow via the dorsal spinocerebellar tract (DSCT). |
31(0,1,1,1) | Details |
| 12171579 | Johnston GA: Medicinal chemistry and molecular pharmacology of (C) receptors. . Alcohol Clin Exp Res. 2010 Jan;34(1):32-8. Epub 2009 Oct 23. (C) receptors belong to the nicotinicoid superfamily of ionotropic receptors that include nicotinic acetylcholine receptors, bicuculline-sensitive (A) receptors, strychnine-sensitive glycine receptors and 5HT3 serotonin receptors. |
31(0,1,1,1) | Details |
| 14767347 | Miyazato M, Sugaya K, Nishijima S, Ashitomi K, Ohyama C, Ogawa Y: Rectal distention inhibits bladder activity via glycinergic and GABAergic mechanisms in rats. Anesth Analg. 2006 Apr;102(4):1114-20. Using urethane anesthesia isovolumetric cystometry was performed before and after distention of the rectum by inflation of a rectal balloon (0 to 3 cm3), followed by the intrathecal injection of strychnine (a glycine receptor antagonist, 0.001 to 10 microg) and/or bicuculline (a (A) receptor antagonist, 0.001 to 1 microg) at the lumbosacral level of the spinal cord. |
31(0,1,1,1) | Details |
| 9007533 | Cimino M, Marini P, Cattabeni F: Interaction of thiocolchicoside with [3H] strychnine binding sites in rat spinal cord and brainstem. J Urol. 2004 Mar;171(3):1353-6. The results suggest that thiocolchicoside behaves as an allosteric compound acting on the strychnine-sensitive glycine receptor in rat brainstem and spinal cord, and that this may provide a possible mechanism for the myorelaxant activity of this colchicoside derivative, the first clinically useful drug acting on this receptor. |
31(0,1,1,1) | Details |
| 15031290 | Ju P, Aubrey KR, Vandenberg RJ: Zn2+ inhibits transport by transporter subtype 1b. Hepatology. 1997 Jul;26(1):107-12. In the central nervous system, is a co-agonist with at the subtype of glutamate receptors and also an agonist at inhibitory, strychnine-sensitive glycine receptors. |
31(0,1,1,1) | Details |
| 11683900 | McCool BA, Farroni JS: Subunit composition of strychnine-sensitive glycine receptors expressed by adult rat basolateral amygdala neurons. Bioorg Med Chem. 2009 Oct 1;17(19):6872-8. Epub 2009 Aug 20. |
25(0,0,4,5) | Details |
| 12923611 | Dudeck O, Lubben S, Eipper S, Knorle R, Kirsch M, Honegger J, Zentner J, Feuerstein TJ: Evidence for strychnine-sensitive glycine receptors in human amygdala. . Brain Res. 2006 Jul 12;1099(1):64-72. Epub 2006 Jun 15. |
22(0,0,3,7) | Details |
| 8700149 | Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, Harris RA: A single amino acid determines differences in actions on strychnine-sensitive glycine receptors. J Neurosci. 1998 May 15;18(10):3715-24. |
15(0,0,2,5) | Details |
| 16144831 | Miller PS, Da Silva HM, Smart TG: Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J Neurophysiol. 2010 Feb;103(2):924-33. Epub 2009 Dec 16. |
13(0,0,2,3) | Details |
| 16820013 | Ericson M, Molander A, Stomberg R, Soderpalm B: elevates levels in the rat nucleus accumbens; antagonism by strychnine. Brain Res. 2007 Jan 26;1130(1):95-102. Epub 2006 Dec 14. It was recently suggested that strychnine-sensitive glycine receptors (GlyR) in the nAcc regulate both basal and -induced mesolimbic DA activity via a neuronal loop involving endogenous activation of nicotinic acetylcholine receptors (nAChR) in the VTA. |
6(0,0,1,1) | Details |
| 9228730 | Gross GW, Harsch A, Rhoades BK, Gopel W: Odor, drug and toxin analysis with neuronal networks in vitro: extracellular array recording of network responses. Vis Neurosci. 2003 Jul-Aug;20(4):373-84. The glycine receptor blocker strychnine reliably generated increased multichannel bursting at 5-20 nM and regular, coordinated bursting above 5 microM. |
6(0,0,1,1) | Details |
| 17309519 | Chen Y, Dai TJ, Zeng YM: Strychnine-sensitive glycine receptors mediate analgesia induced by emulsified inhalation anaesthetics in thermal nociception but not in chemical nociception. J Biol Chem. 2004 Jun 11;279(24):25598-604. Epub 2004 Apr 5. The present study was designed to investigate the role of strychnine-sensitive glycine receptors in analgesia induced by emulsified inhalation anaesthetics. |
6(0,0,1,1) | Details |
| 9300267 | Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, Watanabe H: Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes. J Neurophysiol. 2005 Dec;94(6):3872-83. Epub 2005 Aug 10. We previously reported that corymine, an alkaloidal compound extracted from the leaves of Hunteria zeylanica native to Thailand, potentiated convulsions induced by either picrotoxin or strychnine. |
5(0,0,0,5) | Details |
| 16262635 | Ruscheweyh R, Sandkuhler J: Long-range oscillatory Ca2+ waves in rat spinal dorsal horn. Eur J Neurosci. 2005 Oct;22(8):1967-76. However, increasing neuronal excitability by application of 4-aminopyridine after pretreatment of the slice with blockers of (RS)-alpha-amino-3--5-methyl-4-isoxazolepropionic acid (AMPA)/kainate, (GABA)(A) and glycine receptors evoked repetitive Ca2+ waves in dorsal horn. |
2(0,0,0,2) | Details |
| 7621814 | Rajendra S, Vandenberg RJ, Pierce KD, Cunningham AM, French PW, Barry PH, Schofield PR: The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element. EMBO J. 1995 Jul 3;14(13):2987-98. Disruption of the loop's tertiary structure by Ser mutations of these Cys residues either prevented receptor assembly on the cell surface, or created receptors unable to be activated by agonists or to bind the competitive antagonist, strychnine. |
2(0,0,0,2) | Details |
| 18710260 | Liu Z, Ramanoudjame G, Liu D, Fox RO, Jayaraman V, Kurnikova M, Cascio M: Overexpression and functional characterization of the extracellular domain of the human alpha1 glycine receptor. Biochemistry. 2008 Sep 16;47(37):9803-10. Epub 2008 Aug 19. The mutant GlyR ECD, named GlyBP, was present in both soluble and membrane-associated fractions after cell lysis, though only the latter appeared to be in a native-like conformation capable of binding strychnine, a GlyR specific antagonist. |
2(0,0,0,2) | Details |
| 7518444 | Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR: Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor. Eur J Pharmacol. 1993 Aug 15;246(3):239-46. Additionally, we report corresponding 56- and 120-fold reductions in the apparent binding affinity (Ki) of to the mutant GlyRs, but no change in the binding affinity of the competitive antagonist, strychnine. |
2(0,0,0,2) | Details |
| 15572161 | Aguayo LG, van Zundert B, Tapia JC, Carrasco MA, Alvarez FJ: Changes on the properties of glycine receptors during neuronal development. Neuroreport. 1994 Jul 21;5(12):1421-4. Parallel to these modifications, the apparent receptor affinity to and strychnine, as well as that of Zn (2+) and increases with time. |
2(0,0,0,2) | Details |
| 18255245 | Yin S, Chen Z, Yu D, Feng Y, Wang J: Local inhibition shapes duration tuning in the inferior colliculus of guinea pigs. J Comp Neurol. 1997 Aug 18;385(1):117-34. In the inferior colliculus (IC) of these mammals, it is recognized that the excitatory responses to sounds are mediated through AMPA and NMDA receptors while the inhibitory input is mediated through and glycine receptors. It was found that the application of bicuculline (BIC, a A blocker) and/or strychnine (STRY, a blocker) eliminated or reduced duration tuning in most units that were duration tuned (32 out of 39 for BIC, 50 out of 64 for STRY, respectively). |
1(0,0,0,1) | Details |
| 16611622 | Stehr CM, Linbo TL, Incardona JP, Scholz NL: The developmental neurotoxicity of fipronil: notochord degeneration and locomotor defects in zebrafish embryos and larvae. Neurosci Lett. 1996 Apr 19;208(2):125-8. Although specifically developed to target insect GABA receptors with low vertebrate toxicity, our results suggest that fipronil impairs the development of spinal locomotor pathways in fish by inhibiting a structurally related glycine receptor subtype. The notochord effects of fipronil were phenocopied by exposure to 70 microM strychnine, a glycinergic receptor antagonist. |
1(0,0,0,1) | Details |
| 17068103 | Vignes JR, Deloire MS, Petry KG, Nagy F: Characterization and restoration of altered inhibitory and excitatory control of micturition reflex in experimental autoimmune encephalomyelitis in rats. Life Sci. 2006 Dec 3;80(1):9-16. Epub 2006 Aug 17. Blockade of glycine receptors in the lumbosacral spinal cord suppressed the stimulation-induced inhibitory effect. |
1(0,0,0,1) | Details |
| 9202334 | Matoba M, Tomita U, Nishikawa T: Characterization of 5,7-dichlorokynurenate-insensitive D-[3H] serine binding to synaptosomal fraction isolated from rat brain tissues. Mol Cells. 2003 Feb 28;15(1):34-9. Strychnine and 7-chlorokynurenate failed to inhibit the binding at 10 microM. The profiles of displacement of the DCK-insensitive D-[3H] serine binding by various amino acids and and glycine receptor-related compounds differ from those of any other defined recognition sites. |
1(0,0,0,1) | Details |
| 12855675 | Li YF, Wu LJ, Li Y, Xu L, Xu TL: Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons. Neuroscience. 2004;124(2):421-8. H+ shifted the EC50 of the concentration-response curve from 49.3 +/- 5.7 microM at external pH 7.4 to 131.5 +/- 8.1 microM at pH 5.5, without altering the Cl- selectivity of the glycine receptor (GlyR), the Hill coefficient and the maximal IGly, suggesting a competitive inhibition of IGly by H+. |
1(0,0,0,1) | Details |
| 16075189 | Davis KA: Contralateral effects and binaural interactions in dorsal cochlear nucleus. Br J Anaesth. 2004 May;92(5):704-11. Epub 2004 Mar 19. This inhibition is abolished and excitation is revealed when strychnine, a glycine-receptor antagonist, is applied to the DCN; application of bicuculline, a GABAA-receptor antagonist, has similar effects but does not block the onset of inhibition. |
0(0,0,0,0) | Details |
| 8248282 | Stone TW: Neuropharmacology of quinolinic and kynurenic acids. Neuron. 2004 Mar 25;41(6):867-79. The pathway includes two compounds, and which are remarkably specific in their pharmacological profiles: one is a selective agonist at receptors sensitive to whereas the other is a selective antagonist at low concentrations at the strychnine-resistant modulatory site associated with the NMDA receptor. |
0(0,0,0,0) | Details |
| 11849303 | Merrywest SD, Fischer H, Sillar KT: Alpha-adrenoreceptor activation modulates swimming via glycinergic and GABAergic inhibitory pathways in Xenopus laevis tadpoles. J Physiol. 2000 Jun 1;525 Pt 2:447-59. We show that NA could still modulate aspects of swimming after blocking either or (A) receptors with strychnine and bicuculline, respectively. |
0(0,0,0,0) | Details |
| 8930293 | Valeyev AY, Hackman JC, Wood PM, Davidoff RA: Pharmacologically novel GABA receptor in human dorsal root ganglion neurons. J Neurochem. 2004 Aug;90(4):962-9. The glycine receptor antagonist strychnine (100 microM) did not alter currents in human DRG cells. 5. |
0(0,0,0,0) | Details |
| 9200726 | Aroniadou-Anderjaska V, Ennis M, Shipley MT: Glomerular synaptic responses to olfactory nerve input in rat olfactory bulb slices. Epilepsia. 2003 Sep;44(9):1145-52. Strychnine, an antagonist of glycine receptors, had similar effects to those of bicuculline, but only at high concentrations that have been previously shown to block (A) receptors; at low concentrations strychnine had no effect. |
0(0,0,0,0) | Details |
| 8265681 | Namba T, Morimoto K, Yamada N, Otsuki S: Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats. J Neurosci Methods. 1999 Feb 1;87(1):97-103. These results demonstrate that this selective strychnine-insensitive glycine receptor antagonist has antiepileptogenic activity and suggest a role for the glycine receptors in the contribution of the NMDA receptor complex to epileptogenic events. |
112(1,2,2,2) | Details |
| 16687139 | Jensen AA, Gharagozloo P, Birdsall NJ, Zlotos DP: Pharmacological characterisation of strychnine and brucine analogues at and alpha7 nicotinic acetylcholine receptors. Neurotoxicol Teratol. 2005 Nov-Dec;27(6):855-9. Epub 2005 Sep 19. In this study, we have characterised the pharmacological properties of tertiary and quaternary analogues as well as bisquaternary dimers of strychnine and brucine at human alpha1 and alpha1beta glycine receptors and at a chimera consisting of the amino-terminal domain of the alpha7 nicotinic receptor (containing the orthosteric ligand binding site) and the ion channel domain of the 5-HT3A serotonin receptor. |
94(0,3,3,4) | Details |
| 8996180 | Witkin JM, Steele TD, Sharpe LG: Effects of strychnine-insensitive glycine receptor ligands in rats discriminating dizocilpine or phencyclidine from saline. Biosens Bioelectron. 1997;12(5):373-93. |
94(0,3,3,4) | Details |
| 10960447 | Zhang Y, Ikejima K, Honda H, Kitamura T, Takei Y, Sato N: prevents apoptosis of rat sinusoidal endothelial cells caused by deprivation of vascular endothelial growth factor. J Physiol. 2002 Apr 15;540(Pt 2):435-46. Furthermore, strychnine (1 micromol/L), a glycine receptor antagonist, inhibited this effect of suggesting the possible involvement of the glycine receptor/chloride channel in the mechanism. |
81(1,1,1,1) | Details |
| 18929557 | Shigemi K, Tsuneyoshi Y, Hamasu K, Han L, Hayamizu K, Denbow DM, Furuse M: induces sedative and hypnotic effects acting at (A) receptors in neonatal chicks. Addict Biol. 2010 Mar 10. similarly induced sedative and hypnotic effects in chicks, but its effect was attenuated by the glycine receptor antagonist strychnine. |
63(0,2,2,3) | Details |
| 11176099 | Kontinen VK, Stanfa LC, Basu A, Dickenson AH: Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy. Neuroscience. 2008 Nov 19;157(2):432-45. Epub 2008 Sep 11. BACKGROUND: Changes in the inhibitory activity mediated by and acting at spinal GABAA receptors and strychnine-sensitive glycine receptors, are of interest in the development of neuropathic pain. |
63(0,2,2,3) | Details |
| 17346892 | Ge LH, Lee SC, Liu J, Yang XL: Glycine receptors are functionally expressed on bullfrog retinal cone photoreceptors. Anesthesiology. 1995 Apr;82(4):963-8. These results suggest that strychnine-sensitive glycine receptors are functionally expressed in bullfrog cones, which may mediate signal feedback from glycinergic interplexiform cells to cones in the outer retina. |
34(0,1,1,4) | Details |
| 8899617 | Nabekura J, Omura T, Akaike N: Alpha 2 adrenoceptor potentiates glycine receptor-mediated response through protein kinase A in rat substantia nigra neurons. Eur J Neurosci. 2002 Jan;15(2):375-83. Both currents were antagonized by 10 (-6) M strychnine, thus indicating that acts on strychnine-sensitive glycine receptor on the SN neurons. 3. |
33(0,1,1,3) | Details |
| 18554813 | Cervetto C, Taccola G: GABAA and strychnine-sensitive glycine receptors modulate -evoked release from rat spinal motoneurons: a possible role in neuroprotection. J Neurophysiol. 2009 Mar;101(3):1211-21. Epub 2008 Dec 17. |
33(0,1,1,3) | Details |
| 12504915 | Maksay G, Biro T: Dual cooperative allosteric modulation of binding to ionotropic glycine receptors. J Neurophysiol. 1993 Jul;70(1):8-19. Glycine receptors (GlyRs) were studied via [(3) H] strychnine binding to synaptosomal membranes of rat spinal cord. |
32(0,1,1,2) | Details |
| 11740501 | Ahmadi S, Lippross S, Neuhuber WL, Zeilhofer HU: PGE (2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Neuroreport. 1997 Sep 29;8(14):3109-12. We identified the inhibitory (strychnine-sensitive) glycine receptor as a specific target of PGE (2). |
32(0,1,1,2) | Details |
| 9755023 | Khandwala H, Loomis CW: Milacemide, a pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. Brain Res Mol Brain Res. 1996 Jan;35(1-2):211-9. The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine (STR) produces reversible, segmentally localized allodynia in the rat. |
32(0,1,1,2) | Details |
| 9356383 | Sherman SE, Luo L, Dostrovsky JO: Altered receptive fields and sensory modalities of rat VPL thalamic neurons during spinal strychnine-induced allodynia. Brain Res. 2003 Mar 21;966(2):288-99. This condition may be modeled experimentally in animals by the intrathecal (i.t.) administration of strychnine, a glycine receptor antagonist. |
31(0,1,1,1) | Details |
| 17383967 | Vandenberg RJ, Shaddick K, Ju P: Molecular basis for substrate discrimination by transporters. Exp Brain Res. 2005 Mar;161(3):351-7. Epub 2004 Oct 14. is an inhibitory neurotransmitter in the spinal cord and brain stem, where it acts on strychnine-sensitive glycine receptors, and is also an excitatory neurotransmitter throughout the brain and spinal cord, where it acts on the family of receptors. |
31(0,1,1,1) | Details |
| 7725349 | Miller GW, Schnellmann RG: Inhibitors of renal transport do not block toxicant-induced influx in the proximal tubule. Anesthesiology. 2001 Jul;95(1):154-64. Further, we propose that toxicant-induced influx is mediated by a novel receptor related to the neuronal strychnine-sensitive glycine receptor and that influx is a key step in cell swelling and lysis. |
31(0,1,1,1) | Details |
| 7897498 | Araki I: Inhibitory postsynaptic currents and the effects of on visually identified sacral parasympathetic preganglionic neurons in neonatal rats. Med Hypotheses. 2008 Nov;71(5):668-81. Epub 2008 Aug 30. The IPSCs were substantially reduced by strychnine (1 microM), a glycine receptor antagonist. |
31(0,1,1,1) | Details |
| 9307100 | Sherman SE, Luo L, Dostrovsky JO: Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus. Eur J Pharmacol. 2009 Jul 1;614(1-3):44-9. Epub 2009 May 13. Experiments in both conscious and anesthetized animals indicate that intrathecal (i.t.) strychnine (STR; glycine receptor antagonist) produces acute, reversible allodynia, as evidenced by inappropriate behavioral and autonomic responses to cutaneous tactile stimuli. |
31(0,1,1,1) | Details |
| 15654288 | Molander A, Soderpalm B: Accumbal strychnine-sensitive glycine receptors: an access point for to the brain reward system. J Neurophysiol. 1997 Aug;78(2):628-37. |
12(0,0,2,2) | Details |
| 18593588 | Park EJ, Choi IS, Cho JH, Nakamura M, Lee JJ, Lee MG, Choi BJ, Moorhouse AJ, Jang IS: modulation of glycine receptors in acutely isolated rat CA3 neurons. . Can J Physiol Pharmacol. 1995 Dec;73(12):1698-705. These pharmacological properties strongly suggest that CA3 neurons express functional strychnine-sensitive glycine receptors containing alpha2 subunits. |
11(0,0,1,6) | Details |
| 8217939 | Zucker CL, Ehinger B: Synaptic connections involving immunoreactive glycine receptors in the turtle retina. EMBO J. 1994 Sep 15;13(18):4223-8. The distribution of glycine receptors in the turtle retina was studied with the aid of a monoclonal antibody that detects the 93-kD protein associated with the strychnine-sensitive glycine receptor. |
10(0,0,1,5) | Details |
| 10992010 | van Zundert B, Albarran FA, Aguayo LG: Effects of chronic treatment on (A) and glycine receptors in mouse glycinergic spinal neurons. J Pharmacol Exp Ther. 2000 Oct;295(1):423-9. Strychnine inhibited the current with smaller potency (29%) in treated neurons, thus the IC (50) increased from 14 +/- 2 nM in control to 18 +/- 6 nM in treated neurons. |
5(0,0,0,5) | Details |
| 14514876 | Cui J, Ma YP, Lipton SA, Pan ZH: Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells. Eur J Pharmacol. 1996 Dec 5;316(2-3):145-51. In the presence of GABAA and GABAC antagonists, strychnine-sensitive currents were evoked in RBCs in retinal slices by puffing kainate onto the inner plexiform layer. |
5(0,0,0,5) | Details |
| 8912198 | Blednov YA, Bleck V, Harris RA: Measurement of glycine receptor function by radioactive uptake. Mol Membr Biol. 2001 Jan-Mar;18(1):13-20. Strychnine inhibited the -stimulated uptake with an IC50 of 0.4 microM. |
5(0,0,0,5) | Details |
| 9279812 | Hussy N, Deleuze C, Pantaloni A, Desarmenien MG, Moos F: Agonist action of on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation. Neuroscience. 2005;131(3):745-58. To evaluate the implication of in the physiology of supraoptic neurones, we (i) investigated the agonist properties of on and GABAA receptors of supraoptic magnocellular neurones acutely dissociated from adult rats, using whole-cell voltage clamp, (ii) studied the effects of and strychnine in vivo by extracellular recordings of supraoptic neurones in anaesthetized rats, and (iii) measured the osmolarity-dependent release of endogenous from isolated supraoptic nuclei by HPLC. 2. |
5(0,0,0,5) | Details |
| 19225173 | Marchenko V, Rogers RF: GABAAergic and glycinergic inhibition in the phrenic nucleus organizes and couples fast oscillations in motor output. Pain. 1997 Sep;72(3):299-308. To test this, the phrenic nuclei (C (4)) of 14 unanesthetized, decerebrate adult male Sprague-Dawley rats were microinjected unilaterally with either 4 mM strychnine (n = 7) or GABAzine (n = 7) to block or (A) receptors, respectively. Power spectral analysis of inspiratory phrenic bursts showed that blockade of inhibition caused significant reduction in the relative power of MFO (A) and glycine receptors) and HFO (A) receptors only). |
2(0,0,0,2) | Details |
| 20152805 | Kubota H, Alle H, Betz H, Geiger JR: Presynaptic glycine receptors on hippocampal mossy fibers. J Neurosci. 1994 Mar;14(3 Pt 2):1701-9. In MFBs, focal puff-application of -evoked currents that were blocked by the GlyR antagonist strychnine. |
2(0,0,0,2) | Details |
| 17046753 | Zimmer MB, Goshgarian HG: not mediates inhibition of latent respiratory motor pathways after spinal cord injury. Eur J Pharmacol. 1993 Apr 15;245(2):183-5. The present study investigated whether spinal -A and/or glycine receptors are involved in the inhibition of the crossed phrenic pathways after a C2 spinal cord hemisection injury. -A receptor (bicuculline and Gabazine) and glycine receptor (strychnine) antagonists were applied directly to the cervical spinal cord (C3-C7), while bilateral phrenic nerve motor output was recorded. |
2(0,0,0,2) | Details |
| 15266648 | Yoshida M, Fukuda S, Tozuka Y, Miyamoto Y, Hisatsune T: Developmental shift in bidirectional functions of -sensitive channels during cortical circuit formation in postnatal mouse brain. table of contents. An antagonist blocking analysis also demonstrated a developmental shift in the receptor target of from glycine receptors to GABAA receptors. |
2(0,0,0,2) | Details |
| 11020764 | Cheng G, Kendig JJ: Enflurane directly depresses AMPA and currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. table of contents. Block of inhibitory A and glycine receptors by bicuculline (20 micrometer) or strychnine (2 micrometer) or both did not significantly reduce the effects of enflurane on -evoked currents. |
1(0,0,0,1) | Details |
| 10460241 | Chery N, de Koninck Y: Junctional versus extrajunctional and (A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord. J Physiol. 1999 Oct 1;520 Pt 1:293-302. To address this issue, miniature IPSCs (mIPSCs) mediated via (A) receptors (A) Rs) and glycine receptors (GlyRs) were recorded from identified laminae I-II neurons in adult rat spinal cord slices. |
1(0,0,0,1) | Details |
| 10200197 | Singer JH, Berger AJ: Contribution of single-channel properties to the time course and amplitude variance of quantal currents recorded in rat motoneurons. Anesth Analg. 2001 Jan;92(1):123-7. We wished to ascertain the contribution of glycine receptor (GlyR)-channel properties to this change in quantal amplitude and to the amplitude variability and time course of mIPSCs. |
1(0,0,0,1) | Details |
| 10082275 | Ren J, Ye JH, Liu PL, Krnjevic K, McArdle JJ: Cocaine decreases the -induced Cl- current of acutely dissociated rat hippocampal neurons. Toxicol Lett. 1995 Mar;76(2):179-84. Because the depression of I (GLY) was noncompetitive, cocaine may act on the glycine receptor- ionophore complex at a site distinct from that to which binds. The cocaine suppression of I (GLY) was unaffected by 1 microM tetrodotoxin and 1 microM strychnine. |
1(0,0,0,1) | Details |
| 7984680 | Wamsley JK, Sofia RD, Faull RL, Narang N, Ary T, Gan XD, McCabe RT: Felbamate: interaction with glycine receptors in human cerebral cortex. Anesth Analg. 2003 Jan;96(1):97-101 |
1(0,0,0,1) | Details |
| 11956334 | Zhang W, Barnbrock A, Gajic S, Pfeiffer A, Ritter B: Differential ontogeny of GABA (B)-receptor-mediated pre- and postsynaptic modulation of and transmission in respiratory rhythm-generating network in mouse. Neuroscience. 2008 Jul 17;154(4):1517-24. Epub 2008 May 3. The effect of CGP on respiratory frequency was diminished in the presence of bicuculline and strychnine in older but not in younger animals. |
0(0,0,0,0) | Details |
| 8705310 | Engblom AC, Eriksson KS, Akerman KE: and GABAA receptor-mediated fluxes in synaptoneurosomes from different parts of the rat brain. Brain Res. 2003 Jan 17;960(1-2):25-35. Strychnine-sensitive, inhibitory glycine receptors have not until lately been considered to play a significant role in neurotransmission in mammalian forebrain regions. |
0(0,0,0,0) | Details |
| 9652343 | Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, Watanabe H: A possible mechanism underlying corymine inhibition of -induced Cl- current in Xenopus oocytes. Urol Int. 2005;74(2):160-5. Co-application with strychnine, a competitive glycine receptor antagonist, or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), a Cl- channel blocker, corymine decreased the ED50 value of strychnine, but did not change that of DIDS. |
0(0,0,0,0) | Details |
| 12957225 | Matsumoto K, Nomura H, Murakami Y, Taki K, Takahata H, Watanabe H: Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain in GABAergic systems. J Neurochem. 1995 Mar;64(3):1026-33. Social isolation of mice for 7 weeks prior to the experiments caused a significant increase of seizure susceptibility to the (A) receptor antagonist picrotoxin but not to the glycine receptor antagonist strychnine or the glutamate receptor agonist kainic acid. |
0(0,0,0,0) | Details |
| 12208085 | St-John WM, Paton JF: Neurogenesis of gasping does not require inhibitory transmission using (A) or glycine receptors. J Physiol. 1995 Jan 1;482 ( Pt 1):29-38. Strychnine was used to block transmission by |
0(0,0,0,0) | Details |
| 9453458 | Darstein M, Loschmann PA, Knorle R, Feuerstein TJ: Strychnine-sensitive glycine receptors inducing [3H]- release in rat caudatoputamen: a new site of action of Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec;356(6):738-45. In the present study acute effects of on [3H]- ([3H]- release induced by activation of strychnine-sensitive glycine receptors in superfused slices of rat caudatoputamen were investigated. |
93(1,1,3,3) | Details |
| 8719405 | Popik P, Lewin A, Berrang B, Nowak G, Layer R, Skolnick P: [3H] 1-aminocyclopropanecarboxylic acid, a novel probe for strychnine- insensitive glycine receptors. J Neurosci. 1997 May 15;17(10):3392-400. [3H] 1-Aminocyclopropanecarboxylic acid (ACPC) exhibits high affinity, specific binding to strychnine-insensitive glycine receptors. |
93(1,1,3,3) | Details |
| 8096423 | Boje KM, Wong G, Skolnick P: Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures. J Physiol. 1995 Sep 1;487 ( Pt 2):395-405. These effects may represent homologous desensitization of the NMDA receptor complex at its strychnine-insensitive glycine receptor induced by prolonged exposure to glycinergic agonists and partial agonists. |
87(1,1,2,2) | Details |
| 8907320 | Currie SN, Lee S: Glycinergic inhibition in the turtle spinal cord regulates the intensity and pattern of fictive flexion reflex motor output. Neuroscience. 1998 May;84(2):519-28. Our observations are consistent with the hypothesis that intraspinal inhibition mediated by strychnine-sensitive glycine receptors regulates the amplitude of fictive flexion reflex motor output and confines the response to the appropriate neural pathways. |
81(1,1,1,1) | Details |
| 7981869 | Wang J, Reichling DB, Kyrozis A, MacDermott AB: Developmental loss of - and -induced depolarization and Ca2+ transients in embryonic rat dorsal horn neurons in culture. Hear Res. 2000 Feb;140(1-2):126-36. This [Ca2+] i response has previously been shown to be due to depolarization and subsequent Ca2+ entry through voltage-gated Ca2+ channels following activation of bicuculline-sensitive GABAA receptors and strychnine-sensitive glycine receptors. |
81(1,1,1,1) | Details |
| 19023642 | Hamasu K, Shigemi K, Tsuneyoshi Y, Yamane H, Sato H, Denbow DM, Furuse M: Intracerebroventricular injection of and D- induces sedative and hypnotic effects by different mechanisms under an acute stressful condition in chicks. Neuropharmacology. 2008 Oct;55(5):793-802. Epub 2008 Jun 21. To clarify the mechanism by which and D- induce sedative and hypnotic effects, the contribution of the strychnine-sensitive glycine receptor (glycine receptor) and glutamate receptor (NMDA receptor) were further investigated. |
63(0,2,2,3) | Details |
| 19085882 | Gimenez C, Zafra F, Lopez-Corcuera B, Aragon C: [Molecular bases of hereditary hyperekplexia] . Neuroscience. 2009 Apr 21;160(1):227-39. Epub 2009 Feb 13. This gene encodes the alpha subunit of the strychnine-sensitive glycine receptor, which plays a crucial role in inhibitory glycinergic neurotransmission that process sensory and motor information. |
62(0,2,2,2) | Details |
| 9144639 | Przegalinski E, Tatarczynska E, Deren-Wesolek A, Chojnacka-Wojcik E: Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist. Microsc Res Tech. 1998 May 1;41(3):263-9. |
62(0,2,2,2) | Details |
| 12505654 | Yu K, Ge SY, Ruan DY: Fe2+ decreases the -induced Cl- current in acutely dissociated rat hippocampal neurons. Cold Spring Harb Symp Quant Biol. 1996;61:333-42. Using standard pharmacological approaches, we found that the currents gated by concentrations of ( |
33(0,1,1,3) | Details |
| 16784797 | Fodor L, Boros A, Dezso P, Maksay G: Expression of heteromeric glycine receptor-channels in rat spinal cultures and inhibition by neuroactive steroids. Eur J Neurosci. 2000 Jun;12(6):1924-30. Glycine receptors of 3-17 days in vitro were characterized via subtype-specific channel blockade by micromolar picrotoxin and cyanotriphenylborate, as well as nanomolar strychnine. |
33(0,1,1,3) | Details |
| 9760138 | Li P, Yang XL: Strong synergism between (A) and glycine receptors on isolated carp third-order neurons. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jan;30(1):51-3. A strong synergistic interaction between the bicuculline-sensitive GABA receptor (A) receptor) and the strychnine-sensitive glycine receptor was observed in third-order neurons acutely isolated from crucian carp retina, with the use of the whole-cell patch-clamp recording technique. |
33(0,1,1,3) | Details |
| 7931499 | Yang L, Pollak GD: and have different effects on monaural response properties in the dorsal nucleus of the lateral lemniscus of the mustache bat. J Neurochem. 2009 Apr;109(1):275-86. Epub 2009 Feb 5. We studied the monaural response properties of 81 neurons in the dorsal nucleus of the lateral lemniscus (DNLL) of the mustache bat before and during the iontophoretic application of antagonists that blocked -A (GABAA) receptors (bicuculline) or glycine receptors (strychnine). |
31(0,1,1,1) | Details |
| 14622582 | Gomeza J, Hulsmann S, Ohno K, Eulenburg V, Szoke K, Richter D, Betz H: Inactivation of the transporter 1 gene discloses vital role of glial uptake in glycinergic inhibition. Neuron. 2003 Nov 13;40(4):785-96. In brainstem slices from GlyT1-deficient mice, in vitro respiratory activity is strikingly reduced but normalized by the glycine receptor (GlyR) antagonist strychnine. |
31(0,1,1,1) | Details |
| 17267752 | Janssen D, Derst C, Buckinx R, Van den Eynden J, Rigo JM, Van Kerkhove E: Dorsal unpaired median neurons of locusta migratoria express ivermectin- and fipronil-sensitive -gated channels. Mol Pain. 2006 Feb 17;2:8. Together with type A and strychnine-sensitive glycine receptors, -gated channels (GluCl) are members of the Cys-loop family of ionotropic receptors, which mediate fast inhibitory neurotransmission. |
31(0,1,1,1) | Details |
| 8997600 | Papp M, Moryl E, Maccecchini ML: Differential effects of agents acting at various sites of the NMDA receptor complex in a place preference conditioning model. Neuroscience. 2005;133(1):175-83. A conditioned place preference paradigm was used to assess the potential rewarding properties of the uncompetitive NMDA receptor antagonist, MK-801 (dizolcipine), the two competitive NMDA receptor antagonists, CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentonoic acid) and its (R)-enantiomer CGP 40116, as well as the partial agonist at strychnine-insensitive glycine receptors, ACPC (1-aminocyclopropanecarboxylic acid). |
31(0,1,1,1) | Details |
| 8982680 | Papp M, Moryl E: Antidepressant-like effects of 1-aminocyclopropanecarboxylic acid and D-cycloserine in an animal model of depression. Biochem Pharmacol. 2004 May 1;67(9):1789-99. Antidepressant activity of partial agonists at strychnine-insensitive glycine receptors, 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine, was studied in a chronic mild stress model of depression. |
31(0,1,1,1) | Details |
| 9466452 | Lin HH, Wu SY, Lai CC, Dun NJ: - and -mediated inhibitory postsynaptic potentials in neonatal rat rostral ventrolateral medulla neurons in vitro. Eur J Pharmacol. 1995 Feb 15;288(3):399-401. Inhibitory synaptic potentials were reversibly eliminated by the (A) receptor antagonist bicuculline (10-20 microM) in six of nine neurons, by the glycine receptor antagonist strychnine (0.1-1 microM) in two and by a combination of bicuculline and strychnine in one neuron. |
31(0,1,1,1) | Details |
| 7714570 | Wu SH, Kelly JB: Inhibition in the superior olivary complex: pharmacological evidence from mouse brain slice. J Pharmacol Exp Ther. 2002 Sep;302(3):1135-45. had a powerful blocking effect on extracellularly recorded action potentials evoked by current-pulse stimulation of the trapezoid body in seven LSO neurons tested after adding the glycine receptor antagonist, strychnine (1 microM), to the bath. |
31(0,1,1,1) | Details |
| 8968539 | Mascia MP, Machu TK, Harris RA: Enhancement of homomeric glycine receptor function by long-chain and anaesthetics. J Neurochem. 2007 Mar;100(5):1143-54. Epub 2007 Jan 8. The effects of n- to dodecanol) and anaesthetics on strychnine-sensitive glycine receptors were studied in Xenopus oocytes expressing homomeric alpha 1 or alpha 2 glycine receptor subunits, with the two electrode voltage-clamp recording technique. 2. |
10(0,0,1,5) | Details |
| 8032902 | Bohlhalter S, Mohler H, Fritschy JM: Inhibitory neurotransmission in rat spinal cord: co-localization of - and GABAA-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining. J Physiol. 1997 Aug 1;502 ( Pt 3):609-21. Most spinal cord neurons respond to both neurotransmitters, suggesting co-expression of GABAA- and strychnine-sensitive glycine-receptors in individual cells. |
10(0,0,1,5) | Details |
| 9522353 | Simpson RK Jr, Huang W: Glycine receptor reduction within segmental gray matter in a rat model in neuropathic pain. table of contents. Using a unilateral sciatic nerve constriction injury model of neuropathic pain, the strychnine sensitive glycine receptor population was studied using immunohistochemical techniques. |
9(0,0,1,4) | Details |
| 16125853 | Deleuze C, Runquist M, Orcel H, Rabie A, Dayanithi G, Alonso G, Hussy N: Structural difference between heteromeric somatic and homomeric axonal glycine receptors in the hypothalamo-neurohypophysial system. J Neurosci. 2005 Jul 13;25(28):6490-8. |
8(0,0,0,8) | Details |
| 16396929 | Balse E, Tessier LH, Forster V, Roux MJ, Sahel JA, Picaud S: Glycine receptors in a population of adult mammalian cones. J Neurophysiol. 1996 Feb;75(2):902-19. These -elicited currents were sensitive to strychnine but not to picrotoxin consistent with the expression of alpha-beta-heteromeric glycine receptors. |
5(0,0,0,5) | Details |
| 16168470 | Findlay GS, Harris RA, Blednov YA: Male transgenic glycine receptor alpha1 (S267Q) mutant mice display a hyperekplexia-like increase in acoustic startle responses. Pharmacol Biochem Behav. 2005 Sep;82(1):215-22. However, decreases in -stimulated strychnine-sensitive radioactive (36Cl-) uptake were not observed in spinal cord and brainstem synaptoneurosomes from transgenic mice. |
4(0,0,0,4) | Details |
| 8387072 | Ling L, Karius DR, Speck DF: Pontine-evoked inspiratory inhibitions after antagonism of GABAA, or glycine receptor. J Assoc Res Otolaryngol. 2003 Mar;4(1):60-73. Epub 2002 Aug 19. After systemic injection of MK-801, bicuculline, or strychnine (antagonists to GABAA, or glycine receptors, respectively), responses to stimulation were again recorded. |
4(0,0,0,4) | Details |
| 8137816 | Taleb O, Betz H: Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density. Br J Pharmacol. 1997 May;121(2):324-30. The low-affinity receptors were readily blocked by nM concentrations of the competitive antagonist strychnine, whereas the high-affinity receptors were more resistant to antagonism by this alkaloid. |
2(0,0,0,2) | Details |
| 17522628 | Zhang LH, Gong N, Fei D, Xu L, Xu TL: uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. J Pharmacol Exp Ther. 1994 Apr;269(1):95-102. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. |
2(0,0,0,2) | Details |
| 12183673 | Martin G, Siggins GR: Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens. Eur J Pharmacol. 1998 May 22;349(2-3):245-52. The current was not blocked by 200 microM picrotoxin and 10 microM zinc, was weakly antagonized by 1 microM strychnine, and was not enhanced by 1 microM zinc. |
2(0,0,0,2) | Details |
| 15081878 | Jensen AA, Kristiansen U: Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay. Brain Res. 2006 Dec 13;1125(1):46-59. Epub 2006 Nov 16. In the patch-clamp assay, the alpha1 GlyR exhibited the properties expected from a strychnine-sensitive -gated chloride channel. |
2(0,0,0,2) | Details |
| 11738262 | Tapia JC, Mentis GZ, Navarrete R, Nualart F, Figueroa E, Sanchez A, Aguayo LG: Early expression of and (A) receptors in developing spinal cord neurons. Neuroscience. 1998 Jan;82(2):429-42. Using fluorometric and immunocytochemical techniques, we found that high concentrations or blockade of glycine receptors increases neurite outgrowth in developing mouse spinal cord neurons. The use of various receptor antagonists (strychnine, bicuculline, DL-2-amino-5-phosphonovalerate [APV], 6-cyano-7-nitroquinoxaline-2,3-dione [CNQX]) revealed that this activity was predominantly glycinergic, and to a smaller extent, GABAergic. |
2(0,0,0,2) | Details |
| 19617896 | Wang HD, Lu XX, Lu DX, Qi RB, Wang YP, Fu YM, Wang LW: inhibits the LPS-induced increase in cytosolic Ca2+ concentration and TNFalpha production in cardiomyocytes by activating a glycine receptor. J Neurophysiol. 1998 Jul;80(1):71-82. GLY did not inhibit TNFalpha production induced by LPS at concentrations below 10 ng/mL but did significantly decrease TNFalpha release stimulated by 100 microg/mL LPS and prevented an LPS-induced increase in [Ca2+] c, which was reversed by strychnine, a glycine receptor antagonist. |
1(0,0,0,1) | Details |
| 9372227 | Karlsson U, Haage D, Johansson S: Currents evoked by and in acutely dissociated neurons from the rat medial preoptic nucleus. Anesth Analg. 2007 Aug;105(2):386-92. The currents evoked by were largely blocked by 1 microM strychnine. In conclusion, the present work demonstrates that neurons from the medial preoptic nucleus of rat directly respond to the inhibitory transmitters and with currents that can be attributed to GABAA receptors and glycine receptors respectively. |
1(0,0,0,1) | Details |
| 7774687 | Yadid G, Goldstein DS, Pacak K, Kopin IJ, Golomb E: Functional alpha 3-glycine receptors in rat . J Neurophysiol. 1999 Apr;81(4):1608-16. The adrenal medulla contains high-affinity strychnine binding sites, presumed to be receptors for |
1(0,0,0,1) | Details |
| 14570250 | Rotolo TC, Dacheux RF: Evidence for GABAA, and GABAB receptors on rabbit OFF-alpha ganglion cells. J Biol Chem. 2009 Dec 25;284(52):36128-36. Epub 2009 Oct 27. Inhibitory synaptic transmission via and glycine receptors plays a crucial role in shaping the excitatory response of neurons in the retina. The amplitudes of strychnine-sensitive -activated currents were always larger than the currents elicited by |
1(0,0,0,1) | Details |
| 8289185 | Kane JM, Staeger MA, Dalton CR, Miller FP, Dudley MW, Ogden AM, Kehne JH, Ketteler HJ, McCloskey TC, Senyah Y, et al.: 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. Alcohol Clin Exp Res. 2005 Jan;29(1):27-37. The anticonvulsant profiles of these 4H-1,2,4-triazoles suggested that they were acting functionally like glycine receptor agonists. |
1(0,0,0,1) | Details |
| 11698544 | Bourque MJ, Kolta A: Properties and interconnections of trigeminal interneurons of the lateral pontine reticular formation in the rat. Brain Res. 2006 May 23;1090(1):134-45. Epub 2006 Apr 21. All EPSPs induced by stimulation of PeriV, PCRt, or NVmt were sensitive to ionotropic glutamate receptor antagonists 6-cyano-7-dinitroquinoxaline and D,L-2-amino-5-phosphonovaleric acid, while IPSPs were blocked by bicuculline and strychnine, antagonists of (A) and glycine receptors. All EPSPs induced by stimulation of PeriV, PCRt, or NVmt were sensitive to ionotropic glutamate receptor antagonists 6-cyano-7-dinitroquinoxaline and D,L-2-amino-5-phosphonovaleric acid, while IPSPs were blocked by bicuculline and strychnine, antagonists of (A) and glycine receptors. |
1(0,0,0,1) | Details |
| 9636118 | Cleland TA, Selverston AI: Inhibitory glutamate receptor channels in cultured lobster stomatogastric neurons. Hear Res. 2000 Sep;147(1-2):125-36. Inhibitory glutamate receptor channels (IGluRs) are ligand-gated ionotropic receptors related to ionotropic and glycine receptors and expressed in neural and muscular tissues. The IGluR was weakly blocked by the chloride channel blocker and the excitatory glutamate receptor antagonist6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), but was not inhibited by bicuculline methiodide, strychnine, gamma--glutamylglycine, or |
1(0,0,0,1) | Details |
| 15243140 | Schilling T, Eder C: A novel physiological mechanism of -induced immunomodulation: Na+-coupled amino acid transporter currents in cultured brain macrophages. J Physiol. 1995 Apr 15;484 ( Pt 2):505-21. -evoked currents of brain macrophages were unaffected by strychnine, Cl (-)-free extracellular solution, N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl]) (NFPS) and amoxapine, but were abolished upon omission of extracellular Na (+). |
0(0,0,0,0) | Details |
| 18497354 | Petit-Jacques J, Bloomfield SA: Synaptic regulation of the light-dependent oscillatory currents in starburst amacrine cells of the mouse retina. J Neurophysiol. 2000 Aug;84(2):1006-11. Strychnine, the blocker of glycine receptors did not affect the initial peak but strongly decreased the oscillations frequency. |
0(0,0,0,0) | Details |
| 16781687 | Molchanova SM, Oja SS, Saransaari P: attenuates D-[3H] release evoked by depolarization in ischemic corticostriatal slices. J Biol Chem. 2007 Dec 7;282(49):36057-67. Epub 2007 Oct 2. The uptake inhibitor (5 mM), the glycine receptor antagonist strychnine (0.1 mM) and the (A) receptor antagonist bicuculline (0.1 mM) did not block the effect. |
0(0,0,0,0) | Details |
| 9236256 | Sandkuhler J, Chen JG, Cheng G, Randic M: Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat. Neuroscience. 2003;122(3):831-41. Bath application of the GABAA receptor antagonist bicuculline and glycine receptor antagonist strychnine did not affect LTD. |
0(0,0,0,0) | Details |
| 15224153 | He DF, Chen FJ, Zhou SC: mediaties the inhibitory effect of lateral amygdaloid nucleus stimulation on the acoustic response of neurons in A I cortex: An in vivo microiontophoretic study. Neuropharmacology. 2002 Dec;43(7):1087-98. In contrast, application of strychnine, a glycine receptor antagonist, could not reverse the inhibitory effect of LA. |
0(0,0,0,0) | Details |
| 17173871 | Molchanova SM, Oja SS, Saransaari P: Inhibitory effect of on veratridine-evoked D-[3H] release from murine corticostriatal slices: involvement of channels and mitochondria. J Neurophysiol. 2004 Sep;92(3):1658-67. Epub 2004 May 12. The glycine receptor antagonist strychnine and the (A) receptor antagonist bicuculline did not block the effect, although picrotoxin, a less specific blocker of agonist-gated channels, completely prevented the effect of on veratridine-induced D-[3H] release. |
0(0,0,0,0) | Details |
| 11274795 | Imboden M, De Saint Jan D, Leulier F, Korn H, Goblet C, Bregestovski P: Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit. J Neurol Sci. 1996 Aug;139 Suppl:76-82. These homomeric channels were activated by and with apparent affinities similar to those reported for zebrafish alphaZ1 glycine receptor, and were also effectively antagonized by nanomolar concentrations of strychnine. |
87(1,1,1,7) | Details |
| 9551830 | Shefchyk SJ, Espey MJ, Carr P, Nance D, Sawchuk M, Buss R: Evidence for a strychnine-sensitive mechanism and glycine receptors involved in the control of urethral sphincter activity during micturition in the cat. Pain. 2004 Nov;112(1-2):156-63. |
87(1,1,2,2) | Details |
| 9432062 | Krenning J, Hughes LF, Caspary DM, Helfert RH: Age-related glycine receptor subunit changes in the cochlear nucleus of Fischer-344 rats. Anesthesiology. 2009 Feb;110(2):326-32. Previous studies have shown that levels of binding for the strychnine-sensitive glycine receptor in the cochlear nucleus (CN) of Fischer (F344) rats decrease with age. |
85(1,1,1,5) | Details |
| 19369365 | Kutscher A, Covey E: Functional role of GABAergic and glycinergic inhibition in the intermediate nucleus of the lateral lemniscus of the big brown bat. Neuroscience. 2005;135(2):475-83. To address the question of what role inhibitory synaptic inputs play in the INLL of the big brown bat (Eptesicus fuscus), we recorded sound-evoked responses of single neurons and iontophoretically applied bicuculline to block (A) receptors or strychnine to block glycine receptors. |
81(1,1,1,1) | Details |
| 20117983 | Cheng J, Wu M, Wu ZH: [Effects of on the discharge activities of the inspiratory neurons in neonatal rat medulla oblongata slices.]. Brain Res. 1997 Sep 26;769(2):203-10. The effect of on the rhythmical respiration was investigated by administration of glycine receptor agonist and its specific antagonist strychnine (STR) into a modified Kreb's perfusion solution (MKS). |
81(1,1,1,1) | Details |
| 8713181 | Chiba C, Saito T: Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina. Mol Cell Neurosci. 2001 Feb;17(2):354-63. Bicuculline and strychnine strongly suppressed the responses to and respectively, suggesting the existence of GABAA receptors and conventional glycine receptors in the spiking cells. |
81(1,1,1,1) | Details |
| 12651653 | Koshizaki M, Kawamata M, Shimada SG, Saito Y, Collins JG: 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Brain Res. 1993 Feb 19;603(2):207-14. We recently reported that type A- and strychnine-sensitive glycine receptor systems partially mediate halothane depression of spinal dorsal horn low-threshold neurons. |
62(0,2,2,2) | Details |
| 17913992 | Zhang HX, Thio LL: enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. J Neurophysiol. 2003 Jul;90(1):89-99. Epub 2003 Mar 26. |
62(0,2,2,2) | Details |
| 9084588 | Kremer E, Lev-Tov A: Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J Physiol. 1993 Nov;471:729-48. Bath application of the glycine receptor antagonist strychnine, or the -A (GABAA) receptor blocker bicuculline, induced in the presence of and a bilaterally synchronous rhythm in any intact or detached segment of the cord and in midsagittally split preparations with few bilaterally intact upper thoracic or lower sacral segments. |
62(0,2,2,2) | Details |
| 15494196 | Cronin JN, Bradbury EJ, Lidierth M: Laminar distribution of GABAA- and glycine-receptor mediated tonic inhibition in the dorsal horn of the rat lumbar spinal cord: effects of picrotoxin and strychnine on expression of Fos-like immunoreactivity. J Neurosci. 2001 May 1;21(9):2974-82. |
33(0,1,1,3) | Details |
| 12960774 | Meier J, Schmieden V: Inhibition of alpha-subunit glycine receptors by quinoxalines. J Neurosci. 1999 Sep 1;19(17):7434-49. Quinoxalines are widely used compounds in electrophysiological studies to separate excitatory and inhibitory neurotransmission mediated by the strychnine-insensitive and strychnine-sensitive glycine receptor GlyR), respectively. |
33(0,1,1,3) | Details |
| 17981090 | Salih MA, Mustafa AA: A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice. Evid Based Complement Alternat Med. 2009 Jul 23. Various doses of strychnine and picrotoxin were used to explore the effect of VF extract on strychnine-sensitive glycine receptors and (A) receptors. |
33(0,1,1,3) | Details |
| 15224160 | Li Z, Luo C, Sun YY, Chen J: [Effects of etomidate on local synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord]. Eur J Pharmacol. 2007 Mar 8;558(1-3):37-42. Epub 2006 Dec 12. Under this condition extracellular superfusion was made with 1 micromol/L TTX and 1 micromol/L strychnine, an antagonist of glycine receptor, for 2 min, and then with consistent application of 50 micromol/L ET, 1 micromol/L TTX and 1 micromol/L strychnine for 1 min. |
31(0,1,1,1) | Details |
| 9294970 | Lanza M, Bonnafous C, Colombo S, Revel L, Makovec F: Characterization of a novel putative cognition enhancer mediating facilitation of effect on strychnine-resistant sites coupled to NMDA receptor complex. Kidney Int. 1996 Feb;49(2):449-60. The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl) amino]-5-oxo- ((S) CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on -evoked release of [3H] from rat hippocampal slices. (S) CR 2249 facilitated -mediated reversion of antagonism at strychnine-insensitive glycine receptors coupled to the NMDA receptor. |
31(0,1,1,1) | Details |
| 9313270 | Khandwala H, Hodge E, Loomis CW: Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat. Sheng Li Xue Bao. 2004 Jun 25;56(3):413-8. The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. |
31(0,1,1,1) | Details |
| 11516560 | Nakayama K, Nishimaru H, Kudo N: Developmental changes in -induced rhythmic activity in the spinal cord of rat fetuses in vitro. J Biol Chem. 2001 Aug 10;276(32):29657-63. Epub 2001 Jun 6. Bath application of strychnine (5 microM), a glycine-receptor antagonist, reduced the frequency of the rhythmic activity to 37% of control at E14.5. |
31(0,1,1,1) | Details |
| 8032669 | Loscher W, Wlaz P, Rundfeldt C, Baran H, Honack D: Anticonvulsant effects of the /NMDA receptor ligands D-cycloserine and but not R-(+)-HA-966 in amygdala-kindled rats. Vis Neurosci. 2005 Nov-Dec;22(6):825-38. Pharmacological intervention at the strychnine-insensitive glycine receptor by high-efficacy partial agonists with systemic bioavailability may be an effective means of increasing seizure-threshold without concomitantly inducing PCP-like adverse effects. |
31(0,1,1,1) | Details |
| 10360746 | Cordi A, Lacoste JM, Audinot V, Millan M: Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Neurosci Lett. 1994 Oct 24;180(2):285-9. |
31(0,1,1,1) | Details |
| 19782664 | Yin H, Lee KE, Park SA, Bhattarai JP, Suh BJ, Jeon JG, Kim BG, Park SJ, Han SK: Inhibitory effects of somatostatin on the substantia gelatinosa neurons of trigeminal subnucleus caudalis via somatostatin type 2 receptors in juvenile mice. Pharmacol Biochem Behav. 1996 May;54(1):73-7. The SST-induced hyperpolarizing response was maintained in the presence of TTX (Na (+) channel blocker), AP-5 (NMDA receptor antagonist), CNQX (non- glutamate receptor antagonist), picrotoxin (A) receptor antagonist) and strychnine (glycine receptor antagonist), respectively, suggesting that SST has direct effects on the postsynaptic SG neurons. |
31(0,1,1,1) | Details |
| 9665886 | Jonas P, Bischofberger J, Sandkuhler J: Corelease of two fast neurotransmitters at a central synapse. . J Med Chem. 1994 Jan 7;37(1):125-32. Unitary inhibitory postsynaptic currents generated at interneuron-motoneuron synapses consisted of a strychnine-sensitive, glycine receptor-mediated component and a bicuculline-sensitive, A receptor-mediated component. |
31(0,1,1,1) | Details |
| 7905831 | Paul IA, Layer RT, Skolnick P, Nowak G: Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or Brain Res. 2003 Jun 6;974(1-2):243-8. These changes were manifested as: (1) a reduction in the potency of to inhibit the binding of 5,7-dichloro [3H] to strychnine-insensitive glycine receptors; and (2) a reduction in the proportion of high affinity, -displaceable [3H] CGP-39653 binding to NMDA receptors. |
31(0,1,1,1) | Details |
| 8255354 | Yadid G, Maor G, Youdim MB, Silberman M, Zinder O: Autoradiographic localization of strychnine-sensitive glycine receptor in bovine adrenal medulla. Neuroreport. 1994 Mar 21;5(7):777-80. |
8(0,0,1,3) | Details |
| 10414351 | Betz H, Kuhse J, Schmieden V, Laube B, Kirsch J, Harvey RJ: Structure and functions of inhibitory and excitatory glycine receptors. . Vis Neurosci. 1999 Mar-Apr;16(2):205-19. The strychnine-sensitive glycine receptor (GlyR) is a pentameric chloride channel protein that exists in several developmentally and regionally regulated isoforms in the CNS. |
8(0,0,1,3) | Details |
| 19860809 | Chau P, Hoifodt-Lido H, Lof E, Soderpalm B, Ericson M: Glycine receptors in the nucleus accumbens involved in the intake-reducing effect of acamprosate. Anesth Analg. 2008 Dec;107(6):1875-83. BACKGROUND: We have previously demonstrated that strychnine-sensitive glycine receptors (GlyRs) in the nucleus accumbens (nAc) and nicotinic acetylcholine receptors (nAChRs) in the ventral tegmental area are involved in mediating (EtOH)-induced elevation of in the rat mesolimbic system. |
7(0,0,1,2) | Details |
| 7689044 | Siebler M, Pekel M, Koller H, Muller HW: Strychnine-sensitive glycine receptors in cultured primary neurons from rat neocortex. J Neurophysiol. 2003 Nov;90(5):3490-500. Epub 2003 Jul 16. |
7(0,0,1,2) | Details |
| 8762070 | Downie DL, Hall AC, Lieb WR, Franks NP: Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes. Eur J Pharmacol. 2005 Oct 3;521(1-3):39-42. Epub 2005 Sep 21. Bath application of gave strychnine-sensitive currents which reversed close to the expected equilibrium potentials for ions. |
4(0,0,0,4) | Details |
| 14614909 | Devignot V, Prado de Carvalho L, Bregestovski P, Goblet C: A novel glycine receptor alpha Z1 subunit variant in the zebrafish brain. . Toxicol Sci. 2006 Jul;92(1):270-8. Epub 2006 Apr 12. Heterologous expression of homomeric GlyRalphaZ1L in human embryonic kidney-293 cells generates -gated strychnine-sensitive channels with no obvious discrepancy with pharmacological properties of GlyRalphaZ1. |
4(0,0,0,4) | Details |
| 15046720 | Young TL, Cepko CL: A role for ligand-gated ion channels in rod photoreceptor development. Mol Pharmacol. 2004 Feb;65(2):453-60. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and (A) receptors plays a role in photoreceptor development in the vertebrate retina. potentiates the production of rod photoreceptors, and this induction is inhibited by strychnine, an antagonist of glycine receptors, and bicuculline, an antagonist of GABA receptors. |
2(0,0,0,2) | Details |
| 19528247 | Morkve SH, Hartveit E: Properties of glycine receptors underlying synaptic currents in presynaptic axon terminals of rod bipolar cells in the rat retina. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2781-5. Epub 2001 Feb 13. Glycinergic IPSCs, recorded in both intact cells and isolated terminals, were strychnine sensitive and displayed fast kinetics with a double-exponential decay. |
2(0,0,0,2) | Details |
| 9565032 | Kirsch J, Betz H: Glycine-receptor activation is required for receptor clustering in spinal neurons. Neuropharmacology. 2005 Sep;49(3):338-49. Here we show that the competitive GlyR antagonist strychnine and L-type Ca2+-channel blockers inhibit the accumulation of GlyR and gephyrin at postsynaptic membrane areas in cultured rat spinal neurons. |
2(0,0,0,2) | Details |
| 9744942 | Tian N, Hwang TN, Copenhagen DR: Analysis of excitatory and inhibitory spontaneous synaptic activity in mouse retinal ganglion cells. Eur J Pharmacol. 1995 Sep 15;284(1-2):109-18. Both GABAA and glycine receptor-mediated sIPSCs had rise times (10-90%) of < 1 ms. |
2(0,0,0,2) | Details |
| 14568560 | Kondratskaya EL, Pankratov YV, Lalo UV, Chatterjee SS, Krishtal OA: Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13421-6. The effect of ginkgolide B on LTP did not alter considerably if GlyRs were blocked by strychnine (2 microM). |
2(0,0,0,2) | Details |
| 11860460 | Pierobon P, Minei R, Porcu P, Sogliano C, Tino A, Marino G, Biggio G, Concas A: Putative glycine receptors in Hydra: a biochemical and behavioural study. Neurochem Int. 2004 Feb;44(3):171-7. Here we report the identification and characterization of glycine receptors in the freshwater polyp Hydra vulgaris (Cnidaria, Hydrozoa) by biochemical and behavioural studies. Saturation experiments revealed the occurrence of one population of binding sites of nanomolar affinity (KD = 33 nm) and low capacity (Bmax = 79 fmol/mg protein) for [(3) H] strychnine. |
2(0,0,0,2) | Details |
| 17196941 | Yan L, Suneja SK, Potashner SJ: Protein kinases regulate glycine receptor binding in brain stem auditory nuclei after unilateral cochlear ablation. Neurosci Lett. 1999 Apr 16;265(2):83-6. We found previously that unilateral cochlear ablation (UCA) in young adult guinea pigs decreased [3H] strychnine binding activity in several brain stem auditory nuclei. |
2(0,0,0,2) | Details |
| 8120831 | Krupp J, Feltz P: Synaptic- and agonist-induced currents in neonatal rat sympathetic preganglionic neurones in vitro. Anesthesiology. 1999 Jan;90(1):165-73. These results suggest that the inhibitory synaptic activity recorded from SPNs in thin, transverse slices of neonatal rat spinal cord is mediated by glycine receptor-gated Cl- channels. It reversed at the equilibrium potential (ECl) and could be reversibly blocked by strychnine (1-10 microM), but not by bicuculline (10 microM) or SR95531 (5-10 microM). 4. |
1(0,0,0,1) | Details |
| 10938255 | Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ: Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs. J Neurophysiol. 1997 Mar;77(3):1155-70. The silent expiratory phase is produced by phasic inhibition of the tonic activity, and approximately 80% of this inhibition is mediated by gamma-aminobutyric acid receptors (A)) and approximately 20% by glycine receptors. |
1(0,0,0,1) | Details |
| 16420443 | Ivanova E, Muller U, Wassle H: Characterization of the glycinergic input to bipolar cells of the mouse retina. Am J Physiol Regul Integr Comp Physiol. 2000 Aug;279(2):R639-49. Here we evaluated the functional properties and subunit composition of glycine receptors (GlyRs) in bipolar cells. |
1(0,0,0,1) | Details |
| 8714526 | Aprison MH, Galvez-Ruano E, Robertson DH, Lipkowitz KB: and GABA receptors: molecular mechanisms controlling ion flux. Neuroreport. 1994 Jan 12;5(4):489-92. In addition, amino acids also involved in stabilizing the interaction between the antagonists strychnine and R5135 at the glycinergic and gabanergic receptors, respectively, have been shown to fit our complex model. We also present two computer-generated color prints, one for the glycine receptor and one for the GABA receptor, which show the quantum mechanically geometry optimized complex formed between receptor side chains, i.e., the part of the amino acids in the polypeptide that interacts with the zwitterionic inhibitory neurotransmitters. |
1(0,0,0,1) | Details |
| 9027402 | Virginio C, Cherubini E: -activated whole cell and single channel currents in rat cerebellar granule cells in culture. J Neurobiol. 1996 Dec;31(4):503-11. current density change drastically during days in culture, the maximal expression being between day 4 and 7, suggesting that the expression of glycine receptor channels is developmentally regulated. The responses to were antagonized by strychnine and picrotoxin with an IC50 of 58 nM and 172 microM, respectively. |
1(0,0,0,1) | Details |
| 11082440 | Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM: Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the (A) receptor. Brain Res. 2000 Apr 17;862(1-2):74-82. Although avermectins weakly inhibited [(3) H] strychnine binding in rat spinal cord, and inhibited responses on primary cultured cortical neurons, activity at glycine receptors did not correlate with either anticonvulsant activity or toxicity. |
0(0,0,0,0) | Details |
| 14551290 | Cheng JK, Chou RC, Hwang LL, Chiou LC: Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. Neurochem Int. 2008 Jan;52(1-2):235-40. Epub 2007 Jun 21. The effects of orexin A and B were abolished by their respective antibodies, but not by naloxone, and were attenuated by suramin and strychnine, the P2X purinergic and glycine receptor antagonists, respectively. |
0(0,0,0,0) | Details |
| 15140905 | Bieda MC, MacIver MB: Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability. Eur J Neurosci. 1998 Nov;10(11):3556-64. Propofol-induced depression of intrinsic excitability was completely reversed by bicuculline and picrotoxin but was strychnine-insensitive, implicating (A) but not glycine receptors. |
0(0,0,0,0) | Details |
| 17537680 | Li DP, Yang Q: Membrane and synaptic properties of nucleus tractus solitarius neurons projecting to the caudal ventrolateral medulla. Br J Pharmacol. 2004 Sep;143(1):19-26. Epub 2004 Aug 9. While the glycine receptor antagonist strychnine had no effect on the firing activity, blockade of (A) receptors with bicuculline significantly increased the firing rate in the majority of labeled NTS neurons. |
0(0,0,0,0) | Details |
| 9829177 | Rodriguez-Contreras A, Calderon F, Lopez-Colome AM: Strychnine-insensitive [3H] binding to synaptosomal membranes from the chick retina. J Med Chem. 2004 Dec 2;47(25):6384-91. |
0(0,0,0,0) | Details |
| 10430508 | Li P, Yang XL: Zn2+ differentially modulates glycine receptors versus GABA receptors in isolated carp retinal third-order neurons. J Physiol. 1998 Feb 15;507 ( Pt 1):25-40. It was previously reported that strychnine-sensitive glycine receptors and GABAA receptors co-existed on carp retinal third-order neurons (amacrine/ganglion cells) (Li, P. and Yang, X.-L., Strong synergism between GABAA and glycine receptors on isolated carp third-order neurons. |
84(1,1,1,4) | Details |
| 14563849 | Chen Z, Dillon GH, Huang R: Molecular determinants of modulation of glycine receptors. . Mol Cell Neurosci. 2002 Oct;21(2):324-40. The effect was voltage-independent and pharmacologically competed with glycine receptor agonist and antagonist strychnine. |
84(1,1,1,4) | Details |
| 7686901 | Reddy GL, Iwamoto T, Tomich JM, Montal M: Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. Biochem Pharmacol. 1995 Mar 1;49(5):687-92. A synthetic 23-mer peptide (M2GlyR) with the amino acid sequence of the putative transmembrane segment M2 of the strychnine-binding alpha subunit of the inhibitory glycine receptor forms anion-selective channels in phospholipid bilayers. |
84(1,1,1,4) | Details |
| 14581726 | Swiader M, Gasior M, Wielosz M, Czuczwar SJ: Influence of some convulsant agents on the protective activity of a novel antiepileptic drug, felbamate, against maximal electroshock in mice. J Neurobiol. 1997 Jun 5;32(6):579-92. It may be concluded that GABAergic inhibition and strychnine-insensitive glycine receptor-mediated events may contribute to the anticonvulsant activity of felbamate. |
81(1,1,1,1) | Details |
| 8939452 | O'Connor V, Phelan PP, Fry JP: Interactions of and strychnine with their receptor recognition sites in mouse spinal cord. Behav Brain Res. 2007 Mar 12;178(1):70-81. Epub 2007 Jan 17. The reagent caused an increase in total and strychnine-specific [3H]-strychnine binding (which we have shown elsewhere to be at a site unrelated to the inhibitory glycine receptor). |
81(1,1,1,1) | Details |
| 10097172 | Garcia-Colunga J, Miledi R: Modulation of nicotinic acetylcholine receptors by strychnine. . J Pharmacol Exp Ther. 2003 Dec;307(3):1065-71. Epub 2003 Oct 9. Strychnine, a potent and selective antagonist at glycine receptors, was found to inhibit muscle (alpha1beta1gammadelta, alpha1beta1gamma, and alpha1beta1delta) and neuronal (alpha2beta2 and alpha2beta4) nicotinic acetylcholine receptors (AcChoRs) expressed in Xenopus oocytes. |
81(1,1,1,1) | Details |
| 8728541 | Przegalinski E, Tatarczynska E, Deren-Wesolek A, Chojnacka-Wojcik E: Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors. Vis Neurosci. 2003 May-Jun;20(3):285-96. |
62(0,2,2,2) | Details |
| 8590073 | Velisek L, Roztocilova L, Kusa R, Mares P: Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. J Androl. 2000 Jan-Feb;21(1):99-106. In these experiments, we tested the anticonvulsant activity of strychnine-insensitive glycine receptor (at the site) antagonist and nonspecific excitatory amino acid receptor antagonist glutamic acid diethylester (GDEE) in the pentylenetetrazol-induced seizure model in developing rats 7, 12, 18, 25, and 90 days old. |
62(0,2,2,2) | Details |
| 12560122 | McCool BA, Frye GD, Pulido MD, Botting SK: Effects of chronic consumption on rat (A) and strychnine-sensitive glycine receptors expressed by lateral/basolateral amygdala neurons. Neuropharmacology. 2009 Sep;57(3):242-9. Epub 2009 Jun 11. Chronic exposure increased the functional expression of (A) receptors in acutely isolated basolateral amygdala neurons without altering strychnine-sensitive glycine receptors. |
50(0,1,4,5) | Details |
| 7860652 | Warner DS, Martin H, Ludwig P, McAllister A, Keana JF, Weber E: In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor site antagonists. Neuroscience. 2001;108(3):493-506. We conclude that pharmacologic antagonism of at the strychnine-insensitive glycine receptor presents a neuroprotective profile similar to that previously observed for antagonists of at the complex with a potential for fewer side effects. |
33(0,1,1,3) | Details |
| 7498252 | Kretschmer BD, Bubser M, Schmidt WJ: Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Brain Res. 1993 Nov 19;628(1-2):263-70. |
33(0,1,1,3) | Details |
| 7752562 | Akagi H, Majima T, Uchiyama M: Function and modulation of the cloned glycine receptor channels expressed in Xenopus oocytes. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8345-50. Epub 2005 May 31. Homomeric glycine receptor channels consisting of alpha 1 or alpha 2 subunit expressed in Xenopus oocytes had an ability to generate Cl- currents, and the currents were suppressed by strychnine, a selective antagonist. |
33(0,1,1,3) | Details |
| 12598250 | Sonner JM, Zhang Y, Stabernack C, Abaigar W, Xing Y, Laster MJ: (A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner. Anesth Analg. 2003 Mar;96(3):706-12 The ED (50) for propofol was also antagonized by strychnine, a non-GABAergic glycine receptor antagonist and convulsant, to determine whether excitation of the central nervous system by a non-GABAergic mechanism could account for the increases in propofol ED (50) observed. |
31(0,1,1,1) | Details |
| 11067975 | Nunez-Abades PA, Pattillo JM, Hodgson TM, Cameron WE: Role of synaptic inputs in determining input resistance of developing brain stem motoneurons. Transplantation. 1996 Dec 15;62(11):1549-58. Spontaneous postsynaptic potentials were sensitive to the combined application of glycine receptor antagonist, strychnine, and the (A) receptor antagonist, bicuculline. |
31(0,1,1,1) | Details |
| 8126564 | Grothe B, Sanes DH: Synaptic inhibition influences the temporal coding properties of medial superior olivary neurons: an in vitro study. J Neurophysiol. 2000 Nov;84(5):2317-29. The glycine receptor antagonist strychnine influenced the response to simulated interaural time differences. |
31(0,1,1,1) | Details |
| 16806306 | Carta M, Murru L, Botta P, Talani G, Sechi G, De Riu P, Sanna E, Biggio G: The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system. J Neurophysiol. 1993 Oct;70(4):1326-38. Thiocolchicoside (TCC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with type A receptors (GABAARs) and strychnine-sensitive glycine receptors in the rat central nervous system. |
31(0,1,1,1) | Details |
| 7635092 | Guillet R, Dunham L: Neonatal exposure and seizure susceptibility in adult rats. Pflugers Arch. 2001 Jan;441(4):444-9. At age 70-90 days, each rat was infused intravenously (i.v.) with picrotoxin (PIC), bicuculline (BIC) [convulsants acting at the /benzodiazepine (GABA/BDZ) receptor], pentylenetetrazol [PTZ, possibly acting at both /BDZ and (NMDA) receptors], (acting at receptors), strychnine (STR, acting at glycine receptors), or kainic acid (KA, acting at the NMDA receptor). |
31(0,1,1,1) | Details |
| 10587285 | File SE, Fluck E, Fernandes C: Beneficial effects of (bioglycin) on memory and attention in young and middle-aged adults. J Neurophysiol. 2001 Nov;86(5):2583-96. This complex can be manipulated in a number of ways, one of which is through the strychnine-insensitive glycine receptor coagonist site. |
31(0,1,1,1) | Details |
| 8951107 | Sanes DH, Hafidi A: Glycinergic transmission regulates dendrite size in organotypic culture. J Neurophysiol. 1994 Jul;72(1):169-79. Cultures were generated at 6-7 days postnatal and grown in serum containing medium with or without the glycine receptor antagonist, strychnine (SN), at 2 microM. |
31(0,1,1,1) | Details |
| 10962179 | Potashner SJ, Suneja SK, Benson CG: Altered glycinergic synaptic activities in guinea pig brain stem auditory nuclei after unilateral cochlear ablation. J Neurosci Res. 1996 Feb 1;43(3):372-81. The specific binding of [(3) H] strychnine was quantified to measure synaptic glycine receptor activity and/or expression. |
31(0,1,1,1) | Details |
| 10327174 | D'Hooge R, De Deyn PP, Van de Vijver G, Antoons G, Raes A, Van Bogaert PP: Uraemic guanidino compounds inhibit -evoked whole cell currents in mouse spinal cord neurones. Eur J Neurosci. 2001 Nov;14(10):1659-66. however, evoked inward whole-cell currents, which were almost completely blocked by strychnine, indicating that the -evoked current might have been due to glycine receptor activation. |
31(0,1,1,1) | Details |
| 17921866 | Zhang M, Cao LH, Yang XL: modulates currents of retinal ganglion cells in rat. Eur J Neurosci. 2006 Jan;23(2):350-64. By using patch clamp techniques, we demonstrate for the first time that -induced currents from a population of isolated ganglion cells in the rat retina are potentiated by of nanomolar concentrations by increasing the efficacy and the channel conductance of the strychnine-sensitive glycine receptor. |
7(0,0,1,2) | Details |
| 9145798 | Kling C, Koch M, Saul B, Becker CM: The frameshift mutation oscillator (Glra1 (spd-ot)) produces a complete loss of glycine receptor alpha1-polypeptide in mouse central nervous system. Biochemistry. 1994 Jun 21;33(24):7718-30. Symptoms of this disorder mimic poisoning by strychnine, the antagonist of the inhibitory glycine receptor. |
7(0,0,0,7) | Details |
| 19020133 | Ahrens J, Leuwer M, Stachura S, Krampfl K, Belelli D, Lambert JJ, Haeseler G: A transmembrane residue influences the interaction of propofol with the strychnine-sensitive alpha1 and alpha1beta receptor. J Physiol. 2007 May 15;581(Pt 1):203-19. Epub 2007 Mar 1. BACKGROUND: Propofol, well known for its anesthetic effects, acts as a positive allosteric modulator of the type A (A)) receptor but also enhances the function of the glycine receptor. |
4(0,0,0,4) | Details |
| 8793743 | Harty TP, Manis PB: -evoked currents in acutely dissociated neurons of the guinea pig ventral cochlear nucleus. Neurosci Lett. 2007 Jan 10;411(2):92-7. Epub 2006 Nov 15. The glycine receptors are therefore principally permeable to 6. The antagonist strychnine was added to the extracellular solution at concentrations of 0.5-500 nM to evaluate its effect on -evoked responses. |
4(0,0,0,4) | Details |
| 12885784 | Li Y, Wu LJ, Legendre P, Xu TL: Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. J Cell Sci. 1998 Feb;111 ( Pt 3):335-45. |
4(0,0,0,4) | Details |
| 16631121 | Zhang LH, Xu L, Xu TL: Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats. Eur J Neurosci. 2001 Oct;14(7):1082-90. Moreover, application increased the paired-pulse ratio (PPR) of PSCs significantly, an effect largely abolished by the GlyR specific antagonist strychnine. |
2(0,0,0,2) | Details |
| 9927632 | Moorhouse AJ, Jacques P, Barry PH, Schofield PR: The startle disease mutation Q266H, in the second transmembrane domain of the human glycine receptor, impairs channel gating. Anesth Analg. 2003 Apr;96(4):1027-31 This was not accompanied by similar changes in agonist displacement of strychnine binding, suggesting that the mutation affects functions subsequent to ligand binding. |
2(0,0,0,2) | Details |
| 11278873 | Shan Q, Haddrill JL, Lynch JW: Ivermectin, an unconventional agonist of the glycine receptor chloride channel. Anesthesiology. 2000 Oct;93(4):1075-84. Relative to -gated currents, ivermectin-gated currents exhibited a dramatically reduced sensitivity to inhibition by strychnine, picrotoxin, and zinc. |
2(0,0,0,2) | Details |
| 15654289 | Molander A, Lof E, Stomberg R, Ericson M, Soderpalm B: Involvement of accumbal glycine receptors in the regulation of voluntary intake in the rat. Br J Pharmacol. 1994 Oct;113(2):471-8. Here this hypothesis was further challenged by examining the influence of bilateral accumbal application of (a GlyR agonist), strychnine (a GlyR competitive antagonist), or Ringer on EtOH intake and preference, as well as on the concomitant DA output in the nAc, in EtOH high-preferring male Wistar rats. |
2(0,0,0,2) | Details |
| 7826634 | Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR: Mutation of an residue in the human glycine receptor transforms and from agonists into competitive antagonists. Hear Res. 1999 Dec;138(1-2):106-14. |
2(0,0,0,2) | Details |
| 12154171 | Mangin JM, Guyon A, Eugene D, Paupardin-Tritsch D, Legendre P: Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra. Tissue Cell. 1998 Apr;30(2):236-50. The application of 1 microM gabazine blocked spontaneous or evoked inhibitory synaptic current, while the addition of 1 microM strychnine had no effect, suggesting a lack of functional glycinergic synapses on DA neurones. |
2(0,0,0,2) | Details |
| 12401451 | Meier J, Juttner R, Kirischuk S, Grantyn R: Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity. Neurosci Lett. 2007 Feb 8;413(1):16-20. Epub 2006 Dec 4. Two distinct stages of inhibitory synaptogenesis in cultured collicular neurons were defined on the basis of strychnine sensitivity of IPSCs, presence of EPSCs, KCC2 expression, and transmitter-induced Ca (2+) responses. |
1(0,0,0,1) | Details |
| 10938323 | Chery N, De Koninck Y: GABA (B) receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord. J Physiol. 2003 Nov 1;552(Pt 3):975-91. Epub 2003 Aug 22. However, whereas both glycine receptors (GlyRs) and (A) receptors (A) Rs) are expressed on the postsynaptic target, under certain conditions inhibitory events appeared to be mediated by GlyRs only. |
1(0,0,0,1) | Details |
| 8159999 | Hu QK, Chen YZ: [Glycine receptors] J Neurochem. 2002 Sep;82(6):1343-51. |
1(0,0,0,1) | Details |
| 12405966 | Chepkova AN, Doreulee N, Yanovsky Y, Mukhopadhyay D, Haas HL, Sergeeva OA: Long-lasting enhancement of corticostriatal neurotransmission by . Neuropharmacology. 2007 Jun;52(8):1586-95. Epub 2007 Mar 14. The fast and reversible inhibition by was accompanied by a depolarization and conductance increase in medium spiny neurons and was sensitive to A and glycine receptor (GlyR) antagonists. The LLETAU was not prevented by - or by GABAA receptor-antagonists, but was sensitive to the GlyR-antagonist strychnine and blocked by the competitive uptake inhibitor guanidinoethylsulphonate (GES, 1 mm). |
1(0,0,0,1) | Details |
| 11312281 | Hatton GI, Yang QZ: Ionotropic receptors and H2 receptors modulate supraoptic neuronal excitability and dye coupling. Brain Res. 1996 Oct 14;736(1-2):189-201. SON (OX) neurons respond to single TM stimuli with fast IPSPs, whose kinetics resemble those of (A) or glycine receptors. IPSPs were blocked by the Cl (-) channel blocker picrotoxin, but not by bicuculline or strychnine, and by H (2), but not by H (1) or H (3) receptor antagonists, suggesting the presence of an ionotropic receptor and the possible nonspecificity of currently used H (2) antagonists. |
1(0,0,0,1) | Details |
| 16672662 | Graham BA, Schofield PR, Sah P, Margrie TW, Callister RJ: Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator. Vis Neurosci. 1993 Sep-Oct;10(5):907-14. Spastic (spa), spasmodic (spd), and oscillator (ot) mice have naturally occurring glycine receptor (GlyR) mutations, which manifest as motor deficits and an exaggerated "startle response." Using whole-cell recording in hypoglossal motoneurons, we compared the physiological mechanisms by which each mutation alters GlyR function. |
1(0,0,0,1) | Details |
| 11500467 | Li X, Bradford BU, Wheeler MD, Stimpson SA, Pink HM, Brodie TA, Schwab JH, Thurman RG: Dietary prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role for -gated chloride channel. Am J Physiol. 1997 Jun;272(6 Pt 1):G1581-6. The inhibitory effect of was reversed by low concentrations of strychnine or -free buffer, and it increased radiolabeled influx nearly fourfold, an effect also inhibited by strychnine. Further, mRNA for the beta subunit of the glycine receptor was detected in splenic macrophages. |
1(0,0,0,1) | Details |
| 20173309 | Nishikawa Y, Sasaki A, Kuraishi Y: Blockade of transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain. Vis Neurosci. 2007 Jul-Aug;24(4):503-11. Intrathecal ALX1393 suppressed dynamic allodynia induced by intrathecal strychnine and |
0(0,0,0,0) | Details |
| 12684256 | Raiteri L, Paolucci E, Prisco S, Raiteri M, Bonanno G: Activation of a transporter on spinal cord neurons causes enhanced release in a mouse model of amyotrophic lateral sclerosis. J Biol Chem. 2007 May 11;282(19):14447-53. Epub 2007 Mar 23. Potentiation of the spontaneous release of both amino acids is likely to be mediated by activation of a transporter, since the effects of were counteracted by the transporter blocker glycyldodecylamide but not by the glycine receptor antagonists strychnine and 5,7-dichlorokynurenate. |
0(0,0,0,0) | Details |
| 9928321 | Kudo N, Nishimaru H: Reorganization of locomotor activity during development in the prenatal rat. Hum Mol Genet. 1994 Nov;3(11):2025-30. The spontaneous activity was not blocked by the glutamate receptor blocker, although it was completely abolished by strychnine, the glycine receptor antagonist. |
0(0,0,0,0) | Details |
| 18182833 | Ahrens J, Leuwer M, Haeseler G: Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics. Toxicol Appl Pharmacol. 2000 Mar 1;163(2):188-94. |
0(0,0,0,0) | Details |
| 8717357 | Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR: The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. Nat Neurosci. 2002 Jan;5(1):34-40. Neither [3H] strychnine binding nor -gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line. |
0(0,0,0,0) | Details |
| 18562558 | Kilb W, Hanganu IL, Okabe A, Sava BA, Shimizu-Okabe C, Fukuda A, Luhmann HJ: Glycine receptors mediate excitation of subplate neurons in neonatal rat cerebral cortex. Eur J Neurosci. 1998 Dec;10(12):3823-39. -induced responses were blocked by the glycinergic antagonist strychnine, but were unaffected by either the GABAergic antagonist gabazine, the N-methyl-d-aspartate-receptor antagonist d-2-amino-5-phosphonopentanoic acid, or picrotoxin and cyanotriphenylborate, antagonists of alpha-homomeric and alpha1-subunit-containing glycine receptors, respectively. |
85(1,1,1,5) | Details |
| 15566307 | Maksay G, Nemes P, Biro T: Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors. J Pharmacol Exp Ther. 2005 May;313(2):751-64. Epub 2005 Feb 1. These (nor) tropeines inhibited [(3) H] strychnine binding to glycine receptors in synaptosomal membranes of rat spinal cord. |
84(1,1,1,4) | Details |
| 19726200 | Maksay G, Vincze Z, Nemes P: Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. Bioorg Med Chem. 2008 Feb 15;16(4):2086-92. Epub 2007 Nov 4. Tropine esters displaced [(3) H] strychnine binding to glycine receptors of rat spinal cord with low Hill slopes. |
83(1,1,1,3) | Details |
| 11212206 | Busselberg D, Bischoff AM, Paton JF, Richter DW: Reorganisation of respiratory network activity after loss of glycinergic inhibition. Science. 1998 Nov 13;282(5392):1277-9. Strychnine (0.03-0.3 microM) was given systemically to block glycine receptors (Gly-R). |
81(1,1,1,1) | Details |
| 11893603 | Dutschmann M, Paton JF: Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Pharmacology. 2009;83(5):270-4. Epub 2009 Mar 21. In an unanesthetized decerebrate in situ arterially perfused brain stem preparation of mature rat, strychnine (0.05-0.2 microM) blockade of glycine receptors caused postinspiratory glottal constriction to occur earlier, shifting from early expiration to inspiration. |
81(1,1,1,1) | Details |
| 9503338 | Russo RE, Nagy F, Hounsgaard J: Inhibitory control of plateau properties in dorsal horn neurones in the turtle spinal cord in vitro. J Neural Transm Suppl. 1997;49:235-44. Blockade of (GABAA) and glycine receptors by their selective antagonists bicuculline (10-50 microM) and strychnine (5-20 microM) enhanced the excitatory response to stimulation of the dorsal root and facilitated the expression of plateau potentials. 3. |
81(1,1,1,1) | Details |
| 10065998 | Wick MJ, Bleck V, Whatley VJ, Brozowski SJ, Nixon K, Cardoso RA, Valenzuela CF: Stable expression of human alpha1 and alpha2 homomeric receptors in mouse L (tk-) cells. Neuroscience. 1997 May;78(2):411-7. Patch-clamp electrophysiological recordings revealed that the alpha1 or alpha2 glycine receptor subunits expressed in these cells form functional glycine receptors that are inhibited by strychnine and picrotoxin. |
46(0,1,3,6) | Details |
| 10683407 | Darstein M, Landwehrmeyer GB, Kling C, Becker CM, Feuerstein TJ: Strychnine-sensitive glycine receptors in rat caudatoputamen are expressed by cholinergic interneurons. J Physiol. 2002 Oct 1;544(Pt 1):253-65. Strychnine-sensitive glycine receptors are ligand-gated anion channels widely expressed in spinal cord and brainstem. |
46(0,1,3,6) | Details |
| 15094457 | Nguyen L, Malgrange B, Breuskin I, Lallemend F, Hans G, Moonen G, Belachew S, Rigo JM: Striatal PSA-NCAM (+) precursor cells from the newborn rat express functional glycine receptors. Neuroreport. 2007 Oct 29;18(16):1675-8. To ascertain whether glycine receptors were functional in vitro, whole-cell patch-clamp recordings demonstrated that triggers inward strychnine-sensitive currents in the majority of these cells. |
40(0,1,2,5) | Details |
| 7582092 | Pastor A, Chvatal A, Sykova E, Kettenmann H: - and -activated currents in identified glial cells of the developing rat spinal cord slice. Brain Res Bull. 1995;38(6):525-9. The involvement of glycine receptors was inferred from the observation that the response was blocked by strychnine and that the induced current reversed close to the Cl- equilibrium potential. |
33(0,1,1,3) | Details |
| 11919275 | Broch L, Morales RD, Sandoval AV, Hedrick MS: Regulation of the respiratory central pattern generator by -dependent inhibition during development in the bullfrog (Rana catesbeiana). J Exp Biol. 2002 Apr;205(Pt 8):1161-9. The glycine receptor antagonist strychnine (2.5-25.0 micromol l (-1)) and the (A) receptor antagonist bicuculline (1-10 micromol l (-1)) inhibited fictive gill ventilation and increased fictive lung ventilation in tadpoles. |
32(0,1,1,2) | Details |
| 12954867 | Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, Harris RA: Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. J Comp Neurol. 1997 Sep 1;385(3):405-14. Strychnine-sensitive glycine receptors (GlyRs) inhibit neurotransmission in the spinal cord and brainstem. |
32(0,1,1,2) | Details |
| 9007841 | Fedele E, Bisaglia M, Raiteri M: modulates the NMDA receptor/nitric oxide/cGMP pathway in the rat cerebellum during in vivo microdialysis. J Neurophysiol. 2009 Apr;101(4):2134-45. Epub 2009 Feb 18. The effect of 200 microM was largely attenuated by 30 microM 7-chloro- and completely abrogated when the concentration of the strychnine-insensitive glycine receptor antagonist was raised to 100 microM. |
31(0,1,1,1) | Details |
| 14742688 | Baker ER, Zwart R, Sher E, Millar NS: Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras. Neuropharmacology. 1997 Jan;36(1):31-7. In agreement with evidence that alpha9alpha10 nAChRs exhibit an atypical pharmacological profile, we have identified specific high-affinity binding of several non-nicotinic ligands including strychnine (a glycine receptor antagonist), bicuculline (a GABAA receptor antagonist), and atropine (a muscarinic acetylcholine receptor antagonist). |
31(0,1,1,1) | Details |
| 18412628 | Czarnecki A, Magloire V, Streit J: Local oscillations of spiking activity in organotypic spinal cord slice cultures. Mol Pharmacol. 1998 Oct;54(4):639-46. Blockade of glycine receptors by strychnine caused a prolongation of oscillations and their spreading in the slice, suggesting that these receptors are mainly involved in the spatial and temporal restriction of oscillations. |
31(0,1,1,1) | Details |
| 18196445 | Yamada T, Terashima T, Kawano S, Furuno R, Okubo T, Juneja LR, Yokogoshi H: Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Neuropharmacology. 2006 Sep;51(4):805-15. Epub 2006 Jun 30. Co-injection of glycine receptor antagonist, strychnine, reduced theanine-induced changes in |
31(0,1,1,1) | Details |
| 7500153 | Lev-Tov A, O'Donovan MJ: imaging of motoneuron activity in the en-bloc spinal cord preparation of the neonatal rat. Bioorg Med Chem Lett. 1999 May 17;9(10):1409-14. Substantial changes in fluorescence of green-labeled motoneurons were also observed during motoneuron bursting induced by bath application of the glycine receptor antagonist strychnine or the potassium channel blocker 4-aminopyridine (4-AP). 7. |
31(0,1,1,1) | Details |
| 11118498 | Smith AJ, Owens S, Forsythe ID: Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive. J Neurophysiol. 1996 Mar;75(3):1271-82. Following blockade of glutamate receptors, a monosynaptic strychnine-sensitive response was evoked on stimulation of the MNTB, indicative of a glycine receptor-mediated IPSC. |
31(0,1,1,1) | Details |
| 9227496 | Ikejima K, Qu W, Stachlewitz RF, Thurman RG: Kupffer cells contain a -gated chloride channel. . Int J Neurosci. 2003 Mar;113(3):293-305. Low concentrations of strychnine (1 microM), a glycine receptor antagonist, reversed the inhibitory effect of completely; however, high concentrations of strychnine (1 mM) mimicked |
31(0,1,1,1) | Details |
| 8834483 | Sherman SE, Loomis CW: Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal and Brain Res Dev Brain Res. 1997 Jan 2;98(1):30-40. The blockade of spinal glycine receptors with intrathecal strychnine produces a reversible allodynia-like state in the rat. |
31(0,1,1,1) | Details |
| 8836221 | Kumamoto E, Murata Y: current in rat septal cholinergic neuron in culture: monophasic positive modulation by Zn2+. J Neurosci Methods. 1997 Sep 5;76(1):21-8. Rat septal cholinergic neurons in culture were endowed with a Cl (-)-selective glycine receptor channel whose activation was sensitive to strychnine and picrotoxin. |
31(0,1,1,1) | Details |
| 9105687 | Mascia MP, Bleck VG, Harris RA: Glycine receptors from long-sleep and short-sleep mice: genetic differences in drug sensitivity. Eur J Pharmacol. 1994 May 23;257(3):217-25. To determine the role of strychnine-sensitive glycine receptors in genetic differences between these mice, effects of propofol, and on responses were compared in Xenopus oocytes expressing mRNA extracted from spinal cord of LS and SS mice. |
7(0,0,1,2) | Details |
| 15654287 | Molander A, Soderpalm B: Glycine receptors regulate release in the rat nucleus accumbens. Brain Res. 2005 Mar 10;1037(1-2):99-106. Recently strychnine-sensitive glycine receptors (GlyR) have attracted some interest in this matter. |
7(0,0,1,2) | Details |
| 14645455 | Han Y, Li P, Slaughter MM: Selective antagonism of rat inhibitory glycine receptor subunits. Neuroscience. 2007 Apr 25;146(1):427-34. Epub 2007 Mar 7. In this study we examined whether strychnine and DCKA selectivity correlated with the subunit composition of the glycine receptor. |
7(0,0,1,2) | Details |
| 9878183 | Suneja SK, Benson CG, Potashner SJ: Glycine receptors in adult guinea pig brain stem auditory nuclei: regulation after unilateral cochlear ablation. Mol Pharmacol. 1999 Sep;56(3):464-72. In young adult guinea pigs, the effects of unilateral cochlear ablation were determined on the specific binding of [3H] strychnine measured in subdivisions of the cochlear nucleus (CN), the superior olivary complex, and the auditory midbrain, after 2, 7, 31, 60, and 147 postlesion days. |
4(0,0,0,4) | Details |
| 9488503 | Tapia JC, Aguayo LG: Changes in the properties of developing glycine receptors in cultured mouse spinal neurons. Brain Res Mol Brain Res. 1997 Apr;45(1):169-72. Picrotoxin (10 microM) inhibited the current to a larger extent in early neurons (46+/-6% of control), and the sensitivity of these receptors to strychnine (IC50) increased from 23+/-3 nM to 9+/-1 nM in mature neurons. |
4(0,0,0,4) | Details |
| 17911099 | Pless SA, Dibas MI, Lester HA, Lynch JW: Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. Neuroscience. 1997 Jul;79(2):425-34. The inhibitors strychnine and picrotoxin elicited fluorescence and current changes as expected for a competitive antagonist and an open channel blocker, respectively. |
4(0,0,0,4) | Details |
| 11139233 | Llanos MN, Ronco AM, Aguirre MC, Meizel S: Hamster sperm glycine receptor: evidence for its presence and involvement in the acrosome reaction. J Biol Chem. 2001 Apr 20;276(16):12556-64. Epub 2001 Jan 18. This stimulation was completely inhibited by 50 microM (+)-bicuculline and by concentrations of strychnine as low as 10-50 nM; both agents are antagonists of neuronal GlyR when used at the concentrations reported in this study. another agonist of the neuronal GlyR, also stimulated the AR. |
2(0,0,0,2) | Details |
| 16111839 | Chan MH, Lee CC, Chen HH: Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels. J Neurophysiol. 1995 Sep;74(3):1109-17. Electrophysiological studies indicated that this solvent directly affects various ligand gated ion channels including (A), nicotinic and glycine receptors. Mice were pretreated with toluene (100-1000 mg/kg, i.p.) or corn oil followed by a timed intravenous infusion of bicuculline, picrotoxin, or strychnine to induce seizures. |
2(0,0,0,2) | Details |
| 11751269 | Bray C, Son JH, Kumar P, Harris JD, Meizel S: A role for the human sperm glycine receptor/Cl (-) channel in the acrosome reaction initiated by recombinant ZP3. J Neurophysiol. 2000 Oct;84(4):1726-36. Furthermore, incubation of human sperm with an antibody directed against the alpha1 subunit of the human spinal cord GlyR or with 50 nM strychnine caused significant inhibition in the rhZP3-initated AR. |
2(0,0,0,2) | Details |
| 8176438 | Trombley PQ, Shepherd GM: exerts potent inhibitory actions on mammalian olfactory bulb neurons. J Physiol. 2002 Sep 1;543(Pt 2):643-53. At moderate concentrations (> 1 microM) strychnine nonselectively antagonized both - and -evoked currents. Recent immunocytochemical and molecular biological studies have demonstrated, however, a widespread distribution of glycine receptors through-out the CNS, including the olfactory bulb. |
2(0,0,0,2) | Details |
| 15287902 | Lobo IA, Trudell JR, Harris RA: Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. J Physiol. 1996 Apr 15;492 ( Pt 2):545-58. In contrast with the wild-type receptor and single mutants, the S267C/A288C double mutant displayed unusual responses, including a tonic leak activity that was closed by strychnine and a run-down of the response upon repeated applications of |
2(0,0,0,2) | Details |
| 16223757 | Gameiro A, Reimann F, Habib AM, O'Malley D, Williams L, Simpson AK, Gribble FM: The neurotransmitters and stimulate glucagon-like peptide-1 release from the GLUTag cell line. J Neurosci Methods. 1995 May;58(1-2):163-6. Expression of (A), (C) and glycine receptor subunits was confirmed by RT-PCR. In support of this idea, -induced currents and GLP-1 release were blocked by strychnine, and currents showed a 58.5 mV shift in reversal potential per 10-fold change in [Cl-], consistent with the activation of a Cl (-)-selective current. |
1(0,0,0,1) | Details |
| 19543795 | Ericson M, Clarke RB, Chau P, Adermark L, Soderpalm B: elevates levels in the rat nucleus accumbens: antagonism by strychnine. Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R1000-9. Epub 2002 Dec 5. Glycine receptors (GlyRs) in the nucleus accumbens (nAc) have recently been suggested to be involved in the reinforcing and -elevating properties of via a neuronal circuitry involving the VTA. |
1(0,0,0,1) | Details |
| 9875360 | Brockhaus J, Ballanyi K: Synaptic inhibition in the isolated respiratory network of neonatal rats. Neuroscience. 1995 Jan;64(1):153-64. Hyperpolarizing IPSPs mediated by GABAA and glycine receptors provide a characteristic pattern of membrane potential oscillations in respiratory neurons, whereas GABAB receptors rather appear to be a feature of non-respiratory neurons, possibly providing excitatory drive to the network. GABAA, receptor-mediated inhibitory postsynaptic potentials (IPSPs) with bicuculline and/or glycinergic IPSPs with strychnine. |
1(0,0,0,1) | Details |
| 12242098 | Luo DG, Li GL, Yang XL: Zn (2+) modulates light responses of color-opponent bipolar and amacrine cells in the carp retina. J Physiol. 1998 Aug 1;510 ( Pt 3):793-804. The Zn (2+) effects persisted in the presence of picrotoxin and strychnine, suggesting that modulation by Zn (2+) of and glycine receptors was unlikely involved. |
0(0,0,0,0) | Details |
| 7916452 | Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O: Allodynia evoked by intrathecal administration of to conscious mice. J Neurophysiol. 2007 Apr;97(4):2642-50. Epub 2007 Jan 31. Intrathecally administered strychnine and the GABAA antagonist bicuculline also induced allodynia in conscious mice. |
0(0,0,0,0) | Details |
| 16469191 | Yu D, Eldred WD: Gycine and interact to regulate the / signaling pathway in the turtle retina. J Neurophysiol. 2009 Aug;102(2):1004-16. Epub 2009 Jun 10. Our data show that blocking glycine receptors (GLYR) with strychnine (STRY) produced moderate increases in -like immunoreactivity -LI) in select types of amacrine and bipolar cells, and strong increases in NO-induced fluorescence (NO-IF). |
0(0,0,0,0) | Details |
| 17112484 | Heesch CM, Laiprasert JD, Kvochina L: RVLM glycine receptors mediate GABAA and GABAB) independent sympathoinhibition from CVLM in rats. J Neurobiol. 2004 Aug;60(2):166-75. The addition of strychnine (300 pmol, 100 nl) to the RVLM eliminated responses to CVLM inhibition, suggesting that a (A) and (B) independent sympathoinhibitory influence from CVLM to RVLM is mediated by glycine receptors. |
83(1,1,1,3) | Details |
| 8723704 | Fubara BM, Casseday JH, Covey E, Schwartz-Bloom RD: Distribution of GABAA, GABAB, and glycine receptors in the central auditory system of the big brown bat, Eptesicus fuscus. J Neurophysiol. 1995 Jan;73(1):256-69. In the subcortical auditory nuclei there appears to be at least a partial complementarity in the distribution of GABAA receptors labeled with 35S-TBPS and glycine receptors labeled with 3H-strychnine, GABAA receptors were concentrated mainly in the inferior colliculus (IC) and medial geniculate nucleus, whereas glycine receptors were concentrated mainly in nuclei below the level of the IC. |
83(1,1,1,3) | Details |
| 9772232 | Burger RM, Pollak GD: Analysis of the role of inhibition in shaping responses to sinusoidally amplitude-modulated signals in the inferior colliculus. J Neurosci. 2001 Aug 15;21(16):6045-57. We recorded responses from ICc neurons evoked by SAM signals before and during the iontophoretic application of several pharmacological agents: bicuculline, a competitive antagonist for -A (GABAA) receptors; strychnine, a competitive antagonist for glycine receptors; the GABAB receptor blocker, phaclofen, and the (NMDA) receptor blocker, (-)-2-amino-5-phosphonopentanoic acid (AP5). |
81(1,1,1,1) | Details |
| 7703434 | Eckenhoff RG, Yang BJ: Absence of pressure antagonism of narcosis in C. elegans. EMBO J. 1996 Mar 15;15(6):1275-82. Because of previous results implicating glycine receptor antagonism as a mechanism of pressure reversal, and our current inability to observe significant behavioral effects of strychnine or inhibition of high affinity strychnine binding, we suggest that an absence of glycine receptors in these organisms is the basis for a lack of pressure antagonism of immobility. |
81(1,1,1,1) | Details |
| 20331561 | Adermark L, Clarke RB, Olsson T, Hansson E, Soderpalm B, Ericson M: Implications for glycine receptors and astrocytes in -induced elevation of levels in the nucleus accumbens. Exp Neurol. 1999 Nov;160(1):215-25. EtOH-induced release was antagonized by local treatment with the glycine receptor antagonist strychnine (20 microM) or (100 microM or 1 mM). |
39(0,1,2,4) | Details |
| 9605343 | Koch U, Sanes DH: Afferent regulation of glycine receptor distribution in the gerbil LSO. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):43-7. Glycine receptors were either labeled with tritiated strychnine (3H-SN) or with an antibody directed against gephyrin, a protein closely associated with the receptor complex. |
38(0,1,1,8) | Details |
| 8015346 | Miller GW, Schnellmann RG: A putative cytoprotective receptor in the kidney: relation to the neuronal strychnine-sensitive glycine receptor. Neuropharmacology. 2009 Oct-Nov;57(5-6):551-5. Epub 2009 Jul 18. |
38(0,1,2,3) | Details |
| 12888217 | Kawa K: facilitates transmitter release at developing synapses: a patch clamp study from Purkinje neurons of the newborn rat. J Appl Physiol. 1993 Mar;74(3):1265-73. Facilitatory effects of were suppressed by strychnine (1 micro M), a specific blocker of the ionotropic glycine receptor, while the effects were also induced by other glycinergic agonists, including alpha- (1 mM), (1 mM) and (500 micro M). |
32(0,1,1,2) | Details |
| 9144769 | Gready JE, Ranganathan S, Schofield PR, Matsuo Y, Nishikawa K: Predicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding site. Alcohol Clin Exp Res. 2003 May;27(5):743-55. Using the glycine receptor alpha 1 subunit, which forms homopentamers, the monomeric and pentameric models define the agonist and antagonist (strychnine) binding sites to a deep crevice formed by an extended loop, which includes the invariant disulfide bridge, between the SH2 and SH3 domains. |
32(0,1,1,2) | Details |
| 9147024 | Tonohiro T, Kaneko T, Tanabe M, Iwata N: Picolinic acid and two types of glycinergic compounds modulate motor function differentially. J Neurophysiol. 1996 Oct;76(4):2447-54. A putative agonist for the strychnine-sensitive glycine receptor picolinic acid was tested for its anticonvulsant activities in mice and muscle-relaxant activities in rats and compared with (I2CA), an antagonist for the strychnine-insensitive glycine receptor. |
31(0,1,1,1) | Details |
| 10591891 | Jovanovic K, Petrov T, Stein RB: Effects of inhibitory neurotransmitters on the mudpuppy (Necturus maculatus) locomotor pattern in vitro. J Physiol. 2009 Aug 1;587(Pt 15):3813-30. Epub 2009 Jun 15. Addition of glycine receptor antagonist strychnine or (A) receptor antagonist bicuculline disrupted the phase relationship between antagonistic motor pools during ongoing locomotion, thereby changing the normal alternating pattern into synchronous EMG bursts. |
31(0,1,1,1) | Details |
| 16006112 | Krause G, Lehmann S, Lehmann M, Freund I, Schreiber E, Baumann W: Measurement of electrical activity of long-term mammalian neuronal networks on semiconductor neurosensor chips and comparison with conventional microelectrode arrays. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2606-12. The (A)-receptor blocker bicuculline was applied to both tissue cultures, the glycine-receptor blocker strychnine to spinal cord cultures. |
31(0,1,1,1) | Details |
| 9266432 | Fossom LH, Skolnick P: Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias. Epilepsia. 1995 Aug;36(8):743-9. |
31(0,1,1,1) | Details |
| 10575119 | Chen L, Kelly JB, Wu SH: The commissure of probst as a source of GABAergic inhibition. . Amino Acids. 2009 Jun 19. Inhibitory postsynaptic responses (IPSPs) evoked by stimulation of the CP were blocked by the (GABA)(A) receptor antagonist bicuculline, but were unaffected by the glycine receptor antagonist strychnine, supporting the conclusion that the crossed inhibitory projection to DNLL from the contralateral DNLL is GABAergic. |
31(0,1,1,1) | Details |
| 11396606 | Lopez-Corcuera B, Geerlings A, Aragon C: neurotransmitter transporters: an update. Pharmacol Biochem Behav. 1993 Oct;46(2):275-81. This action of is mediated by the strychnine-sensitive glycine receptor, whose activation produces inhibitory post-synaptic potentials. |
31(0,1,1,1) | Details |
| 16805771 | Betz H, Laube B: Glycine receptors: recent insights into their structural organization and functional diversity. Brain Res. 1997 Oct 31;773(1-2):173-80. Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal cord, brainstem and other regions of the CNS. |
7(0,0,1,2) | Details |
| 12718443 | Zhang K, Weinberg JM, Venkatachalam MA, Dong Z: protection of PC-12 cells against injury by ATP-depletion. J Biol Chem. 1993 Jul 15;268(20):14608-15. In addition, we have examined the role played by glycine receptors in cytoprotective effects of the amino acid. Of interest, strychnine, an antagonist of glycine receptor, was also protective. |
4(0,0,0,4) | Details |
| 16554506 | Ghavanini AA, Mathers DA, Kim HS, Puil E: Distinctive glycinergic currents with fast and slow kinetics in thalamus. . Brain Res. 1994 Apr 11;642(1-2):59-69. We examined functional properties of inhibitory postsynaptic currents (IPSCs) evoked by medial lemniscal stimulation, spontaneous IPSCs (sIPSCs), and single-channel, extrasynaptic currents evoked by glycine receptor agonists or in rat ventrobasal thalamus. We identified synaptic currents by reversal at E (Cl) and sensitivity to elimination by strychnine, (A) antagonists, or combined application. |
4(0,0,0,4) | Details |
| 10188956 | David-Watine B, Goblet C, de Saint Jan D, Fucile S, Devignot V, Bregestovski P, Korn H: Cloning, expression and electrophysiological characterization of glycine receptor alpha subunit from zebrafish. J Neurophysiol. 2001 Oct;86(4):1632-43. When expressed in Xenopus oocytes or a human cell line (BOSC 23), alphaZ1 forms a homomeric receptor which is activated by and antagonized by strychnine. |
4(0,0,0,4) | Details |
| 16107637 | Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, Burnashev N: Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids. Toxicol Lett. 2006 Jan 25;160(3):179-84. Epub 2005 Aug 18. We also demonstrate that, in the presence of a (A) receptor antagonist, GlyRs may contribute to the generation of seizure-like activity induced by short bursts (seven stimuli) of high-frequency stimulation of inputs to hippocampal CA1 region, because this activity was diminished by selective GlyR antagonists (strychnine and ginkgolides B and J). |
2(0,0,0,2) | Details |
| 10886333 | Belachew S, Malgrange B, Rigo JM, Rogister B, Leprince P, Hans G, Nguyen L, Moonen G: triggers an intracellular influx in oligodendrocyte progenitor cells which is mediated by the activation of both the ionotropic glycine receptor and Na+-dependent transporters. J Physiol. 2003 Sep 1;551(Pt 2):617-33. Epub 2003 Aug 8. |
2(0,0,0,2) | Details |
| 10462533 | Schmieden V, Kuhse J, Betz H: A novel domain of the inhibitory glycine receptor determining antagonist efficacies: further evidence for partial agonism resulting from self-inhibition. Br J Pharmacol. 1996 Dec;119(7):1331-6. The antagonists strychnine, nipecotic acid, and displayed reduced potencies at recombinant GlyRs formed from alpha1 subunits, in which 104, 108, or 112 were replaced by |
2(0,0,0,2) | Details |
| 7861131 | Jursky F, Nelson N: Localization of neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. Neurochem Int. 1995 Oct-Nov;27(4-5):301-11. A correlation was observed between the pattern we obtained and previously reported strychnine binding studies. |
2(0,0,0,2) | Details |
| 11564428 | Fontana G, Taccola G, Galante J, Salis S, Raiteri M: AMPA-evoked release from cultured spinal cord motoneurons and its inhibition by and Synapse. 1998 Mar;28(3):185-94. The release of [(3) H] evoked by alpha-amino-3--5-methyl-4-isoxazole (AMPA) and its inhibition mediated by (A) and glycine receptors were studied in superfused cultured rat embryo spinal cord motoneurons prelabeled with [(3) H] acting at strychnine-sensitive receptors, also inhibited the effect of AMPA, but only in part. |
2(0,0,0,2) | Details |
| 7728534 | Koch M, Friauf E: Glycine receptors in the caudal pontine reticular formation: are they important for the inhibition of the acoustic startle response?. Am J Pathol. 2001 Mar;158(3):1021-8. First we provided evidence for the presence of the strychnine-sensitive inhibitory GlyR on PnC neurons by immunocytochemical labeling using an antibody against the alpha 1 subunit of the GlyR. |
2(0,0,0,2) | Details |
| 9133365 | Han Y, Zhang J, Slaughter MM: Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells. J Neurophysiol. 2004 Jan;91(1):248-57. Epub 2003 Jul 23. Physiological and pharmacological properties of possible subtypes of the native glycine receptor were investigated in retinal neurons using whole-cell voltage-clamp techniques. The responses could be distinguished pharmacologically: one was sensitive to strychnine and the other to 5,7-dichlorokynurenic acid. |
1(0,0,0,1) | Details |
| 10799671 | Ye J: Physiology and pharmacology of native glycine receptors in developing rat ventral tegmental area neurons. Br J Pharmacol. 1994 Sep;113(1):165-70. |
1(0,0,0,1) | Details |
| 11024065 | Ali DW, Drapeau P, Legendre P: Development of spontaneous glycinergic currents in the Mauthner neuron of the zebrafish embryo. Channels. 2008 Jan-Feb;2(1):13-8. Epub 2008 Mar 12. Point-per-point amplitude histograms of the decay of synaptic events at all stages resulted in the detection of similar single channel conductances estimated as approximately 45 pS, indicating the presence of heteromeric glycine receptors (GlyRs) from the onset of synaptogenesis. Miniature inhibitory postsynaptic currents (mIPSCs) were isolated and recorded in the presence of TTX (1 microM), (1 mM), and bicuculline (10 microM) and were found to be sensitive to strychnine (1 microM). |
1(0,0,0,1) | Details |
| 15928085 | Hirata H, Saint-Amant L, Downes GB, Cui WW, Zhou W, Granato M, Kuwada JY: Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit. J Neurophysiol. 2008 Aug;100(2):698-707. Epub 2008 Jun 18. Similar simultaneous contractions are observed in wild-type embryos treated with strychnine, a blocker of the inhibitory glycine receptor (GlyR). Similar simultaneous contractions are observed in wild-type embryos treated with strychnine, a blocker of the inhibitory glycine receptor (GlyR). |
1(0,0,0,1) | Details |
| 12919385 | Kirchner A, Breustedt J, Rosche B, Heinemann UF, Schmieden V: Effects of and on epileptiform activity induced by removal of Mg2+ in combined rat entorhinal cortex-hippocampal slices. J Neurosci Methods. 1996 Oct;68(2):253-7. Strychnine at concentrations <1 micro M abolished these effects. Recent studies indicate the expression of glycine receptor (GlyR) in hippocampus and neocortex. |
1(0,0,0,1) | Details |
| 9114241 | Shao XM, Feldman JL: Respiratory rhythm generation and synaptic inhibition of expiratory neurons in pre-Botzinger complex: differential roles of glycinergic and GABAergic neural transmission. J Neurosci. 2000 Nov 1;20(21):7905-13. Bath application of the glycine receptor antagonist strychnine (STR; 5-10 microM) reversibly blocked these inspiratory-phase IPSPs, whereas the -A (A)) receptor antagonist bicuculline (BIC; 10-100 microM) had no effect on these IPSPs. |
0(0,0,0,0) | Details |
| 11900860 | Kondratskaya EL, Lishko PV, Chatterjee SS, Krishtal OA: BN52021, a platelet activating factor antagonist, is a selective blocker of -gated chloride channel. Br J Pharmacol. 1994 May;112(1):97-106. When co-applied with strychnine (STR), a competitive glycine receptor antagonist, BN52021 does not alter the IC50 value for strychnine. |
0(0,0,0,0) | Details |
| 8816361 | del Carmen Garcia M, Enero MA, Celuch SM: Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats. Eur J Pharmacol. 2008 Dec 3;599(1-3):86-90. Epub 2008 Sep 30. The glycine-receptor antagonist strychnine (25 micrograms, i.t.) did not modify the hypotension induced by either (in the presence of prazosin) or |
0(0,0,0,0) | Details |
| 15209420 | Biro T, Maksay G: Allosteric modulation of glycine receptors is more efficacious for partial rather than full agonists. J Physiol. 2002 Feb 15;539(Pt 1):191-200. Allosteric modulation of [3H] strychnine binding to glycine receptors (GlyRs) was examined in synaptosomal membranes of rat spinal cord. |
83(1,1,1,3) | Details |
| 19286654 | Pless SA, Lynch JW: Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain. J Physiol. 2003 Dec 15;553(Pt 3):895-909. Epub 2003 Sep 26. In an attempt to resolve ligand-dependent movements in the ligand-binding domain, we employed voltage-clamp fluorometry on alpha1 glycine receptors to compare changes mediated by the agonist, and by the antagonist, strychnine. |
83(1,1,1,3) | Details |
| 16630584 | Bongianni F, Mutolo D, Nardone F, Pantaleo T: GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control. Brain Res. 2009 Dec 22;1304:49-56. Epub 2009 Sep 24. Similar effects were observed after glycine receptor blockade by strychnine. |
83(1,1,1,3) | Details |
| 17704076 | Fournier S, Allard M, Roussin S, Kinkead R: Developmental changes in central O2 chemoreflex in Rana catesbeiana: the role of noradrenergic modulation. J Neurosci. 2004 Oct 13;24(41):8961-74. Blocking (A)/glycine receptors with a bicuculine/strychnine mixture (1.25 micromol l (-1)/1.5 micromol l (-1), respectively) or activation of (B) pre-synaptic autoreceptors with baclofen (0.5 micromol l (-1)) prevented the lung burst response to hypoxia and to the alpha (1)-agonist (25 micromol l (-1)) in both stage groups. |
81(1,1,1,1) | Details |
| 11406196 | Balduini W, De Angelis V, Mazzoni E, Depoortere H, Cattabeni F, Cimino M: Autoradiographic localization of [3H] thiocolchicoside binding sites in the rat brain and spinal cord. J Neurophysiol. 2007 Feb;97(2):1610-20. Epub 2006 Nov 22. Furthermore, the observed sensitivity to strychnine in the spinal cord indicates an interaction also with strychnine-sensitive glycine receptors, suggesting that the pharmacological effects of thiocolchicoside may be the result of its interaction with different receptor populations. |
81(1,1,1,1) | Details |
| 8220914 | Yadid G, Pacak K, Golomb E, Harvey-White JD, Lieberman DM, Kopin IJ, Goldstein DS: stimulates striatal release in conscious rats. Anesthesiology. 2004 Nov;101(5):1167-76. The results suggest that dopaminergic cells in the substantia nigra synthesize strychnine-sensitive glycine receptors and transport the receptors to terminals in the striatum. |
38(0,1,2,3) | Details |
| 9401974 | Boehm S, Harvey RJ, von Holst A, Rohrer H, Betz H: Glycine receptors in cultured chick sympathetic neurons are excitatory and trigger neurotransmitter release. J Neurophysiol. 1997 Apr;77(4):1853-60. The classical glycine receptor antagonist strychnine reversibly reduced -induced currents, with half-maximal inhibition occurring at 62 nM. |
38(0,1,1,8) | Details |
| 8103091 | Zhou ZJ, Fain GL, Dowling JE: The excitatory and inhibitory amino acid receptors on horizontal cells isolated from the white perch retina. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):534-7. GLY-activated currents were inhibited by the glycine receptor antagonist strychnine (STRYCH). |
38(0,1,2,3) | Details |
| 19091929 | Sanchez A, Mustapic S, Zuperku EJ, Stucke AG, Hopp FA, Stuth EA: Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo. Biosens Bioelectron. 1997;12(8):827-35. Multibarrel micropipettes were used to record extracellular unit activity of individual IHMNs during local antagonism of (A) receptors with bicuculline and picrotoxin or glycine receptors with strychnine. |
32(0,1,1,2) | Details |
| 9268120 | Friauf E, Hammerschmidt B, Kirsch J: Development of adult-type inhibitory glycine receptors in the central auditory system of rats. Acta Otolaryngol. 1996 Sep;116(5):697-704. Here we have investigated the spatiotemporal distribution of adult-type, strychnine-sensitive glycine receptors (GlyRs) in the rat auditory system by using a specific antibody against the ligand-binding alpha1 GlyR subunit. |
32(0,1,1,2) | Details |
| 14552874 | Song Z, Hatton GI: and the control of basal hormone release from rat neurohypophysis. . Brain Res. 2004 Sep 24;1021(2):232-40. The other receptor (s) involved in actions is postulated to be strychnine-insensitive glycine receptors. |
32(0,1,1,2) | Details |
| 15381290 | Srinivasan G, Friauf E, Lohrke S: Functional glutamatergic and glycinergic inputs to several superior olivary nuclei of the rat revealed by optical imaging. Neurosci Lett. 1996 Feb 23;205(2):75-8. Postsynaptic components were distinguished pharmacologically with the glycine receptor blocker strychnine and the alpha-amino-3--5-methyl-4-isoxazolepropionate (AMPA)/kainate receptor blocker 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). |
31(0,1,1,1) | Details |
| 15756069 | Miyazato M, Sugaya K, Nishijima S, Morozumi M, Ohyama C, Ogawa Y: Rectal distention inhibits the spinal micturition reflex via glycinergic or GABAergic mechanisms in rats with spinal cord injury. Br J Pharmacol. 1996 Jun;118(3):493-502. Isovolumetric cystometry was performed before and after distention of the rectum by inflation of a rectal balloon, followed by intrathecal injection of strychnine (a selective glycine receptor antagonist) or bicuculline (a (A) receptor antagonist) into the lumbosacral cord. |
31(0,1,1,1) | Details |
| 16360285 | Otsuguro K, Ohta T, Ito S: modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro. Exp Neurol. 2003 Oct;183(2):330-7. Unlike Zn (2+), strychnine (5 microM), a glycine receptor antagonist, and (S),9 (R)-(-)-bicuculline methobromide (10 microM), a (A) receptor antagonist, potentiated both fast polysynaptic reflex potential and slow ventral root potential. |
31(0,1,1,1) | Details |
| 18367344 | Venard C, Boujedaini N, Belon P, Mensah-Nyagan AG, Patte-Mensah C: Regulation of neurosteroid biosynthesis in the rat spinal cord by and the alkaloidal analogs strychnine and gelsemine. J Physiol. 2000 Dec 15;529 Pt 3:681-98. The alkaloid strychnine, well-known as a glycine receptor (Gly-R) antagonist, blocked stimulatory effect on 3alpha,5alpha-THP formation. |
31(0,1,1,1) | Details |
| 8930257 | Straka H, Dieringer N: Uncrossed disynaptic inhibition of second-order vestibular neurons and its interaction with monosynaptic excitation from vestibular nerve afferent fibers in the frog. Neuroscience. 2008 Apr 22;153(1):154-61. Epub 2008 Feb 19. Disynaptic IPSPs superimposed upon apparently pure EPSPs were revealed by bath application of the glycine receptor antagonist strychnine (0.5-5 microM) or of the -A (GABAA) receptor antagonist bicuculline (0.5-2 microM). |
31(0,1,1,1) | Details |
| 8815212 | Ramirez JM, Quellmalz UJ, Richter DW: Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. Eur J Neurosci. 2000 Mar;12(3):994-1001. Blockade of glycine receptors by strychnine increased the frequency of rhythmic XII activity in neonatal and older mice (P0-22). |
31(0,1,1,1) | Details |
| 9019549 | Galante RJ, Kubin L, Fishman AP, Pack AI: Role of -mediated inhibition in respiratory rhythmogenesis in an in vitro brainstem of tadpole, Rana catesbeiana. Jpn J Physiol. 1994;44 Suppl 2:S91-6. To investigate the role of chloride channel-dependent inhibitory mechanisms mediated by (A) and/or glycine receptors on fictive lung and gill ventilation, we superfused the isolated brainstems with agonists, antagonists (bicuculline and/or strychnine) or a -free solution while recording multi-unit activity from the facial motor nucleus. 2. |
31(0,1,1,1) | Details |
| 12356896 | Johnson SM, Wilkerson JE, Wenninger MR, Henderson DR, Mitchell GS: Role of synaptic inhibition in turtle respiratory rhythm generation. Biol Reprod. 2002 Jan;66(1):91-7. Strychnine (a glycine receptor antagonist) increased amplitude and frequency, and decreased burst duration, but only at relatively high concentrations (10-100 microM). |
31(0,1,1,1) | Details |
| 11770058 | Weber M, Richardson R: Centrally administered corticotropin-releasing hormone and peripheral injections of strychnine hydrochloride potentiate the acoustic startle response in preweanling rats. J Neurophysiol. 1994 Feb;71(2):761-7. In the present study, the authors report that peripheral injections of strychnine hydrochloride, a glycine receptor antagonist, and intracerebroventricular infusions of corticotropin releasing hormone (CRH) both potentiated the acoustic startle response (ASR) in 16-18-day-old rats. |
31(0,1,1,1) | Details |
| 19200346 | Lee EA, Cho JH, Choi IS, Nakamura M, Park HM, Lee JJ, Lee MG, Choi BJ, Jang IS: Presynaptic glycine receptors facilitate spontaneous release onto hilar neurons in the rat hippocampus. Neuroscience. 1999 Apr;90(1):303-17. This facilitatory effect of was blocked by 1 microM strychnine, a specific glycine receptor antagonist, but was not affected by 30 microM picrotoxin. |
6(0,0,0,6) | Details |
| 12153532 | Gisselmann G, Galler A, Friedrich F, Hatt H, Bormann J: Cloning and functional characterization of two glycine receptor alpha-subunits from the perch retina. Eur J Neurosci. 2002 Jul;16(1):69-80. Functional expression of the perch subunits in HEK-293 cells yielded robust -gated currents sensitive to strychnine. |
3(0,0,0,3) | Details |
| 7578693 | Melendrez CS, Meizel S: Studies of porcine and human sperm suggesting a role for a sperm glycine receptor/Cl- channel in the zona pellucida-initiated acrosome reaction. Biol Reprod. 1995 Sep;53(3):676-83. We then employed 1) strychnine, an antagonist of neuronal glycine receptor/Cl- channels at nanomolar concentrations and of GABAA receptor/Cl- channels at micromolar concentrations and 2) (+)-bicuculline, an antagonist of neuronal GABAA receptor/Cl- channels that inhibits glycine receptor/Cl- channels only at higher concentrations. |
3(0,0,0,3) | Details |
| 11395484 | Breitinger HG, Villmann C, Becker K, Becker CM: Opposing effects of molecular volume and charge at the hyperekplexia site alpha 1 (P250) govern glycine receptor activation and desensitization. table of contents. |
3(0,0,0,3) | Details |
| 12660352 | Thio LL, Shanmugam A, Isenberg K, Yamada K: Benzodiazepines block alpha2-containing inhibitory glycine receptors in embryonic mouse hippocampal neurons. J Med Chem. 1995 Sep 15;38(19):3720-40. and activate strychnine-sensitive currents in a dose-dependent manner. |
2(0,0,0,2) | Details |
| 9374187 | Tapia JC, Espinoza F, Aguayo LG: Differential intracellular regulation of cortical (A) and spinal glycine receptors in cultured neurons. Neurochem Int. 2006 Nov;49(6):577-83. Epub 2006 Jun 19. Activation of G proteins with internal FAl4- induced an inhibition of the (A) current, but potentiated the amplitude of the strychnine-sensitive Cl- current. |
2(0,0,0,2) | Details |
| 17357155 | Speranskiy K, Cascio M, Kurnikova M: Homology modeling and molecular dynamics simulations of the glycine receptor ligand binding domain. Neuroscience. 2001;104(4):1043-55. In addition, a complex structure with strychnine antagonist in the putative binding site is proposed based on docking simulation using Autodock program. |
2(0,0,0,2) | Details |
| 15836436 | Pan C, Bai X, Fan L, Ji Y, Li X, Chen Q: Cytoprotection by against ATP-depletion-induced injury is mediated by glycine receptor in renal cells. Neuroscience. 1998 Jul;85(2):383-94. Furthermore, the mutation of Tyr202 to in GlyRa1 blocked the -mediated cytoprotection, while the mutation of Tyr202 to abolished the cytoprotection by strychnine. |
2(0,0,0,2) | Details |
| 16449194 | Maas C, Tagnaouti N, Loebrich S, Behrend B, Lappe-Siefke C, Kneussel M: Neuronal cotransport of glycine receptor and the scaffold protein gephyrin. Neurosci Lett. 1994 Feb 28;168(1-2):147-50. |
2(0,0,0,2) | Details |
| 10670525 | Sato Y, Son JH, Meizel S: The mouse sperm glycine receptor/chloride channel: cellular localization and involvement in the acrosome reaction initiated by J Neurochem. 2006 Jun;97(6):1600-10. The -initiated AR was significantly inhibited by 50 nM strychnine, a neuronal GlyR antagonist. |
2(0,0,0,2) | Details |
| 11549740 | LeBeau FE, Malmierca MS, Rees A: Iontophoresis in vivo demonstrates a key role for (A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig. J Physiol. 2005 Dec 15;569(Pt 3):761-72. Epub 2005 Oct 13. Application of bicuculline or strychnine in these neurons, to block inhibition mediated by (A) or glycinergic receptors, respectively, increases firing rate primarily within the boundaries of the control response area. In this group, blockade of (A) and glycine receptors increases firing rate but also changes response area shape, with most becoming more V-shaped. |
1(0,0,0,1) | Details |
| 11246169 | Hatta K, Ankri N, Faber DS, Korn H: Slow inhibitory potentials in the teleost Mauthner cell. Neuroscience. 2010 Mar 31;166(3):1008-22. Epub 2010 Jan 6. This suggests developmental modifications and/or a switch in the assembly of glycine receptor subtypes. That is, they persisted in the presence of strychnine at doses that abolished the fast ones and they were more sensitive to bicuculline. |
1(0,0,0,1) | Details |
| 9622238 | Kira T, Harata N, Sakata T, Akaike N: Kinetics of sevoflurane action on - and -induced currents in acutely dissociated rat hippocampal neurons. J Neurophysiol. 2009 Jun;101(6):3063-74. Epub 2009 Mar 25. The reversible and differential modulation of (A) and glycine receptors might underlie a part of the anaesthetic actions and less adverse clinical effects of sevoflurane. Pretreatment with 3 x 10 (-8) M strychnine markedly prolonged the time to peak of the -induced ICl. |
1(0,0,0,1) | Details |
| 16645195 | Orer HS, Gebber GL, Barman SM: Medullary lateral tegmental field neurons influence the timing and pattern of phrenic nerve activity in cats. Exp Neurol. 1998 Dec;154(2):473-88. Fourth, blockade of glycine receptors significantly decreased central respiratory rate by causing proportional increases in Ti and Te and significantly reduced I-burst amplitude. |
1(0,0,0,1) | Details |
| 19826900 | Hernandes MS, Troncone LR: as a neurotransmitter in the forebrain: a short review. Neurosci Lett. 1994 Mar 28;170(1):167-70. The description of its involvement in the mechanism of action of the potent neurotoxin strychnine pushed further the concept of inhibitory transmitter. This review encompasses a few of these aspects as the role of the different glycine receptors (GlyRs) in intracellular balance, transporters, / co-release, /NMDA receptor interaction, glycine receptors in acute effects and advocates a more relevant role for as a stimulatory transmitter in forebrain areas. |
1(0,0,0,1) | Details |
| 17604007 | Eto K, Arimura Y, Nabekura J, Noda M, Ishibashi H: The effect of zinc on glycinergic inhibitory postsynaptic currents in rat spinal dorsal horn neurons. J Neural Transm. 2009 Dec;116(12):1551-60. Epub 2009 Oct 14. These results suggest that, in addition to an action on the postsynaptic glycine receptors, zinc may depolarize the presynaptic nerve terminals, leading to an activation of voltage-dependent Na (+) and Ca (2+) channels that in turn increases release. |
1(0,0,0,1) | Details |
| 7982280 | Komatsu H, Nogaya J, Ueki M, Yokono S, Ogli K: Possible participation of and glycine receptors but not GABAA receptors in enflurane-induced opisthotonus in mice. Neurochem Int. 2002 Jun;40(7):647-53. The effects of pretreatment of antagonists dizocilpine (MK-801; DIZ) and ketamine (KET), GABAA antagonists picrotoxin (PIC), pentylenetetrazol (PTZ) and antagonist strychnine (STR) on the incidence of EIO were determined. |
0(0,0,0,0) | Details |
| 12205196 | Dutschmann M, Paton JF: Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat. Eur J Pharmacol. 1995 Jun 23;280(1):37-45. We developed an arterially perfused neonatal rat preparation (postnatal age 0-4 days) to assess the effects of blocking glycine receptors with systemically administered strychnine (0.5-1 microM). |
83(1,1,1,3) | Details |
| 15777757 | Xu YX, Shi JS, Jiang ZL: Inhibitory influence of ginsenoside Rb (3) on activation of strychnine-sensitive glycine receptors in hippocampal neurons of rat. Behav Neurosci. 2001 Dec;115(6):1273-82. |
83(1,1,1,3) | Details |
| 9824468 | Belachew S, Rogister B, Rigo JM, Malgrange B, Mazy-Servais C, Xhauflaire G, Coucke P, Moonen G: Cultured oligodendrocyte progenitors derived from cerebral cortex express a glycine receptor which is pharmacologically distinct from the neuronal isoform. J Anat. 2002 Oct;201(4):319-23. The oligodendrocyte progenitors glycine receptor (GlyR) differs from the corresponding neuronal receptor: [3H] strychnine binding data and the strychnine inhibition curve of -induced currents in oligodendrocyte progenitor cultures suggest the existence of two strychnine binding sites on the oligodendroglial GlyR. |
83(1,1,1,3) | Details |
| 19628662 | Venard C, Boujedaini N, Mensah-Nyagan AG, Patte-Mensah C: Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Formation in the Spinal Cord and Limbic System. J Physiol. 2007 Jan 15;578(Pt 2):439-50. Epub 2006 Oct 26. The stimulatory action of G. sempervirens and gelsemine (5 cH) on 3alpha,5alpha-THP production was blocked by strychnine, the selective antagonist of glycine receptors. |
81(1,1,1,1) | Details |
| 8387928 | Maksay G: Kinetic cooperative effect of glycine receptor agonists and antagonists on the dissociation of strychnine binding. Neuroscience. 1995 Aug;67(3):713-9. |
81(1,1,1,1) | Details |
| 8545484 | Layer RT, Popik P, Olds T, Skolnick P: Antidepressant-like actions of the polyamine site antagonist, eliprodil (SL-82.0715). Eur J Pharmacol. 1996 Dec 27;318(1):201-4. Chronic treatment with eliprodil produced both a significant downregulation of beta-adrenoceptors and a reduction in the potency of to inhibit [3H] 5,7-dichlorokynurenic acid binding to strychnine-insensitive glycine receptors in neocortical membranes. |
81(1,1,1,1) | Details |
| 8071846 | Faiman CP, Viu E, Skolnick P, Trullas R: Differential effects of compounds that act at strychnine-insensitive glycine receptors in a punishment procedure. J Pharmacol Exp Ther. 1994 Aug;270(2):528-33. The anxiolytic and memory-impairing effects of compounds that act at strychnine-insensitive (SI) glycine receptors were examined and compared with those of a competitive antagonist, 2-amino-7-phosphonoheptanoic acid (AP7); a use-dependent channel blocker, dizocilpine; and a benzodiazepine agonist, diazepam (DZP). |
37(0,1,2,2) | Details |
| 12614680 | Vale C, Fonfria E, Bujons J, Messeguer A, Rodriguez-Farre E, Sunol C: The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with (A) and -gated channels in primary cultures of cerebellar granule cells. J Neurosci. 1998 Jun 15;18(12):4646-55. The strychnine-sensitive glycine receptor also regulates Cl (-)-flux inhibitory responses. |
37(0,1,1,7) | Details |
| 19409375 | Liu Y, Hu C, Tang Y, Chen J, Dong M, Song T, Zhang X, Zhao J: Clozapine inhibits strychnine-sensitive glycine receptors in rat hippocampal neurons. Rev Neurol. 2008 Dec 16-31;47(12):648-52. |
37(0,1,2,2) | Details |
| 7700536 | Luque JM, Nelson N, Richards JG: Cellular expression of transporter 2 messenger RNA exclusively in rat hindbrain and spinal cord. Neuroscience. 1998 Jul;85(2):427-41. The distribution of transporter 2 messenger RNA-containing cell bodies was very different to that of other transporter messenger RNAs transporter 1a and glycine transporter 1b), but similar to that of known -immunoreactive neurons and correlated very well with that of strychnine-sensitive glycine receptors in most CNS regions except cerebellum. |
37(0,1,2,2) | Details |
| 14593111 | Breitinger U, Breitinger HG, Bauer F, Fahmy K, Glockenhammer D, Becker CM: Conserved high affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha1-subunit. Biochem Biophys Res Commun. 2006 Jun 9;344(3):721-6. Epub 2006 Apr 17. The strychnine-sensitive glycine receptor (GlyR) is a ligand-gated chloride channel composed of ligand binding alpha- and gephyrin anchoring beta-subunits. |
32(0,1,1,2) | Details |
| 19382904 | Ye JH, Sokol KA, Bhavsar U: Glycine receptors contribute to hypnosis induced by . J Neurochem. 1994 Jun;62(6):2457-63. We compared the LORR induced by systematic administration of and of ketamine in the absence and presence of the selective glycine receptor antagonist strychnine. |
32(0,1,1,2) | Details |
| 17294103 | Polina YA, Amakhin DV, Kozhanov VM, Kurchavyi GG, Veselkin NP: Three types of inhibitory miniature potentials in frog spinal cord motoneurons: possible and cotransmission. Nature. 1998 Apr 16;392(6677):717-20. Strychnine (1 microM), a blocker of glycine receptors, led to a reduction in the number of fast receptors and an increase in the number of slow potentials. |
31(0,1,1,1) | Details |
| 10517820 | Iizuka M: Intercostal expiratory activity in an in vitro brainstem-spinal cord-rib preparation from the neonatal rat. Alcohol Clin Exp Res. 2009 Jun;33(6):1069-74. Epub 2009 Mar 23. The coordinated reciprocal motor activity between the C4 ventral root and IIM changed to a largely overlapping pattern when strychnine (5-10 microM), a glycine receptor antagonist, was added to the perfusate. 5. |
31(0,1,1,1) | Details |
| 9658029 | Koch U, Grothe B: GABAergic and glycinergic inhibition sharpens tuning for frequency modulations in the inferior colliculus of the big brown bat. J Neurosci. 1999 Sep 1;19(17):7342-55. We recorded the response of 56 single units in the central nucleus of the IC to SFM stimuli before and during the application of the -A (GABAA) receptor antagonist bicuculline or the glycine receptor antagonist strychnine. |
31(0,1,1,1) | Details |
| 12888218 | Cheng G, Randic M: Involvement of intracellular and protein phosphatases in long-term depression of A-fiber-mediated primary afferent neurotransmission. Neuroscience. 2003;122(3):799-805. LTD of both monosynaptic and polysynaptic EPSPs was induced in 16 of 24 SG neurons by HFS of dorsal root in either the presence or absence of the (A) receptor antagonist bicuculline and the glycine receptor antagonist strychnine. |
31(0,1,1,1) | Details |
| 8774451 | Kotak VC, Sanes DH: Developmental influence of glycinergic transmission: regulation of NMDA receptor-mediated EPSPs. Brain Res Dev Brain Res. 1993 Jun 8;73(2):289-92. Second, continuous release of a glycine receptor antagonist, strychnine (SN), was used to decrease transmission. |
31(0,1,1,1) | Details |
| 11024105 | Narikawa K, Furue H, Kumamoto E, Yoshimura M: In vivo patch-clamp analysis of IPSCs evoked in rat substantia gelatinosa neurons by cutaneous mechanical stimulation. FEBS Lett. 1994 Aug 15;350(1):71-6. The evoked IPSCs were blocked by either a glycine-receptor antagonist, strychnine (4 microM), or a (A)-receptor antagonist, bicuculline (20 microM). |
31(0,1,1,1) | Details |
| 19321642 | Iwamoto Y, Kaneko H, Yoshida K, Shimazu H: Role of glycinergic inhibition in shaping activity of saccadic burst neurons. J Neurophysiol. 1995 Aug;74(2):495-505. To elucidate the role of this inhibition, we studied discharge patterns of horizontal MLBNs following iontophoretic application of strychnine, a glycine-receptor antagonist, in alert cats. |
31(0,1,1,1) | Details |
| 8624016 | Onaka M, Minami T, Nishihara I, Ito S: Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice. Neuroscience. 2000;96(1):33-9. Intrathecal administration of strychnine (strychnine-sensitive glycine receptor antagonist) or bicuculline (GABAA antagonist) was reported to induce allodynia. |
31(0,1,1,1) | Details |
| 8088343 | Wlaz P, Baran H, Loscher W: Effect of the /NMDA receptor partial agonist, D-cycloserine, on seizure threshold and some pharmacodynamic effects of MK-801 in mice. J Neurophysiol. 1996 Nov;76(5):3555-8. Acute treatment of mice with D-cycloserine (a high efficacy, partial agonist at strychnine-insensitive glycine receptors) resulted in dose- and time-dependent increases in the threshold for electrically induced tonic seizures. |
31(0,1,1,1) | Details |
| 16942030 | Gelmi ML, Pocar D, Pontremoli G, Pellegrino S, Bombardelli E, Fontana G, Riva A, Balduini W, Carloni S, Cimino M, Johnson F: 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. The biological activity of the 3-demethoxy-3-glycosylaminothiocolchicines (7) was evaluated on and strychnine-sensitive glycine receptors present in rat brain and spinal cord. |
6(0,0,1,1) | Details |
| 9143005 | Kimura N, Perry SF, Remmers JE: Strychnine eliminates reciprocation and augmentation of respiratory bursts of the in vitro frog brainstem. Neurosci Lett. 1997 Mar 28;225(1):9-12. The nature of neurotransmission responsible for burst reciprocity and augmentation was investigated by applying the glycine receptor blocker, strychnine. |
6(0,0,1,1) | Details |
| 12183767 | Fuzessery ZM, Wenstrup JJ, Hall JC, Leroy S: Inhibition has little effect on response latencies in the inferior colliculus. J Neurosci Res. 1995 Aug 15;41(6):775-81. To test this hypothesis, response latencies were measured in the inferior colliculi of the pallid and mustached bats before and during the blockade of GABAa and glycine receptors. Multibarrel "piggyback" electrodes were used to iontophoretically apply bicuculline and strychnine sequentially while recording from single neurons. |
3(0,0,0,3) | Details |
| 9518706 | Grudt TJ, Henderson G: and GABAA receptor-mediated synaptic transmission in rat substantia gelatinosa: inhibition by mu-opioid and GABAB agonists. Neurochem Res. 1995 Aug;20(8):915-22. Bicuculline-sensitive and strychnine-sensitive inhibitory postsynaptic currents (IPSCs) could be evoked in neurones of the rat substantia gelatinosa of the spinal trigeminal nucleus pars caudalis. 2. The decay of the glycine receptor-mediated mIPSCs was fitted by a single exponential, whereas the decay of the GABAA receptor-mediated mIPSCs could in some instances be fitted by a single exponential, but in other instances required two exponentials. 3. |
3(0,0,0,3) | Details |
| 10537076 | Vafa B, Lewis TM, Cunningham AM, Jacques P, Lynch JW, Schofield PR: Identification of a new ligand binding domain in the alpha1 subunit of the inhibitory glycine receptor. Gen Pharmacol. 1997 Apr;28(4):555-60. |
3(0,0,0,3) | Details |
| 10077667 | Han Y, Wu SM: Modulation of glycine receptors in retinal ganglion cells by zinc. Neuroreport. 2004 Mar 22;15(4):583-7. This biphasic regulatory action of zinc acted selectively on the fast component of the -induced current mediated by the strychnine-sensitive GlyRs, but not on the slow component mediated by the 5,7-dichlorokynurenic acid-sensitive GlyRs. |
2(0,0,0,2) | Details |
| 10218865 | Wlaz P, Ebert U, Loscher W: Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive antagonist CGP 40116 in the amygdala kindling model in rats. Neuroreport. 1998 Aug 24;9(12):2875-9. The discovery that glutamate's activity at the (NMDA) receptor is positively modulated by and polyamines has led to a new pharmacological strategy that NMDA receptor-mediated events could be antagonized indirectly at the strychnine-insensitive co-agonist site (B) receptor) and the polyamine modulatory site. Recently we demonstrated that ifenprodil and L-701,324 (7-chloro-4--3 (3-phenoxy) phenyl-2 (H) quinoline), polyamine and glycine, receptor antagonists, respectively, at subeffective doses markedly increased after-discharge threshold (ADT) when applied together in amygdala-kindled rats. |
2(0,0,0,2) | Details |
| 18303577 | Wu J, Kohno T, Georgiev SK, Ikoma M, Ishii H, Petrenko AB, Baba H: activates and A receptors in rat substantia gelatinosa neurons. Sheng Li Ke Xue Jin Zhan. 1993 Jul;24(3):267-8. We found that seemed to have higher efficacy than on glycine receptors in SG neurons. |
2(0,0,0,2) | Details |
| 17656439 | Mitchell EA, Gentet LJ, Dempster J, Belelli D: GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids. Neuropharmacology. 2004 Dec;47(7):985-93. In this study, we have compared the actions of 5alpha3alpha and minaxolone upon inhibitory transmission mediated by both (A) and strychnine-sensitive GlyRs in lamina II neurones of juvenile (P15-21) rats. |
2(0,0,0,2) | Details |
| 15302677 | Miller PS, Harvey RJ, Smart TG: Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. Eur J Neurosci. 2006 Jun;23(12):3225-9. The sensitivities of the splice variants to the competitive antagonist, strychnine, and to the biphasic modulator Zn (2+), were comparable. |
2(0,0,0,2) | Details |
| 15066993 | Castaldo P, Stefanoni P, Miceli F, Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL, Annunziato L, Taglialatela M: A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Physiol. 2009 Jun 1;587(Pt 11):2499-510. Epub 2009 Apr 9. Gly-gated Cl (-) currents were similarly antagonized by low concentrations of strychnine in both wild-type (wt) and R218Q GlyRA1 channels, suggesting that the Arg-218 residue plays a crucial role in GlyRA1 channel gating, with only minor effects on the agonist/antagonist binding site, a hypothesis supported by our molecular model of the GlyRA1 subunit. |
2(0,0,0,2) | Details |
| 19699270 | Wang H, Brozoski TJ, Turner JG, Ling L, Parrish JL, Hughes LF, Caspary DM: Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus. J Neurosci. 1993 Jul;13(7):2749-57. Consistent with decreased alpha (1) subunit protein levels, strychnine binding studies showed significant tinnitus-related decreases in the number of GlyR binding sites, supporting tinnitus-related changes in the number and/or composition of GlyRs. Message and protein levels of alpha (1-3,) and beta glycine receptor subunits (GlyRs), and the anchoring protein, gephyrin, were measured in DCN fusiform cells 4 months following sound exposure. |
1(0,0,0,1) | Details |
| 10077865 | Zhang H, Xu J, Feng AS: Effects of -mediated inhibition on direction-dependent frequency tuning in the frog inferior colliculus. Life Sci. 1996;59(17):1415-21. We performed single unit recordings and investigated the unit's free-field frequency tuning, and/or the unit's response to the interaural level differences (under dichotic stimulation), before and during local applications of antagonists specific to A and glycine receptors. Application of strychnine produced no change in frequency tuning. |
1(0,0,0,1) | Details |
| 9121816 | Sorkin LS, Puig S: Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Neuroreport. 2002 Sep 16;13(13):1653-6. In this study, we sought to characterize the effect of focal glycine-receptor inhibition on spontaneous and evoked activity in dorsal horn neurons of the chloralose-anesthetized cat. |
1(0,0,0,1) | Details |
| 15730878 | Hinckley C, Seebach B, Ziskind-Conhaim L: Distinct roles of glycinergic and GABAergic inhibition in coordinating locomotor-like rhythms in the neonatal mouse spinal cord. Br J Pharmacol. 1997 Oct;122(3):584-90. Strychnine (0.5 microM), a glycine receptor antagonist, did not change the pattern of spontaneous activity that consisted of random single spikes and discharges of variable durations and intervals. Blocking glycine receptors increased tonic discharges, and in most preparations it reduced the phase correlation between the alternating rhythms. |
1(0,0,0,1) | Details |
| 10465348 | Shuto H, Kataoka Y, Fujisaki K, Nakao T, Sueyasu M, Miura I, Watanabe Y, Fujiwara M, Oishi R: Inhibition of system involved in cyclosporine-induced convulsions. . Clin Exp Pharmacol Physiol. 1994 Jun;21(6):495-9. Cyclosporine (50 mg/kg, i.p.) significantly enhanced the intensity of convulsions induced by bicuculline (GABA receptor antagonist), but not those induced by strychnine (glycine receptor antagonist), quisqualic acid or kainic acid (glutamate receptor agonists). |
0(0,0,0,0) | Details |
| 8867136 | Wu SH, Kelly JB: In vitro brain slice studies of the rat's dorsal nucleus of the lateral lemniscus. Mol Pharmacol. 1993 Jul;44(1):198-203. The IPSPs evoked by stimulation of the lateral lemniscus were blocked by the glycine receptor antagonist strychnine, but not by the GABA receptor antagonist bicuculline, whereas the IPSPs elicited by stimulation of the commissure of Probst were blocked by bicuculline but not strychnine. |
0(0,0,0,0) | Details |
| 8313155 | Gundlach AL, Kortz G, Burazin TC, Madigan J, Higgins RJ: Deficit of inhibitory glycine receptors in spinal cord from Peruvian Pasos: evidence for an equine form of inherited myoclonus. Infect Immun. 2001 Sep;69(9):5883-91. We now report the occurrence of similar stimulus-induced myoclonus in individual, pure-bred Peruvian Paso horses and an associated, specific deficiency in the density of [3H] strychnine binding to inhibitory glycine receptors sites in spinal cord of these animals. |
83(1,1,1,3) | Details |
| 15033889 | Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ: The interaction of anaesthetic steroids with recombinant and GABAA receptors. Neuroscience. 1994 Sep;62(1):205-16. BACKGROUND: Anaesthetic steroids are established positive allosteric modulators of GABAA receptors, but little is known concerning steroid modulation of strychnine-sensitive glycine receptors, the principal mediators of fast, inhibitory neurotransmission in the brain stem and spinal cord. |
82(1,1,1,2) | Details |
| 10896896 | Goodchild AK, Van Deurzen BT, Sun QJ, Chalmers J, Pilowsky PM: Spinal (A) receptors do not mediate the sympathetic baroreceptor reflex in the rat. Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun;138(2):193-202. Spinal (A) receptors were blocked by an intrathecal injection of bicuculline methiodide, whereas glycine receptors were blocked with strychnine. |
82(1,1,1,2) | Details |
| 10440100 | Balduini W, Cimino M, Depoortere H, Cattabeni F: Characterization of [3H] thiocolchicoside binding sites in rat spinal cord and cerebral cortex. Vis Neurosci. 2000 Mar-Apr;17(2):243-54. Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H] ([3H] and [3H] strychnine binding, suggesting an interaction with both and strychnine-sensitive glycine receptors. |
81(1,1,1,1) | Details |
| 10557336 | Palma E, Fucile S, Barabino B, Miledi R, Eusebi F: Strychnine activates neuronal alpha7 nicotinic receptors after mutations in the ring and transmitter binding site domains. J Cereb Blood Flow Metab. 1995 Mar;15(2):188-96. Recent work has shown that strychnine, the potent and selective antagonist of glycine receptors, is also an antagonist of nicotinic (AcCho) receptors including neuronal homomeric alpha7 receptors, and that mutating -247 of the alpha7 nicotinic AcCho receptor-channel domain (L247Talpha7; mut1) converts some nicotinic antagonists into agonists. |
81(1,1,1,1) | Details |
| 11380521 | Patten D, Foxon GR, Martin KF, Halliwell RF: An electrophysiological study of the effects of propofol on native neuronal ligand-gated ion channels. J Neurophysiol. 1998 Nov;80(5):2229-36. To gain some insight into the effects of propofol at a range of native neuronal receptors, the present study has used an extracellular recording technique and determined its effects at (A), 5-HT3, P2X and nicotinic (nACh) receptors of the rat isolated vagus nerve and the (A) and strychnine-sensitive glycine receptor of the rat isolated optic nerve. |
37(0,1,2,2) | Details |
| 7602541 | Paton JF, Richter DW: Role of fast inhibitory synaptic mechanisms in respiratory rhythm generation in the maturing mouse. Eur J Pharmacol. 1998 Aug 7;354(2-3):239-44. On-going inhibitory postsynaptic potentials of neurones located in the ventral respiratory group region of tilted sagittal slices from both immature and mature mice were sensitive to low concentrations of either bicuculline or strychnine (1-5 microM) indicating an absence of a maturational change in the sensitivity of GABAA and glycine receptors to their respective antagonists.(ABSTRACT TRUNCATED AT 250 WORDS) |
37(0,1,2,2) | Details |
| 7500136 | Cowley KC, Schmidt BJ: Effects of inhibitory amino acid antagonists on reciprocal inhibitory interactions during rhythmic motor activity in the in vitro neonatal rat spinal cord. Acta Pharmacol Sin. 2009 Aug;30(8):1107-14. Epub 2009 Jul 20. However, addition of the GABAA receptor antagonist bicuculline, or the glycine receptor antagonist strychnine, transformed alternating flexor-extensor and left-right activity into patterns characterized by bilaterally synchronous rhythmic activation of all hindlimb ENGs. |
32(0,1,1,2) | Details |
| 20018830 | Jiang Z, Shen W: Role of neurotransmitter receptors in mediating light-evoked responses in retinal interplexiform cells. J Neurochem. 1993 Nov;61(5):1692-7. The light-evoked inhibitory postsynaptic currents (L-IPSCs) in IP cells were primarily mediated by strychnine-sensitive glycine receptors with a small component of (C) receptors. |
32(0,1,1,2) | Details |
| 19959465 | Melzer N, Villmann C, Becker K, Harvey K, Harvey RJ, Vogel N, Kluck CJ, Kneussel M, Becker CM: Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3234-8. The strychnine-sensitive glycine receptor (GlyR) is a ligand-gated ion channel that mediates fast synaptic inhibition in the vertebrate central nervous system. |
32(0,1,1,2) | Details |
| 19523966 | Mok MH, Fricker AC, Weil A, Kew JN: Electrophysiological characterisation of the actions of at ligand-gated ion channels. J Neurosci. 2005 Aug 17;25(33):7499-506. KynA inhibited AMPA-evoked currents to a similar degree in cultured hippocampal neurons and a human GluR2 (flip/unedited) cell line (IC (50): 433 and 596 muM, respectively) and at higher concentrations, kynA also inhibited the strychnine-sensitive glycine receptor ( approximately 35% inhibition by 3 mM kynA). |
31(0,1,1,1) | Details |
| 9819238 | Moore DR, Kotak VC, Sanes DH: Commissural and lemniscal synaptic input to the gerbil inferior colliculus. Neurosci Lett. 1999 Jul 9;269(2):75-8. Excitatory and inhibitory synaptic responses were characterized by sequentially exposing the slice to ionotropic glutamate receptor antagonists [6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) + aminophosphonpentanoic acid (AP-5), or a gamma-aminobutryic acid type A receptor antagonist (bicuculline), and a glycine receptor antagonist (strychnine). |
31(0,1,1,1) | Details |
| 7562904 | Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al.: Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido [3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3--5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity. J Physiol. 2009 Aug 15;587(Pt 16):4063-75. Epub 2009 Jun 29. The compounds were tested for their affinity to the AMPA, kainate, and strychnine-insensitive glycine receptor sites. |
31(0,1,1,1) | Details |
| 17122321 | Kulesza RJ Jr, Kadner A, Berrebi AS: Distinct roles for and in shaping the response properties of neurons in the superior paraolivary nucleus of the rat. Biochem Biophys Res Commun. 2003 Jun 27;306(2):376-81. To determine the roles of and in shaping SPON responses, we recorded from single units in the SPON of anesthetized rats before, during, and after application of the glycine receptor antagonist strychnine, the (A) receptor antagonist bicuculline, or both drugs applied simultaneously. |
31(0,1,1,1) | Details |
| 12431848 | Papp M, Gruca P, Willner P: Selective blockade of drug-induced place preference conditioning by ACPC, a functional NDMA-receptor antagonist. Neuropharmacology. 2001 Jun;40(8):1044-9. ACPC (1-aminocyclopropanecarboxylic acid) is a partial agonist at the strychnine-insensitive glycine receptor site on the NMDA receptor complex, and a functional antagonist. |
31(0,1,1,1) | Details |
| 11238050 | Dong Z, Venkatachalam MA, Weinberg JM, Saikumar P, Patel Y: Protection of ATP-depleted cells by impermeant strychnine derivatives: implications for cytoprotection. J Med Chem. 2007 May 3;50(9):2245-8. Epub 2007 Apr 6. The glycine receptor antagonist strychnine shares this protective activity. |
31(0,1,1,1) | Details |
| 8845730 | Heilbronn E, Jarlebark L, Lawoko G: Cholinergic and purinergic signalling in outer hair cells of mammalian cochlea. Eur J Pharmacol. 2006 Jan 13;530(1-2):15-22. Epub 2005 Dec 20. Strychnine, a glycine receptor blocker suggested to interfere with cholinergic sites of the efferent OHC synapse, was found to bind to OHC (cold strychnine for unspecific binding). |
31(0,1,1,1) | Details |
| 11516417 | Su CK: Intraspinal amino acid neurotransmitter activities are involved in the generation of rhythmic sympathetic nerve discharge in newborn rat spinal cord. J Appl Physiol. 2006 Aug;101(2):521-30. Epub 2006 Apr 27. In contrast, strychnine (Stry, glycine receptor antagonist) consistently reduced qSND in a dose-dependent manner. |
31(0,1,1,1) | Details |
| 16951512 | Chen YP, Cao DQ, Tan CH, Xu JM, Chang YT: [Effect of morphine on dorsal horn projection neurons in neuropathic pain rats]. Brain Res. 1995 Feb 6;671(1):63-72. The glycine receptor antagonist strychnine at 4 micromol/L significantly decreased the effect of morphine in nerve-injured, normal, and sham operation rats. |
31(0,1,1,1) | Details |
| 10368424 | Bieda MC, Copenhagen DR: action potentials are not required for light-evoked release of or from retinal amacrine cells. J Neurophysiol. 1999 Jun;81(6):3092-5. To isolate release from GABAergic amacrine cells, we used the glycine receptor blocker strychnine. |
6(0,0,1,1) | Details |
| 16182281 | Jensen AA: Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay. Pharmazie. 1999 Dec;54(12):923-5. |
3(0,0,0,3) | Details |
| 8859906 | Roberts RJ, Shelton CJ, Daniels S, Smith EB: activation of human homomeric alpha 1 glycine receptors is sensitive to pressure in the range of the high pressure nervous syndrome. Neuroscience. 2006;138(1):281-91. Epub 2005 Dec 19. elicited a concentration-dependent inward current which reversed polarity at -25 mV and was antagonised by nanomolar concentrations of strychnine. |
3(0,0,0,3) | Details |
| 7910635 | Wahl P, Elster L, Schousboe A: Identification and function of glycine receptors in cultured cerebellar granule cells. J Pharmacol Exp Ther. 1993 Mar;264(3):1248-52. In contrast, strychnine (20 microM) antagonized the inhibitory effect of (1 mM) but not that of isoguvacine (150 microM). |
3(0,0,0,3) | Details |
| 17646495 | Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM: Anesthetic-like modulation of a type A, strychnine-sensitive and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Mol Pharmacol. 1999 Feb;55(2):386-95. METHODS: We tested this prediction by applying to a NR1/NR2A N-methyl-d-aspartate receptor, to a wild-type alpha (1) beta (2) and anesthetic-resistant alpha (1)(S270I) beta (2) gamma-amino- type A receptor, and to a homomeric alpha (1) wild type and anesthetic-resistant alpha (1) S267I glycine receptor. |
3(0,0,0,3) | Details |
| 7595762 | Saitoh I, Suga N: Long delay lines for ranging are created by inhibition in the inferior colliculus of the mustached bat. Neuroreport. 2008 Feb 12;19(3):333-7. STR (glycine receptor antagonist) and/or BMI -A (GABAA) receptor antagonist] injections into the ALD shortened the best delays of delay-tuned neurons in the FM-FM area with little change in their response patterns. Responses of single delay-tuned neurons in the FM-FM area of the auditory cortex were recorded with a -wire microelectrode, and the effects of iontophoretic microinjections of strychnine (STR) and/or bicuculline methiodide (BMI) into the ALD were examined on the responses of these neurons. 2. |
2(0,0,0,2) | Details |
| 9183739 | Withers MD, St John PA: Embryonic rat spinal cord neurons change expression of glycine receptor subtypes during development in vitro. J Neurophysiol. 2008 Aug;100(2):993-1006. Epub 2008 May 21. However, the extent to which responses to were blocked by the antagonist strychnine differed significantly between the first few days and 8 days in culture. |
2(0,0,0,2) | Details |
| 15745952 | Ster J, Colomer C, Monzo C, Duvoid-Guillou A, Moos F, Alonso G, Hussy N: Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors. J Physiol. 2006 Mar 1;571(Pt 2):391-401. Epub 2006 Jan 5. |
2(0,0,0,2) | Details |
| 15976053 | Chesnoy-Marchais D: The estrogen receptor modulator tamoxifen enhances spontaneous glycinergic synaptic inhibition of hypoglossal motoneurons. J Physiol. 1999 Oct 1;520 Pt 1:121-37. The increase in miniature amplitude is consistent with the increase in postsynaptic glycine receptor sensitivity previously reported. |
2(0,0,0,2) | Details |
| 10963763 | Huang RQ, Dillon GH: Direct inhibition of glycine receptors by a kinase inhibitor. Ann N Y Acad Sci. 1998 Nov 16;860:306-17. Coapplication of with reversibly inhibited the strychnine-sensitive, -activated current recorded from hypothalamic neurons. |
2(0,0,0,2) | Details |
| 15748848 | Grudzinska J, Schemm R, Haeger S, Nicke A, Schmalzing G, Betz H, Laube B: The beta subunit determines the ligand binding properties of synaptic glycine receptors. Basic Clin Pharmacol Toxicol. 2007 Mar;100(3):165-9. |
2(0,0,0,2) | Details |
| 11172926 | Sergeeva OA, Eriksson KS, Haas HL: Glycine receptor mediated responses in rat histaminergic neurons. . Curr Top Med Chem. 2002 Aug;2(8):903-13. We compared strychnine-sensitive -mediated currents with maximal currents activated by 0.5 mM) which were blocked by gabazine. |
1(0,0,0,1) | Details |
| 16503963 | Kusudo K, Ikeda H, Murase K: Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging. Neuroscience. 2009 Dec 1;164(2):747-59. Epub 2009 Aug 20. The inhibition of excitation was unaffected by bicuculline and strychnine, antagonists of (A) and glycine receptors, respectively. The inhibition of excitation was unaffected by bicuculline and strychnine, antagonists of (A) and glycine receptors, respectively. |
1(0,0,0,1) | Details |
| 15490133 | Barth A, Nguyen LB, Barth L, Newell DW: -induced neurotoxicity in organotypic hippocampal slice cultures. J Neurophysiol. 1997 Nov;78(5):2296-308. Purely excitatory glycine receptors composed of NR1 and NR3/NR4 NMDA receptor subunits have recently been described, raising the possibility of excitotoxic effects mediated by alone. Stimulation or inhibition (strychnine) of the inhibitory strychnine-sensitive glycine receptors did not produce any neurotoxicity. |
1(0,0,0,1) | Details |
| 19515958 | Peterson DC, Nataraj K, Wenstrup J: Glycinergic inhibition creates a form of auditory spectral integration in nuclei of the lateral lemniscus. J Neurophysiol. 2008 Aug;100(2):598-608. Epub 2008 Mar 19. To understand the mechanisms underlying this suppression in NLL neurons, we examined the roles of glycinergic and GABAergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (GlyRs), or bicuculline, an antagonist to type A receptors (A) Rs). To understand the mechanisms underlying this suppression in NLL neurons, we examined the roles of glycinergic and GABAergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (GlyRs), or bicuculline, an antagonist to type A receptors (A) Rs). |
1(0,0,0,1) | Details |
| 14658766 | Rotolo TC, Dacheux RF: Two neuropharmacological types of rabbit ON-alpha ganglion cells express GABAC receptors. J Neurophysiol. 2006 Jun;95(6):3438-48. Epub 2006 Mar 22. In conclusion, the presence of different functional and glycine receptors determined physiologically correlated well with the specific and glycine receptor immunolabeling for two neuropharmacological types of rabbit ON-alpha ganglion cells. Both cell types demonstrated strychnine-sensitive -activated currents and bicuculline-sensitive GABAA-activated currents. |
1(0,0,0,1) | Details |
| 10517806 | Ehrlich I, Lohrke S, Friauf E: Shift from depolarizing to hyperpolarizing action in rat auditory neurones is due to age-dependent Cl- regulation. Br J Pharmacol. 1996 Nov;119(5):1013-21. -evoked currents were reversibly blocked by strychnine. This indicates that Cl- is the principle ion permeating glycine receptors, but is also consistent with a low relative (10-20 %) permeability for HCO3-. |
1(0,0,0,1) | Details |
| 18417693 | Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB: Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight. Eur J Pharmacol. 2009 Jun 24;613(1-3):68-73. Epub 2009 Apr 24. Furthermore, the CNQX/d-AP-5-resistant response was blocked by l-AP-4, meclofenamic acid, quinine, or strychnine but not by bicuculline. |
0(0,0,0,0) | Details |
| 10670445 | Ishikawa T, Marsala M, Sakabe T, Yaksh TL: Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal or (A) receptor antagonist. J Neurosci. 2001 Sep 15;21(18):7110-6. Intrathecal strychnine antagonist) or bicuculline (A) antagonist) yields a touch-evoked agitation that is blocked by N-methyl-D-aspartate receptor antagonism. |
0(0,0,0,0) | Details |
| 12144849 | Chitravanshi VC, Sapru HN: Microinjections of into the pre-Botzinger complex inhibit phrenic nerve activity in the rat. J Neurophysiol. 2003 Mar;89(3):1339-42. Epub 2002 Nov 6. The specificity of strychnine as an antagonist for glycine receptors was established by its lack effect on (A) receptors; muscimol was used as a (A) receptor agonist. |
82(1,1,1,2) | Details |
| 18053729 | Maksay G, Nemes P, Vincze Z, Biro T: Synthesis of (nor) tropeine (di) esters and allosteric modulation of glycine receptor binding. J Neurochem. 1999 Nov;73(5):2158-66. Modulation of [3H] strychnine binding to glycine receptors of rat spinal cord was examined with a ternary allosteric model. |
82(1,1,1,2) | Details |
| 10675640 | Devau G: induced concentration changes in vestibular type I sensory cells. Neuroscience. 2004;128(3):617-34. may also activate the strychnine-sensitive glycine receptor-gated channel. |
82(1,1,1,2) | Details |
| 9661296 | Fatima-Shad K, Barry PH: Morphological and electrical characteristics of postnatal hippocampal neurons in culture: the presence of bicuculline- and strychnine-sensitive IPSPs. Brain Res. 2007 Mar 2;1135(1):102-6. Epub 2007 Jan 2. The coincident reversal potentials for IPSCs and for GABAA and -evoked currents, and the sensitivity of the IPSCs to bicuculline or strychnine, indicated that these IPSCs were Cl-(-) dependent and mediated by either GABAA or glycine receptors. |
81(1,1,1,1) | Details |
| 7477420 | Dar DE, Zinder O: Strychnine affects catecholamine secretion from bovine adrenal medulla chromaffin cells. table of contents. Strychnine might be acting on a regulatory site of the nicotinic-cholinergic receptor, which is genetically similar to the strychnine-binding 48 KD subunit of the glycine receptor. |
81(1,1,1,1) | Details |
| 9157329 | Sato K, Momose-Sato Y, Hirota A, Sakai T, Kamino K: Optical studies of the biphasic modulatory effects of on excitatory postsynaptic potentials in the chick brainstem and their embryogenesis. Br J Pharmacol. 1997 Feb;120(4):690-4. The enhancing effect was insensitive to strychnine, but the reducing effect was blocked by strychnine, suggesting that the former effect was induced by which increased binding to N-methyl-D-aspartate receptors, and the latter resulted from an increase in conductance through the strychnine-sensitive inhibitory glycine receptors in postsynaptic neurons. |
81(1,1,1,1) | Details |
| 8714523 | Puebla L, Arilla E: increases the number of somatostatin receptors and somatostatin-mediated inhibition of the adenylate cyclase system in the rat hippocampus. Brain Res. 2007 Sep 7;1168:32-7. Epub 2007 Jul 27. This effect seems to be mediated by inhibitory strychnine-sensitive glycine receptors since pretreatment with the antagonist strychnine (80 micrograms/100 g body weight, intravenously) abolished this response. |
37(0,1,2,2) | Details |
| 12937280 | Morrison JL, Sood S, Liu H, Park E, Liu X, Nolan P, Horner RL: Role of inhibitory amino acids in control of hypoglossal motor outflow to genioglossus muscle in naturally sleeping rats. Chembiochem. 2002 Nov 4;3(11):1042-52. Microdialysis probes were implanted into the hypoglossal motor nucleus for perfusion of artificial cerebrospinal fluid (ACSF) and strychnine (glycine receptor antagonist, 0.1 mM) either alone or combined with bicuculline (GABAA antagonist, 0.1 mM) during room air and CO2-stimulated breathing. |
32(0,1,1,2) | Details |
| 8930324 | Peng YB, Lin Q, Willis WD: Effects of and glycine receptor antagonists on the activity and PAG-induced inhibition of rat dorsal horn neurons. Jpn J Physiol. 1995;45(5):849-67. The GABAA receptor antagonist, bicuculline, was tested on 19 cells, whereas the glycine receptor antagonist, strychnine, was tested on 17 cells. |
32(0,1,1,2) | Details |
| 7475222 | Ueno S, Nabekura J, Ishibashi H, Akaike N, Mori T, Shiga M: Photolysis of a newly synthesized caged activates the glycine receptor of rat CNS neurons. J Neurophysiol. 1995 Jul;74(1):1-11. The functions of 12 different newly synthesized caged glycines were examined on strychnine-sensitive glycine receptors on rat hypothalamic neurons using photochemical and physiological methods. |
32(0,1,1,2) | Details |
| 15045581 | Scappaticci AA, Jacques R, Carroll JE, Hufnagel LA, Kass-Simon G: Immunocytochemical evidence for an NMDA1 receptor subunit in dissociated cells of Hydra vulgaris. Br J Pharmacol. 1998 Sep;125(2):263-70. They support other behavioral and biochemical evidence for a -sensitive, strychnine-insensitive, glycine receptor in hydra and suggest that the glutamatergic AMPA/kainate- system is an early evolved, phylogenetically old, behavioral control mechanism. |
31(0,1,1,1) | Details |
| 9915325 | Hall SR, Milne B, Loomis C: Spinal action of ketorolac, S (+)- and R (-)- on non-noxious activation of the oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia. Cell Tissue Res. 2004 May;316(2):263-70. Epub 2004 Mar 25. BACKGROUND: Blockade of spinal glycine receptors with intrathecal strychnine produces an allodynia-like state in the anesthetized rat. |
31(0,1,1,1) | Details |
| 8951717 | Nishimaru H, Iizuka M, Ozaki S, Kudo N: Spontaneous motoneuronal activity mediated by and in the spinal cord of rat fetuses in vitro. J Biol Chem. 2005 Nov 11;280(45):37877-84. Epub 2005 Sep 6. The glycine receptor antagonist strychnine (10 microM) completely blocked spontaneous bursts at E14.5-15.5. |
31(0,1,1,1) | Details |
| 8242398 | Layer RT, Bland LR, Skolnick P: MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity. Neuropsychopharmacology. 2002 Nov;27(5):727-43. The objectives of the present study were to examine whether comparable reductions in METH-induced damage could be obtained by compounds acting at strychnine-insensitive glycine receptors on the NMDA receptor complex. |
31(0,1,1,1) | Details |
| 8334524 | Kubin L, Kimura H, Tojima H, Davies RO, Pack AI: Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition. Nutr Cancer. 2001;40(2):197-204. The inhibitory amino acid receptor antagonists, strychnine (glycine receptors) or bicuculline (GABAA receptors), were injected (100-250 nl; 1.0-2.5 mM) into one XII nucleus (the other served as control) in an attempt to reduce or abolish the depression subsequently induced by pontine carbachol. |
31(0,1,1,1) | Details |
| 17522127 | Johnson SM, Wiegel LM, Majewski DJ: Are pacemaker properties required for respiratory rhythm generation in adult turtle brain stems in vitro?. J Exp Biol. 2007 Sep;210(Pt 17):3015-26. During synaptic inhibition blockade with bicuculline (50 microM; (A) channel blocker) and strychnine (50 muM; glycine receptor blocker), rhythmic motor activity persisted, and burst frequency was directly correlated with extracellular KCl (0.5-10.0 mM; P = 0.005). |
31(0,1,1,1) | Details |
| 7730987 | Yoshimura M, Nishi S: Primary afferent-evoked - and -mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro. J Cell Biol. 2006 Jan 30;172(3):441-51. The short IPSP was reversibly blocked by the glycine receptor antagonist strychnine (0.5-2 microM), while the long IPSP was reversibly blocked by the GABAA receptor antagonist bicuculline (10-20 microM). 3. |
31(0,1,1,1) | Details |
| 16467527 | Kato G, Yasaka T, Katafuchi T, Furue H, Mizuno M, Iwamoto Y, Yoshimura M: Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. Brain Res. 2001 Jun 15;904(1):112-25. Serotonin receptor antagonists were unexpectedly without effect, but a GABAA receptor antagonist, bicuculline, or a glycine receptor antagonist, strychnine, completely suppressed the RVM stimulation-induced increase in IPSCs. |
31(0,1,1,1) | Details |
| 9300767 | Willott JF, Milbrandt JC, Bross LS, Caspary DM: immunoreactivity and receptor binding in the cochlear nucleus of C57BL/6J and CBA/CaJ mice: effects of cochlear impairment and aging. Neurosci Lett. 2001 Jul 6;307(1):1-4. The number (Bmax) of strychnine-sensitive glycine receptors (GlyR) decreased significantly in the dorsal CN of old C57 mice. |
6(0,0,1,1) | Details |
| 9421890 | Harsch A, Ziegler C, Gopel W: Strychnine analysis with neuronal networks in vitro: extracellular array recording of network responses. Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R320-31. This paper reports on substance-dependent major changes in spontaneous native activity patterns by the synaptically active (glycine receptor blocker) strychnine. |
6(0,0,1,1) | Details |