| Name | KCC2 |
|---|---|
| Synonyms | Electroneural potassium chloride cotransporter 2; Electroneutral potassium chloride cotransporter 2; Erythroid K Cl cotransporter 2; KCC 2; KCC2; Neuronal K Cl cotransporter; SLC12A5; Solute carrier family 12 member 5… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12401451 | Meier J, Juttner R, Kirischuk S, Grantyn R: Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity. Mol Cell Neurosci. 2002 Oct;21(2):324-40. Two distinct stages of inhibitory synaptogenesis in cultured collicular neurons were defined on the basis of strychnine sensitivity of IPSCs, presence of EPSCs, KCC2 expression, and transmitter-induced Ca (2+) responses. |
32(0,1,1,2) | Details |
| 16905250 | Wang W, Xu TL: homeostasis differentially affects (A) receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture. Neurosci Lett. 2006 Oct 2;406(1-2):11-6. Epub 2006 Aug 14. The potassium-chloride cotransporter 2 (KCC2)-dependent intracellular level determines whether neurons respond to and/or by depolarization or hyperpolarization. Moreover, inhibition of KCC2 did not change the depressive effect of strychnine on neuronal circuits. |
4(0,0,0,4) | Details |
| 14741396 | Shibata S, Kakazu Y, Okabe A, Fukuda A, Nabekura J: Experience-dependent changes in intracellular Cl- regulation in developing auditory neurons. Neurosci Res. 2004 Feb;48(2):211-20. Implanted strychnine pellets also prevented the decrease in [Cl-](i) in most neurons. In some of these neurons in which [Cl-](i) remained high, there was a lack of expression of the K+-Cl- cotransporter 2 (KCC2) mRNA. |
1(0,0,0,1) | Details |