| 11740501 |
Ahmadi S, Lippross S, Neuhuber WL, Zeilhofer HU: PGE (2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci. 2002 Jan;5(1):34-40.
We identified the inhibitory (strychnine-sensitive) glycine receptor as a specific target of PGE (2).
Inhibition of glycine receptors occurred via a postsynaptic mechanism involving the activation of EP2 receptors, cholera-toxin-sensitive G-proteins and cAMP-dependent protein kinase. |
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