| Name | Substance P |
|---|---|
| Synonyms | Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17207575 | Parker D, Gilbey T: Developmental differences in neuromodulation and synaptic properties in the lamprey spinal cord. Neuroscience. 2007 Mar 2;145(1):142-52. Epub 2007 Jan 3. This increase in inhibition contributed to the reduced effects of substance P in larvae, as premigratory adult-like modulation could be evoked when inhibition was blocked with strychnine. |
35(0,1,1,5) | Details |
| 11498962 | Wang DS, Xu TL, Li JS: Modulation of -activated currents by substance P in rat sacral dorsal commissural neurons. Sheng Li Xue Bao. 1999 Aug;51(4):361-70. The modulatory effect of substance P (SP) on strychnine-sensitive (Gly) response was examined in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using nystatin perforated patch recording configuration under voltage-clamp conditions. |
7(0,0,1,2) | Details |
| 11784734 | Svensson E, Grillner S, Parker D: Synaptically evoked membrane potential oscillations induced by substance P in lamprey motor neurons. J Neurophysiol. 2002 Jan;87(1):113-21. Blocking glycinergic inputs with strychnine resulted in large depolarizing plateaus and bursts of spikes. |
7(0,0,0,7) | Details |
| 9742176 | Parker D, Grillner S: Cellular and synaptic modulation underlying substance P-mediated plasticity of the lamprey locomotor network. J Neurosci. 1998 Oct 1;18(19):8095-110. |
6(0,0,0,6) | Details |
| 16467532 | Torsney C, MacDermott AB: Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J Neurosci. 2006 Feb 8;26(6):1833-43. Lamina I and III neurokinin 1 (NK1) receptor expressing (NK1R+) dorsal horn neurons, many of which are projection neurons, are required for the development of this hypersensitivity and are therefore likely to be a component of this proposed pathway. Blockade of local GABAergic and glycinergic inhibition with bicuculline (10 microm) and strychnine (300 nm), respectively, revealed significant A fiber input to lamina I NK1R+ neurons that was predominantly Abeta fiber mediated. |
1(0,0,0,1) | Details |
| 8867247 | Nagy I, Woolf CJ: Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics. Pain. 1996 Jan;64(1):59-70. The amplitude of the cumulative VRP generated by repetitive inputs (1 and 10 Hz) was also significantly reduced as was the depolarization produced by bath application of (100 microM) or substance P (SP, 1 microM) in the presence or absence of tetrodotoxin (TTX) (300 nM). Application of the opiate, GABAA and GABAB receptor antagonists, naloxone (1 microM), strychnine (100 microM), bicuculline (100 microM) and phaclofen (100 microM) did not alter the depressant effects of lignocaine on the VRP. |
1(0,0,0,1) | Details |
| 7684071 | Calligaro DO, O'Malley PJ, Monn JA: beta-Amyloid (25-35) or substance P stimulates [3H] MK-801 binding to rat cortical membranes in the presence of and J Neurochem. 1993 Jun;60(6):2297-303. The compounds do not appear to act through the strychnine-insensitive binding site because neither beta-amyloid (25-35) nor substance P displaced [3H] binding. |
2(0,0,0,2) | Details |
| 9080374 | Russo RE, Nagy F, Hounsgaard J: Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord. J Physiol. 1997 Mar 1;499 ( Pt 2):459-74. Application of a supposed neuromodulator, substance P (1-2 microM) produced a transient depolarization (4 +/- 0.6 mV) lasting 4-6 min during continued application of substance P. The tetanic stimulus facilitated wind-up and after-discharges even when fast synaptic transmission was blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10-20 microM), (+/-)-2-amino-5-phosphonopentanoic acid (AP5, 100 microM), bicuculline (10-20 microM) and strychnine (5-20 microM). 2. |
2(0,0,0,2) | Details |
| 17418495 | Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K: Respiratory activity in brainstem of fetal mice lacking decarboxylase 65/67 and vesicular GABA transporter. Neuroscience. 2007 May 25;146(3):1044-52. Epub 2007 Apr 5. Strychnine reversed inspiratory-phase hyperpolarization to large depolarization in expiratory neurons. Substance P induced hyperpolarizing potentials in medullary neurons of GAD65-/-:67-/- mice. |
1(0,0,0,1) | Details |
| 11069593 | Zaninetti M, Raggenbass M: Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. Eur J Neurosci. 2000 Nov;12(11):3975-84. Their sensitivity to TGOT was compared to that of substance P (SP). These peptide-enhanced IPSCs were blocked by bicuculline, but not by strychnine, and reversed near 0 mV, indicating that they were mediated by A receptors. |
1(0,0,0,1) | Details |
| 16510772 | Sebe JY, van Brederode JF, Berger AJ: Inhibitory synaptic transmission governs inspiratory motoneuron synchronization. J Neurophysiol. 2006 Jul;96(1):391-403. Epub 2006 Mar 1. To test whether elevating slice excitability is sufficient to reduce oscillation power, Substance P was bath applied alone. |
1(0,0,0,1) | Details |
| 8728864 | Perry SF, McLean HA, Kogo N, Kimura N, Kawasaki H, Sakurai M, Kabotyanski EA, Remmers JE: The frog brainstem preparation as a model for studying the central control of breathing in tetrapods. Braz J Med Biol Res. 1995 Nov-Dec;28(11-12):1339-46. RESPONSE TO SUBSTANCE P AND PHYSALAEMIN: Similar to but the frequency of fictive inspirations decreases below control values. RESPONSE TO STRYCHNINE: The normal temporal sequence in firing of motor neurons of cranial nerves is disrupted and all nerves are synchronously active. |
1(0,0,0,1) | Details |
| 7687278 | St John PA, Stephens SL: Adult-type glycine receptors form clusters on embryonic rat spinal cord neurons developing in vitro. J Neurosci. 1993 Jul;13(7):2749-57. The time course of development and the cellular and subcellular distributions of adult-type, strychnine-binding glycine receptors (GlyRs) were examined on rat spinal cord neurons in vitro using both the GlyR antagonist strychnine and a specific antibody against the receptor. This contrasted with the observation that these neurons began to express receptors for substance P within 24 hr in culture. |
1(0,0,0,1) | Details |
| 8867090 | Cammack C, Logan SD: Excitation of rat sympathetic preganglionic neurones by selective activation of the NK1 receptor. J Auton Nerv Syst. 1996 Feb 5;57(1-2):87-92. Perfusion of substance P (SP; 0.1-10 microM) depolarised 7 out of 15 neurones tested and the selective NK1 receptor agonist GR73632 (0.075-5 microM) depolarised 14 out of 24 neurones. In 3 neurones, GR73632 evoked both a depolarising response and inhibitory postsynaptic potentials (IPSPs) and in the one neurone tested, the IPSPs were blocked by strychnine (20 microM), suggesting that NK1 receptors may also be found upon inhibitory glycinergic interneurones. |
1(0,0,0,1) | Details |
| 16360285 | Otsuguro K, Ohta T, Ito S: modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro. Neuroscience. 2006;138(1):281-91. Epub 2005 Dec 19. Unlike Zn (2+), strychnine (5 microM), a glycine receptor antagonist, and (S),9 (R)-(-)-bicuculline methobromide (10 microM), a (A) receptor antagonist, potentiated both fast polysynaptic reflex potential and slow ventral root potential. |
0(0,0,0,0) | Details |
| 19244526 | Miraucourt LS, Moisset X, Dallel R, Voisin DL: inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. J Neurosci. 2009 Feb 25;29(8):2519-27. First, we showed that disinhibition with strychnine selectively induced dynamic but not static mechanical allodynia. |
0(0,0,0,0) | Details |