Protein Information

Name c fos
Synonyms Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
9243614 Sakai N, Yamamoto T: Conditioned taste aversion and c-fos expression in the rat brainstem after administration of various USs. Neuroreport. 1997 Jul 7;8(9-10):2215-20.

4(0,0,0,4) Details
10686090 Vergnes M, Boehrer A, Reibel S, Simler S, Marescaux C: Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA (A) receptor in rats with genetic absence epilepsy. Exp Neurol. 2000 Feb;161(2):714-23.

The susceptibility to convulsions induced by threshold doses of various GABA receptor antagonists and inhibitors of GABA synthesis, kainic acid and strychnine, was compared in GAERS and in nonepileptic rats from a selected control strain (NE).
The brain structures involved in the drug-elicited convulsive seizures were mapped by c-Fos immunohistochemistry.
2(0,0,0,2) Details
10408246 Le Guen S, Catheline G, Besson JM: Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat. Eur J Pharmacol. 1999 May 28;373(1):1-11.

Administration of an antagonist at the strychnine-insensitive glycine site of the NMDA receptor ((+)-HA-966: R (+)-3-Amino-1-hydroxypyrrolidin-2-one) did not affect the development of morphine tolerance.
2(0,0,0,2) Details
12930797 Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, Figueroa DJ, Wittmann M, Lemaire W, Conn PJ: The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl] sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci. 2003 Aug 20;23(20):7586-91.

Glycine acts as a necessary coagonist for glutamate at the NMDA receptor (NMDAR) complex by binding to the strychnine-insensitive glycine-B binding site on the NR1 subunit.
Furthermore, (+)-NFPS induced a pattern of c-Fos immunoreactivity comparable with the atypical antipsychotic clozapine and enhanced prepulse inhibition of the acoustic startle response in DBA/2J mice, a strain with low basal levels of prepulse inhibition.
1(0,0,0,1) Details