Protein Information

Name P5 6
Synonyms HCP5P6; HLA complex P5 pseudogene 6; P5 06; P5 6; P5.4; bPG8G10.1; HLA complex P5 pseudogene 6s; bPG8G10.1s

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
12888217 Kawa K: Glycine facilitates transmitter release at developing synapses: a patch clamp study from Purkinje neurons of the newborn rat. Brain Res Dev Brain Res. 2003 Aug 12;144(1):57-71.

The effects of glycine showed maximum at P5-6 for EPSCs and at P9-10 for IPSCs and decreased thereafter.
Facilitatory effects of glycine were suppressed by strychnine (1 micro M), a specific blocker of the ionotropic glycine receptor, while the effects were also induced by other glycinergic agonists, including alpha-L-alanine (1 mM), L-serine (1 mM) and taurine (500 micro M).
1(0,0,0,1) Details
11067975 Nunez-Abades PA, Pattillo JM, Hodgson TM, Cameron WE: Role of synaptic inputs in determining input resistance of developing brain stem motoneurons. J Neurophysiol. 2000 Nov;84(5):2317-29.

Comparing across age groups, there was a significantly larger percent change in R (n) with the addition of high Mg (2+) at postnatal days 13 to 15 (P13-15; 36%) than that found at P5-6 (21%).
Spontaneous postsynaptic potentials were sensitive to the combined application of glycine receptor antagonist, strychnine, and the GABA (A) receptor antagonist, bicuculline.
1(0,0,0,1) Details