| Name | alkaline phosphatase |
|---|---|
| Synonyms | ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11449466 | Janbaz KH, Gilani AH: Studies on preventive and curative effects of on chemical-induced hepatotoxicity in rodents. Fitoterapia. 2000 Feb;71(1):25-33. Pretreatment of animals with (4 mg/kg; orally twice daily for 2 days) prevented the - or CCl4-induced rise in serum levels of alkaline phosphatase (ALP) and aminotransaminases (AST and ALT), suggestive of hepatoprotection. Pretreatment of animals with a single oral dose of (4 mg/kg) induced prolongation of the pentobarbital (60 mg/kg, i.p.)-induced sleeping time as well as increased strychnine (0.3 mg/kg; i.p.)-induced toxicity, suggestive of inhibitory effect on microsomal drug metabolizing enzymes, cytochrome P450s (CYPs). |
1(0,0,0,1) | Details |
| 9182798 | Gustincich S, Feigenspan A, Wu DK, Koopman LJ, Raviola E: Control of release in the retina: a transgenic approach to neural networks. Neuron. 1997 May;18(5):723-36. Dopaminergic, interplexiform amacrines (DA cells) were labeled in transgenic mice with human placental alkaline phosphatase, an enzyme that resides on the outer surface of the cell membrane. |
1(0,0,0,1) | Details |
| 18989868 | Nogueira CW, Borges LP, Souza AC: Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats. J Appl Toxicol. 2009 Mar;29(2):156-64. Pre-treatment with a single dose of (PhSe) 2 prevented the effect of strychnine, a substrate for CYPs, abolishing lethality in mice. The liver and kidney were utilized for determination of histopathology, biochemical (ALT) and alanine (AST) aminotransferases, alkaline phosphatase (ALP), total bilirrubin (TB) and gamaglutamyl transferase (GGT)] and toxicological parameters [thiobarbituric reactive species (TBARS) levels, catalase activity, nonprotein thiols (NPSH) and aminolevulinate dehydratase (-ALA-D) activity]. |
1(0,0,0,1) | Details |
| 8909978 | Gilani AH, Janbaz KH, Akhtar MS: Selective protective effect of an extract from Fumaria parviflora on -induced hepatotoxicity. Gen Pharmacol. 1996 Sep;27(6):979-83. Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4. The plant extract (500 mg/kg; orally) caused significant prolongation in pentobarbital (75 mg/ kg)-induced sleep as well as increased strychnine-induced lethality in mice (P < 0.05), suggestive of an inhibitory effect on microsomal drug metabolizing enzymes (MDME). 6. |
1(0,0,0,1) | Details |
| 10478828 | Janbaz KH, Gilani AH: Potentiation of and carbon tetrachloride-induced hepatotoxicity in rodents by the food additive vanillin. Food Chem Toxicol. 1999 Jun;37(6):603-7. When tested for its possible interaction with pentobarbital (75 mg/kg, i.p.) and strychnine (0.9 mg/kg, i.p.), it caused reduction in pentobarbital-induced sleep in mice as well as preventing the animals against the lethal effect of strychnine, suggestive of an induction of microsomal drug metabolizing enzymes. |
0(0,0,0,0) | Details |