| Name | alpha 2 adrenergic |
|---|---|
| Synonyms | Alpha 2A Adrenoceptor; ZNF32; ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; Alpha 2A adrenergic receptor… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14645455 | Han Y, Li P, Slaughter MM: Selective antagonism of rat inhibitory glycine receptor subunits. J Physiol. 2004 Feb 1;554(Pt 3):649-58. Epub 2003 Nov 28. In conclusion, the comparative effectiveness of strychnine and DCKA can be used to distinguish between the alpha1, alpha2 and alpha2* receptor responses. |
6(0,0,1,1) | Details |
| 17110030 | Han SK, Park JR, Park SA, Chun SW, Lee JC, Lee SY, Ryu PD, Park SJ: inhibits substantia gelatinosa neurons in mice trigeminal subnucleus caudalis via alpha (2) and beta adrenoceptors. Neurosci Lett. 2007 Jan 10;411(2):92-7. Epub 2006 Nov 15. The majority (60/71, 85%) of neurons tested were hyperpolarized by NA application, and these hyperpolarizing effects were mimicked both by the alpha (2) adrenergic agonist, clonidine (18/28, 64%) and the beta adrenergic agonist, isoproterenol (9/24, 38%). NA-induced hyperpolarizing effects were maintained in the presence of tetrodotoxin (TTX), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), d,l-2-amino-5-phosphonopentanoic acid (AP5), picrotoxin and strychnine, a Na (+) channel, ionotropic glutamate receptor, (A) and glycine receptor antagonists, respectively, indicating that the effects of NA are direct on the postsynaptic SG neurons. |
2(0,0,0,2) | Details |
| 10065998 | Wick MJ, Bleck V, Whatley VJ, Brozowski SJ, Nixon K, Cardoso RA, Valenzuela CF: Stable expression of human alpha1 and alpha2 homomeric receptors in mouse L (tk-) cells. J Neurosci Methods. 1999 Feb 1;87(1):97-103. Patch-clamp electrophysiological recordings revealed that the alpha1 or alpha2 glycine receptor subunits expressed in these cells form functional glycine receptors that are inhibited by strychnine and picrotoxin. In order to measure expression of the alpha1 or alpha2 receptor protein, we produced a new anti-alpha1/alpha2 glycine receptor antibody (anti-alpha GR). |
2(0,0,0,2) | Details |
| 11929913 | Pan YZ, Li DP, Pan HL: Inhibition of glutamatergic synaptic input to spinal lamina II (o) neurons by presynaptic alpha (2)-adrenergic receptors. J Neurophysiol. 2002 Apr;87(4):1938-47. Activation of spinal alpha (2)-adrenergic receptors by the descending noradrenergic system and alpha (2)-adrenergic agonists produces analgesia. The miniature excitatory postsynaptic currents (mEPSCs) were recorded in the presence of tetrodotoxin, bicuculline, and strychnine. |
2(0,0,0,2) | Details |
| 8594938 | Li YW, Bayliss DA, Guyenet PG: C1 neurons of neonatal rats: intrinsic beating properties and alpha 2-adrenergic receptors. Am J Physiol. 1995 Dec;269(6 Pt 2):R1356-69. The present study seeks to describe some of the intrinsic properties of bulbospinal C1 cells and to establish whether they have alpha 2-adrenergic inhibitory "autoreceptors." RVL bulbospinal cells (retrogradely labeled with microbeads) were recorded in thin slices from 3- to 7-day-old rats with patch electrodes containing Lucifer yellow. Blockade of fast postsynaptic potentials with plus bicuculline plus strychnine or with a low-Ca (2+)-high-Mg2+ medium failed to reduce their firing rate. |
2(0,0,0,2) | Details |
| 11849303 | Merrywest SD, Fischer H, Sillar KT: Alpha-adrenoreceptor activation modulates swimming via glycinergic and GABAergic inhibitory pathways in Xenopus laevis tadpoles. Eur J Neurosci. 2002 Jan;15(2):375-83. Both alpha1- and alpha2-receptor activation influences the GABAergic pathway controlling the duration of swimming episodes and is involved in the glycinergic modulation of the swimming rhythm and its longitudinal co-ordination, with alpha2-receptors additionally affecting swimming frequency through GABAergic pathways. We show that NA could still modulate aspects of swimming after blocking either or (A) receptors with strychnine and bicuculline, respectively. |
1(0,0,0,1) | Details |
| 8816361 | del Carmen Garcia M, Enero MA, Celuch SM: Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats. J Auton Nerv Syst. 1996 Jun 10;59(1-2):17-26. The glycine-receptor antagonist strychnine (25 micrograms, i.t.) did not modify the hypotension induced by either (in the presence of prazosin) or The hypotensive responses induced by low doses of i.t. injected catecholamines seem to involve the activation of spinal alpha 2A-adrenoceptors and the stimulation of an inhibitory GABAergic neuron in the spinal cord. |
1(0,0,0,1) | Details |
| 7916452 | Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O: Allodynia evoked by intrathecal administration of to conscious mice. Pain. 1994 May;57(2):217-23. Intrathecally administered strychnine and the GABAA antagonist bicuculline also induced allodynia in conscious mice. |
0(0,0,0,0) | Details |