Protein Information

Name yl 1
Synonyms Protein YL 1; Swc2; TCFL 1; TCFL1; Transcription factor like 1; Transformation suppressor gene YL 1; VPS72; Vacuolar protein sorting associated protein 72 homolog…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
8739842 Tutka P, Turski WA, Kleinrok Z, Czuczwar SJ: Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice. J Neural Transm. 1996;103(3):307-14.

Aminophylline reversed the protective action of both, D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid (D-CPP-ene-a competitive NMDA antagonist) and valproate (used as a conventional antiepileptic drug for comparative purposes) against maximal electroshock-induced seizures.
1(0,0,0,1) Details
7865177 Carlsson ML, Engberg G, Carlsson A: Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDA antagonists and clonidine in monoamine-depleted mice. J Neural Transm Gen Sect. 1994;95(3):223-33.


In this paper we report on how the partial glycine agonists D-cycloserine (high intrinsic activity) and (+)-HA-966 [(+)-3-amino-1-hydroxypyrrolid-2-one; low intrinsic activity] affect this response; the interaction with both an uncompetitive and a competitive NMDA antagonist was investigated. (+)-HA-966 was found to counteract the locomotor stimulation produced by clonidine combined with either an uncompetitive (MK-801 = dizocilpine) or a competitive [D-CPPene = 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid] NMDA antagonist.
1(0,0,0,1) Details