Protein Information

Name vanilloid receptor 1
Synonyms Capsaicin receptor; OTRPC 1; Osm 9 like TRP channel 1; TRP vanilloid 1; TRPV 1; TRPV1; Transient receptor potential cation channel subfamily V member 1…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
16107637 Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, Burnashev N: Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids. J Neurosci. 2005 Aug 17;25(33):7499-506.

These effects of cannabinoids were observed in the presence of cannabinoid CB1/CB3, vanilloid receptor 1 antagonists, and the G-protein inhibitor GDPbetaS, suggesting a direct action of cannabinoids on GlyRs.
We also demonstrate that, in the presence of a GABA (A) receptor antagonist, GlyRs may contribute to the generation of seizure-like activity induced by short bursts (seven stimuli) of high-frequency stimulation of inputs to hippocampal CA1 region, because this activity was diminished by selective GlyR antagonists (strychnine and ginkgolides B and J).
1(0,0,0,1) Details
19348729 Han SK, Park SA, Jeon JG, Chang KW, Ahn DK, Oh SB, Park SJ: Functional type I vanilloid receptor expression by substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice. Neurosci Lett. 2009 Mar 20;452(3):228-31. Epub 2009 Jan 29.

The aim of this study was to investigate the existence of functional TRPV1 receptor by substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc), which is implicated in the processing of nociceptive information from orofacial regions.
Capsaicin-induced depolarization was maintained in 20 out of 32 (63%) SG neurons in the presence of amino acid and voltage-dependent sodium channel blockers (10 microM CNQX, 20 microM AP-5, 0.5 microM TTX, 50 microM picrotoxin and 2 microM strychnine).
4(0,0,0,4) Details
16503963 Kusudo K, Ikeda H, Murase K: Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging. Mol Pain. 2006 Feb 17;2:8.

The inhibition of excitation was unaffected by bicuculline and strychnine, antagonists of GABA (A) and glycine receptors, respectively.
4(0,0,0,4) Details