| 18930740 |
Gupta R, Deshpande SB: 3-Nitropropionic acid depresses spinal reflexes involving GABAergic and glycinergic transmission in neonatal rat spinal cord in vitro. Life Sci. 2008 Nov 21;83(21-22):756-60. Epub 2008 Oct 5.
AIMS: 3-Nitropropionic acid (3-NPA) is a naturally occurring fungal toxin that leads to ATP-depletion by inhibiting mitochondrial succinate dehydrogenase and produces chemical anoxia.
Superfusion of bicuculline (GABAA receptor antagonist; 1 microM), or strychnine (glycineA receptor antagonist; 1 microM) antagonized the 3-NPA-induced depression of reflexes significantly. |
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