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Melendrez CS, Meizel S: Studies of porcine and human sperm suggesting a role for a sperm glycine receptor/Cl- channel in the zona pellucida-initiated acrosome reaction. Biol Reprod. 1995 Sep;53(3):676-83.
Recent evidence indicates the involvement of a unique progesterone receptor resembling a GABAA receptor/Cl- channel in the latter event.
We then employed 1) strychnine, an antagonist of neuronal glycine receptor/Cl- channels at nanomolar concentrations and of GABAA receptor/Cl- channels at micromolar concentrations and 2) (+)-bicuculline, an antagonist of neuronal GABAA receptor/Cl- channels that inhibits glycine receptor/Cl- channels only at higher concentrations. |
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