Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7525935 Farrington H, Mendelsohn F, Chan S, Reinlib L, Guggino SE: Strychnine-binding proteins in intestinal cells: novel brucine binding site with binding affinities for alkaloids. J Pharmacol Exp Ther. 1994 Nov;271(2):1074-9.

Agents that bind to cytochrome P450IID6 also displace [3H] strychnine binding, which implies that the binding site may have some properties similar to the catalytic site of this cytochrome P450 enzyme.
81(1,1,1,1) Details
7906730 Fujisaki H, Mise M, Ishii Y, Yamada H, Oguri K: Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase. J Pharmacol Exp Ther. 1994 Feb;268(2):1024-31.
81(1,1,1,1) Details
11334263 Takekawa K, Kitamura S, Sugihara K, Ohta S: Non-enzymatic reduction of aliphatic tertiary amine N-oxides mediated by the haem moiety of cytochrome P450. Xenobiotica. 2001 Jan;31(1):11-23.

4(0,0,0,4) Details
9285065 Takekawa K, Sugihara K, Kitamura S, Tatsumi K: Nonenzymatic reduction of brucine N-oxide by the heme group of cytochrome P450. Biochem Mol Biol Int. 1997 Aug;42(5):977-81.

3(0,0,0,3) Details