Protein Information

Name P19
Synonyms CDK inhibitor p19INK4D; P19; CDKN2D; Cell cycle inhibitor Nur77 associating protein; Cyclin dependent kinase 4 inhibitor 2D; Cyclin dependent kinase 4 inhibitor D p19; Cyclin dependent kinase inhibitor 2D p19 inhibits CDK4; Cyclin dependent kinase 4 inhibitor D…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
8719337 Magnuson DS, Morassutti DJ, McBurney MW, Marshall KC: Neurons derived from P19 embryonal carcinoma cells develop responses to excitatory and inhibitory neurotransmitters. Brain Res Dev Brain Res. 1995 Dec 21;90(1-2):141-50.

Responses to glycine were strychnine sensitive and also showed age-related changes from depolarizing to biphasic character.
7(0,0,0,7) Details
12154171 Mangin JM, Guyon A, Eugene D, Paupardin-Tritsch D, Legendre P: Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra. J Physiol. 2002 Aug 1;542(Pt 3):685-97.

In juvenile rats (P19-P22), both the GlyR main conductance state (46-55 pS) and the mean open time (6.8 ms) were decreased.
The application of 1 microM gabazine blocked spontaneous or evoked inhibitory synaptic current, while the addition of 1 microM strychnine had no effect, suggesting a lack of functional glycinergic synapses on DA neurones.
1(0,0,0,1) Details
9819238 Moore DR, Kotak VC, Sanes DH: Commissural and lemniscal synaptic input to the gerbil inferior colliculus. J Neurophysiol. 1998 Nov;80(5):2229-36.

Frontal midbrain slices were obtained from postnatal day (P) 9-P19 gerbils, and whole cell recordings were made under current- (n = 22) or voltage-clamp (n = 52) conditions.
Excitatory and inhibitory synaptic responses were characterized by sequentially exposing the slice to ionotropic glutamate receptor antagonists [6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) + aminophosphonpentanoic acid (AP-5), or kynurenic acid)], a gamma-aminobutryic acid type A receptor antagonist (bicuculline), and a glycine receptor antagonist (strychnine).
1(0,0,0,1) Details