| Name | amino acid transporter |
|---|---|
| Synonyms | Amino acid transporter variant; amino acid transporter; amino acid transporters |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17432963 | Rutter AR, Fradley RL, Garrett EM, Chapman KL, Lawrence JM, Rosahl TW, Patel S: Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci. 2007 Mar;25(6):1757-66. In the mammalian central nervous system, transporter-mediated reuptake may be critical for terminating the neurotransmitter action of at the strychnine insensitive site of the NMDA receptor. The Na (+) independent amino acid transporter -serine- transporter 1 (Asc-1) has been proposed to account for synaptosomal uptake by virtue of its high affinity for and widespread neuronal expression throughout the brain. |
1(0,0,0,1) | Details |
| 16973698 | Wersinger E, Schwab Y, Sahel JA, Rendon A, Pow DV, Picaud S, Roux MJ: The transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells. J Physiol. 2006 Nov 15;577(Pt 1):221-34. Epub 2006 Sep 14. In addition, excitatory amino acid transporters (EAAT) have a Cl (-) conductance which is gated by the joint binding of Na (+) and but thermodynamically uncoupled to the flux of In these later cells, application of on the axon terminal evoked a current that reversed at E (Cl), was insensitive to bicuculline, TPMPA, strychnine, dl-AP5, CNQX and MCPG, but blocked by the transporter inhibitor dl-tBOA. |
1(0,0,0,1) | Details |
| 15229213 | Wong KY, Adolph AR, Dowling JE: Retinal bipolar cell input mechanisms in giant danio. J Neurophysiol. 2005 Jan;93(1):84-93. Epub 2004 Jun 30. Picrotoxin, strychnine, and tetrodotoxin were used to isolate the effects of the analogs to the photoreceptor-bipolar cell synapse. Under photopic conditions, the group III metabotropic glutamate receptor (mGluR) antagonist (RS)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) only slightly reduced the b-wave, whereas the excitatory amino acid transporter (EAAT) blocker dl-threo-beta-benzyl-oxyaspartate (TBOA) removed most of it. |
1(0,0,0,1) | Details |
| 7694180 | Yadid G, Youdim MB, Zinder O: Uptake and receptor sites for in isolated bovine adrenal medulla chromaffin cells. Neuroscience. 1993 Aug;55(4):1147-52. These sites are inherently distinct since the effects of strychnine and temperature on binding are significantly different. The relative activity of the uptake inhibitors indicate that in the chromaffin cell, uptake is carried out by a System A amino acid transporter mechanism. |
1(0,0,0,1) | Details |
| 15758056 | Wong KY, Dowling JE: Retinal bipolar cell input mechanisms in giant danio. J Neurophysiol. 2005 Jul;94(1):265-72. Epub 2005 Mar 9. Specific agonists were puffed in the presence of picrotoxin, and strychnine to identify glutamate receptors on these cells. Most Cabs responded to both the alpha-amino-3--5-methyl-4-isoxazolepropionate (AMPA)/kainate receptor agonist kainate and the excitatory amino acid transporter (EAAT) substrate D- and both responses were localized to the dendrites. |
1(0,0,0,1) | Details |
| 15243140 | Schilling T, Eder C: A novel physiological mechanism of -induced immunomodulation: Na+-coupled amino acid transporter currents in cultured brain macrophages. J Physiol. 2004 Aug 15;559(Pt 1):35-40. Epub 2004 Jul 8. -evoked currents of brain macrophages were unaffected by strychnine, Cl (-)-free extracellular solution, N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl]) (NFPS) and amoxapine, but were abolished upon omission of extracellular Na (+). |
1(0,0,0,1) | Details |