| 11960677 |
Chen HH, Chan MH: Developmental lead exposure differentially alters the susceptibility to chemoconvulsants in rats. Toxicology. 2002 May 1;173(3):249-57.
Sprague-Dawley rats were exposed to lead (Pb) acetate (0.2% w/v) in drinking water from postnatal day (PN) 1 through PN 25 followed by discontinuing Pb exposure for 25 days.
Pb exposure significantly decreased pentylenetetrazol (PTZ)-, picrotoxin (PIC)-, and strychnine (STRY)-induced, but increased N-methyl-D-aspartate (NMDA) and 4-aminopyridine (4-AP)-induced convulsion thresholds at PN 25. |
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