| Name | GLYT1 |
|---|---|
| Synonyms | GLYT1; GLYT1; GLYT1A; GLYT1B; GLYT1C; GlyT 1; Glycine transporter 1B; Glycine transporter type 1 A… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7700536 | Luque JM, Nelson N, Richards JG: Cellular expression of transporter 2 messenger RNA exclusively in rat hindbrain and spinal cord. Neuroscience. 1995 Jan;64(2):525-35. The distribution of transporter 2 messenger RNA-containing cell bodies was very different to that of other transporter messenger RNAs transporter 1a and glycine transporter 1b), but similar to that of known -immunoreactive neurons and correlated very well with that of strychnine-sensitive glycine receptors in most CNS regions except cerebellum. |
31(0,1,1,1) | Details |
| 15031290 | Ju P, Aubrey KR, Vandenberg RJ: Zn2+ inhibits transport by transporter subtype 1b. J Biol Chem. 2004 May 28;279(22):22983-91. Epub 2004 Mar 18. In the central nervous system, is a co-agonist with at the subtype of glutamate receptors and also an agonist at inhibitory, strychnine-sensitive glycine receptors. The GLYT1 subtypes of transporters (GLYTs) are responsible for regulation of at excitatory synapses, whereas a combination of GLYT1 and GLYT2 subtypes of transporters are used at inhibitory glycinergic synapses. |
5(0,0,0,5) | Details |
| 15588724 | Raiteri L, Stigliani S, Siri A, Passalacqua M, Melloni E, Raiteri M, Bonanno G: taken up through GLYT1 and GLYT2 heterotransporters into glutamatergic axon terminals of mouse spinal cord elicits release of by homotransporter reversal and through anion channels. Biochem Pharmacol. 2005 Jan 1;69(1):159-68. effect was insensitive to strychnine or 5,7-dichlorokynurenic acid, but was prevented by the transporter blocker glycyldodecylamide. |
4(0,0,0,4) | Details |
| 15207356 | Whitehead KJ, Pearce SM, Walker G, Sundaram H, Hill D, Bowery NG: Positive N-methyl-D-aspartate receptor modulation by selective transporter-1 inhibition in the rat dorsal spinal cord in vivo. Neuroscience. 2004;126(2):381-90. In this study we have employed the selective transporter-1 (GlyT-1) and GlyT-2 transporter inhibitors R-(-)-N-methyl-N-[3-[(4-trifluoromethyl) phenoxy]-3-phenyl-propyl] (1:1) lithium salt (Org 24598) and 4-benzyloxy-3,5-dimethoxy-N-[1-(dimethylaminocyclopently) methyl] benzamide (Org 25543), respectively, and microdialysis perfusion to determine the effect of GlyT transporter inhibition on extracellular amino acid concentrations in the lumbar dorsal spinal cord of the halothane-anaesthetised rat. Co-administration by reverse dialysis of the selective -R channel blocker MK-801 (0.5 mM) or the selective antagonist of the strychnine-insensitive site, 7-chlorokynurenic acid (1 mM), with Org 24598 (10 microM) did not affect the uptake inhibition-induced increase in efflux, but did significantly attenuate the increase in extracellular |
4(0,0,0,4) | Details |
| 11259500 | Raiteri L, Raiteri M, Bonanno G: is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter J Neurochem. 2001 Mar;76(6):1823-32. concentration dependently elicited [(3) H] release which was insensitive to strychnine or 5,7-dichlorokynurenic acid, but was Na (+) dependent and sensitive to the uptake blocker glycyldodecylamide. |
3(0,0,0,3) | Details |
| 17462677 | Igartua I, Solis JM, Bustamante J: -induced long-term synaptic potentiation is mediated by the transporter GLYT1. Neuropharmacology. 2007 Jun;52(8):1586-95. Epub 2007 Mar 14. This LTP-GLY is independent of both strychnine-sensitive glycine receptors and nifedipine-sensitive channels. |
3(0,0,0,3) | Details |
| 9861038 | Bergeron R, Meyer TM, Coyle JT, Greene RW: Modulation of N-methyl-D-aspartate receptor function by transport. . Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15730-4. Data obtained from whole-cell patch-clamp recordings of hippocampal pyramidal neurons, in vitro, demonstrated that exogenous and transporter type 1 (GLYT1) antagonist selectively enhanced the amplitude of the component of a glutamatergic excitatory postsynaptic current. The effect was blocked by 2-amino-5-phosphonovaleric acid and 7-chloro- but not by strychnine. |
3(0,0,0,3) | Details |
| 17383967 | Vandenberg RJ, Shaddick K, Ju P: Molecular basis for substrate discrimination by transporters. J Biol Chem. 2007 May 11;282(19):14447-53. Epub 2007 Mar 23. is an inhibitory neurotransmitter in the spinal cord and brain stem, where it acts on strychnine-sensitive glycine receptors, and is also an excitatory neurotransmitter throughout the brain and spinal cord, where it acts on the family of receptors. There are two Na (+)/Cl (-)-dependent transporters, GLYT1 and GLYT2, which control extracellular concentrations and these transporters show differences in substrate selectivity and blocker sensitivity. |
2(0,0,0,2) | Details |
| 11396606 | Lopez-Corcuera B, Geerlings A, Aragon C: neurotransmitter transporters: an update. Mol Membr Biol. 2001 Jan-Mar;18(1):13-20. This action of is mediated by the strychnine-sensitive glycine receptor, whose activation produces inhibitory post-synaptic potentials. It is believed that the termination of the different synaptic actions of is produced by rapid re-uptake through two -and--coupled transporters, GLYT1 and GLYT2, located in the plasma membrane of glial cells or pre-synaptic terminals, respectively. |
1(0,0,0,1) | Details |
| 20173309 | Nishikawa Y, Sasaki A, Kuraishi Y: Blockade of transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain. J Pharmacol Sci. 2010 Mar 19;112(3):352-60. Epub 2010 Feb 20. is an inhibitory neurotransmitter in the spinal dorsal horn and its extracellular concentration is regulated by glial transporter (GlyT) 1 and neuronal GlyT2. Intrathecal ALX1393 suppressed dynamic allodynia induced by intrathecal strychnine and |
1(0,0,0,1) | Details |
| 10886333 | Belachew S, Malgrange B, Rigo JM, Rogister B, Leprince P, Hans G, Nguyen L, Moonen G: triggers an intracellular influx in oligodendrocyte progenitor cells which is mediated by the activation of both the ionotropic glycine receptor and Na+-dependent transporters. Eur J Neurosci. 2000 Jun;12(6):1924-30. -triggered Ca2+ influx in OP cells actually results from an initial depolarization that is the consequence of the activation of both the ionotropic glycine receptor (GlyR) and Na+-dependent transporters, most probably the transporters 1 (GLYT1) and/or 2 (GLYT2) which are colocalized in these cells. |
1(0,0,0,1) | Details |
| 7823028 | Jursky F, Tamura S, Tamura A, Mandiyan S, Nelson H, Nelson N: Structure, function and brain localization of neurotransmitter transporters. J Exp Biol. 1994 Nov;196:283-95. A correlation as observed between the pattern we obtained and that observed previously from strychnine binding studies. A genomic clone of two of the transporters (GLYT1a and GLYT1b) revealed that they derive from differential splicing of a single gene. |
1(0,0,0,1) | Details |
| 17970719 | Issberner JP, Sillar KT: The contribution of the NMDA receptor site to rhythm generation during fictive swimming in Xenopus laevis tadpoles. Eur J Neurosci. 2007 Nov;26(9):2556-64. Epub 2007 Oct 23. (100 microm), another endogenous agonist at this site, triggered similar effects to but only when applied in the presence of strychnine. Manipulations of endogenous levels using or ALX 5407 (inhibitors of the re-uptake protein, GlyT1b), produced similar effects to site agonists, including increased episode durations, and modulations in cycle period and burst amplitude. |
1(0,0,0,1) | Details |
| 18602930 | Perry KW, Falcone JF, Fell MJ, Ryder JW, Yu H, Love PL, Katner J, Gordon KD, Wade MR, Man T, Nomikos GG, Phebus LA, Cauvin AJ, Johnson KW, Jones CK, Hoffmann BJ, Sandusky GE, Walter MW, Porter WJ, Yang L, Merchant KM, Shannon HE, Svensson KA: Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. Epub 2008 Jun 17. In support of these findings, immuno-staining with pan-GlyT1 and GlyT1a antibodies showed a higher abundance of immunoreactivity in the brain stem/cerebellum as compared to the frontal cortical/hippocampal brain areas in four different species studied, including the mouse, rat, monkey and human. In addition, the inhibitory effects of ALX5407 on cerebellar levels of in the mouse could be reversed by the A receptor antagonist strychnine but not the B receptor antagonist L-701324. |
1(0,0,0,1) | Details |