| Name | slc6a5 |
|---|---|
| Synonyms | GLYT2; NET1; SLC6A5; GlyT 2; GlyT2; Sodium and chloride dependent glycine transporter 2; Solute carrier family 6 member 5; GlyT 2s… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15207356 | Whitehead KJ, Pearce SM, Walker G, Sundaram H, Hill D, Bowery NG: Positive N-methyl-D-aspartate receptor modulation by selective transporter-1 inhibition in the rat dorsal spinal cord in vivo. Neuroscience. 2004;126(2):381-90. In this study we have employed the selective transporter-1 (GlyT-1) and GlyT-2 transporter inhibitors R-(-)-N-methyl-N-[3-[(4-trifluoromethyl) phenoxy]-3-phenyl-propyl] (1:1) lithium salt (Org 24598) and 4-benzyloxy-3,5-dimethoxy-N-[1-(dimethylaminocyclopently) methyl] benzamide (Org 25543), respectively, and microdialysis perfusion to determine the effect of GlyT transporter inhibition on extracellular amino acid concentrations in the lumbar dorsal spinal cord of the halothane-anaesthetised rat. Co-administration by reverse dialysis of the selective -R channel blocker MK-801 (0.5 mM) or the selective antagonist of the strychnine-insensitive site, 7-chlorokynurenic acid (1 mM), with Org 24598 (10 microM) did not affect the uptake inhibition-induced increase in efflux, but did significantly attenuate the increase in extracellular |
1(0,0,0,1) | Details |
| 18815261 | Rousseau F, Aubrey KR, Supplisson S: The transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. J Neurosci. 2008 Sep 24;28(39):9755-68. The neuronal transporter GlyT2 is one of the critical presynaptic factors, because glycinergic transmission is impaired in knock-out GlyT2 (-/-) mice and mutations in the human GlyT2 gene slc6a5 are sufficient to cause hyperekplexia. |
1(0,0,0,1) | Details |
| 20173309 | Nishikawa Y, Sasaki A, Kuraishi Y: Blockade of transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain. J Pharmacol Sci. 2010 Mar 19;112(3):352-60. Epub 2010 Feb 20. Intrathecal ALX1393 suppressed dynamic allodynia induced by intrathecal strychnine and |
0(0,0,0,0) | Details |